Digital Commons Network^™

Ang Dalumat At Parikala Ng “Liwanag” At “Dilim” Sa Loob At Labas Ng Lente Ng Kamera (The Concepts And Paradoxes Of “Liwanag” And “Dilim” Within And Beyond The Camera Lens), Jay Jomar F. Quintos

Akda: The Asian Journal of Literature, Culture, Performance

Sinisiyasat ng sanaysay na ito ang dalumat at parikala na nakapaloob sa “liwanag” at “dilim” sa imahinasyong pangkultura sa Pilipinas. Sa ganang ito, tinutukoy ko ang iba’t ibang balon ng sanggunian tulad ng epiko, pasyon, materyal na pangrebolusyon, at pelikulang katatakutan upang matunton kung papaano nabago ang kayarian ng mga elemento ng “liwanag” at “dilim.” Susuriin ko ang anim na episodyo mula sa serye ng pelikulang katatakutang Shake, Rattle, and Roll na tahasang naghahayag ng “liwanag” at “dilim” sa paraan nito ng pag-iilaw at pagsasalaysay. Sa ganitong konteksto ng pagsusuri maaaring makita ang mariing artikulasyon at pag-unawa sa kung minsa’y …

Sukrita’S Yellow: A Kaleidoscope Of Timeless Poemlets, Girija Sharma

Akda: The Asian Journal of Literature, Culture, Performance

No abstract provided.

Redbird Scholar, Vol. 10, No. 1 (Fall 2024), Illinois State University, Office Of The Vice President For Research And Graduate Studies

Redbird Scholar

No abstract provided.

Shocking Sentences, John B. Meixner Jr.

Scholarly Works

Harsh recidivist sentencing penalties, like three-strikes laws, have been criticized heavily among both academics and practitioners on a number of different grounds. Most arguments focus on how sentences arising from these penalties are disproportionate—that there is no sensible relationship between the wrong committed and the sentence imposed. Those critiques are valid, but there’s another important problem with recidivist sentencing penalties that has been overlooked: they lead to sentences that are totally unexpected—indeed, shocking—to the defendants who face them. Many recidivist sentencing penalties cause large leaps in sentencing exposure that amount to exponential growth when compared with a defendant’s prior sentences. …

Fall 2024, John M. Pfau Library

Peacock – John M. Pfau Library Newsletter

In this issue:

• Rising Above the Flood: The Library Commons p.1-2
• The Fantasy and Science Fiction Book Cafe Saga p. 6
• Great Horned Owls and the Pfau Library p. 8 - 9

Understanding Bicuspid Aortic Valve: Global Prevalence, Genetic Factors, Long- Term Outcomes, Treatment Approaches And Knowledge Gaps, Grace Sligh

Honors Projects

Bicuspid aortic valve (BAV) disease is the most common congenital heart condition in the world, with a prevalence of 0.5 to 2.0 %, with the highest predominance in Caucasian men. This disease causes two leaflets to form instead of the typical three leaflet and can lead to many complications. This paper explores the global prevalence of BAV, highlighting observed variations between ethnicities and geographical background. It also examines the genetic factors contributing to the condition, including known hereditary patterns and emerging genetic insights. This review also addresses risk factors associated with BAV, such as environmental and developmental influences, as well …

Nh 4-H Youth Enrollment Paper Form, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Sample Lesson Of Maple Tales, Sarah Grosvenor

UNH Cooperative Extension

No abstract provided.

Feral Camel, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

No abstract provided.

Feral Donkey, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

Donkeys (Equus asinus) were first imported in substantial numbers to Australia in 1866 by Sir Thomas Elder. They were used as pack and draught animals in outlying areas of Western Australia (WA) until the 1930s. They were eventually replaced by the motor vehicle, and unwanted donkeys were released to the wild, where they became feral. The first record of feral donkeys is from the Kimberley in the early 1930s, but it is possible they became feral much earlier.

Blackbird, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

The introduced common blackbird (Turdus merula) is a pest in eastern Australia. It damages commercial fruit crops and may compete with native birds. The species is prohibited in Western Australia and individuals found here are destroyed.

The Western Australian Organism List (WAOL) contains information on the area(s) in which this pest is declared and the control and keeping categories to which it has been assigned in Western Australia (WA). For more information, see our website at dpird.wa.gov.au.

Feral Goat, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

The goat (Capra hircus) was one of the first animals to be domesticated, 8 to 10 thousand years ago. Archaeological work indicates the earliest attempts at domestication were in dry hills surrounding the Mediterranean basin. The ability of goats to utilise the coarse browse of mountainous areas made them suitable for domestication, in preference to sheep. With large-scale domestication of goats throughout the world, goats escaped and established feral goat herds on most continents. Overgrazing by goats has caused severe environmental damage, worldwide.

Goats arrived in Australia with the first fleet. They were introduced to many areas by early settlers …

Rabbit Control: 1080 Versus Pindone, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity factsheets

There are two toxins available for controlling pest rabbits in Western Australia: 1080 and pindone. This factsheet provides a brief summary of the main characteristics of both vertebrate pesticides. 1080 is generally the preferred toxin for rabbit control in Western Australia (WA).

Any attempt to reduce the impact of rabbits on the productivity of any agricultural enterprise (for example, pasture, crops, tree farms, horticulture) should be undertaken as part of a pest management plan.

This strategy should be proactive rather than reactive to a problem. It should also include a long term strategy for dealing with potential rabbit damage, including …

Privacy Law’S Role In An Information Economy, Sari Mazzurco

Cardozo Law Review

What do we lose when we lose our privacy? A slew of recently enacted state laws suggest that the loss of privacy is merely a loss of individual choice in the market exchange of services for personal information. This Article argues that a loss of privacy risks something greater: the collapse of complex and fluid social identity. Without privacy, individuals cannot nurture their own senses of self because they are no longer free to try on different social roles across diverse relationships. Pervasive, private data collection threatens multifaceted selfhood by eliminating the boundaries that make social roles distinct and hindering …

Theistic Illiberal Constitutionalism: A Review Of Adrian Vermeule’S Common Good Constitutionalism, Kyron J. Huigens

Articles

Adrian Vermeule’s Common Good Constitutionalism drew a remarkable amount of attention from constitutional law scholars when it was published in 2020. About eighteen months later, Vermeule published a piece complaining that the critics had missed the point, that they had ignored the natural law jurisprudence that grounds the work. He was correct. This Review addresses Vermeule’s natural law jurisprudence, emphasizing the fact that it is a religious natural law jurisprudence. His arguments are in the tradition of ScholasticismAristotelian logic incorporated into Christian theology by St. Thomas Aquinas. Scholasticism is a remarkably weak foundation for constitutional jurisprudence. It is a vast …

The Promise And Perils Of Smart (City) Bots As Educational Tools, Thomas Menkhoff, Siew Ning Kan, Shaohui Foong

Research Collection Lee Kong Chian School Of Business

Written from an educator’s perspective, the paper aims to examine the increasing use of chatbot technology capable of answering user queries in various fields such as commerce, public service delivery, urban areas, higher education etc. by simulating human conversation through text messages or voice commands. We analyse why smart bots have become popular technologies in the context smart cities; shed light on different types of bots (chatbots, large language models such as ChatGPT, flying bots); and explain how we use bots as teaching tool in an introductory AI for business course. A key argument putting forward is that smart bots …

Green Utopias: A Possible Green Ground For Performing Arts Training, Renee Newman, Alexa Taylor, Luke Cowling, Jason Garbenis, Tom Heath, Fleur Kingsland, Vahri Mckenzie, Jeremy Neideck, Richard Reddrop, Simon Stewart

Research outputs 2022 to 2026

No abstract provided.

Pkmyt1 Is A Marker Of Treatment Response And A Therapeutic Target For Cdk4/6 Inhibitor-Resistance In Er+ Breast Cancer, Anran Chen, Beom-Jun Kim, Aparna Mitra, Craig T Vollert, Jonathan T Lei, Diana Fandino, Meenakshi Anurag, Matthew V Holt, Xuxu Gou, Jacob B Pilcher, Matthew P Goetz, Donald W Northfelt, Susan G Hilsenbeck, C Gary Marshall, Marc L Hyer, Robert Papp, Shou-Yun Yin, Carmine De Angelis, Rachel Schiff, Suzanne A W Fuqua, Cynthia X Ma, Charles E Foulds, Matthew J Ellis

Faculty, Staff and Students Publications

Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER+) breast cancer, however drug resistance is common. In this study, proteogenomic analyses of patient-derived xenografts (PDXs) from patients with 22 ER+ breast cancer demonstrated that protein kinase, membrane-associated tyrosine/threonine one (PKMYT1), a WEE1 homolog, is estradiol (E2) regulated in E2-dependent PDXs and constitutively expressed when growth is E2-independent. In clinical samples, high PKMYT1 mRNA levels associated with resistance to both ET and CDK4/6 inhibition. The PKMYT1 inhibitor lunresertib (RP-6306) with gemcitabine selectively and synergistically reduced the viability of ET and palbociclib-resistant ER+ breast …

Tracking Implementation Of Shark-Related Measures And Actions In The Mediterranean Region In The Context Of International Law, Jason Lowther, Lydia Koehler

School of Law, Humanities and Social Sciences

We present national implementation progress on international and regional legal obligations up to 2020 and discuss recent developments in shark conservation management in the region. This study provides insights into the complexity of implemented measures and actions related to shark conservation and fisheries management, governed by various legal instruments. Measures were primarily identified through regional fisheries management organisations (RFMO) reports, reports of Focal Point meetings under the Barcelona Convention, and national reports under the Convention on Biological Diversity (CBD) and the Convention on Migratory Species (CMS). A total of 208 implemented measures across different categories were found. The most common …

Exploring Children’S Attitudes Towards Digital Good/Bad Through Hybrid Arts Practices. Final Project Report., Dylan Yamada-Rice, John Potter, Steve Love, Eleanor Dare, Angus Main, Richard Nash

School of Art, Design and Architecture

This report shares the findings of a project funded by the Economic and Social Research Council’s (ESRC) Digital Good Network that sought to explore children’s attitudes towards notions of digital good and conversely digital bad through hybrid arts practice. The project built on our previous work that has centred on one or more emerging technologies, exploring what this might mean in terms of children’s entertainment, play, education and/or health. To tie in with the wider Network’s provocation about whether a digital good society is possible and if so what it would look like, we connected our ideas to a project …

Global Presence And Penetrance Of, Jaroslaw Dulski, Matthew Baker, Samantha A Banks, Michael Bayat, Rose Bruffaerts, Gabriela Ortiz Cruz, Caio C Disserol, Kristen S Fisher, Jainy N Jose, Bernadette Kalman, Orhun H Kantarci, Dmytro Maltsev, Catherine Middleton, Gabriela Novotni, Dijana Plaseska-Karanfilska, Salmo Raskin, Josiane Souza, Helio A Teive, Zbigniew K Wszolek

Faculty, Staff and Students Publications

Objectives: To highlight the worldwide presence of CSF1R-related disorder (CSF1R-RD), discuss its penetrance, and provide the first haplotype analysis.

Methods: Data on patients worldwide were collected, including demographics, genotype, family history, and clinical status. For haplotype analysis, polymorphisms of short tandem repeats in 3 distinct families with CSF1R p.Ile794Thr variant were examined.

Results: Nineteen new patients were included, at a mean age of 38.7 years (ranging from 11 to 74 years), from 14 families from the Americas, Asia, Australia, and Europe, including the first from Mexico, North Macedonia, and Ukraine. Fifteen CSF1R variants were found, including 8 …

Effect Of Heat Stress On The Expression Of Circulating Cyto(Chemo)Kine And Inflammatory Markers In Broiler Chickens Selected For High- Or Low-Water Efficiency, Elizabeth S. Greene, Travis Tabler, Walter G. Bottje, Sara Orlowski, Sami Dridi

Poultry Science Faculty Publications and Presentations

Background:

Water scarcity is a current, significant global concern that will only increase under the pressure of climate change. Improving water efficiency of poultry is a new and promising area to help temper agriculture's future impact on fresh water availability. Here, we explored the effects of acute heat stress (HS) on circulating stress and inflammatory markers in 2 lines of broilers divergently selected for water efficiency. Methods:

Male chicks from low (LWE) and high water efficient (HWE) lines were raised in 12 environmental chambers (2 pens/chamber, 6 chambers/line, 20 birds/pen) under normal conditions until day 28. On day 29, birds …

Prazosin As An Adjuvant To Increase Effectiveness Of Duloxetine In A Rat Model Of Oxaliplatin-Induced Peripheral Neuropathy, Monica A. Wagner, Naji Ayyash

Faculty Scholarship

Objectives: Duloxetine, the only American Society of Clinical Oncology (ASCO) treatment recommended for chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors, is not effective for 40% of survivors. This study examined the ability of a duloxetine-prazosin combination to prevent the development of allodynia and hyperalgesia in a rat model of oxaliplatin-induced peripheral neuropathy (OPIN). Methods: Female (n = 24) and male (n = 41) rats were started on duloxetine (15 mg), prazosin (2 mg), or a duloxetine-prazosin combination one week prior to administration of the chemotherapy drug, oxaliplatin, and continued the duloxetine-prazosin combination for 32 days. Behavioral testing for mechanical allodynia …

Law School Announcements 2024-2025, Law School Announcements Editors

Announcements

• Officers and Faculty
• The Law School - History
• Programs of Instruction
• Curriculum
• Student Activities and Organizations
• Funds and Endowments

Distinct Landscape And Clinical Implications Of Therapy-Related Clonal Hematopoiesis, Koichi Takahashi, Daisuke Nakada, Margaret Goodell

Faculty, Staff and Student Publications

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation therapy. With the increased use of genetic analysis in oncological care, the detection of t-CH among cancer patients is becoming increasingly common. t-CH arises through the selective bottleneck imposed by chemotherapies and potentially through direct mutagenesis from chemotherapies, resulting in a distinct mutational landscape enriched with mutations in DNA damage-response pathway genes such as TP53, PPM1D, and CHEK2. Emerging evidence sheds light on the mechanisms of t-CH development and potential strategies to mitigate its emergence. Due to its unique characteristics that predominantly …

Human Embryonic Genetic Mosaicism And Its Effects On Development And Disease, Sarah M Waldvogel, Jennifer E Posey, Margaret A Goodell

Center on Aging Staff Publications

Nearly every mammalian cell division is accompanied by a mutational event that becomes fixed in a daughter cell. When carried forward to additional cell progeny, a clone of variant cells can emerge. As a result, mammals are complex mosaics of clones that are genetically distinct from one another. Recent high-throughput sequencing studies have revealed that mosaicism is common, clone sizes often increase with age and specific variants can affect tissue function and disease development. Variants that are acquired during early embryogenesis are shared by multiple cell types and can affect numerous tissues. Within tissues, variant clones compete, which can result …

The Effects Of An Evidence-Based Instructional Program On Science Teaching To Students With Special Needs In Inclusive Classrooms, Huda A. Almumen, Yaqoub J. Jafer

Journal of Educational and Psychological Studies

Abstract:The current study aimed to investigate the impact of an evidence-based instructional program consisting of: Explicit Instruction (EI) along with Numbered Heads Together (NHT) in comparison to the traditional, hand raising (HR) technique on fourth-grade students with and without special needs’ daily science quiz scores. Additionally, the researchers sought to explore the impact of the interventional program on the cumulative, pre and post-test performances of participants. Using mixed methods—single-subject, alternating treatment (comparing the interventional program [EI & NHT] to HR), and quasi-experimental designs—data were collected. Data were analyzed using a measure of central tendency (mean scores) of daily science quiz …

Dna Methylation-Derived Immune Cell Proportions And Cancer Risk In Black Participants, Christopher S Semancik, Naisi Zhao, Devin C Koestler, Eric Boerwinkle, Jan Bressler, Rachel J Buchsbaum, Karl T Kelsey, Elizabeth A Platz, Dominique S Michaud

Faculty, Staff and Student Publications

Prior cohort studies assessing cancer risk based on immune cell subtype profiles have predominantly focused on White populations. This limitation obscures vital insights into how cancer risk varies across race. Immune cell subtype proportions were estimated using deconvolution based on leukocyte DNA methylation markers from blood samples collected at baseline on participants without cancer in the Atherosclerosis Risk in Communities Study. During a mean of 17.5 years of follow-up, 668 incident cancers were diagnosed in 2,467 Black participants. Cox proportional hazards regression was used to examine immune cell subtype proportions and overall cancer incidence and site-specific incidence (lung, breast, and …

Tau Is Required For Glial Lipid Droplet Formation And Resistance To Neuronal Oxidative Stress, Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism. We found that overexpressing Tau in glia disrupts LDs in flies and rat neuron-astrocyte co-cultures, sensitizing the glia to toxic, neuronal LPOs. Using a new fly tau loss-of-function allele and RNA-mediated interference, we found that endogenous Tau is required for glial LD formation and protection against neuronal LPOs. Similarly, …

Cerebellar Deep Brain Stimulation As A Dual-Function Therapeutic For Restoring Movement And Sleep In Dystonic Mice, Luis E Salazar Leon, Linda H Kim, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Dystonia arises with cerebellar dysfunction, which plays a key role in the emergence of multiple pathophysiological deficits that range from abnormal movements and postures to disrupted sleep. Current therapeutic interventions typically do not simultaneously address both the motor and non-motor symptoms of dystonia, underscoring the necessity for a multi-functional therapeutic strategy. Deep brain stimulation (DBS) is effectively used to reduce motor symptoms in dystonia, with existing parallel evidence arguing for its potential to correct sleep disturbances. However, the simultaneous efficacy of DBS for improving sleep and motor dysfunction, specifically by targeting the cerebellum, remains underexplored. Here, we test the effect …