Digital Commons Network^™

Jibu Customer Carbon Savings In Rwanda, Lauren Kelley, Lia Kraaijvanger

Silicon Valley Sociological Review

Jibu Inc. is a social enterprise in Rwanda that addresses the essential service need for clean drinking water. The following report aims to understand Jibu’s potential for acquiring a carbon credit certification by investigating customers’ water treatment methods before becoming Jibu customers. Data was collected on Jibu customers by way of a quantitative survey that uncovered customer profiles and carbon savings. Our analysis reveals that before purchasing Jibu water, many current customers treated water at home using carbon-emitting practices such as boiling water with charcoal or gas. Jibu customers are now reducing carbon emissions since they are no longer boiling …

Potential Of Critical Mineral And Cytotoxicity Activity Of Gadolinium Complex As Anti-Amoebic Agent By Viability Studies And Flow Cytometry Techniques, Eny Kusrini, Fatimah Hashim, Azrina Aziz, Muhamad Fairus Noor Hassim, Anwar Usman, Lee D. Wilson, El-Sayed Negim, Agus Budi Prasetyo

AUIQ Complementary Biological System

The screening of lanthanide as a critical mineral and used as an anti-amoebic agent is important to identify the safest method and mode of cell death to eliminate this microorganism from the host. In this study, gadolinium ion (Gd³⁺) that complexed with a short acyclic triethylene glycol (EO3) and in the presence of picric acid (HPic) as counter anion for anti-amoebic activity was explored. The trivalent Gd³⁺ complexed with EO3 and HPic via one-pot synthesis reaction using a mole ratio of gadolinium nitrate salt, EO3 ligand and HPic in a mole ratio 1:3:4 to produce [Gd(Pic)_{2 …}

Ebenezer Tatum Church History, Ebenezer United Methodist Church, Tatum

Methodist Local Church Records

No abstract provided.

The Paradox Of Visibility: Anti-Blackness, Pathologization, And The Limitations Of Canadian Criminal Law, Danardo Sanjay Jones

PhD Dissertations

This dissertation offers a quadripartite analysis of the endemic nature of anti-Black racism within Canadian criminal law, contributing to the growing body of Canadian critical race theory (CRT) literature and advancing the field of race-conscious doctrinal work on Canadian criminal law. Each chapter engages the system along different axes: (a) the temporal, procedural axis – moving from policing to the trial process to criminal sentencing; (b) the micro to the macro axis, with chapters that range from an individual case study to an analysis of a small constellation of recent court decisions, to a more theoretical analysis of foundational theories …

Distracted Driving: Identification, Contributing Factors, And Safety Countermeasures, Ahmed Sajid Hasan

Theses and Dissertations

Distracted driving is a hazardous behavior responsible for 25% of all fatal traffic crashes in New Jersey. While traditional methods such as surveys, videos, and simulations have been used to identify and evaluate distracted driving events, these approaches primarily provide cross-sectional data that fails to capture the true rate of distraction on the road. This study addresses this limitation by collecting longitudinal data on distracted driving events across selected corridors in New Jersey. A data collection team continuously drove through these corridors, manually counting and video recording driver distraction events. The collected data was then analyzed to assess the significance …

Gad178.2 2d Asset Design For Games: Part 2, Sae University College

Exemplars

This submission acts as an exemplar for receiving a high distinction for GAD178 Project 2 at SAE University College

Animal Science News (September 24, 2024), Department Of Animal Science

Animal Science Newsletters

No abstract provided.

Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation, Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang

USF Patents

Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.

Burden Of Diabetes Mellitus In The Medically Underserved Rio Grande Valley, John M. Gaddis, Elias Arellano, Kassandra Pulido, Tyler Torres, Dominic Chau-Zanetti, Natasha N. Quailes, Andres Suarez Parraga

School of Medicine Publications

Introduction

Diabetes mellitus (DM) encompasses metabolic disorders characterized by elevated blood sugar. This study aimed to evaluate the prevalence and associated metrics of DM in the Rio Grande Valley (RGV), a low-income and medically underserved region in the United States, and compare these metrics to the national averages from 2012 to 2022.

Methods

A retrospective cross-sectional analysis was conducted using publicly accessible data from the Centers for Medicare and Medicaid Services (CMS). Metrics analyzed included DM prevalence, average principal cost, rates of emergency department visits, hospitalizations, screenings, and prevalence of obesity. Data from the RGV counties were compared to national …

Neuroprotective Effects Of Magnesium: Implications For Neuroinflammation And Cognitive Decline, Veer Patel, Nuraly S. Akimbekov, William B. Grant, Carolyn Dean, Xiaoqian Fang, Mohammed S. Razzaque

School of Medicine Publications

Neurodegenerative diseases, which are characterized by progressive neuronal loss and cognitive decline, are a significant concern for the aging population. Neuroinflammation, a shared characteristic of these diseases, is implicated in their pathogenesis. This article briefly summarizes the role of magnesium, an essential mineral involved in numerous enzymatic reactions and critical for neuronal bioactivity, in the context of neuroinflammation and cognitive decline. The potential neuroprotective effects of magnesium, including the mechanisms of neuroprotection by magnesium through maintaining neuronal ion homeostasis, reducing inflammation, and preventing excitotoxicity, are also described. Additionally, we discuss the impact of inadequate magnesium on neuroinflammation and its potential …

Conformational Ensembles In Klebsiella Pneumoniae Fimh Impact Uropathogenesis, Edward D B Lopatto, Jerome S Pinkner, Denise A Sanick, Robert F Potter, Lily X Liu, Jesús Bazán Villicaña, Kevin O Tamadonfar, Yijun Ye, Maxwell I Zimmerman, Nathaniel C Gualberto, Karen W Dodson, James W Janetka, David A Hunstad, Scott J Hultgren

2020-Current year OA Pubs

No abstract provided.

Spatiotemporal Relationships Between Neuronal, Metabolic, And Hemodynamic Signals In The Awake And Anesthetized Mouse Brain, Xiaodan Wang, Jonah A Padawer-Curry, Annie R Bice, Byungchan Kim, Zachary P Rosenthal, Jin-Moo Lee, Manu S Goyal, Shannon L Macauley, Adam Q Bauer

2020-Current year OA Pubs

Neurovascular coupling (NVC) and neurometabolic coupling (NMC) provide the basis for functional magnetic resonance imaging and positron emission tomography to map brain neurophysiology. While increases in neuronal activity are often accompanied by increases in blood oxygen delivery and oxidative metabolism, these observations are not the rule. This decoupling is important when interpreting brain network organization (e.g., resting-state functional connectivity [RSFC]) because it is unclear whether changes in NMC/NVC affect RSFC measures. We leverage wide-field optical imaging in Thy1-jRGECO1a mice to map cortical calcium activity in pyramidal neurons, flavoprotein autofluorescence (representing oxidative metabolism), and hemodynamic activity during wake and ketamine/xylazine anesthesia. …

Cd103+ Cdc1 Dendritic Cell Vaccine Therapy For Osteosarcoma Lung Metastases, Yuanzheng Yang, Yifan Zhou, Jian Wang, You Zhou, Stephanie S Watowich, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: We generated a CD103+DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response. Methods: A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction. K7M3 cells were injected into mice bilaterally. Right-sided tumors received PBS (control) or cDCV. Left-sided tumors were untreated. Tumor growth was compared between the vaccine-treated and untreated tumor on the contralateral side and compared to the control group. The immune cell profiles of the tumors, and tumor-draining lymph nodes (TdLNs) and spleen were evaluated. …

Immunity And Protective Efficacy Of A Plant-Based Tobacco Mosaic Virus-Like Nanoparticle Vaccine Against Influenza A Virus In Mice, Adthakorn Madapong, Erika M. Petro-Turnquist, Richard J. Webby, Allison A. Mccormick, Eric A. Weaver

School of Biological Sciences: Faculty Publications

Background: The rapid production of influenza vaccines is crucial to meet increasing pandemic response demands. Here, we developed plant-made vaccines comprising centralized consensus influenza hemagglutinin (HA-con) proteins (H1 and H3 subtypes) conjugated to a modified plant virus, tobacco mosaic virus (TMV) nanoparticle (TMV-HA-con). Methods: We compared immune responses and protective efficacy against historical H1 or H3 influenza A virus infections among TMV-HA-con, HA-con protein combined with AddaVax™ adjuvant, and whole-inactivated virus vaccine (Fluzone®). Results: Immunogenicity studies demonstrated robust IgG, IgM, and IgA responses in the TMV-HA-con and HA-con protein vaccinated groups, with relatively low induction of interferon (IFN)-γ⁺ T-cell …

Cd8Α Structural Domains Enhance Gucy2c Car-T Cell Efficacy, Trevor R. Baybutt, Ariana A. Entezari, Adi Caspi, Ross E. Staudt, Robert D. Carlson, Scott A. Waldman, Adam E. Snook

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite success in treating some hematological malignancies, CAR-T cells have not yet produced similar outcomes in solid tumors due, in part, to the tumor microenvironment, poor persistence, and a paucity of suitable target antigens. Importantly, the impact of the CAR components on these challenges remains focused on the intracellular signaling and antigen-binding domains. In contrast, the flexible hinge and transmembrane domains have been commoditized and are the least studied components of the CAR. Here, we compared the hinge and transmembrane domains derived from either the CD8ɑ or CD28 molecule in identical GUCY2C-targeted third-generation designs for colorectal cancer. While these structural …

In Vivo Crispr Screens Identify Mga As An Immunotherapy Target In Triple-Negative Breast Cancer, Xu Feng, Chang Yang, Yuanjian Huang, Dan Su, Chao Wang, Lori Lyn Wilson, Ling Yin, Mengfan Tang, Siting Li, Zhen Chen, Dandan Zhu, Shimin Wang, Shengzhe Zhang, Jie Zhang, Huimin Zhang, Litong Nie, Min Huang, Jae-Il Park, Traver Hart, Dadi Jiang, Kuirong Jiang, Junjie Chen

Faculty, Staff and Student Publications

Understanding the mechanisms underlying immune evasion is crucial for developing novel anticancer modalities. To systematically uncover tumor-intrinsic genetic modulators involved in immune escape in tumor microenvironment, we performed genome-scale in vivo CRISPR screens in two syngeneic models and later expanded up to seven syngeneic models with a focused validation library. These data help us better understand tumor immune evasion and pave the way for developing effective therapeutics. Importantly, we uncovered that Mga depletion elicited an antitumor immune response and inhibited tumor growth in triple-negative breast cancer. Our findings suggest that Mga may play a role in modulating the tumor immune …

Stimulation Of An Entorhinal-Hippocampal Extinction Circuit Facilitates Fear Extinction In A Post-Traumatic Stress Disorder Model, Ze-Jie Lin, Xue Gu, Wan-Kun Gong, Mo Wang, Yan-Jiao Wu, Qi Wang, Xin-Rong Wu, Xin-Yu Zhao, Michael X Zhu, Lu-Yang Wang, Quanying Liu, Ti-Fei Yuan, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Effective psychotherapy of post-traumatic stress disorder (PTSD) remains challenging owing to the fragile nature of fear extinction, for which the ventral hippocampal CA1 (vCA1) region is considered as a central hub. However, neither the core pathway nor the cellular mechanisms involved in implementing extinction are known. Here, we unveil a direct pathway, where layer 2a fan cells in the lateral entorhinal cortex (LEC) target parvalbumin-expressing interneurons (PV-INs) in the vCA1 region to propel low-gamma-band synchronization of the LEC-vCA1 activity during extinction learning. Bidirectional manipulations of either hippocampal PV-INs or LEC fan cells sufficed for fear extinction. Gamma entrainment of vCA1 …

Rapidly Evaluating Species At Risk Using Endemic Plants Of Kosrae, Federated States Of Micronesia, Wayne Law, Megan Chellew, Kenneth R. Wood, David H. Lorence, Carlos Cianchini, Jacob Sanney

Faculty and Staff Publications & Presentations

The International Union for Conservation of Nature (IUCN)'s Red List of Threatened Species is regarded as the primary source of global extinction risk for species. Despite this importance, the IUCN has assessed less than 20% of the world′s estimated 400,000 flowering plants due to issues like insufficient data or a lack of experts. Thousands of conservation status assessments were generated recently in response to the call to action by the revised Target 2 of the Global Strategy for Plant Conservation (GSPC), “An assessment of the conservation status of all known plant species, as far as possible, to guide conservation action.” …

The Trim4 E3 Ubiquitin Ligase Degrades Tpl2 And Is Modulated By Oncogenic Kras, Sapana Bansod, Paarth B Dodhiawala, Yutong Geng, Ashenafi Bulle, Peng Liu, Lin Li, Reid Townsend, Patrick M Grierson, Jason M Held, Hema Adhikari, Kian-Huat Lim

2020-Current year OA Pubs

Loss-of-function mutations in the C terminus of TPL2 kinase promote oncogenesis by impeding its proteasomal degradation, leading to sustained protein expression. However, the degradation mechanism for TPL2 has remained elusive. Through proximity-dependent biotin identification (BioID), we uncovered tripartite motif-containing 4 (TRIM4) as the E3 ligase that binds and degrades TPL2 by polyubiquitination of lysines 415 and 439. The naturally occurring TPL2 mutants R442H and E188K exhibit impaired TRIM4 binding, enhancing their stability. We further discovered that TRIM4 itself is stabilized by another E3 ligase, TRIM21, which in turn is regulated by KRAS. Mutant KRAS recruits RNF185 to degrade TRIM21 and …

Olfactory Deficit And Gastrointestinal Dysfunction Precede Motor Abnormalities In Alpha-Synuclein G51d Knock-In Mice, Youngdoo Kim, Joseph Mcinnes, Jiyoen Kim, Yan Hong Wei Liang, Surabi Veeraragavan, Alexandra Rae Garza, Benjamin David Webst Belfort, Benjamin Arenkiel, Rodney Samaco, Huda Yahya Zoghbi

Faculty, Staff and Students Publications

Many Parkinson’s disease (PD) models overexpress α-Synuclein using heterologous promoters, which is adequate to demonstrate that excessive α-Synuclein is toxic but not ideal for learning the precise ontogeny of the disease pathogenesis, specifically where the disease starts and how it progresses. To answer these questions, it is beneficial to generate a mouse model expressing a disease-causing mutation under the endogenous promoter. Here, we generated three Snca knock-in mice. Among them, homozygous Snca^G51D mice develop motor deficits by 9 mo of age. These mice exhibit olfactory and gastrointestinal abnormalities by 6 mo. They lose dopaminergic neurons and have reduced dopamine …

Vol. 22, No. 9 - Whole No. 64, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 22, No. 5 - Whole No. 60, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 22, No. 4 - Whole No. 59, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 22, No. 3 - Whole No. 58, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 22, No. 1 - Whole No. 56, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Development Of Intensive Grassland Systems: From Science To Practice, D G. Mccall, G W. Sheath

IGC Proceedings (1977-2023)

Level of nnimal production from grassland is determined by the amount of pasture grown, pasture utilisation and animal conversion efficiency. The key components affecting production are pasture growth and animal conversion efficiency. These arc mainly influenced by environment, genetics and through inputs to maintain soil fertility or animal health. Systems development aims to link pasture growth and animal conversion through efficient strategies for pasture utilisation. The means of influencing pasture utilisation is through adjustments to animal feed demand, feed supply or grazing management. Stock policies that adjust the pattern and level of feed demand are of greatest significance in developing …

The Ecology Of Grazing Management, R K. Heitschmidt

IGC Proceedings (1977-2023)

The broad objective of this paper is to review the fundamental principles of grazing management as a means of assessing the inherent value of intensive and extensive grazing systems. Conceptual analyses of intensive and extensive grazing systems reveal that the fundamental differences between intensive and extensive grazing systems are related to differences in non-grazing rather than grazing tactics. Intensive grazing systems employ a wide array of non-grazing tactics in an attempt to overcome the inherent ecological constraints that limit secondary (i.e., livestock) productivity in extensively grazed systems. Moreover, analyses of the ecological or true efficiency of various agricultural production systems …

Intensive Grazing Of Alfalfa By Beef Steers, M Rasnake, W R. Burris, G D. Lacefield, J Randolph, N Gay, L Davis

IGC Proceedings (1977-2023)

In the temperate region of North America, high temperature and moisture deficit cause low forage growth during the summer of most years, making it difficult to grow beef (Bos taurus), calves through summer grazing. Alfalfa (Medicago sativa), offers some potential to provide high dry matter production during summer if an effective system of grazing can be developed. The objective of this study was to test a system of intensive grazing of beef steers on alfalfa to maximise live-weight gains/ha and maintain plant population. Alfalfa was no-till seeded into a 6.5 ha field in autumn 1988 after …

Use Of Brassica Forage Crops To Extend The Grazing Season In The North-East Usa, G A. Jung, H W. Harpster, M G. Lambert, K T. Leath, R A. Byers

IGC Proceedings (1977-2023)

Forage turnip (Brassica rapa L,) can be made available for animal utilisation in late summer or In late autumn-early winter, when cool­season grass pastures have a low animal carrying capacity. field trials were conducted to identify and quantify factors that influence turnip yield in December or January and to determine whether these factors affect turnip cultivars similarly. Different levels of production in late autumn-winter were attributed to summer drought, foliar diseases, freezing temperatures and rate of leaf senescence. In all instances, the effects of these factors varied with turnip cultivar. However, cultivar ranking generally was the same whether mean …

Interactions Of Rotational And Continuous Grazing With Stocking Rate On Warm And Cool-Season Pastures, David I. Bransby

IGC Proceedings (1977-2023)

With more intense commercialisation of electric fencing many production and economic advantages have been claimed for rotational grazing compared with continuous grazing. However, very little research data are available from the south-eastern USA to verify these claims, Therefore, the objective of this study was to evaluate animal performance under conditions of continuous and IO-paddock rotational grazing on cool- and warm-season pastures commonly used in this region. Three 2-year grazing experiments were conducted, one each on a mixed rye-annual ryegrass (Secale cereale-Lolium multiflorum) pasture, Coastal bermudagrass ( Cynodon hybrid) and Pensacola bahiagrass (Paspalum notatum). In each experiment continuous …