Digital Commons Network^™

Harnessing Gold Nanomaterials For Advanced Multicolor Colorimetric Biosensors In Food Hazards Detection, Longyingzi Xie, Chenxi Guo, Lu Yang, Yue He

Journal of Food and Drug Analysis

Hazards such as pathogenic bacteria, mycotoxins, pesticides, antibiotics, heavy metal ions, etc., cause serious food safety problems worldwide due to their toxicity and frequent contamination. Rapid screening is an effective way for food safety control, which highly relies on the development of sensitive, specific, and convenient detection methods. The multicolor colorimetric biosensors based on gold nanomaterials have evolved into advanced tools for detecting various hazards in food, with intuitive readout. The excellent localized surface plasmon resonance (LSPR) properties of gold nanomaterials enable them to exhibit bright colors when used as chromophores. In addition, the small changes in the morphology of …

Functional Gold Nanoparticles For Analysis And Delivery Of Nucleic Acids, Po-Tsang Huang, Yen-Ling Chen, Yi-Hui Lin, Chun-Chi Wang, Huan-Tsung Chang

Journal of Food and Drug Analysis

Gold nanoparticles (AuNPs) have become the rising stars in the field of nanotechnology and made a revolution in exploiting the profundity of genomics due to their distinguished properties such as stability, ease in preparation and conjugation, biocompatibility, and unique optical properties. These characteristics have greatly expanded their applications such as sensitive and selective quantitation of nucleic acids and as effective carriers for specifically delivering various important molecules/biomolecules to various targets, which are the cornerstone in treating genetic disorders. This review comprehensively discusses the most recent progress in utilization of AuNPs in quantitation and delivery of nucleic acids. The future prospects …

Cgm-Induced Extracellular Trap Formation Augments Inflammation, Joseph Cavataio, Kenneth Wood B.S., Jean Gabriel De Souza Ph.D., Ulrike Klueh Ph.D.

Medical Student Research Symposium

Background and Aims: Subcutaneous continuous glucose monitoring (CGM) devices serve an important role in diabetes management but are prone to biofouling and ensuant device failure. CGM Implantation of CGM devices incites an inflammatory response with initial skin penetration. One specific response is NETosis, in which leukocytes, (e.g. neutrophils), release nuclear DNA to ensnare foreign antigens designated. This study aimed to determine the factors responsible for CGM-induced NETosis.

Methods: In vitro commercial Libre 2 glucose sensors were evaluated for their ability to induce NETosis. These studies utilized flow cytometry and time-lapse imaging, multiplex cytokine panel assessment, and scanning electron …

The War With The Squirrels, Tally Brennan

PoemMemoirStory (literary magazine)

pp. 111-121

Unfinished, Kim Aubry

PoemMemoirStory (literary magazine)

pp. 101-110

Cracking Open, Patricia Brieschke

PoemMemoirStory (literary magazine)

pp. 64-76

There Was Loneliness Before, Colette Jonopulos

PoemMemoirStory (literary magazine)

p. 27

Pms 7 (Complete Issue), Poemmemoirstory Staff

PoemMemoirStory (literary magazine)

No abstract provided.

Gesture-Driven Attribute Transfer For Visual Assets Using Generative Artificial Intelligence, Manasa Babu

Defensive Publications Series

This disclosure describes techniques that use generative artificial intelligence (gen-AI) to enable the rapid merging of visual assets using drag/pinch gestures to create an output visual that draws on individual attributes of the constituent visual assets. The techniques, effectively a design paradigm, enable non-technical users with little or no design skills to combine a reference visual (asset) with an original asset to create a new, merged asset. The techniques can accelerate productivity, reduce design time, increase design possibilities, increase decision-making speed, and democratize the design and management of visual assets. Example use cases include user interface design, photo editing, icon …

Surgical Treatment Of Intra-Abdominal Vaginal Cyst Severely Adhered To Associated Organs In A Dog, Nithida Boonwittaya, Anchisa Suvisit, Piraya Jaiyangyeun, Wallaya Phongphaew, Kasamapohn Hutachinda

The Thai Journal of Veterinary Medicine

A twelve-year-old female Shih Tzu was presented for investigation and treatment of a vaginal mass. Partial resection, intracavitary fluid drainage and mucosal lining curettage had been made in the previous laparotomy. Computed tomography (CT) and perioperative gross appearance revealed a large vaginal cyst extended into the pelvic canal that was adhering to the bladder trigone, both ureters, the urethra and the descending colon. The mass was resected completely. The dog recovered uneventfully. To the author’s knowledge, this is the first report of a canine intra-abdominal vaginal mass that was preoperatively evaluated using CT and the histological result was most consistent …

Treatment Strategies Of Biliary Stones Through Multiple Liver Lobectomy And Cholecystectomy In A Dog, Jae-Hwan Jung, Seoung-Yob Ahn, Mu-Young Kim, Hun-Young Yoon

The Thai Journal of Veterinary Medicine

A 12-year-old spayed female Maltese dog weighing 3 kg was referred to our Veterinary Medical Teaching Hospital for the evaluation of gallstones. The dog had a history of splenectomy and underlying Cushing’s syndrome and had received ursodeoxycholic acid for 2 months. The dog presented with clinical symptoms, including icterus, vomiting, anorexia, lethargy, and abdominal pain. Radiography, ultrasonography, and computed tomography revealed choleliths in the gallbladder, cystic duct, common bile duct, and the hepatic ducts of the quadrate, left medial, and left lateral lobes. In addition, we identified atrophy and cirrhosis of the corresponding lobes of the liver. The choleliths were …

Prediction Of Ehrlichia Canis And Babesia Canis In Canine Blood Sample By Mindray Bc-5000 Vet Hematology Analyzer, Sorawat Thongsahuan, Hansuk Buncherd, Supinya Thanapongpichat, Sataporn Noosong, Siriyaporn Choobunsong, Kanitta Srinoun

The Thai Journal of Veterinary Medicine

Tick-borne diseases caused by the Babesia canis (B. canis) and Ehrlichia canis (E. canis), have been increasing recently in clinical veterinary. In veterinary clinics, complete blood counts (CBCs) are commonly analyzed using automated flow cytometric analyzers like the Mindray BC-5000 Vet hematology analyzer. In this study, the predictive significance of the diagnostic blood parasites B. canis and E. canis obtained from hematological parameter were measured. Red blood cell (RBC) and platelet parameters firstly discriminated the canine blood parasites infection from those healthy dogs. The diagnostic performance of absolute number of monocytes between B. canis and E. …

Monorchidism With Ipsilateral Renal Agenesis In A Cat, Jinyoung Choi, Sungin Lee

The Thai Journal of Veterinary Medicine

A 1-year-old intact male ragdoll weighing 5.9 kg was presented for general wellness examination and castration. Upon physical examination, neither testes could be palpated in the scrotum. Blood test results (complete blood cell count, serum biochemistry and electrolyte analysis) showed no remarkable findings. Radiographic and ultrasound examination did not detect the right kidney and testis in the abdominal cavity. However, we were unable to visualize the right kidney and testis in the abdominal cavity. An exploratory laparotomy for cryptorchidism revealed that although the left testis was intact, there was no right kidney, ureter and ipsilateral testis in the abdominal cavity. …

2024-2025 Ursinus College Course Catalogue, Office Of The Registrar

Ursinus College Catalogues, 1869-Present

A digital copy of the 2024-2025 Ursinus College Catalog. It contains details of the curriculum, departmental requirements and courses of instruction as well as the Open Questions core requirements, experiential learning and the Common Intellectual Experience (CIE). Academic policies, special opportunities and scholarships, off-campus programs and graduation requirements are also outlined.

The Bison, September, 13, 2024

The Bison Newspapers

No abstract provided.

Designing Legal Writing Problems For The Nextgen-Eration, Jaclyn Celebrezze, Lauren E. Sancken, Carrie Sanford, Amanda K. Stephen, David Ziff

Presentations

No abstract provided.

Predicting Spatiotemporal Patterns Of Productivity And Grazing From Multispectral Data Using Neural Network Analysis Based On System Complexity, Amanda J. Ashworth, A. Avila, H. Smith, T. E. Winzeler, P. Owens, C. Flynn, P. O'Brien, D. Philipp, J. Su

Environmental Dynamics Faculty Publications and Presentations

Remote sensing tools, along with Global Navigation Satellite System cattle collars and digital soil maps, may help elucidate spatiotemporal relationships among soils, terrain, forages, and animals. However, standard computational procedures preclude systems-level evaluations across this continuum due to data inoperability and processing limitations. Deep learning, a subset of neural network, may elucidate efficiency of livestock production and linkages within the livestock-grazing environment. Consequently, we applied deep learning to environmental remote sensing data to (1) develop predictive models for yield and forage nutrition based on vegetation indices and (2) at a pixel-level (per 55 m²), identify how grazing is …

Impact And Characterization Of Serial Structural Variations Across Humans And Great Apes., Wolfram Höps, Tobias Rausch, Michael Jendrusch, Jan O Korbel, Fritz J Sedlazeck, Human Genome Structural Variation Consortium (Hgsvc), Christine R Beck, Charles Lee

Faculty Research 2024

Modern sequencing technology enables the systematic detection of complex structural variation (SV) across genomes. However, extensive DNA rearrangements arising through a series of mutations, a phenomenon we refer to as serial SV (sSV), remain underexplored, posing a challenge for SV discovery. Here, we present NAHRwhals ( https://github.com/WHops/NAHRwhals ), a method to infer repeat-mediated series of SVs in long-read genomic assemblies. Applying NAHRwhals to haplotype-resolved human genomes from 28 individuals reveals 37 sSV loci of various length and complexity. These sSVs explain otherwise cryptic variation in medically relevant regions such as the TPSAB1 gene, 8p23.1, 22q11 and Sotos syndrome regions. Comparisons …

Highly Accurate And Precise Determination Of Mouse Mass Using Computer Vision, Malachy Guzman, Brian Q Geuther, Gautam S Sabnis, Vivek Kumar

Faculty Research 2024

Changes in body mass are key indicators of health in humans and animals and are routinely monitored in animal husbandry and preclinical studies. In rodent studies, the current method of manually weighing the animal on a balance causes at least two issues. First, directly handling the animal induces stress, possibly confounding studies. Second, these data are static, limiting continuous assessment and obscuring rapid changes. A non-invasive, continuous method of monitoring animal mass would have utility in multiple biomedical research areas. We combine computer vision with statistical modeling to demonstrate the feasibility of deter- mining mouse body mass by using video …

Perceived Naturalness Biases Objective Behavior In Both Trivial And Meaningful Contexts, Brian P. Meier, Eric Noreen, Michael Fellman, Courtney Lappas, Li-Jun Ji

Psychology Faculty Publications

Research shows that perceived naturalness can bias beliefs about the positivity of items such as food, human talent, and vaccines. Yet, this research focuses on self-reports, which leaves open the implications it has for behavior. In four studies (N = 492), this research team tested if perceived naturalness impacts trivial and meaningful behaviors. Participants were asked to consume a purported natural/synthetic performance drink (Study 1), test a purported natural/synthetic drug that would be injected (Study 2), eat chocolate containing a purported natural/synthetic cocoa described as causing stomach discomfort (Study 3), or choose a sticker purportedly made with natural/synthetic ink …

2024-09-13 Minutes & Appendices, Longwood University

Board of Visitors Meeting Minutes 1964-

No abstract provided.

An Analytical Approach For Simulating Effects Of Avalanches On Mountain Goat Population Dynamics: Implications For Management And Conservation, Kevin White, Taal Levi, Eran Hood, Gabriel J. Wolken, Erich H. Peitzsch, Yves Bühler, Katreen Wikstrom Jones, Chris T. Darimont

Faculty, Staff, and Students

Mountain environments with snow avalanche hazard cover about 6% of Earth’s land area and occur on all continents. Whereas human risks associated with avalanche hazard have been widely studied, little is known about how avalanche activity affects population dynamics in mountain wildlife. Globally, 32 species of mountain ungulates across 70 countries occupy avalanche-prone terrain. Avalanches comprise the leading cause of mortality in coastal Alaskan mountain goats (mean = 36%, range = 23 - 65%, depending on area), and disproportionately remove prime-aged individuals from populations. The implications of such rates and patterns of mortality on population growth rate are likely to …

The Impact Of Hypertension On Clinical Outcomes In Moyamoya Disease: A Multicenter, Propensity Score-Matched Analysis, Basel Musmar, Joanna Roy, Hammam Abdalrazeq, Elias Atallah, Kareem El Naamani, Ching-Jen Chen, Roland Jabre, Hassan Saad, Jonathan Grossberg, Adam Dmytriw, Aman Patel, Mirhojjat Khorasanizadeh, Christopher Ogilvy, Ajith Thomas, Andre Monteiro, Adnan Siddiqui, Gustavo Cortez, Ricardo Hanel, Guilherme Porto, Alejandro Spiotta, Anthony Piscopo, David Hasan, Mohammad Ghorbani, Joshua Weinberg, Shahid Nimjee, Kimon Bekelis, Mohamed Salem, Jan-Karl Burkhardt, Akli Zetchi, Charles Matouk, Brian Howard, Rosalind Lai, Rose Du, Rawad Abbas, Georgios Sioutas, Abdelaziz Amllay, Alfredo Munoz, Nabeel Herial, Stavropoula Tjoumakaris, Michael Gooch, Robert Rosenwasswer, Pascal Jabbour

Department of Neurosurgery Faculty Papers

BACKGROUND: Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by progressive steno-occlusive changes in the internal carotid arteries, leading to an abnormal vascular network. Hypertension is prevalent among MMD patients, raising concerns about its impact on disease outcomes. This study aims to compare the clinical characteristics and outcomes of MMD patients with and without hypertension.

METHODS: We conducted a multicenter, retrospective study involving 598 MMD patients who underwent surgical revascularization across 13 academic institutions in North America. Patients were categorized into hypertensive (n=292) and non-hypertensive (n=306) cohorts. Propensity score matching (PSM) was performed to adjust for baseline differences.

RESULTS: …

Effect Of Cemented Vs Uncemented On Outcomes For Hemiarthroplasty In The Elderly: A Meta-Analysis Of Randomized Clinical Trials, Yuning Feng, Jun Wan, Haidong Deng, Lvlin Chen, Yangchun Xiao, Tiangui Li, Jialing He, Peng Wang, Weelic Chong, Yang Hai, Lu Jia, Yu Zhang

Department of Medical Oncology Faculty Papers

PURPOSE: In patients undergoing hemiarthroplasty in the elderly, the choice of the cemented method remains controversial. This meta-analysis was undertaken to compare the impact of cemented vs uncemented on outcomes for hemiarthroplasty in the elderly.

METHODS: This study included randomized controlled trials comparing the postoperative effects of cemented vs uncemented in patients with hemiarthroplasty. With no language restrictions, we searched Medline (Ovid), Embase (Ovid), Cochrane Central Register of Controlled Trials (Cochrane Collaboration), Clinical Trials.gov, the ISRCTN registry, as well as gray literature with no language restrictions from January 1966 to April 2023. Data were quantitatively summarized using a random-effects model. …

Comparison Of Multi-Parallel Quantitative Real-Time Pcrs Targeting Different Dna Regions And Detecting Soil-Transmitted Helminths In Stool, Marina Papaiakovou, Rubén O Cimino, Nils Pilotte, Julia Dunn, D Timothy J Littlewood, Steven A Williams, Alejandro J Krolewiecki, Rojelio Mejia

Faculty, Staff and Students Publications

BACKGROUND: Soil-transmitted helminths infect an estimated 18% of the world's population, causing a significant health burden. Microscopy has been the primary tool for diagnosing eggs from fecal samples, but its sensitivity drops in low-prevalence settings. Quantitative real-time polymerase chain reaction (qPCR) is slowly increasing in research and clinical settings. However, there is still no consensus on preferred qPCR targets.

METHODS: We aimed to compare soil-transmitted helminth (STH) DNA detection methods by testing naïve stool samples spiked with known quantities of STH eggs and larvae. DNA extracts from spiked samples were tested using independent quantitative realtime PCR (qPCR) assays targeting ribosomal …

Impact And Characterization Of Serial Structural Variations Across Humans And Great Apes, Wolfram Höps, Tobias Rausch, Michael Jendrusch, Jan O Korbel, Fritz J Sedlazeck

Faculty, Staff and Students Publications

Modern sequencing technology enables the systematic detection of complex structural variation (SV) across genomes. However, extensive DNA rearrangements arising through a series of mutations, a phenomenon we refer to as serial SV (sSV), remain underexplored, posing a challenge for SV discovery. Here, we present NAHRwhals ( https://github.com/WHops/NAHRwhals ), a method to infer repeat-mediated series of SVs in long-read genomic assemblies. Applying NAHRwhals to haplotype-resolved human genomes from 28 individuals reveals 37 sSV loci of various length and complexity. These sSVs explain otherwise cryptic variation in medically relevant regions such as the TPSAB1 gene, 8p23.1, 22q11 and Sotos syndrome regions. Comparisons …

Insights Into Past Extreme Environments Through Ancient Biomolecules, Ioana Nicoleta Meleg, Magdalena Năpăruş-Aljancic, Yuichi Naito, Hervé Bocherens, Axel Barlow

FRONTIERS UNBOUND: Exploring Extreme Environments

No abstract provided.

Breathe Easy: The Potential Of Vitamins As Adjunct Therapy In Asthma Management, Elena Dike, Alex Zuo

Research Colloquium

Asthma, a prevalent respiratory disease, imposes a heavy burden on patients and healthcare systems. This research poster reviews recent findings on the potential of Vitamins A, C and E as adjunct therapies in asthma management. Comprehensive searches in PubMed, the NIH and Google Scholar identify multiple relevant publications and articles. Key results indicate that Vitamin A reduces Th2/Th17 levels and ROS, protecting the airway epithelium; Vitamin C decreases inflammatory cells and increases cGMP levels, reducing airway hyper-reactivity; and Vitamin E reduces eosinophils, basophils and neutrophils while also reducing ROS. These findings suggest that increasing intake of these vitamins, under medical …

Characterization Of Peripheral Neuropathy In Hiv-1 Transgenic Rats, Jose Rios, Sophia Leslie, Mahmoud Youssef, Hiram Garcia, Justin Mills, Maria Sophia Malbas, Joshua Nwose, Briana Garcia, Zayd Ayas, Emmanuel Franco, Khalid Benamar

Research Colloquium

In 2021, an estimated 38.4 million people were living with Human immunodeficiency virus-1 (HIV). While the introduction of antiretroviral therapies (ART) has dramatically improved the length of survival of individuals, peripheral neuropathy still affects as many as 50% of HIV-infected individuals. The most frequently reported clinical manifestation of HIV-associated peripheral neuropathy is distal sensory polyneuropathy (HIV-DSP), and it is one of the most common neurologic complications of HIV in the combination antiretroviral therapies (cART) era. Despite these gaps in knowledge, no small animal model mimics peripheral neuropathy in PLWH, and the ART era is available. The main goal here is …

Microglia In Post-Mortem Hippocampal Brain Tissue Of Male And Female Neonates After Hie, Kassandra M. Pulido, Angela N. Viaene, Amelia J. Eisch, Danielle G. Barber

Research Colloquium

Background: Hypoxic-ischemic encephalopathy (HIE) is the second-leading cause of neonatal morbidity and mortality worldwide. There are sex differences in the pathophysiology of HIE, particularly in microglia, which are critical in the immune response. Prior work highlights microglial aggregation in the hippocampus of human infants as a marker for HIE, but it is unknown whether this differs by sex.

Aim: We compare the microglial response in post-mortem hippocampal tissue from male and female neonates diagnosed with HIE vs. Controls who expired from other causes.

Methods: Using a retrospective cohort design, we reviewed medical records of neonates with hippocampal tissue in the …