Digital Commons Network^™

Repurposing Bt-11 To Treat Alzheimer’S Disease: Exploring The Glutathione-S-Transferase Lancl2 As A Target, Emily Birnbaum

Dissertations, Theses, and Capstone Projects

Approximately 99.6% of potential Alzheimer’s drugs fail, thus developing successful drugs is a high priority. The failure at developing successful drugs relates to the complex nature of the disease itself. Many components act together to trigger a cascade that ultimately results in neurodegeneration and cognitive dysfunction associated with the disease. In building a multiplex model of Alzheimer’s it is important to understand its specific biological mechanisms. One of these key pathological mechanisms is neuroinflammation. Understanding the pathways involved in neuroinflammation in Alzheimer’s is an urgent need, as it poses a promising avenue for future effective therapeutics. Specifically, as many investigational …

Loneliness And The Urban American (Non-)Romantic, Sarah C. Cook

Dissertations, Theses, and Capstone Projects

Loneliness, also known as ‘perceived social isolation,’ is an increasingly common feeling among Americans. It can be critically unhealthy when chronic, and recent revelations about its health effects have garnered a significant amount of media attention. Although statistical evidence tells us that marriage is the strongest defense against loneliness, over a third of Millennials and Gen-Zers say marriage is outdated; and census data shows that living alone is both one of the fastest-growing demographics in America, as well as a relatively stable housing arrangement. After examining existing research and media reports on loneliness itself in some depth, including factors that …

Variability In Associations Among Seabirds And Marine Mammals: Causes And Consequences, Samantha A. Monier

Dissertations, Theses, and Capstone Projects

Marine predators today face multifaceted stressors from changing climate to changing prey availability, and these changes are occurring at unprecedented speeds. Any alteration to a species’ environment has the potential to disrupt social networks and thus, how animals obtain and transfer information. Interspecific social interactions in the form of local enhancement and facilitation are a critical, but not yet well-understood, component of seabird foraging; of immediate concern is that anthropogenic changes may be altering the quantity and quality of positive species interactions, with consequences for the species involved.

While we know these interactions are not immutable, less is known about …

Active Galactic Nuclei - The Arrhythmic Beat Of A Galactic Heart, Henry James Best V

Dissertations, Theses, and Capstone Projects

Active Galactic Nuclei (AGN) are generally believed to be supermassive black holes (SMBHs) at the center of galaxies which are actively accreting material from the host galaxy. Through this process, they emit radiation across the electromagnetic spectrum both as a smooth continuum and emission lines. However, there is a great variety of the signals we observe–some faint, some bright, some variable and others steady. The wide array of signals produced by AGN is believed to encode both the geometry and the physics surrounding these SMBHs, making them a valuable target for understanding the high gravity limit, their feedback mechanisms to …

Development Of Collagen Mimetic Mini-Fibrils With Tunable Collagenase Susceptibility, Jui Chaugule

Dissertations, Theses, and Capstone Projects

Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid sequences, first form the rod-shaped collagen triple helix. These triple helices further self-assemble laterally in a specific manner to form fibrils having the characteristic 67 nm axially repeating structure known as the D-period. Enzymatic digestion of collagen fibrils by matrix metalloproteinases (MMPs) is critical for several physiological processes and is of particular consequence during wound healing. Many of the mechanisms of …

Future Land, Futures Lost: Planning The Crisis On The Louisiana Coast, Sheehan Moore

Dissertations, Theses, and Capstone Projects

South Louisiana is rapidly losing coastal land to the combined forces of subsidence, sea-level rise, and worsening storms, accelerated by the effects of flood control engineering and extractive industrial development. With erosion threatening homes and industry alike, the state has marshaled a response on a massive economic and geographic scale: its Coastal Master Plan recommends $50 billion in river sediment diversions, barrier island restoration, and other projects over fifty years. This dissertation is about the emergence of Louisiana’s coast as a place from this knot of human and environmental relations, as an object for governance and a container for political …

Establishing A Murine Model Of Malaria-Associated Acute Kidney Injury And Demonstrating The Contribution Of Extrinsic Apoptosis To Tubular Necrosis, Johanna Bensalel-Lyampe

Dissertations, Theses, and Capstone Projects

Malaria-associated acute kidney injury (MAKI) is a form of severe malaria (SM), which is usually caused by Plasmodium falciparum infection. Until recently, the impact of this particular complication of SM was severely underestimated and research in this area has been neglected. There is in fact a high prevalence (40-60%) of MAKI in SM patients and the associated risk of mortality and development of comorbidities is high. Furthermore, pediatric patients that recover often develop long-term complications such as chronic kidney disease or neurocognitive defects. The need for adjunctive therapies and early diagnostic biomarkers specific to this SM complication is critical but …

Living Color: Aesthetic Surfaces And Political Life In Brazil, Samuel E. Novacich

Dissertations, Theses, and Capstone Projects

This dissertation is about the manipulation of appearances – of both the human body and the built environment – in Rio de Janeiro, Brazil. Focused on Afro-aesthetic makeup and tanning practices as well as urban renewal projects, this ethnographic study reveals how the making over of both the skin and the urban landscape shape social inequalities and contribute to productions of race, gender, and national belonging. While some of the aesthetic technologies examined herein may be characterized as “bottom up” – or as the self-fashioning tactics of marginalized Afro-Brazilians – others constitute “top down” infrastructural interventions led by the state …

The Epigenetic Impact Of Dietary Choline On Growth Outcomes Of Children Exposed To Gestational Diabetes Mellitus, Ismail Kadam

Dissertations, Theses, and Capstone Projects

Maternal insulin resistance and hyperglycemia lead to gestational diabetes mellitus (GDM) which can cause fetal hyperinsulinemia, ultimately leading to excessive fetal growth associated with macrosomia and increased adiposity at birth. Increased placental macronutrient transport and epigenetic changes in growth and metabolic genes affected by GDM contribute to fetal overgrowth and can result in complications such as overweight/obesity, insulin resistance/type 2 diabetes, cardiovascular disease risk factors, as well as cognitive impairment later in life. Choline, an essential nutrient, participates in lipid and energy metabolism by providing methyl groups for DNA methylation and thus may overcome the hypomethylation of growth and metabolic …

Play In The Undercommons: The Transformative Power Of Fugitive Practice In A Multiracial, International Teacher Inquiry Collective, Kushya Sugarman

Dissertations, Theses, and Capstone Projects

Though scholars have begun to position youth’s fugitivity, refusal, and disengagement as logical responses to hostile environments, and as part of a larger legacy of Black speculative planning and action, most teachers do not. Elementary teachers, especially in urban contexts, notoriously struggle with “classroom management” and teachers across contexts cite behavior challenges, such as “disruptive” behavior, as the number one challenge facing our schools. In fact, up to 50% of novice teachers leave the profession in the first five years due to students’ behaviors. This dissertation interrogates the common trope of the wayward student who must be controlled. I consider …

Competitive And Noncompetitive Credit Assignment To Reward Cues In The Lateral Orbitofrontal Cortex, Mihwa Kang

Dissertations, Theses, and Capstone Projects

This dissertation investigates the mechanisms underlying variations in credit assignment to reward cues, with a focus on the lateral orbitofrontal cortex (lOFC). The lOFC has long been implicated in signaling reward expectancies, with controversy as to whether it signals the economic value of future outcomes, their sensory features to guide behavior or both. However, whether the lOFC signals the relative (competition-dependent) or absolute (contiguity-dependent) credit of cues is unknown. To address this, I employed a combination of novel behavioral assays, in-vivo electrophysiological recordings and optogenetic stimulation in rats. In Chapter 2, I tested the suitability of a self-initiating variant of …

Reviving Hysteria: The Nineteenth Century At The End Of The Twentieth, Christina Quintana

Dissertations, Theses, and Capstone Projects

This dissertation explores popular and medical representations of female madness in two time periods: the late nineteenth and late twentieth centuries. I argue that 1990s American culture produced an abundance of texts, images, and narratives that revitalized the iconography and medical discourses of late nineteenth-century hysteria. Analyzing popular texts, films, and cultural touchstones of the 1990s, I explore how Victorian ideas about women’s minds—such as the inherent feebleness of the female brain and nervous system; the fatalistic, life-altering effects of female puberty; the association between hysteria and deviant female sexuality; and the implicit racialization of hysteria and female madness more …

Brain Injury And Psychosocial Trauma: Outcomes Among Justice-Involved Individuals, Mahathi D. Kosuri

Dissertations, Theses, and Capstone Projects

Justice-involved individuals experience disproportionately high rates of both traumatic brain injuries (TBI) and psychosocial traumas. However, these traumas have yet to be conceptualized together, leaving a chasm of research on how they interact and influence this population. The current study was the first to measure the effects of TBIs as well as psychosocial trauma among justice-involved men, within the context of executive functioning, history of justice involvement, and recidivism. A sample of men (N=95) from a private correctional facility were given the Ohio State University Traumatic Brain Injury Questionnaire (OSU-TBI-ID), the Lifetime Stressor Checklist- Revised (LSC-R), along with …

Black Horror Film And The Role Of Mood In Race Perception, Nicholas P. Whittaker

Dissertations, Theses, and Capstone Projects

Contemporary discussions of black or antiracist art are often haunted by an air of pessimism. This pessimism rests on the intuition that art cannot change the political realities of antiblackness and/or our relationships with blackness. In this dissertation, I resist this hegemonic view by arguing that black horror films generate a particular, politically-valuable aesthetic experience. Specifically, they allow us to experience blackness and black people as unintelligible. This, I argue, runs counter to everyday experience of blackness; when blackness appears unintelligible, we lose the sense of satisfied comprehension that characterizes our everyday experiences of it. I argue that these films …

Ordinary Care: Affective Politics Of Migration And The Everyday Lives Of Syrian Refugees In Istanbul, Yasemin Ozer

Dissertations, Theses, and Capstone Projects

This dissertation makes two significant interventions into the literature on Syrian refugees in Turkey and the anthropology of migration and refugee studies more broadly. First, it focuses on the everyday lives of working-class urban refugees and argues that “ordinary care” is a crucial means by which they build sustainable and dignified lives while living in precarity in an often hostile environment in the aftermath of war and displacement. Ordinary care, as I theorize in this ethnography, includes sharing of resources, information, and advice as well as the formation of mutual relationships between kin, neighbors, and friends. Compared to the more …

"White Slaves Of California": Race, Religion, And The Railroad In Maria Amparo Ruiz De Burton's The Squatter And The Don, Katie Buonanno

Dissertations, Theses, and Capstone Projects

In The Squatter and the Don (1885), Maria Amparo Ruiz de Burton depicts the decline of the Alamars, a patrician Californio family, in the years after California was annexed by the United States. This thesis explores the different rhetorical maneuvers Ruiz de Burton makes to place the Californios in a broad, enfranchising Anglo-American national paradigm. The novel negotiates the messy, competing histories of Spanish, Mexican, and American colonialism, ultimately making the case for the enduring presence of Spanish missionization in the region, as well as the cultural assimilability of the Californio population. While the novel has frequently been read as …

Individual Differences In Wild Asian Elephant Behavior: Links Between Innovation And Responses To Novelty Across A Mosaic Landscape, Sarah L. Jacobson

Dissertations, Theses, and Capstone Projects

An animal’s responses to a novel or changing environment are influenced by a number of behavioral traits and cognitive abilities associated with flexible decision making. Animals also exhibit strong consistency in some behavioral responses, described as personality traits, which may influence their ability to adjust to environmental changes. It is important to investigate both flexibility and consistency in behavior, as well as how these two characteristics interact with each other, to understand the range of individual variation in behavior and decision making within a species. This knowledge can also help us understand how some species and individuals within a species …

The Crisis Of Market Society And The Fascist Solution In The Work Of Karl Polanyi, Nicholas E. Reynolds

Dissertations, Theses, and Capstone Projects

The revival of interest in the work of Karl Polanyi, which has generated valuable lines of inquiry across disciplines, has largely neglected Polanyi’s extensive writings on fascism. This dissertation argues that Karl Polanyi should be considered a theorist of fascism, one whose thinking revolves around the concept of a “fascist solution” arising as a consequence of a terminal deadlock of market society. This dissertation surveys two decades of Polanyi’s work to construct a full picture of his theory of fascism and its importance for his broader theorizing about the dynamics of capitalist societies. Polanyi makes at least three specific contributions …

Newly Synthesized Pyroglutamate Amide And Its Neuroprotective Effect Against Neurotoxicity Induced Cell Death In Alzheimer's Disease, Nourelhouda Joutey Elamrani

Dissertations, Theses, and Capstone Projects

The neurodegenerative disorder is an umbrella term for a range of conditions that affects the neurons in the human brain causing neuronal cell death. The common pathway is the excitotoxicity, a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity leading to the cell death. One of the most common neurodegenerative disorders is Alzheimer’s disease (AD), which represents 60 – 70% of cases and it ranked fourth cause of mortality in the USA. In Alzheimer’s disease, glutamate released from astrocytes and activates extrasynaptic N-methyl-D-aspartate …

Representation Without Taxation? A Historical Review Of Newfoundland And Labrador’S Municipal System And Quasi-Municipal Structures, Gregory French

Dalhousie Law Journal

Newfoundland and Labrador is unique among Canadian provinces in its municipallevel governmental structures, and in particular, its substantial lack thereof. The province does not have a system of counties or an operating form of regional government. Many areas of the province operate without a formal municipal government and avoid property taxation by operating on a limited fee-for-service model of local government, or in some cases a total lack of sub-provincial government. Tens of thousands of residents live within this tax-free model today. This paper explores how this anomalous situation came to be, the issues it creates in modern society and …

The Role Of Pornography In The "Rough Sex" Defence In Canada, Lise Gotell, Isabel Grant, Elizabeth Sheehy

Dalhousie Law Journal

Drawing upon the authors’ earlier research studying the consent defence when it is used to suggest that the complainant agreed to “rough sex” involving violence, this paper develops an extended analysis of the complex role of pornography in these decisions. This paper focuses on a subset of “rough sex” cases, where pornography played a role in “scripting” the accused’s behaviour. Thematically, these cases included: those where the accused had a substantial history of consumption of violent pornography; cases in which the accused forced the complainant to view pornography as part of the assault; cases where the accused recorded the attack, …

Assessment Of Novel Protein Ingredient Arthrospira Platensis And Soybean Genotype Amino Acid And Oil Selection Improvements On Broiler Performance For A 28-42 D Feeding Period, Savannah C. Wells-Crofton, Kenneth B. Nelson, Garrett J. Mullenix, Craig W. Maynard, Michael T. Kidd

Poultry Science Faculty Publications and Presentations

Two experiments were conducted to assess the efficiency of including the novel protein ingredient Arthrospira platensis or improved soybean meal in a broiler diet. The first experiment aimed to determine the feeding value of soybean meal produced from varieties of soybeans bred for increased amino acid content (SBAA) and improved oil content (SBO) compared to a conventional soybean variety in an ANOVA design fed to Cobb 500 female broilers for 28–42 d. The SBAA and SBO soybeans contained overall higher amino acid content and lower oligosaccharide content compared to the conventional soybean variety in addition to improved oil quality. The …

Research Note: Carcass Yield And Meat Quality In High- And Low-Water Efficient Broiler Lines Exposed To Heat Stress, Sara Orlowski, Elizabeth Greene, Kentu Lassiter, Travis Tabler, Walter Bottje, Sami Dridi

Poultry Science Faculty Publications and Presentations

Heat stress (HS) and water scarcity are significant challenges to sustainable poultry production worldwide. It is, therefore, critical to identify effective strategies to prevent, withstand, or adapt to these challenges. After four generations of divergent selection for water efficiency, the present study was undertaken to determine the effect of HS on meat quality and muscle myopathy incidences in high (HWE)- and low (LWE)-water efficient broilers. Day-old male chicks (240 chicks/line) were allotted randomly by line and body weight-matched groups to 12 controlled-environmental chambers (2 pens/chamber). At d29, birds were exposed to 2 environmental conditions …

Glycine, Serine, And Arginine Additions To Cobb 500 Female Broilers Fed Dietary Variations In Crude Protein, M. A. Anas, N.S.B.M. Atapattu, K. B. Nelson, S. W. Crafton, Michael T. Kidd

Poultry Science Faculty Publications and Presentations

This study investigated the effects of supplemental Gly, Ser, and Arg on growth performance, carcass traits, footpad dermatitis, and litter ammonia emission of broilers fed low-protein diets from 18 to 42 d of age. A total 576 one-day-old female Cobb 500 broilers were divided into 6 dietary treatments: 1) control, high CP (HCP 20%), 2) medium CP (MCP 18%), 3) low CP (LCP 16%), 4) LCP + 0.20% Gly+Ser, 5) LCP + 0.20% Arg, and 6) LCP + 0.20% Gly+Ser + 0.20% Arg. Although BW gain and feed intake were not affected by treatments, reducing CP to LCP (16% CP) …

Early 1,25-Dihydroxyvitamin D3-Glycosides Supplementation: An Efficient Feeding Strategy Against Bacterial Chondronecrosis With Osteomyelitis Lameness In Broilers Assessed By Using An Aerosol Transmission Model, Andi Asnayanti, Khawla Alharbi, Anh Dang Trieu Do, Layla Al-Mitib, Kathrin Buhler, Jan Dirk Van Der Klis, Javier Gonzalez, Michael T. Kidd, Adnan A. Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a leg disorder in broilers leading to huge economic losses, food safety concerns, and animal welfare issues in the poultry industry. The active metabolite of vitamin D₃, 1,25-dihydroxyvitamin D₃, plays pivotal roles in mineral homeostasis, bone health, and immune systems which are essential for protection against BCO. Thus, we hypothesized that supplementation with a Solanum glaucophyllum-derived source of 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃-glycosides) would be an effective measure to control lameness. Here, we report the optimum concentration of 1,25(OH)₂D₃-glycosides …

Advancements In Legged Walking Robots: Review, Zaineb Wared Matteb, Sadeq Hussein, Nabil Hassan Hadi

Iraqi Journal of Computers, Communications, Control and Systems Engineering

The purpose of this review is to contribute to the body ofknowledge surrounding legged walking robots, specifically those utilizingfour legs. It aims to inform researchers, engineers, and enthusiasts about theadvancements, potential applications, and future prospects of these robots,ultimately driving further research and development in this exciting field.The review covered the most recent research articles in the field of designingand manufacturing robots, as well as how to choose the mechanism ofactuator between hydraulic or electric systems and their impact on theweight increase and energy consumption, or potential noise generationduring the operation like Bigdog robot. The payload was also assessed, witha comparison …

Study On The Storage Stability And Rheological Property Of Bio-Oil/Lignin Composite-Modified Asphalt, Guixiu Guo, Junfeng Gao, Dongzhao Jin, Xuan Wang, Yanqiu Bi, Peng Guo

Michigan Tech Publications

The objective of this study is to investigate the storage stability and rheological property of bio-oil/lignin composite-modified asphalt. The composite-modified asphalt with different proportions of bio-oil was prepared and cured at 105 °C, 135 °C, and 165 °C for 24 h and 48 h. The storage stability of the composite-modified asphalt was evaluated based on the softening point difference, the storage stability index derived from rotational viscosity, the segregation rate based on temperature sweep, and the non-recoverable creep compliance measured through the Multiple Stress Creep Recovery test. The storage stability of bio-oil/lignin composite-modified asphalt was evaluated through testing and analysis …

Effects Of Increased Nitrate Intake From Beetroot Juice On Blood Markers Of Oxidative Stress And Inflammation In Older Adults With Hypertension, Rebeka Fejes, Nina Pilat, Martin Lutnik, Stefan Weisshaar, Anna M. Weijler, Karsten Krüger, Agnes Draxler, Laura Bragagna, Jonathan M. Peake, Richard J. Woodman, Kevin D. Croft, Catherine P. Bondonno, Jonathan M. Hodgson, Karl Heinz Wagner, Michael Wolzt, Oliver Neubauer

Research outputs 2022 to 2026

Background: Vascular oxidative stress and low-grade inflammation are important in the pathology of cardiovascular disorders, including hypertension. Cell culture and animal studies suggest that inorganic dietary nitrate may attenuate oxidative stress and inflammation through nitric oxide (NO), and there is a need to investigate whether this translates to humans. Aim: In this randomised, placebo-controlled crossover study, by measuring a combination of multiple blood biomarkers, we evaluated whether previously reported benefits of dietary nitrate translate to a reduced oxidative stress and an improved inflammation status in 15 men and women (age range: 56–71 years) with treated hypertension. Methods: We investigated the …

Lessons Learnt From Broad-Spectrum Coronavirus Antiviral Drug Discovery, Andrew A Bolinger, Jun Li, Xuping Xie, Hongmin Li, Jia Zhou

Faculty, Staff and Student Publications

Introduction: Highly pathogenic coronaviruses (CoVs), such as severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome CoV (MERS-CoV), and the most recent SARS-CoV-2 responsible for the COVID-19 pandemic, pose significant threats to human populations over the past two decades. These CoVs have caused a broad spectrum of clinical manifestations ranging from asymptomatic to severe distress syndromes (ARDS), resulting in high morbidity and mortality.

Areas covered: The accelerated advancements in antiviral drug discovery, spurred by the COVID-19 pandemic, have shed new light on the imperative to develop treatments effective against a broad spectrum of CoVs. This perspective discusses strategies and …

Early And Enduring: Targeting The Endothelium For Blood-Brain Barrier Protection, Silin Wu, Xuefang Sophie Ren, Yejie Shi

Faculty, Staff and Student Publications

The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.