Digital Commons Network^™

Renewing Our Vows: The Lawyer's Oath And Our Pledge To Democracy, Colin M. Black

Suffolk University Law School Faculty Works

For centuries, lawyers have sworn to an oath as a prerequisite to admission. The oath, barely evolved from their historical roots, represents the guiding commitment lawyers make to democratic principles of honesty, integrity, fairness, and the rule of law. This commitment is in exchange for the power and privilege of belonging to the legal profession. However, the ethical landscape for legal practitioners has evolved, particularly in response to the alarming events of the 2020 U.S. presidential election. These events revealed significant lapses in the judgment and conduct among some lawyers, exposing the need for a recommitment to the democratic principles …

Curriculum Inquiry To Strengthen Teacher Preparation For Supporting Multilingual Learners In Rural Settings, Christiana K. Kfouri, Marjorie W. Rowe

The Rural Educator

Multilingual learners (MLs) represent a substantial, growing segment of the PreK–12 population, including in rural areas. Several forces contribute to the increase of ML students in rural schools (e.g., immigrant labor, refugee crises). As we undergo a major cultural shift from a society that was (misguidedly) viewed as monolingual to one that is now undoubtedly multilingual, many teacher education programs have not sufficiently transformed how they prepare educators for linguistic and cultural diversity. Rural teachers indicate that teacher preparation does not include effective strategies and resources instrumental to meeting the cultural, linguistic, and academic needs of MLs. Moreover, educators may …

Htlv-1 Infected T Cells Cause Bone Loss Via Small Extracellular Vesicles, Nitin Kumar Pokhrel, Haniya Habib, Shamreethaa Seeniraj, Ancy Joseph, Daniel Rauch, Linda Cox, Robert Sprung, Petra Erdmann Gilmore, Qiang Zhang, Robert Reid Townsend, Lee Ratner, Katherine N Weilbaecher, Deborah J Veis, Et Al.

2020-Current year OA Pubs

Adult T cell leukaemia (ATL), caused by infection with human T- lymphotropic virus type 1 (HTLV-1), is often complicated by hypercalcemia and osteolytic lesions. Therefore, we studied the communication between patient-derived ATL cells (ATL-PDX) and HTLV-1 immortalized CD4+ T cell lines (HTLV/T) with osteoclasts and their effects on bone mass in mice. Intratibial inoculation of some HTLV/T leads to a profound local decrease in bone mass similar to marrow-replacing ATL-PDX, despite the fact that few HTLV/T cells persisted in the bone. To study the direct effect of HTLV/T and ATL-PDX on osteoclasts, supernatants were added to murine and human osteoclast …

Neuroimmune Interactions In The Development And Chronification Of Migraine Headache, Jintao Zhang, Roli Simoes, Tingting Guo, Yu-Qing Cao

2020-Current year OA Pubs

Migraine is highly prevalent and debilitating. The persistent headaches in this condition are thought to arise from the activation and sensitization of the trigeminovascular pathway. Both clinical and animal model studies have suggested that neuroimmune interactions contribute to the pathophysiology of migraine headache. In this review, we first summarize the findings from human studies implicating the dysregulation of the immune system in migraine, including genetic analyses, measurement of circulatory factors, and neuroimaging data. We next discuss recent advances from rodent studies aimed at elucidating the neuroimmune interactions that manifest at various levels of the trigeminovascular pathway and lead to the …

Three Classes Of Propofol Binding Sites On Gabaa Receptors, Zi-Wei Chen, Satyanarayana M Chintala, John Bracamontes, Yusuke Sugasawa, Spencer R Pierce, Balazs R Varga, Edward H Smith, Christopher J Edge, Nicholas P Franks, Wayland W L Cheng, Gustav Akk, Alex S Evers

2020-Current year OA Pubs

Propofol is a widely used anesthetic and sedative that acts as a positive allosteric modulator of gamma-aminobutyric acid type A (GABA

New Insights Into Innate Immunity In Alzheimer's Disease: From Apoe Protective Variants To Therapies, Yun Chen, David M Holtzman

2020-Current year OA Pubs

Recent discoveries of rare variants of human APOE may shed light on novel therapeutic strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective variant [APOE3 Christchurch (APOE3ch, R136S)] as an example. We summarize human AD and mouse amyloidosis and tauopathy studies from the past 5 years that have been associated with this R136S variant. We also propose a potential mechanism for how this point mutation might lead to protection against AD pathology, from the molecular level, to cells, to mouse models, and potentially, to humans. Lastly, we extend our discussion of the recent insights gained regarding different …

Morphology And Molecular Systematics Support A New Species Of Pseudogonatodes (Squamata: Gekkota: Sphaerodactylidae) From Venezuela With A Remarkable Telescoped Skull, Walter E. Schargel, Christian Hernández-Morales, Juan D. Daza, Micheal J. Jowers, Andres Camilo Montes-Correa, Mayke De Freitas, Kathryn A. Sullivan, Tony Gamble, Aaron M. Bauer, Gilson A. Rivas

Biological Sciences Faculty Research and Publications

We describe a new species of miniaturized gecko (genus Pseudogonatodes) from the Peninsula de Paria in northeastern Venezuela. Externally, the new species resembles Pseudogonatodes furvus and Pseudogonatodes manessi, from the Sierra Nevada de Santa Marta in Colombia and the Central Coastal Range in Venezuela, respectively; however, it differs from these species in terms of molecular genetic data (12S rRNA, 16S rRNA, and c-mos), osteological characters, and scale counts. The new species is unique in skull osteology, and we adopt the term ‘telescoped’ from the literature to describe the overlap of bones in the snout, in particular the …

Pkmyt1 Is A Marker Of Treatment Response And A Therapeutic Target For Cdk4/6 Inhibitor-Resistance In Er+ Breast Cancer, Anran Chen, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

Endocrine therapies (ET) with cyclin-dependent kinase 4/6 (CDK4/6) inhibition are the standard treatment for estrogen receptor-α-positive (ER+) breast cancer, however drug resistance is common. In this study, proteogenomic analyses of patient-derived xenografts (PDXs) from patients with 22 ER+ breast cancer demonstrated that protein kinase, membrane-associated tyrosine/threonine one (PKMYT1), a WEE1 homolog, is estradiol (E2) regulated in E2-dependent PDXs and constitutively expressed when growth is E2-independent. In clinical samples, high PKMYT1 mRNA levels associated with resistance to both ET and CDK4/6 inhibition. The PKMYT1 inhibitor lunresertib (RP-6306) with gemcitabine selectively and synergistically reduced the viability of ET and palbociclib-resistant ER+ breast …

Mucosal Adenovirus Vaccine Boosting Elicits Iga And Durably Prevents Xbb.1.16 Infection In Nonhuman Primates, Matthew Gagne, James Brett Case, Igor P Dmitriev, Elena A Kashentseva, Baoling Ying, David T Curiel, Michael S Diamond, Et Al.

2020-Current year OA Pubs

A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit transmission. We compared protection against heterologous XBB.1.16 challenge in nonhuman primates (NHPs) ~5 months following intramuscular boosting with bivalent mRNA encoding WA1 and BA.5 spike proteins or mucosal boosting with a WA1-BA.5 bivalent chimpanzee adenoviral-vectored vaccine delivered by intranasal or aerosol device. NHPs boosted by either mucosal route had minimal virus replication in the nose and lungs, respectively. By contrast, protection by intramuscular mRNA was limited to the lower airways. The mucosally delivered vaccine elicited durable airway IgG …

A Modular Chemigenetic Calcium Indicator For Multiplexed In Vivo Functional Imaging, Helen Farrants, Christian Monroy Hernandez, Yao Chen, Et Al.

2020-Current year OA Pubs

Genetically encoded fluorescent calcium indicators allow cellular-resolution recording of physiology. However, bright, genetically targetable indicators that can be multiplexed with existing tools in vivo are needed for simultaneous imaging of multiple signals. Here we describe WHaloCaMP, a modular chemigenetic calcium indicator built from bright dye-ligands and protein sensor domains. Fluorescence change in WHaloCaMP results from reversible quenching of the bound dye via a strategically placed tryptophan. WHaloCaMP is compatible with rhodamine dye-ligands that fluoresce from green to near-infrared, including several that efficiently label the brain in animals. When bound to a near-infrared dye-ligand, WHaloCaMP shows a 7× increase in fluorescence …

Dopamine-Mediated Interactions Between Short- And Long-Term Memory Dynamics, Cheng Huang, Junjie Luo, Seung Je Woo, Lucas A Roitman, Jizhou Li, Vincent A Pieribone, Madhuvanthi Kannan, Ganesh Vasan, Mark J Schnitzer

2020-Current year OA Pubs

In dynamic environments, animals make behavioural decisions on the basis of the innate valences of sensory cues and information learnt about these cues across multiple timescales

Dominantly Inherited Muscle Disorders: Understanding Their Complexity And Exploring Therapeutic Approaches, Andrew R Findlay

2020-Current year OA Pubs

Treatments for disabling and life-threatening hereditary muscle disorders are finally close to becoming a reality. Research has thus far focused primarily on recessive forms of muscle disease. The gene replacement strategies that are commonly employed for recessive, loss-of-function disorders are not readily translatable to most dominant myopathies owing to the presence of a normal chromosome in each nucleus, hindering the development of novel treatments for these dominant disorders. This is largely due to their complex, heterogeneous disease mechanisms that require unique therapeutic approaches. However, as viral and RNA interference-based therapies enter clinical use, key tools are now in place to …

Employing Multi-Omics Analyses To Understand Changes During Kidney Development In Perinatal Interleukin-6 Animal Model, Ganesh Panzade, Tarak Srivastava, Daniel P. Heruth, Mohammad H. Rezaiekhaligh, Jianping Zhou, Zhen Lyu, Mukut Sharma, Trupti Joshi

Biomedical Sciences

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality globally. Maternal obesity during pregnancy is linked to systemic inflammation and elevated levels of the proinflammatory cytokine interleukin-6 (IL-6). In our previous work, we demonstrated that increased maternal IL-6 during gestation impacts intrauterine development in mice. We hypothesized that IL-6-induced inflammation alters gene expression in the developing fetus. To test this, pregnant mice were administered IL-6 or saline during mid-gestation. Newborn mouse kidneys were analyzed using mRNA-seq, miRNA-seq and whole-genome bisulfite-seq (WGBS). A multi-omics approach was employed to quantify mRNA gene expression, miRNA expression and DNA methylation, using …

Type I Ifn Signaling In The Absence Of Irgm1 Promotes M. Tuberculosis Replication In Immune Cells By Suppressing T Cell Responses, Sumanta K Naik, Michael E Mcnehlan, Yassin Mreyoud, Rachel L Kinsella, Asya Smirnov, Chanchal Sur Chowdhury, Samuel R Mckee, Neha Dubey, Reilly Woodson, Darren Kreamalmeyer, Christina L Stallings

2020-Current year OA Pubs

Polymorphisms in the IRGM gene are associated with susceptibility to tuberculosis in humans. A murine ortholog of Irgm, Irgm1, is also essential for controlling Mycobacterium tuberculosis (Mtb) infection in mice. Multiple processes have been associated with IRGM1 activity that could impact the host response to Mtb infection, including roles in autophagy-mediated pathogen clearance and expansion of activated T cells. However, what IRGM1-mediated pathway is necessary to control Mtb infection in vivo and the mechanistic basis for this control remains unknown. We dissected the contribution of IRGM1 to immune control of Mtb pathogenesis in vivo and found that Irgm1 deletion leads …

Real-Time Navigation System For Breast Cancer Surgery With Pre- And Intra-Operative Imaging Using Neural Networks, Motaz Alqaoud

Biomedical Engineering Theses & Dissertations

Breast cancer is one of the most frequently diagnosed malignancies in women worldwide, necessitating precise diagnosis and treatment. Breast-conserving surgery (BCS) is the primary treatment for nonpalpable cases, yet current approaches often lack accuracy due to the absence of real-time 3D imaging during surgery. This limitation impairs surgeons’ ability to visualize tumor locations, compromising outcomes and potentially leading to repeat surgeries with higher risks, undesirable cosmetic results, increased costs, and, in some cases, mastectomy. Thus, there is a critical need for a navigation system to facilitate accurate tumor excision in nonpalpable breast cancer through real-time patient-specific 3D tracking.

This study …

Feasibility Study Of Oyster Shell Filtration Media For Stormwater Pollutants Removal, Sadiq Omer

Civil & Environmental Engineering Theses & Dissertations

The depletion of resources has raised interest in reusing or incorporating by-products into alternative materials. In the effort for net zero emissions, waste reduction, and a circular economy, it is crucial to reinvent the alternative utilization strategy for by-products as construction materials sustainably. This research examines the alternative utilization strategy for oyster shell by-products in regular stormwater pollutant removal best management practices (BMPs).

Numerous research has examined the utilization of oyster shell waste as a construction material in Asia and Europe, specifically focusing on the physical properties of crushed oyster shells as alternatives for aggregates. No studies have been identified …

Literacy Leadership: Power In The Discourse Of Learning, Melissa Guinn Crawley Twisdale

Educational Leadership & Workforce Development Theses & Dissertations

The phenomenon of teacher learning, especially within literacy education pedagogy, has rarely been a topic of educational research. The nature of ongoing teacher learning is as challenging to study as student learning in that, learning in and of itself is not widely defined in the educational research literature. Equally challenging is the topic of literacy for which there are numerous and varying definitions, many of which carry political and controversial connotations (Aukerman & Schuldt, 2021). The term science of reading, for example, often carries an intensive focus on assessed reading proficiency as the primary goal of reading instruction, although the …

Intercellular Mitochondrial Transfer Contributes To Microenvironmental Fate Redirection Of Mammary Cancer Cells, Julie Sofie Bjerring

Biomedical Sciences Theses & Dissertations

The dynamic cellular microenvironment, made up of resident cells and various macromolecules, differs markedly across tissues in the body. The multidirectional signals that cells receive from this microenvironment, along with the signaling they send back, heavily influence their physiology and behavior. Recent important findings have further validated this notion as the mammary microenvironment has been shown to suppress tumor progression by redirecting cancer cells to adopt a normal mammary epithelial progenitor fate in vivo. However, the mechanism(s) driving changes in metabolic reprogramming and cancer fate redirection is understudied. The work presented in this dissertation focuses on exploring the impact of …

Examining The Effects Of Video Camera Angles On Interpersonal Impressions, Rachel Valerie Ball

Psychology Theses & Dissertations

The effect of different camera angles on the perceptions of the speaker formed over a virtual interaction, especially in the context of telehealth encounters, has not been systematically investigated. The present study explored how vertical and horizontal angles impact perceptions of a healthcare provider in a video encounter using a 2 (angle type: eye level vs. alternate angle) X 2 (video order: eye level presented first vs. alternate angle presented first) mixed design. Participants watched two different segments of an encounter where camera angle was examined within subjects and order of presentation was examined between subjects. It was hypothesized that …

Interstate Conflict Initiation And The Age Of International Leaders, Katelyn L. Laplaunt

Student Publications

The 2024 presidential election in the United States amplified concerns regarding the age of international leaders and their ability to lead. Current research indicates that differences in individual characteristics such as ideology, biological sex, and aggression, can cause leaders to interact with foreign countries in varying ways. Especially important is the manner in which a leader’s age might impact their tendency to initiate interstate conflict, as the effects of these conflicts can have major impacts on the international system. In alignment with my hypothesis, most research indicates that older leaders will initiate fewer interstate conflicts than younger leaders. This is …

“Indescribable But Never To Be Forgotten”: Challenging The Gender Roles Of Victorian Era Women And Expanding Cultural Horizons Through Travels Abroad, Camryn Counsil

Student Publications

Between the years of 1862-8, the Webb-Black family traveled the world on a Grand Tour to countries such as Italy, Austria, and France. In letters home to their aunts, half-sisters Augusta, Menah, and Julia detailed their journeys within the physical and cultural spheres of the places they visited. Later copied into a bound volume, these epistles gave voice to women’s thoughts, emotions, and conflicts when exploring the realm of the unknown. From a young age, Victorian girls were taught to suppress their opinions and merely expect a life of motherhood. However, the women of these letters pushed beyond what was …

Bacillus Thuringiensis Cry14a Family Proteins As Novel Anthelmintics Against Gastrointestinal Nematode Parasites, Duy Hoang, Kelly Flanagan, Qian Ding, Nicholas R. Cazeault, Hanchen Li, Stefani Díaz-Valerio, Florentina Rus, Esther A. Darfour, Elizabeth Kass, Katherine H. Petersson, Martin Krarup Nielsen, Heiko Liesegang, Gary R. Ostroff, Raffi V. Aroian

Veterinary Science Faculty Publications

Bacillus thuringiensis crystal (Cry) proteins have been expressed in commercial transgenic crops for nearly 30 years, providing safe and effective control of insect pests and significantly reducing the application of hazardous chemical pesticides. B. thuringiensis crystal proteins have also been shown to target parasitic nematodes, including plant parasitic nematodes. Recently, transgenic soybean crops expressing Cry14Ab have been shown to provide control against the soybean cyst nematode Heterodera glycines, marking the first time a crystal protein is being commercialized in transgenic crops for control of a nematode pest. However, apart from H. glycines and the free-living nematode, Caenorhabditis elegans, the breadth …

Arthropod Arbiters: Natural Enemy Communities Mediate The Effects Of Landscape And Local-Scale Complexity On Lygus-Induced Crop Loss In Organic Strawberries, Adrian Lu, David J. Gonthier, Amber Sciligo, Karina Garcia, Taiki Chiba, Gila Juárez, Claire Kremen

Entomology Faculty Publications

Sustainable pest management requires growers and regional land managers to consider the relationships among pest management practices, pest and natural enemy communities, crop loss, and multi-scalar habitat complexity. However, the causal links among these variables, in particular potential interactions between landscape and local-scale habitat complexity, remain underexplored. In the context of organically managed strawberry crops in California’s Central Coast, we tested the independent effects of landscape and local habitat complexity gradients on arthropod communities and crop loss using a piecewise structural equation model (PSEM). We found that landscape-scale woody habitat proportion indirectly decreased crop loss through its positive effect on …

Trends And Patterns In Hypertension-Related Deaths: A Comprehensive Analysis Using Center For Disease Control And Prevention's Wide-Ranging Online Data For Epidemiologic Research (Cdc Wonder) Data, Oyinlola O. Fasehun, Joycelyn Adjei-Mensah, Wisdom S. Ugorji, Victoria O. Titus, Oluwatobi O. Asade, Damilola A. Adeyemo, Okelue E. Okobi

School of Medicine Publications

Hypertension (HTN) is a leading cause of cardiovascular morbidity and mortality worldwide. Despite advances in treatment, including the development and use of vasodilator-β-blocker combination and treatment with antihypertensive agents, HTN-related deaths have shown concerning trends. As such, the objective of this study is to examine the trends, disparities, and demographic variations in HTN-related mortality over a decade and to identify key factors contributing to these patterns, including genetics, dietary habits, structural discrimination in access to healthcare, lifestyle choices, and secondary hypertension, which is due to underlying conditions like kidney disease, hormonal disorders, or certain medications. To attain this objective, this …

Saraqib Thobe Identification In The May Weber Ethnographic Collection, Gretchen Rojewski

Department of Anthropology

The artistic tradition of embroidery in communities across the Arabian Peninsula has long served as a means of expressing local identity, values, and craftsmanship through the decoration of garments. Distinctive patterns, stylistic choices, and color palettes allow for the regional identification of embroidered clothing. This research examines a Syrian thobe housed in the May Weber Ethnographic Collection at Loyola University Chicago, using physical analysis and comparative study to identify its origins. By analyzing the garment’s embroidery patterns, construction techniques, and aesthetic details, this study not only determines the likely regional provenance of the thobe but also explores the broader cultural …

The Use Of Insect Cell Line Sf21 For Ecotoxicity Testing, Trevor Grigg, Richard D. Handy, Richard A. Billington

School of Biological and Marine Sciences

Insect cell lines are finding utility in many areas of biology, but their application as an in vitro tool for ecotoxicity testing has been given less attention. Our study aimed to demonstrate the utility and sensitivity of Sf21 cells to commonly used fungicides: Propiconazole and CuSO₄, as well as dimethyl sulphoxide (DMSO) an industrial solvent. Sf21 cells were readily cultured from frozen stocks in 3-4 days and showed utility as an invertebrate in vitro acute toxicity test. The data showed the threshold levels of cell survivability against propiconazole and CuSO₄. The EC₅₀ values were 135.1 …

The International Legal Framework Of Oceanic Shipping Of Carbon Dioxide For Permanent Storage, Carolina Arlota, Michael B. Gerrard

Faculty Scholarship

The Intergovernmental Panel on Climate Change defines carbon dioxide capture and storage (CCS) as “a process in which a relatively pure stream of carbon dioxide (CO2) from industrial and energy-related sources is separated (captured), conditioned, compressed, and transported to a storage location for long-term isolation from the atmosphere.” Therefore, CCS encompasses a series of steps, at minimum: capturing carbon dioxide, its transportation to a storage site, and its injection into the subsurface for permanent storage. As such, CCS does not refer to any single activity or technology. This Article focuses on the transportation aspect of CCS and, more precisely, …

Triumphant Philanthropists: Inventing An American Tradition In Milwaukee, Wisconsin, And The Nation, 1844-1930, Margaret Nettesheim-Hoffmann

Dissertations (1934 -)

This dissertation explores the development of American philanthropic foundations and the invention of philanthropic traditions, forms, and conventions in the United States during the Gilded Age and Progressive Era. The rapid accumulation of wealth during the late nineteenth and early twentieth centuries posed a series of complex economic, social, and political tensions for the nation following the end of the Civil War, and the invention of the philanthropic foundation by leading businessmen sought to solve those tensions through the planned and systemized redistribution of wealth. This exploration of philanthropy’s history suggests that American capitalists invented a “new” philanthropic tradition in …

Macronutrients In Human Milk And Early Childhood Growth—Is Protein The Main Driver?, Jie Ma, Debra J. Palmer, Ching Tat Lai, Susan L. Prescott, Nina D’Vaz, Philip Vlaskovsky, Lisa F. Stinson, Zoya Gridneva, Donna T. Geddes

Research outputs 2022 to 2026

Background: Infant growth trajectories reflect current health status and may predict future obesity and metabolic diseases. Human milk is tailored to support optimal infant growth. However, nutrient intake rather than milk composition more accurately predicts growth outcomes. Although the role of protein leverage in infant growth is unclear, protein intake is important for early infancy growth.

Materials and methods: This study of exclusively breastfeeding mothers with allergies (n = 161) from the Infant Fish Oil Supplementation Study assessed relationships between intake of human milk macronutrients and infant growth. Human milk fat, protein and lactose concentrations were measured at 3 months …

A New Era Of Deference: From Chevron To Loper Bright, Daniel E. Walters

Faculty Scholarship

Deference to administrative agencies’ interpretations of ambiguous statutory provisions has been a hallmark of administrative law and regulatory policy for the past forty years. The Supreme Court recently upended that settled allocation of power between agencies and courts, granting interpretive primacy to courts even where statutes essentially require policy choices. However, questions remain about precisely how courts will exercise this policymaking authority that agencies used to exercise, as well as about the multiple “offramps” from this nondeferential standard that the Court left open. Rather than a new era of nondeference, it is just as likely we are embarking on a …