Digital Commons Network^™

The Chanticleer, 2024-10-03, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

The Indiana Statesman, October 3, 2024, Indiana State University

Student Newspaper

Vice Presidential Debate; Family Weekend; Spanish Film Festival, fall at Indiana State

Issue 453: October 3-17, 2024, The Local Voice

The Local Voice

No abstract provided.

Arid1a-Baf Coordinates Zic2 Genomic Occupancy For Epithelial-To-Mesenchymal Transition In Cranial Neural Crest Specification., Samantha M Barnada, Aida Giner De Gracia, Cruz Morenilla-Palao, Maria Teresa López-Cascales, Chiara Scopa, Francis J Waltrich, Harald M M Mikkers, Maria Elena Cicardi, Jonathan Karlin, Davide Trotti, Kevin A Peterson, Samantha A Brugmann, Gijs W E Santen, Steven B Mcmahon, Eloísa Herrera, Marco Trizzino

Faculty Research 2024

The BAF chromatin remodeler regulates lineage commitment including cranial neural crest cell (CNCC) specification. Variants in BAF subunits cause Coffin-Siris syndrome (CSS), a congenital disorder characterized by coarse craniofacial features and intellectual disability. Approximately 50% of individuals with CSS harbor variants in one of the mutually exclusive BAF subunits, ARID1A/ARID1B. While Arid1a deletion in mouse neural crest causes severe craniofacial phenotypes, little is known about the role of ARID1A in CNCC specification. Using CSS-patient-derived ARID1A[thorn]/ induced pluripotent stem cells to model CNCC specification, we discovered that ARID1A- haploinsufficiency impairs epithelial-to-mesenchymal transition (EMT), a process necessary for CNCC delamination and migration …

The Comment, October 3, 2024, Bridgewater State University

The Comment

No abstract provided.

The Genomes Of All Lungfish Inform On Genome Expansion And Tetrapod Evolution, Manfred Schartl, Joost M. Woltering, Iker Irisarri, Kang Du, Susanne Kneitz, Martin Pippel, Thomas Brown, Paolo Franchini, Jing Li, Ming Li, Mateus Adolfi, Sylke Winkler, Josane De Freitas Sousa, Zhuoxin Chen, Sandra Jacinto, Evgeny Z. Kvon, Luis Rogério Correa De Oliveira, Erika Monteiro, Danielson Baia Amaral, Thorsten Burmester, Domitille Chalopin, Alexander Suh, Eugene Myers, Oleg Simakov, Igor Schneider, Axel Meyer

Faculty Publications

The genomes of living lungfishes can inform on the molecular-developmental basis of the Devonian sarcopterygian fish–tetrapod transition. We de novo sequenced the genomes of the African (Protopterus annectens) and South American lungfishes (Lepidosiren paradoxa). The Lepidosiren genome (about 91 Gb, roughly 30 times the human genome) is the largest animal genome sequenced so far and more than twice the size of the Australian (Neoceratodus forsteri)¹ and African² lungfishes owing to enlarged intergenic regions and introns with high repeat content (about 90%). All lungfish genomes continue to expand as some transposable elements (TEs) are still active today. In particular, …

Oregon State Rank Assessment For Obscure Bumblebee (Bombus Caliginosus), Jesse Laney, Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for obscure bumblebee (Bombus caliginosus) using NatureServe methodology, 2024.

Health Matters! Coloring And Activity Booklet (16-Pages), Your Very Favorite, Children's Health, Lorraine Sheldon, May Bressler

English

Health Matters! is a English-language health literacy resource designed for pediatric patients and their families. Written at an approximately 6th-grade reading level, it supports patient education through engaging coloring and activity pages.

This booklet version includes a smaller selection of materials from the larger Health Matters! book. Developed for use in both hospital settings and the broader community, the resource promotes learning through interactive, age-appropriate activities.

This printable PDF version contains the complete collection of activities and comprises 16 pages. The resource was commissioned by Children's Health and prepared by Your Very Favorite.

Oregon State Rank Assessment For Goose Lake Tui Chub (Siphateles Bicolor Thalassinus), Jesse Laney

Institute for Natural Resources Publications

Oregon state conservation status assessment for Goose Lake tui chub (Siphateles bicolor thalassinus) using NatureServe methodology, 2024.

Two Lives, Shruti Trehan Mbbs

Journal of Wellness

A busy oncologist makes a decision to leave her busy, thriving, community practice in the Mid-West and moves to a Veterans Affairs hospital in South Florida in the quest for a better work-life balance.

The Cowl - V. 88 N. 3 - October 3, 2024

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 3 - October 3, 2024. 16 pages.

The Colby Echo (2024-10-03), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

Application Of Combined Geophysical And Archaeological Survey Techniques: A Case Study Of Singida Region, Tanzania, Makarius Peter Itambu, Eliah Mwamakimbula1, Nasra Yahaya, Jasmine Kilela

Tanzania Journal of Science

The seismically active Singida region in central Tanzania lies at the edge of the East African Rift System (EARS) which is locally designated the Gregory Rift. The archaeological record of the region, especially in the eastern part of the Ikungi District, unlike that of northern Tanzania, is comparatively unknown, despite early archaeological expeditions hinting at its potential. Recent research in the eastern area suggests that it preserves a long record of hominin occupation spanning the Early to Late Stone Age. This interdisciplinary field work, carried out between August 2022 to August 2023, resulted in the discovery of a relatively deep …

Oregon State Rank Assessment For Flightless Haliplid Beetle (Apteraliplus Parvulus), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for flightless haliplid beetle (Apteraliplus parvulus) using NatureServe methodology, 2024.

The Impact Of Covid-19 Response Measures On The Mental Health And Well-Being Of Teachers At Predominately Black Schools, Llewellyn Cooper

Walden Dissertations and Doctoral Studies

Teachers in predominately Black schools had limited access to mental health resources during the COVID-19 pandemic. The purpose of this generic qualitative study was to explore how the response to COVID-19 affected the mental health and well-being (MHWB) of teachers at predominately Black schools during the pandemic to gain an in-depth understanding of their experiences regarding MHWB. The study participants were eight teachers at various schools in the state of Alabama. The goal was to understand how teachers experienced MHWB support during the COVID-19 pandemic, how teachers’ MHWB were affected when there were rapid adjustments to curricula changes, and how …

Arid1a-Baf Coordinates Zic2 Genomic Occupancy For Epithelial-To-Mesenchymal Transition In Cranial Neural Crest Specification, Samantha M. Barnada, Aida Giner De Gracia, Cruz Morenilla-Palao, Maria Teresa López-Cascales, Chiara Scopa, Francis J. Waltrich, Harald M.M. Mikkers, Maria Elena Cicardi, Jonathan Karlin, Davide Trotti, Kevin A. Peterson, Samantha A. Brugmann, Gijs W.E. Santen, Steven B. Mcmahon, Eloísa Herrera, Marco Trizzino

Department of Biochemistry and Molecular Biology Faculty Papers

The BAF chromatin remodeler regulates lineage commitment including cranial neural crest cell (CNCC) specification. Variants in BAF subunits cause Coffin-Siris syndrome (CSS), a congenital disorder characterized by coarse craniofacial features and intellectual disability. Approximately 50% of individuals with CSS harbor variants in one of the mutually exclusive BAF subunits, ARID1A/ARID1B. While Arid1a deletion in mouse neural crest causes severe craniofacial phenotypes, little is known about the role of ARID1A in CNCC specification. Using CSS-patient-derived ARID1A induced pluripotent stem cells to model CNCC specification, we discovered that ARID1A-haploinsufficiency impairs epithelial-to-mesenchymal transition (EMT), a process necessary for CNCC delamination and migration from …

Syntaxin 3b: A Snare Protein Required For Vision, Himani Dey, Mariajose Perez-Hurtado, Ruth Heidelberger

Faculty, Staff and Student Publications

Syntaxin 3 is a member of a large protein family of syntaxin proteins that mediate fusion between vesicles and their target membranes. Mutations in the ubiquitously expressed syntaxin 3A splice form give rise to a serious gastrointestinal disorder in humans called microvillus inclusion disorder, while mutations that additionally involve syntaxin 3B, a splice form that is expressed primarily in retinal photoreceptors and bipolar cells, additionally give rise to an early onset severe retinal dystrophy. In this review, we discuss recent studies elucidating the roles of syntaxin 3B and the regulation of syntaxin 3B functionality in membrane fusion and neurotransmitter release …

Categorical Differences: Social Identity Heuristics Predict Differences In Cognitive Empathy, Corey Ronald Sims

Walden Dissertations and Doctoral Studies

The current study aimed to identify if there was a relationship between cross-ethnic racial identity and cognitive empathy for others and whether social and personal identities mediated this effect. Self-categorization theory was used as the theoretical framework. In this study, it was hypothesized that cross-ethnic racial identity significantly predicts empathic accuracy, and that social and personal identities mediate this relationship. A non-experimental, researcher-designed survey was used to collect participant data and demographic characteristics. Participant inclusion criteria were an age between 18 and 55, U.S. citizenship, and a self-identification as Asian American, Black American, Hispanic American, or White American. The Cross-Ethnic …

The Pace Of Life For Forest Trees, Lalasia Bialic-Murphy, Robert M. Mcelderry, Adriane Esquivel-Muelbert, Johan Van Den Hoogen, Pieter A. Zuidema, Oliver L. Phillips, Edmar Almeida De Oliveira, Patricia Alvarez Loayza, Esteban Alvarez-Davila, Luciana F. Alves, Vinícius Andrade Maia, Simone Aparecida Vieira, Lidiany Carolina Arantes Da Silva, Alejandro Araujo-Murakami, Eric Arets, Julen Astigarraga, Fabrício Baccaro, Timothy Baker, Olaf Banki, Jorcely Barroso, Lilian Blanc, Damien Bonal, Frans Bongers, Kauane Maiara Bordin, Roel Brienen, Marcelo Brilhante De Medeiros, José Luís Camargo, Felipe Carvalho Araújo, Carolina V. Castilho, Wendeson Castro

School of Geography, Earth and Environmental Sciences

Tree growth and longevity trade-offs fundamentally shape the terrestrial carbon balance. Yet, we lack a unified understanding of how such trade-offs vary across the world's forests. By mapping life history traits for a wide range of species across the Americas, we reveal considerable variation in life expectancies from 10 centimeters in diameter (ranging from 1.3 to 3195 years) and show that the pace of life for trees can be accurately classified into four demographic functional types. We found emergent patterns in the strength of trade-offs between growth and longevity across a temperature gradient. Furthermore, we show that the diversity of …

A Ligation-Independent Sequencing Method Reveals Trna-Derived Rnas With Blocked 3′ Termini, Alessandro Scacchetti, Emily J Shields, Natalie A Trigg, Grace S Lee, Jeremy E Wilusz, Colin C Conine, Roberto Bonasio

Faculty, Staff and Students Publications

Despite the numerous sequencing methods available, the diversity in RNA size and chemical modification makes it difficult to capture all RNAs in a cell. We developed a method that combines quasi-random priming with template switching to construct sequencing libraries from RNA molecules of any length and with any type of 3' modifications, allowing for the sequencing of virtually all RNA species. Our ligation-independent detection of all types of RNA (LIDAR) is a simple, effective tool to identify and quantify all classes of coding and non-coding RNAs. With LIDAR, we comprehensively characterized the transcriptomes of mouse embryonic stem cells, neural progenitor …

Inflammation-Induced Epigenetic Imprinting Regulates Intestinal Stem Cells, Dongchang Zhao, Visweswaran Ravikumar, Tyler J Leach, Daniel Kraushaar, Emma Lauder, Lu Li, Yaping Sun, Katherine Oravecz-Wilson, Evan T Keller, Fengju Chen, Laure Maneix, Robert R Jenq, Robert Britton, Katherine Y King, Ana E Santibanez, Chad J Creighton, Arvind Rao, Pavan Reddy

Faculty, Staff and Students Publications

It remains unknown whether, and how intestinal stem cells (ISC) adapt to inflammatory exposure, and if the adaptation leaves scars will affect their subsequent regeneration. We investigated the consequences of inflammation on Lgr5+ISCs in well-defined clinically relevant models of gastrointestinal acute graft-versus-host disease (GI GVHD). Utilizing single cell transcriptomics, organoid, metabolic, epigenomic and in vivo models we found that Lgr5+ISCs undergo metabolic changes that lead to accumulation of succinate, which reprograms its epigenome. These changes reduced the ability of ISCs to differentiate and regenerate ex vivo in serial organoid cultures and also in vivo following serial transplantation. Furthermore, ISCs demonstrated …

Leptomeningeal Metastases From Solid Tumors: A Society For Neuro-Oncology And American Society Of Clinical Oncology Consensus Review On Clinical Management And Future Directions, Jessica A Wilcox, Ugonma N Chukwueke, Myung-Ju Ahn, Ayal A Aizer, Tejus A Bale, Dieta Brandsma, Priscilla K Brastianos, Susan Chang, Mariza Daras, Peter Forsyth, Livia Garzia, Michael Glantz, Isabella C Glitza Oliva, Priya Kumthekar, Emilie Le Rhun, Seema Nagpal, Barbara O'Brien, Elena Pentsova, Eudocia Quant Lee, Jan Remsik, Roberta Rudà, Inna Smalley, Michael D Taylor, Michael Weller, Jeffrey Wefel, Jonathan T Yang, Robert J Young, Patrick Y Wen, Adrienne A Boire

Faculty, Staff and Students Publications

Leptomeningeal metastases (LM) are increasingly becoming recognized as a treatable, yet generally incurable, complication of advanced cancer. As modern cancer therapeutics have prolonged the lives of patients with metastatic cancer, specifically in patients with parenchymal brain metastases, treatment options, and clinical research protocols for patients with LM from solid tumors have similarly evolved to improve survival within specific populations. Recent expansions in clinical investigation, early diagnosis, and drug development have given rise to new unanswered questions. These include leptomeningeal metastasis biology and preferred animal modeling, epidemiology in the modern cancer population, ensuring validation and accessibility of newer leptomeningeal metastasis diagnostics, …

Kenyon Collegian - October 3, 2024

The Kenyon Collegian

No abstract provided.

Effects Of Lactate On Corticospinal Excitability: A Scoping Review, Jess T. Gibson, Hudson J. Barr, Shaun G. Boe

International Journal of Exercise Science

International Journal of Exercise Science 17(2): 1429-1443, 2024. Aerobic exercise has been shown to impact corticospinal excitability (CSE), however the mechanism(s) by which this occurs is unclear. Some evidence suggests an increase in blood lactate concentration resulting from exercise may be what is driving these changes in corticospinal excitability. The extent of literature examining this effect and whether it is consistent across the literature is unknown. As such, the objective of this scoping review was to summarize the existing literature examining the effect of lactate on corticospinal excitability and to determine any trend(s) in the effect. Embase, CINAHL, Medline, SPORTDiscus, …

Called: A Pentecostal Theology Of Vocation, Martin W. Mittelstadt

Spiritus: ORU Journal of Theology

In this essay, I propose a Pentecostal theology of vocation that extends out of the Full Gospel and prophethood of all believers. Though Pentecostals devote considerable attention to church-related/religious vocations, Pentecostals must reimagine vocational implications for fullness of the Spirit on all believers. All Pentecostals are called to embody the dual impulses of the Fivefold Gospel. They are being saved, sanctified, baptized in the Spirit, healed, and living in eager anticipation of Jesus’ return. At the same time, all Pentecostals become saving agents with Christ; they perform holy love; they engage in Spirit-inspired witness; they offer healing balm for a …

Varieties Of Healing: A Catholic Perspective, Andrew Prevot

Spiritus: ORU Journal of Theology

This article contributes to Catholic-Pentecostal ecumenical dialogue by offering a particular Catholic perspective on the shared Christian belief in Christ is the Healer. More specifically, it distinguishes several ways in which humans are called to participate in the healing work of Christ. It considers Catholic approaches to sacramental, charismatic, miraculous, biomedical, psychotherapeutic, social, and ecological healing. It reflects on the historical background, contemporary significance, and interconnections of these diverse areas of healing, while distinguishing such a holistic understanding of healing from the narrower concept of a cure. Acknowledging the problem of unhealed sufferers, it argues against blaming such persons for …

Initiation Sacraments And Directions For Catholic-Pentecostal Dialogue: An Essay For The Exploratory Usccb/Pccna Dialogue, Kimberly H. Belcher

Spiritus: ORU Journal of Theology

This article surveys Roman Catholic understandings of initiation sacraments. It traces historical developments and current practices for the sacraments of baptism, confirmation, and Holy Communion. Throughout attention is paid to the areas where convergences and issues for further discussion between Roman Catholics and Pentecostals emerge.

Phytochemical Profiling And Antioxidant Potential Of Methanol Extract Of Vitis Vinifera L Seeds., Sindhuja Lakshmi, Kesavaram Padmavathy Dr, Thirunavukarasu Umaarasu Dr, Dhandapani Prabu Dr

Chulalongkorn Medical Journal

Background: Grapes are the most widely consumed fruit around the world. Grape seed comprises a group of polyphenols are known to have a broad pharmacological and therapeutic activities. The grape seed extract was known to have counteract against oxidative stress by its free radical scavenging activity.

Objectives: To identify the major phytocompounds of grape seed methanol extract and to evaluate its antioxidant activity

Methods: In this study, the methanol extract of the grape seed was subjected to Gas Chromatography-Mass Spectrometry to identify the major phytochemical compounds and further antioxidant activity was also evaluated by DPPH method using AOAC (Association of …

Histone 3 And 4 Acetylation Patterns In Nodular Goiter And Well-Differentiated Thyroid Tumors Compared With Normal Thyroid Tissue, Somboon Keelawat

Chulalongkorn Medical Journal

Purpose To estimate histone modification (hypoacetylation or hyperacetylation) in thyroid lesions, using immunohistochemistry compared with their normal counterpart.

Methods FFPE sections of surgically removed PTC, FA, FTC, and nodular goiter samples were collected from the archives of the Department of Pathology, Faculty of Medicine, Chulalongkorn University from 2016-2018 and stained with anti-acetyl histone 3 antibody (H3K9/K14ac) and anti-acetyl histone 4 antibody (H4K5,8,12 and 16ac). The intensity and proportion of immunostaining of the lesions and their normal thyroid tissue counterparts were automatically scored by Aperio Image Scope software.

Results A total of 147 benign and malignant thyroid lesions cases, including 28 …

Diversity Of Porifera Along The Coasts Of Türkiye, Alper Evcen, Bülent Topaloğlu

Turkish Journal of Zoology

This study compiled data on the distribution of sponge species on the coasts of Türkiye. The checklist consists of 183 speciesbelonging to 52 families, 16 orders, and 3 classes. The orders Haplosclerida (32 species), Poecilosclerida (28 species), Tetractinellida (26species), Dictyoceratida (21 species), and Suberitida (18 species) have the highest numbers of species found in the region. The Aegeancoast has the highest number of sponge species (155 species), followed by the Sea of Marmara (84 species), the Levantine coast (50species), and the Black Sea coast (24 species). Among the species, Niphates toxifera and Paraleucilla magna are alien species. A total of …