Digital Commons Network^™

Navigating Past The Tragedy Of The Commons, Maximilian Theriot, Walter E. Block

Journal of New Finance

Privatization of environmental resources is a promising approach for mitigating the tragedy of the commons. The present paper focuses on the impact and theoretical underpinnings of privatization within economic structures. The first part lays out a strong ethical case against state ownership, rooted in the belief that the state's claim to ownership inherently involves coercion, which likens taxation to theft due to its compulsory nature. The second part provides evidence that privatization leads to enhanced profitability and efficiency across sectors. The third part discusses the necessity of robust corporate governance and legal reforms post-privatization to ensure environmental protections are not …

Mutation In Prkra Results In Cerebellar Abnormality And Reduced Elf2Α Phosphorylation In A Model Of Dyt-Prkra, Samuel B. Burnett, Allison M. Culver, Tricia A. Simon, Taylor Rowson, Kenneth Frederick, Kristina Palmer, Stephen A. Murray, Shannon W. Davis

Faculty Publications

Variants in the PRKRA gene, which encodes PACT, cause the early-onset primary dystonia DYT-PRKRA, a movement disorder associated with disruption of coordinated muscle movements. PACT and its murine homolog RAX activate protein kinase R (PKR; also known as EIF2AK2) by a direct interaction in response to cellular stressors to mediate phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Mice homozygous for a naturally arisen, recessively inherited frameshift mutation, Prkra^lear-5J, exhibit progressive dystonia. In the present study, we investigated the biochemical and developmental consequences of the Prkra^lear-5J mutation. Our results indicated that the …

Glucose Metabolism Controls Monocyte Homeostasis And Migration But Has No Impact On Atherosclerosis Development In Mice, Alexandre Gallerand, Gyu Seong Heo, Hannah Luehmann, Yongjian Liu, Et Al.

2020-Current year OA Pubs

Monocytes directly contribute to atherosclerosis development by their recruitment to plaques in which they differentiate into macrophages. In the present study, we ask how modulating monocyte glucose metabolism could affect their homeostasis and their impact on atherosclerosis. Here we investigate how circulating metabolites control monocyte behavior in blood, bone marrow and peripheral tissues of mice. We find that serum glucose concentrations correlate with monocyte numbers. In diet-restricted mice, monocytes fail to metabolically reprogram from glycolysis to fatty acid oxidation, leading to reduced monocyte numbers in the blood. Mechanistically, Glut1-dependent glucose metabolism helps maintain CD115 membrane expression on monocytes and their …

Policy-Relevant Differences Between Secondhand And Thirdhand Smoke: Strengthening Protections From Involuntary Exposure To Tobacco Smoke Pollutants, Georg E Matt, Lydia Greiner, Rachael A Record, Heather Wipfli, Jamie Long, Nathan G Dodder, Eunha Hoh, Nicolas Lopez Galvez, Thomas E Novotny, Penelope J E Quintana, Hugo Destaillats, Xiaochen Tang, Antoine M Snijders, Jian-Hua Mao, Bo Hang, Suzaynn Schick, Peyton Jacob, Prue Talbot, E Melinda Mahabee-Gittens, Ashley L Merianos, Thomas F Northrup, Lara Gundel, Neal L Benowitz

Faculty, Staff and Student Publications

Starting in the 1970s, individuals, businesses and the public have increasingly benefited from policies prohibiting smoking indoors, saving thousands of lives and billions of dollars in healthcare expenditures. Smokefree policies to protect against secondhand smoke exposure, however, do not fully protect the public from the persistent and toxic chemical residues from tobacco smoke (also known as thirdhand smoke) that linger in indoor environments for years after smoking stops. Nor do these policies address the economic costs that individuals, businesses and the public bear in their attempts to remediate this toxic residue. We discuss policy-relevant differences between secondhand smoke and thirdhand …

Low-Frequency Stimulation Of Corpus Callosum Suppresses Epileptiform Activity In The Cortex Through Γ-Aminobutyric Acid Type B Receptor And Slow Afterhyperpolarization-Mediated Reduction In Tissue Excitability, Nrupen Pakalapati, Chia Chu Chiang, Dominique M. Durand

Faculty Scholarship

Objective: Deep brain stimulation, particularly low-frequency stimulation (LFS) targeting fiber tracts, has emerged as a potential therapy for drug-resistant epilepsy (DRE) and for generalized epilepsy, both of which pose significant treatment challenges. LFS diffusely suppresses seizures in the cortex when applied to fiber tracts like the corpus callosum (CC). Nevertheless, the specific processes responsible for suppressing epileptic activity in the cortex induced by LFS remain unclear. This study investigates the mechanisms underlying the antiepileptic effect in the cortex of LFS of the CC in coronal rodent brain slices. Methods: An in vitro 4-aminopyridine (4-AP) seizure model of cortical seizures was …

The Evolution Of Community Engagement Strategies In The Context Of Advancements In Artificial Intelligence Technologies, Erika Grodzki, Stefanie Powers, Gary Carlin, Hung Chum Kao

Faculty and Staff Publications & Presentations

As the AI landscape continues to evolve, the need for communities to nurture, inform, and challenge these technologies becomes paramount. This panel addresses the importance of traditional and AI driven strategies in terms of community engagement. Four case studies are reviewed to show how AI technologies are being implemented in communities. While AI offers numerous benefits, it is important not to overlook the value of human interaction in building and maintaining thriving community engagement. AI cannot replicate emotional intelligence and authentic relationship building - critical components of community engagement.

A Research And Development Strategy For Whitegrass Pasture: The Dominant Cool Temperate Rangeland Species Of The Falkland Islands, G M. Hoppe, J A. Kerr

IGC Proceedings (1977-2023)

Whitegrass (Cortaderia pilosa), the dominant rangeland plant species in the Falkland Islands, has been estimated to cover approximately 60% of the land area, It generally grows on peat soils and exhibits a range of growth forms depending upon soil drainage, The climate of the islands is cool oceanic with on annual precipitation of 300-650 mm. A brief history of agricultural research (established only in 1975) and work areas is presented. A major constraint to the productivity of the Falkland Islands sheep industry is poor utilisation of whilegrnss·dominant pasture. To develop new management strategies for whitegrass aimed at improved …

Phosphate Fertilizer For Pasture Maintenance In Southern Brazil, O.L P. De Oliverira

IGC Proceedings (1977-2023)

The study was conducted in the south of Brazil at the Brazilian Agricultural Research Enterprise, BMBRAPA. A winter-cultivated pasture stocked for 14 years with different stocking rates ended with different soil phosphorus (P) levels. To evaluate additional pho·sphate fertiliser response on this area, a pot experiment in the glasshouse was carried out. Levels of 0, 20, 40, 80 and 160 kg/ha of P20s were applied on a soil with 12.0, 12.5 and 17.0 ppm of available soil P, respectively, from low, medium and high stocking rates. White clover (Trifolium repens L.) was grown in pots of 2 kg of …

Growing Up Queer, Yocelin Rios

CouRaGeouS Cuentos: A Journal of Counternarratives

No abstract provided.

Brownness, Ariana Bucio

CouRaGeouS Cuentos: A Journal of Counternarratives

No abstract provided.

Creando Comunidad, Amy Angon

CouRaGeouS Cuentos: A Journal of Counternarratives

No abstract provided.

A Pocket Guide To Korea, 1956, Department Of Defense

Ephemera

A reproduction of the original 50 page Pocket Guide to Korea published by the Department of Defense and the Office of Armed Forces Information and Education; price 20 cents; 1956.

Using Young Adult Literature And Visual Commentary With Multilingual Learners In Middle Grades Social Studies, Malorie Noles

Teaching Social Studies in the Peach State

In this article, I share how I used young adult literature with my seventh grade students to foster critical thinking and curiosity and deepen students’ understanding of different cultures. The specific focus is the young adult novel, Brothers’ Keeper, and how I utilized a visual commentary project to support multilingual learners in my classroom. The purpose of the lesson is to model how young adult novels can not only tie to the curriculum, but how visual commentary can support the language development of multilingual learners through multimodal means.

A Review Of 3d Printing Technology In Drug Design Applications, Hasanain Shakir Mahmood, Jinan M. Al-Mousawy, Jamal Ali Ashoor, Ashti M.H. Saeed, Alaa Abdul Razzaq Al-Nuaimi, Pegah Khosravian

Maaen Journal for Medical Sciences

Sustainable technologies such as Additive manufacturing or three-dimensional printing (3D printing) have resulted in drastic changes in a number of industries including healthcare and pharmaceuticals. The current review focuses on the achievements accomplished on the effectiveness of three-dimensional printing in the field of drug designing and development. This technology is very precise and can be customized and that gives a way of developing complicated drug delivery systems and individualized medications. Promising areas of focus are the development of particular formulations of medicinal preparations, identification of new approaches to the drug release and potential creation of specific drug production for specific …

Piezosurgery - Modern Dentistry's Innovative Tool - A Review Article, Amjed Kadhim Al-Naaly, Ahmed Fadhel Al-Quisi

Maaen Journal for Medical Sciences

Background: In implantology, piezosurgery is a novel and cutting-edge method of bone surgery. Various ultrasonic frequencies can be used for selective cutting, which preserves essential anatomical structures by only operating on solidified hard tissues. Piezoelectric osteotomy is a technique that can be used to precisely and safely prepare receptor sites for procedure implants, acquire bone grafts classified as autogenous (blocks and particles), perform osteotomies used for alveolar crest bone expansion, lift the maxillary sinus, and remove dental implants. Clinically and physiologically, the outcomes are outstanding, especially regarding osteocyte vitality.

Objectives: This review aims to highlight the advantages and …

Interlaboratory Evaluation Of Bretziella Fagacearum Molecular Detection Assays To Guide The Edna Monitoring Of Oak Wilt Disease, Marie Krystel Gauthier, Abdelmadjid Djoumad, Tara L Bal, Guillaume J Bilodeau, Marc F Digirolomo, Meher Ony, Denita Hadziabdic, Kelsey C Mclaughlin, Laura Miles, Isabel Munck, Karen Lynn Snover-Clift, Philippe Tanguay

Michigan Tech Publications

Oak wilt disease, caused by the fungus Bretziella fagacearum, can kill mature red oaks within months of infection, severely affecting biodiversity, landscapes, and industries. The disease, originally only present in the United States, was officially reported for the first time in Canada in June 2023. The aim of this study was to suggest a standardized assay and sample processing method to optimize oak wilt detection both in infection centers and ahead of the disease front. Two previously published molecular assays, a Nested PCR and a TaqMan qPCR, were compared to detect B. fagacearum in a variety of samples in a …

Coastal Wetlands In The Anthropocene, John Day, Edward Anthony, Robert Costanza, Douglas Edmonds, Joel Gunn, Charles Hopkinson, Michael E. Mann, James Morris, Michael Osland, Tracy Quirk, Andre Rovai, John Rybczyk, Thomas Spencer, Jessica Stephens, Jaia Syvitski, Robert Twilley, Jenneke Visser, John R. White

Faculty Publications

We review the functioning and sustainability of coastal marshes and mangroves. Urbanized humans have a 7,000-year-old enduring relationship to coastal wetlands. Wetlands include marshes, salt flats, and saline and freshwater forests. Coastal wetlands occur in all climate zones but are most abundant in deltas. Mangroves are tropical, whereas marshes occur from tropical to boreal areas. Quantification of coastal wetland areas has advanced in recent years but is still insufficiently accurate. Climate change and sea-level rise are predicted to lead to significant wetland losses and other impacts on coastal wetlands and the humans associated with them. Landward migration and coastal retreat …

Marijuana Legalization And Opioid Use Disorder In Ontario, Canada, From 2015 To 2021, Luke Ome Agada

Walden Dissertations and Doctoral Studies

This study examined the trends in opioid-related hospitalizations and deaths in Ontario, Canada, from 2015, to 2021, with a particular focus on the periods before and after cannabis legalization. The social problem addressed was the ongoing opioid crisis, exacerbated by rising opioid-related health issues. Grounded in the harm reduction theory, this research explored whether cannabis legalization could serve as a substitute to mitigate opioid use disorder. Data were extracted from the Discharge Database, Emergency Department Database, National Ambulatory Care Reporting System, and Hospital Morbidity Database. Analysis using the generalized estimation equation (GEE) method revealed a significant increase in opioid-related hospitalizations, …

Determination Of A New Spring-Flying Species Of The Pterourus Glaucus Complex (Papilionidae) In Southern New England, Harry Pavulaan

The Taxonomic Report of the International Lepidoptera Survey

The Pterourus glaucus complex in three southern New England states is analyzed for cryptic speciation. What was historically considered to be one species, P. glaucus (Linnaeus, 1758), was recently split to separate P. canadensis (Rothschild & Jordan, 1906) at species rank (Hagen et al., 1991). Additionally, P. appalachiensis Pavulaan & Wright, 2002, was described as an Appalachian Mountain endemic. The western member of the complex, P. rutulus (Lucas, 1852), has frequently been considered a subspecies of P. glaucus (Scott, 1986; Tyler, Brown & Wilson, 1994), as was P. alexiares (Höpffer, 1866) (Tyler, Brown & …

The Comment, October 18, 2024, Bridgewater State University

The Comment

No abstract provided.

Antifibrotic Treatment Response Comparison Of Progressive Pulmonary Fibrosis And Idiopathic Pulmonary Fibrosis, Berna Akinci Özyürek, Kerem Ensari̇oglu, Tugce Sahi̇n Ozdemi̇rel, Esma Sevi̇l Akkurt, Ozlem Ozdag, Esma Zenbi̇lli̇

Turkish Journal of Medical Sciences

Background/Aim: Idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) are two entities categorized fibrotic lung diseases. With a similar clinical presentation and treatment modalities in many cases, the line differentiating two diseases may not be evident. We aimed to evaluate the effectiveness of antifibrotic treatment and the course of fibrotic lung diseases. Material and Methods: The study included patients diagnosed with IPF and PPF who were given antifibrotic treatment and followed up for one year in our clinic. At one year, treatment response and radiological evaluation were investigated by high-resolution computed tomography. Results: Eighty-seven patients were included in the …

Vitamin D3 Alleviates Intestinal Injury In Necrotizing Enterocolitis And Lipopolysaccharide-Induced Inflammatory Response In Dendritic Cells In Rats, Bo Ke, Chaoyu Li, Song Li, Jingjing Yan, Leke Sun

Turkish Journal of Medical Sciences

Background/aim: Necrotizing enterocolitis (NEC) is a serious condition that predominantly affects premature infants and involves an aberrant immune response and inflammatory cytokine release resulting in intestinal epithelial damage. The current study investigated the immunoregulatory effects of vitamin D3 on the maturation and activation of dendritic cells (DCs) and the antiinflammatory impact on the intestines in a neonatal rat model of NEC.Materials and methods: Inflammatory damage to intestinal tissue was assessed via morphological changes and apoptosis and DC expression of costimulatory molecules, inflammatory factors, and immunoregulatory factors by immunohistochemical staining, quantitative real-time PCR, and immunofluorescence. The fluorescein isothiocyanate-ovalbumin (FITC-OVA) uptake assay …

Discovery Of Genes That Positively Affect Biomass And Stress Associated Traits In Poplar, Tatyana Georgieva, Yordan Yordanov, Elena Yordanova, Md Rezaul Khan, Kaiwen Lyu, Victor Busov

Michigan Tech Publications

Woody biomass serves as a renewable resource for various industries, including pulp and paper production, construction, biofuels, and electricity generation. However, the molecular mechanisms behind biomass traits are poorly understood, which significantly curtails the speed and efficiency of their improvement. We used activation tagging to discover genes that can positively affect tree biomass-associated traits. We generated and screened under greenhouse conditions a population of 2,700 independent activation tagging lines. A total of 761 lines, which had significantly and positively affected at least one biomass-associated trait, were discovered. The tag was positioned in the genome for forty lines which were affected …

Hydrodynamic Exposure – On The Quest To Deriving Quantitative Metrics For Mariculture Sites, Oliver Lojek, Nils Goseberg, Heidi Moe Føre, Tobias Dewhurst, Thea Bölker, Kevin Gerald Heasman, Bela H. Buck, David W. Fredriksson, Samuel Rickerich

Faculty Publications

This work attempts to define metrics for hydrodynamic exposure, using known oceanographic variables to provide a universal site assessment method for mariculture structures. Understanding environmental conditions driving open-ocean mariculture siting is crucial in establishing consistent ocean governance, minimizing adverse environmental impacts, and facilitating economically sustainable farm operations. To provide a metric of oceanic conditions and associated requirements for structural design and operation of aquaculture systems, six Exposure Indices (EI) are proposed that consider physical energy levels related to hydrodynamic forces at a site. Four of the proposed indices consider only environmental conditions, while the other two also consider the dimensions …

Post-Transcriptional Methylation Of Mitochondrial-Trna Differentially Contributes To Mitochondrial Pathology, Sunita Maharjan, Howard Gamper, Yuka Yamaki, Thomas W. Christian, Robert Y. Henley, Nan-Sheng Li, Takeo Suzuki, Tsutomu Suzuki, Joseph A. Piccirilli, Meni Wanunu, Erin L. Seifert, Douglas C. Wallace, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Human mitochondrial tRNAs (mt-tRNAs), critical for mitochondrial biogenesis, are frequently associated with pathogenic mutations. These mt-tRNAs have unusual sequence motifs and require post-transcriptional modifications to stabilize their fragile structures. However, whether a modification that stabilizes a wild-type (WT) mt-tRNA would also stabilize its pathogenic variants is unknown. Here we show that the N¹-methylation of guanosine at position 9 (m¹G9) of mt-Leu(UAA), while stabilizing the WT tRNA, has a destabilizing effect on variants associated with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes). This differential effect is further demonstrated, as removal of the m¹G9 …

Nonclinical Profile Of Pf-06952229 (Mdv6058), A Novel Tgfβri/Activin Like Kinase 5 Inhibitor Supports Clinical Evaluation In Cancer, Mausumee Guha, Stephane Thibault, Son Pham, Sebastian Bernales, Rama Pai, Francisco J Herrera, Theodore R Johnson, Allison Vitsky, Tina Fernando, Martin Finkelstein

Faculty, Staff and Student Publications

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic …

Association Between Systemic Zinc And Oxidative Stress Levels And Periodontal Inflamed Surface Area, Ayşegül Sari, Serdar Doğan, Luigi Nibali

Turkish Journal of Medical Sciences

Background/aim: Zinc is a structural component of some enzymes. The aim of this study was to evaluate the potential associations between serum zinc and oxidative stress levels and periodontal inflamed surface area (PISA).Materials and methods: This study included 90 patients divided into three groups: a periodontitis group (P; n = 30), a gingivitis group (G; n = 30), and a periodontal health group (PH; n = 30). Periodontal parameters were recorded and PISA values were calculated. Serum total antioxidant status (TAS), total oxidant status (TOS), and zinc levels were examined biochemically. Oxidative stress index (OSI) levels were calculated.Results: All clinical …

Thoracic Trauma In The Geriatric Population And Possible Preventive Measures: A Retrospective Analysis Of 261 Cases, Mehmet Çeti̇n, Necati̇ Solak, Büşra Özdemi̇r Çi̇fli̇k, İlteri̇ş Türk, Sebahatti̇n Sefa Ermancik, Koray Aydoğdu

Turkish Journal of Medical Sciences

Background/aim: The rise in the proportion of the elderly population within society is concurrently escalating their vulnerability to traumas, notably falls associated with age-related comorbidities.Materials and Methods: The retrospective analysis involved the examination of data pertaining to patients aged 65 and above who were admitted to our clinic for inpatient treatment following thoracic trauma. Various parameters were statistically compared between the groups with indoor and outdoor traumas.Results: 59.4% of the 261 patients included in the study were male, and the average age in the entire sample was calculated as 75.52±7.79. 136 patients (52%) had indoor trauma, while 125 (48%) had …

The Socioeconomic And Environmental Niche Of Protected Areas Reveals Global Conservation Gaps And Opportunities, David Mouillot, Laure Velez, Camille Albouy, Nicolas Casajus, Joachim Claudet, Vincent Delbar, Rodolphe Devillers, Tom B Letessier, Nicolas Loiseau, Stéphanie Manel, Laura Mannocci, Jessica Meeuwig, Nicolas Mouquet, Ana Nuno, Louise O'Connor, Valeriano Parravicini, Julien Renaud, Raphael Seguin, Marc Troussellier, Wilfried Thuiller

School of Biological and Marine Sciences

The global network of protected areas has rapidly expanded in the past decade and is expected to cover at least 30% of land and sea by 2030 to halt biodiversity erosion. Yet, the distribution of protected areas is highly heterogeneous on Earth and the social-environmental preconditions enabling or hindering protected area establishment remain poorly understood. Here, using fourteen socioeconomic and environmental factors, we characterize the multidimensional niche of terrestrial and marine protected areas, which we use to accurately establish, at the global scale, whether a particular location has preconditions favourable for paestablishment. We reveal that protected areas, particularly the most …

Inshore Fisheries And Conservation Authorities: Fisheries Regulator Or Environmental Backstop? The Complexities Of Section 153 Marine & Coastal Access Act 2009, Emma Bean, Jason Lowther, Mike Williams

School of Law, Humanities and Social Sciences

Since the introduction of the Marine and Coastal Access Act 2009 (‘MCAA'), fishing within England's inshore marine area has been managed by Inshore Fisheries and Conservation Authorities (IFCAs). The powers and duties of IFCAs are contained in section 153 of MCAA and include a conservation remit; requiring IFCAs to have regard to the sustainability of fisheries activities and to conservation of the inshore marine environment. The inclusion of conservation in the name of these bodies and references to sustainability in their duties leads to questions as to the scope of IFCAs’ remit in relation to conservation. An examination of the …