Digital Commons Network^™

Ethical Responsibility In The Design Of Artificial Intelligence (Ai) Systems, David K. Mcgraw

International Journal on Responsibility

This article aims to provide an overview of the ethical questions surrounding the responsibilities of designers of artificial intelligence (AI) systems. First, the author delves into the philosophical underpinnings of this responsibility, examining various ethical theories to grasp the moral obligations individuals have towards others and society. The author contends that designers of technology bear the responsibility of considering the broader societal implications of their creations. Subsequently, the author scrutinizes the fundamental question of whether AI systems present unique ethical concerns compared to conventional technologies, pinpointing factors such as complexity, opacity, autonomy, unpredictability, uncertainty, and the potential for significant social …

Gait Measurement Descriptions Of Human Tracks, Robert Speiden

International Journal of Missing Persons

Search and rescue missions use a variety of tools to find missing persons, one of which can be visual tracking. Trackers detect, interpret and document information about human contact with the ground. Humans typically move on two feet at various speeds. Movement as an obligate biped leaves a series of footprints that alternates from one side to the other. This pattern of footfalls is rather simple, and the footfalls can be easily divided into descriptive dimensions.

This work summarized published measurements of bipedal gait ground contact points in 70 resources. Four resource types were surveyed including 33 biomechanical gait analysis …

The Many Ways Of Wakanda: Viewpoint Diversity In Black Panther And Its Implications For Civics Education, Justin Frank Martin

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Like many of its superhero film predecessors, Black Panther (2018) achieved widespread popularity both domestically and internationally. Although the film examines the focal character T’Challa’s (Black Panther) attempt to balance his dual responsibilities as king and protector of Wakanda, the viewpoint diversity displayed by its citizens suggests that the film’s central character is Wakandan society. Drawing on events and themes from the film, the essay argues that social domain theory (SDT)—a theory that attempts to explain the development of sociomoral concepts across the lifespan—provides a useful lens to examine Wakandans’ viewpoint diversity as portrayed in the film, specifically with regards …

Habitat Preferences Of The Hiwassee Crayfish (Cambarus Hiwasseensis) And Appalachian Brook Crayfish (Cambarus Bartonii Cavatus) In A Headwater Stream, Johnathan G. Davis

Georgia Journal of Science

The Hiwassee crayfish Cambarus hiwasseensis (CH) is an endemic species to the Hiwassee River watershed in north Georgia and western North Carolina that is sympatric with the more widespread Appalachian Brook crayfish Cambarus bartonii cavatus (CB). This was the first study to investigate CH habitat use, comparing CH habitat to CB habitat in Corn Creek, a small, second-order stream in the Hiwassee River watershed. From August to November 2016 and January to April 2018, 15 habitat parameters were measured for 154 1-m² quadrants randomly sampled from an 800-m stream reach. Mann-Whitney U tests compared habitat parameters between present and …

(Un)Conscious Representation: Race, Gender, Ideology [Dialogue: The Interdisciplinary Journal Of Popular Culture And Pedagogy, Volume 7, Issue 3 (Fall 2020)], Kirk Peterson, Anna S. Cohenmiller

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

(Un)conscious Representation: Race, Gender, Ideology [Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy, Volume 7, Issue 3 (Fall 2020)]

Editorial

Making the Invisible Visible through Popular Culture, Kirk Peterson and Anna S. CohenMiller

Articles

Visuality of Race in Popular Culture: Teaching Racial Histories and Iconography in Media, Joni Boyd Acuff and Amelia M. Kraehe

Unmasking Male Voices in Woman Hollering Creek: Contributions to Pedagogy and Masculinity Studies, Ramón J. Guerra and Joan Latchaw

D&D Beyond Bikini-Mail: Having Women at the Table, Daniel Carlson

A Heartbeat Away: Popular Culture’s Role in Teaching Presidential Succession, Jay Wendland

Pop Culture and …

A Heartbeat Away: Popular Culture’S Role In Teaching Presidential Succession, Jay L. Wendland

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

The role of popular culture in civic education is important. Many television viewers learn about the American political process through various dramatized depictions. The 25th Amendment has often received much attention from Hollywood, as it provides writers, directors, and producers a tool with which to further dramatize presidential succession. Through the television shows West Wing, Designated Survivor, Commander in Chief, Madam Secretary, and Political Animals, viewers are exposed to storylines revolving around the 25th Amendment. By viewing these dramatized versions of presidential succession, viewers are better able to understand the process and political science instructors …

D&D Beyond Bikini-Mail: Having Women At The Table, Daniel Carlson

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Dungeons and Dragons represents a space that is often treated as an echo chamber for young (usually white) men to act out fantasies of power and control, which makes up for their inability to perform such actions in the real world. Using the work of Sherry Turkle and Michelle Dickey, I posit that this game is a nuanced location acting as a safe space for people to act out different aspects of their identity or life experiences in a low-risk environment enhanced by the connections made between the players and their characters. In this work, I have utililzed feminist frames …

Visuality Of Race In Popular Culture: Teaching Racial Histories And Iconography In Media, Joni Boyd Acuff, Amelia M. Kraehe

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

The repetition of racist imagery from historical to contemporary popular culture is indicative of a lack of visual culture education among artists, designers, and other creative cultural producers working today. This paper addresses the dearth of resources for teaching visual codes and conventions of racial iconography that are recycled in popular media and contribute to the fabrication of racial differences, maintenance of racial hierarchies, and normalization of white supremacist ideology. Inspired by Critical Race Theory in art and visual culture education, the essay proposes teaching tactics and sites/sights that can support students in developing visual understandings of race in popular …

Editorial: Making The Invisible Visible Through Popular Culture, Kirk Peterson, Anna S. Cohenmiller

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Editorial for Dialogue: The The Interdisciplinary Journal of Popular Culture and Pedagogy Volume 7, Issue 3 (Fall 2020), (Un)conscious Representation: Race, Gender, Ideology.

Renegade Or Paragon?: Categorizing Narrative Choice In Video Game Storylines, Graham Oliver

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Choices made during video game gameplay set the stories told in that media apart from other media. Narrative-affecting choices have existed since the earliest games, from character creation in role-playing games to performance-based narrative changes in Metroid to morality-based choices in Ogre Battle. In the contemporary gaming landscape, some games derive a significant portion of their gameplay from character decisions: exploration, dialogue options, quick-time event reactions, etc. In this article, I give a history and breakdown of how choices have existed and evolved in gaming narratives since their inception. I then propose three categories for significant narrative choices: aesthetic, …

Finding The Sacred In The Profane: The Mardi Gras In Basile, Louisiana, Luc Guglielmi

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

In Basile, a small community in Southwest Louisiana, there would not be any Mardi Gras without Ash Wednesday and vice-versa. Most of the people in Basile speak of Ash Wednesday when defining the Mardi Gras as there is a reciprocal spiritual relationship between Mardi Gras and Ash Wednesday. The people from Basile, therefore, in giving equal spiritual value to these two feasts, assign a liturgical value to Mardi Gras because they need, and will admit this freely, to have a good Mardi Gras in order to enter into the sacred season of Lent.

Mardi Gras performs a function that is …

Appendix 1: College Of Medicine Departmental Synoptic Histories, J. G. Reves

MUSC Faculty Bookshelf

This is a multi-contributor compilation of the histories of all the academic departments in the College of Medicine. It was edited by Philippa Newfield, MD, and J.G. Reves, MD. Each department in the College of Medicine has a history and the histories are told primarily by the chairs of the departments.

Analysis Of Cns Autoimmunity In Genetically Diverse Mice Reveals Unique Phenotypes And Mechanisms., Emily A Nelson, Anna L. Tyler, Taylor Lakusta-Wong, Karolyn G Lahue, Katherine C Hankes, Cory Teuscher, Rachel M Lynch, Martin T Ferris, J Matthew Mahoney, Dimitry N Krementsov

Faculty Research 2024

Multiple sclerosis (MS) is a complex disease with significant heterogeneity in disease course and progression. Genetic studies have identified numerous loci associated with MS risk, but the genetic basis of disease progression remains elusive. To address this, we leveraged the Collaborative Cross (CC), a genetically diverse mouse strain panel, and experimental autoimmune encephalomyelitis (EAE). The 32 CC strains studied captured a wide spectrum of EAE severity, trajectory, and presentation, including severe-progressive, monophasic, relapsing remitting, and axial rotary-EAE (AR-EAE), accompanied by distinct immunopathology. Sex differences in EAE severity were observed in 6 strains. Quantitative trait locus analysis revealed distinct genetic linkage …

Using Computational Thinking To Explore And Support Equity And Social Justice, Leslie Keiler, Sherone Smith-Sanchez, Zena Cooper, Natasha Cox-Magno, Lisa Dunn-Lockhart, Kara Hudon, Clare Pawson, Xin Bai

Publications and Research

Brief summary of presentation, suitable for inclusion in our conference program.

We explore the experience of teacher candidates who went to schools much like where they are preparing to teach. We investigate the implementation of Computational thinking-based (CT) learning experiences and examine the social justice implications. We investigate the impacts on their thinking about social justice and the faculty’s reflections on CT integration.

Leveraging The Power Of Storytelling To Encourage And Empower Children Towards Strong Passwords, Rizu Paudel, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

With the increasing use of computer and smartphones by children, their online safety has been of major concern due to their limited security knowledge and skills. User authentication is pivotal for their security protection, where a body of work focused on children’s password practices. The insights from these studies highlight children’s lack of awareness and skills in creating a strong password. However, there is a dearth in existing literature to understand the scopes of designs for encouraging and empowering children towards strong passwords. As we begin to address this gap, we leveraged the power of storytelling to foster user attachment, …

The Importance Of Including Maternal Immune Activation In Animal Models Of Hypoxic-Ischemic Encephalopathy, Bailey Collins, Elise A. Lemanski, Elizabeth Wright-Jin

Department of Medicine Faculty Papers

Hypoxic-ischemic encephalopathy (HIE) is a perinatal brain injury that is the leading cause of cerebral palsy, developmental delay, and poor cognitive outcomes in children born at term, occurring in about 1.5 out of 1000 births. The only proven therapy for HIE is therapeutic hypothermia. However, despite this treatment, many children ultimately suffer disability, brain injury, and even death. Barriers to implementation including late diagnosis and lack of resources also lead to poorer outcomes. This demonstrates a critical need for additional treatments for HIE, and to facilitate this, we need translational models that accurately reflect risk factors and interactions present in …

Volume Cxliv, Number 7, November 8, 2024, Lawrence University

The Lawrentian

No abstract provided.

Multi-Organ Gene Expression Analysis And Network Modeling Reveal Regulatory Control Cascades During The Development Of Hypertension In Female Spontaneously Hypertensive Rat, Eden Hornung, Sirisha Achanta, Alison Moss, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Hypertension is a multifactorial disease with stage-specific gene expression changes occurring in multiple organs over time. The temporal sequence and the extent of gene regulatory network changes occurring across organs during the development of hypertension remain unresolved. In this study, female spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats were used to analyze expression patterns of 96 genes spanning inflammatory, metabolic, sympathetic, fibrotic, and renin-angiotensin (RAS) pathways in five organs, at five time points from the onset to established hypertension. We analyzed this multi-dimensional dataset containing ~15,000 data points and developed a data-driven dynamic network model that accounts for …

Modeling Antisense Oligonucleotide Therapy In Mecp2 Duplication Syndrome Human Ipsc-Derived Neurons Reveals Gene Expression Programs Responsive To Mecp2 Levels, Sameer S Bajikar, Yehezkel Sztainberg, Alexander J Trostle, Harini P Tirumala, Ying-Wooi Wan, Caroline L Harrop, Jesse D Bengtsson, Claudia M B Carvalho, Davut Pehlivan, Bernhard Suter, Jeffrey L Neul, Zhandong Liu, Paymaan Jafar-Nejad, Frank Rigo, Huda Y Zoghbi

Faculty, Staff and Students Publications

Genomic copy-number variations (CNVs) that can cause neurodevelopmental disorders often encompass many genes, which complicates our understanding of how individual genes within a CNV contribute to pathology. MECP2 duplication syndrome (MDS or MRXSL in OMIM; OMIM#300260) is one such CNV disorder caused by duplications spanning methyl CpG-binding protein 2 (MECP2) and other genes on Xq28. Using an antisense oligonucleotide (ASO) to normalize MECP2 dosage is sufficient to rescue abnormal neurological phenotypes in mouse models overexpressing MECP2 alone, implicating the importance of increased MECP2 dosage within CNVs of Xq28. However, because MDS CNVs span MECP2 and additional genes, we generated human …

Plasma Proteome Alterations Of Laying Hens Subjected To Heat Stress And Fed A Diet Supplemented With Pequi Oil (Caryocar Brasiliense Camb.): New Insights In The Identification Of Heat Stress Biomarkers, Joyce Da Silva, Luane Andrade, Paola Rodrigues, Laís Cordeiro, Gabrieli Lima, Júlia Lopes, Elis Castillo, Renata Martins, Andrey Assunção, José Vieira, Marília Busalaf, Jiri Adamec, José Sartori, Pedro Padilha

School of Medicine Faculty Publications

Heat stress can disrupt the balance between the heat poultry release into the environment and the heat they generate. Pequi oil has antioxidant properties, which may mitigate the heat stress effects. This study aimed to investigate the response of laying hens to pequi oil supplementation under heat stress using a proteomic approach. A total of 96 Lohmann White laying hens with 26 weeks old were housed in a completely randomized design with a 2 × 2 factorial arrangement. They were housed in two climate chambers, thermal comfort temperature ± 24.04 °C with the relative humidity ± 66.35 and heat stress …

The Rna Receptor Rig-I Binding Synthetic Oligodeoxynucleotide Promotes Pneumonia Survival, Yongxing Wang, Vikram V Kulkarni, Jezreel Pantaleóngarcía, Michael K Longmire, Mathilde Lethier, Stephen Cusack, Scott E Evans

Faculty, Staff and Student Publications

Pneumonia is a worldwide threat to public health, demanding novel preventative and therapeutic strategies. The lung epithelium is a critical environmental interface that functions as a physical barrier to pathogen invasion while also actively sensing and responding to pathogens. We have reported that stimulating lung epithelial cells with a combination therapeutic consisting of a diacylated lipopeptide and a synthetic CpG oligodeoxynucleotide (ODN) induces synergistic pneumonia protection against a wide range of pathogens. We report here that mice deficient in TLR9, the previously described receptor for ODN, still displayed partial ODN-induced protection. This prompted us to seek an alternate ODN receptor, …

Flocs As Vectors For Microplastics In The Aquatic Environment, Nan Wu, Stuart Grieve, Andrew Manning, Kate Spencer

School of Biological and Marine Sciences

No abstract provided.

Ephb4-Rasa1 Inhibition Of Piezo1 Ras Activation Drives Lymphatic Valvulogenesis, Di Chen, Yipei Tang, Philip E Lapinski, David Wiggins, Eva M Sevick, Michael J Davis, Philip D King

Faculty, Staff and Student Publications

BACKGROUND: EPHB4 (ephrin receptor B4) and the RASA1 (p120 Ras GTPase-activating protein) are necessary for the development of lymphatic vessel (LV) valves. However, precisely how EPHB4 and RASA1 regulate LV valve development is unknown. In this study, we examine the mechanisms by which EPHB4 and RASA1 regulate the development of LV valves.

METHODS: We used LV-specific inducible EPHB4-deficient mice and EPHB4 knockin mice that express a form of EPHB4 that is unable to bind RASA1 yet retains protein tyrosine kinase activity (EPHB4 2YP) to study the role of EPHB4 and RASA1 in LV valve development in the embryo and LV …

Microglia Drive Diurnal Variation In Susceptibility To Inflammatory Blood-Brain Barrier Breakdown, Jennifer H. Lawrence, Asha Patel, Melvin W. King, Collin J. Nadarajah, Richard Daneman, Erik S. Musiek

2020-Current year OA Pubs

The blood-brain barrier (BBB) is critical for maintaining brain homeostasis but is susceptible to inflammatory dysfunction. While transporter-dependent efflux of some lipophilic substrates across the BBB shows circadian variation due to rhythmic transporter expression, basal transporter-independent permeability and leakage is nonrhythmic. Whether daily timing influences BBB permeability in response to inflammation is unknown. Here, we induced systemic inflammation through repeated LPS injections either in the morning (ZT1) or evening (ZT13) under standard lighting conditions; we then examined BBB permeability to a polar molecule that is not a transporter substrate, sodium fluorescein. We observed clear diurnal variation in inflammatory BBB permeability, …

Hurp Facilitates Spindle Assembly By Stabilizing Microtubules And Working Synergistically With Tpx2, Venecia Alexandria Valdez, Meisheng Ma, Bernardo Gouveia, Rui Zhang, Sabine Petry

2020-Current year OA Pubs

In vertebrate spindles, most microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing microtubules. Hepatoma up-regulated protein (HURP) is a microtubule-associated protein that has been implicated in spindle assembly, but its mode of action is yet to be defined. In this study, we show that HURP is necessary for RanGTP-induced branching microtubule nucleation in Xenopus egg extract. Specifically, HURP stabilizes the microtubule lattice to promote microtubule formation from γ-TuRC. This function is shifted to promote branching microtubule nucleation through enhanced localization to TPX2 condensates, which form the core of the branch site on microtubules. …

Evaluating The Effectiveness Of Personalized Wet Lab Training On Phacoemulsification Surgery Learning Curve, Karen L. Christopher, Jennifer L. Patnaik, Cara E Capitena Young, Jeffrey R Soohoo, Michael J. Taravella, Mina B. Pantcheva

Journal of Academic Ophthalmology

Purpose To assess the impact of individualized one-on-one wet lab training on the learning curve of phacoemulsification cataract surgery among ophthalmology residents. Methods This prospective study involved 15 ophthalmology residents at a single institution between 2016 and 2019. Each resident participated in tailored training sessions focusing on phacoemulsification surgical steps, guided by an experienced cataract surgeon. Proficiency across 11 procedural steps was evaluated using a 5-level ordinal scale, and data on complications, case times, and proficiency scores were collected and analyzed using multiple regression models. Competency was defined as resident trainee performance of a surgical case without complication and level …

Dynamic Pricing System For Recommerce Transaction, Madhusudan St

Defensive Publications Series

The present disclosure related to a technique for real-time dynamic pricing recommendations. The technique includes fetching historical data and transactional information related to the plurality of products and corresponding similar products based on queries. The technique further include calculating optimal pricing recommendations based on the fetched historical data and transactional information. Subsequently, the technique include distributing price recommendations for recommerce transaction to the plurality of merchants

“No Te Voy A Dejar Nunca”: Culture And Second Language Acquisition For Survival In Fear The Walking Dead, Sharon M. Nuruddin

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Popular culture reinforces and shapes the beliefs and values of the individual, the community, and the masses. It can also transmit hidden messages about aspects of human behavior that are reiterated in scholarly research. In the field of education, particularly in world language teacher education, film and television can be used as an effective tool for examining how we acquire a second language. Using a symbolic convergence theory perspective (SCT) (Bormann, 1972), I employ Sellnow’s (2014) three-step process for the rhetorical analyses of mediated popular culture texts to reveal “covert messages” (p. 9) within the popular American Movie Channel (AMC) …

Criminals As Heroes: Problems And Pedagogy In Popular Culture [Dialogue: The Interdisciplinary Journal Of Popular Culture And Pedagogy Volume 6, Issue 2 (August 2019)], Anna S. Cohenmiller, Kelli Bippert

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Criminals as Heroes: Problems and Pedagogy in Popular Culture [Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy Volume 6, Issue 2 (August 2019)]

Editorial

Critically Evaluating the Fictional World through Popular Culture, Kelly Bippert and Anna CohenMiller

Guest Editorial

What Hot Criminals, Anti-Heroes, and Bob Dylan Can Teach Us, Kathryn (“Kate”) Lane and Roxie James

Articles

If Androids Dream, Are They More Than Sheep?: Westworld, Robots and Legal Rights, Amanda DiPaolo

Nature vs. Nurture in Albuquerque: What Breaking Bad and Better Call Saul Teach Us About How We Talk about Criminals, Max Romanowski

Breaking the Rules: Playing Criminally in …

Breaking The Rules: Playing Criminally In Video Games, James Tregonning

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Video games have long courted controversy for their frequent valorisation of criminality. However, in this article, I consider heroic criminals in video games from a different perspective. I focus on two games – Lucas Pope’s Papers, Please (2013) and Osmotic Studio’s Orwell (2016) – that position the player as a low-level government operative in a fictional authoritarian regime. Players are expected to process information for their governments, although they are also given opportunities to undermine or subvert the regime. Thus, the trope of heroic criminal is used to comment on the function and role of the state. It becomes …