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Investigating The Role Of Cd44 In Her2+ Breast Cancer Cells During Cancer Cell Redirection, Holly Caroline Jordan Campbell

All Dissertations

Despite a rise in survival rates of breast cancer patients due to advances in modern medicine, breast cancer is the most common type of cancer in women and is the second leading cause of cancer death in the United States. Early detection and a more personalized treatment of breast cancer has slowly improved patient outcomes. Nevertheless, there are impediments to better patient outcomes due to the complexity of the disease physiology. Therefore, there is a demand for a comprehensive understanding of cancer development as well as a need to understand tumor progression for enhanced therapies for patients.

Previous in vivo …

Determination Of Human Hair Components By Spectrophotometric Methods For The Diagnosis Of Thyroid Diseases, Fatima H. Salih, Shaimaa S. Mahdi, Alaa H. Ali

Baghdad Science Journal

Human hair is a vital tissue, rich in minerals and vitamins that have an effective role in the production of enzymes, hormones and other substances necessary for normal growth, it is considered an indicator of any defect in the performance of body functions at all stages of life, so the use of hair in the diagnosis of diseases is a challenge in the clinical laboratory, as it will be easy to frequently monitor diseases, and it will have an impact on medical research and treatment. For instance, hypothyroidism occurs when the thyroid gland does not secrete enough thyroid hormone into …

Deep Oxidative Desulfurization Utilizing Hybrid Keggin Catalyst With 1-Methyl-3-Octyl Imidazolium Hexafluorophosphate, Yasmeen Mundher, Hussein Q Hussein, Ban A. Al-Tabbakh

Baghdad Science Journal

Deep oxidative desulfurization is a crucial topic for environmental catalysis research for producing a low-sulfur diesel. One of the effective catalysts that have been used recently for oxidative desulfurization of the refractory sulfur compound from model diesel is Keggin-type polyoxometalate. In this work, a Keggin-type catalyst TBAPW11O39, model diesel, Hydrogen peroxide (H2O2) and 1- methy l-3-octyl imidazolium hexafluorophosphate (OMIM(PF6)) were tested under different reaction conditions. The sulfur compound dibenzothiophene (DBT) in model diesel was captured in ionic liquid (IL) and then oxidized to produce related sulfones with H2O2 as an oxidant using TBAPW11O39, in a batch reactor. The impacts of …

Bernoulli Polynomials Method For Solving Integral Equations With Singular Kernel, Muna M. Mustafa, Heba A. Abd-Alrazak

Baghdad Science Journal

There is always an interest in an effective technique to generate a numerical solution of integral equations with singular or weakly singular kernels more precisely because numerical methods have limitations. In this study, integral equations with singular or weakly singular kernels are solved using the Bernoulli polynomial approach. The primary goal of this study is to provide an approximate solution to such problems in the form of a polynomial in a series of straightforward steps. Also, assuming that the denominator of the kernel will never be zero or have an imaginary value due to the selected nodes of the unique …

Preparation And Study Of The Optical Properties Of Recycled Materials Of Polymethyl Methacryalate Doped With Different Ratios Of 4-(2- Pyridylazo) Resorcinol Monosodium Salt Hydrate, Zainab J. Sweah, Fatima H. Malk, Muhsen Chelab Muhsen, Baheya Abdulbaqi

Baghdad Science Journal

This paper presents an incoming method of developing a novel optical sensor using polymethylmethacrylate was reused with the presence of the ethanol-derived resin from Frankincense (1:1) (wt:wt%-(2-Pyridylazo) Resorcinol Monosodium Salt Hydrate) (azo dye) by solution casting technique. The prepared samples were Scanning Electron Microscopes(SEM),and studied by UV-VIS spectrophotometer for wavelengths 400-800nm, the absorbance increased; however, when it exceeded 7%, the absorbance value decreased, and the behavior was identical to that of the transmittance. The absorption coefficient and Extinction coefficient and optical energy gap at 5% is the best value. were also computed. Based on the results obtained the study was …

Investigation Of Curing Kinetics Analysis And Their Effects On Properties Of Epoxy: Polystyrene Blending, Zahraa Imran Mousa, Najim. A.Saad

Baghdad Science Journal

The effect of curing conditions, such as temperature, concentration of toughening material, such as polystyrene, on epoxy resin cure kinetics was studied, along with the effects of curing parameters, such as degree of cure (α) and glass transition temperature (Tg), mechanical properties, thermal properties (TGA), and morphology of epoxy and its blends. Tg, degree of cure, and thermal stability measures were calculated from a DSC chart, mechanical properties (tensile strength, elastic modulus, and elongation at break) were measured using a universal tensile machine, the curing process was the same for all samples with varying temperatures, and the morphology of fracture …

An Object Detection Model Based On Augmented Reality For Iraqi Archaeology, Suha Dh. Athab, Abdulamir Abdullah Karim

Baghdad Science Journal

The culture of Iraq, which boasts a rich history, serves as evidence of the magnificence of human civilization. Nonetheless, safeguarding and highlighting this valuable cultural legacy has become a significant worry in a time characterized by technological progress. Augmented Reality (AR) offers a powerful tool for preserving and presenting historical sites. The aim of this research is to leverage AR technology as a means to ensure the continued preservation and dynamic presentation of Iraq's cultural heritage. This study explores the capabilities of CNNs as the basis of AR's development. CNN is used as an essential initial step in constructing AR …

On Pre­ Open Regular Spaces, Afraa R. Sadek

Baghdad Science Journal

In this paper, certain types of regularity of topological spaces have been highlighted, which fall within the study of generalizations of separation axioms. One of the important axioms of separation is what is called regularity, and the spaces that have this property are not few, and the most important of these spaces are Euclidean spaces. Therefore, limiting this important concept to topology is within a narrow framework, which necessitates the use of generalized open sets to obtain more good characteristics and preserve the properties achieved in general topology. Perhaps the reader will realize through the research that our generalization preserved …

Lung Ct Image Segmentation Using Vgg-16 Network With Image Enhancement Based On Bounded Turning Mittag-Leffler Function, Ali M. Hasan, Mohammed Khalaf, Bayan M. Sabbar, Rabha W. Ibrahim, Hamid A. Jalab, Farid Meziane

Baghdad Science Journal

Automated segmentation of diseases considered a necessary initial step in routine diagnosis. Lung diseases that affect the lungs, such as pneumonia or lung collapse can result in areas of consolidation or atelectasis, where lung tissue becomes denser or collapses. It can be challenging to accurately segment such areas, as they may exhibit similar characteristics to adjacent structures. This study proposes a lung CT image segmentation method which includes two steps: (1) a new image enhancement model that uses the bounded turning Mittag-Leffler function to improve the CT images for better segmentation outcomes. (2) a new modified VGG-16 for infection of …

Identification Of Some Biochemical Indicators To Indicate The Contamination Of Some Fish Farms In Hilla City/ Iraq, Layla Mustafa A.A. Alkatrani, Zahraa Hussein Obaid, Jasim Mohammed Salman

Baghdad Science Journal

In order to establish the possibility of determined biochemical indicators of possible pollution in Al-Forat fish farm (A) and Hussein Ajimi fish farm (B) as well as wild fish samples as a control from Shatt Al-Hilla River (C). Oxidative stress factors and antioxidant enzyme activity were determined in common carp Cyprinus carpio blood serum from two fish farms. Reactive Oxygen Species (ROS), Superoxide Dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx) and Hydrogen peroxide (H2O2) performance were chosen as pollution bioindicators, as well as Total Protein (TP) as a general bio indicator for fish health. Results showed an increase in all …

Genetic Prevalence Of Antifungal Resistance Gene In Cancer Patients With Oropharyngeal Candidiasis From Iraq, Muhamed Abd Ulrahman Majeed, Abdulameer Jasim Mohammed, Omar Sadik Shalal

Baghdad Science Journal

As the population of immunocompromised patients grew, yeast infections became more common. There has been a significant rate of morbidity and mortality among patients with Candidiasis demonstrating increased resistance to antifungal medications. The main aim of this study was to determine the virulence gene of Candida albicans, evaluate antifungals used for Candidiasis, and biofilm formation, which is isolated from the mouth of individuals in the Baghdad Governorate From 1st October 2022 to 28th February 2023. This study included 120 oral swabs collected from people who had oral candidiasis, with an age group between10-65 including both Genders. The results obtained showed …

Spectrophotometric Determination Of 4-Ethylphenol Using Cloud Point Extraction In Different Water Samples, Alaa Mousa Imran, Saadiyah Ahmed Dhahir, Ahmed Jassim Muklive

Baghdad Science Journal

This study describes the development of an easy, inexpensive, accurate and fast spectrophotometric technique for the determination of 4-ethylphenol. The primary method involves converting 3-nitroaniline to the diazonium salt and then reacting with 4-ethylphenol in an alkaline medium. It is yellow in color and has a maximum absorption at 426 nm. It obeys Beer's law in a linear range of 5-12 µg mL-1 with a correlation coefficient of 0.9994 and a molar absorptivity 6.0024 x 103 L. mol-1. cm-1. Cloud point extraction was used to quantify trace amounts of phenol using TritonX-114 as a surfactants, and subsequently, a measurement procedure …

Intelligent System For Student Performance Prediction Using Machine Learning, Mustafa S. Ibrahim Alsumaidaie, Ahmed Adil Nafea, Abdulrahman Abbas Mukhlif, Ruqaiya D. Jalal, Mohammed M Al-Ani

Baghdad Science Journal

Accurately predicting student performance remains a significant challenge in the educational sector. Identifying students who need additional support early can significantly impact their academic outcomes. This study aims to develop an intelligent solution for predicting student performance using supervised machine learning algorithms. This proposed focus on addressing the limitations of existing prediction models and enhancing prediction accuracy. In this work employed three supervised machine learning algorithms: Random Forest, Extra Trees, and K-Nearest Neighbors. The steps of research methodology contained (data collection, preprocessing, feature identification, model construction, and evaluation). This paper utilized a dataset comprising 24,000 training instances and 6,000 testing …

Seedling Growth Of Primed Seed Under Drought Stress In Sorghum, Mohammad Omar Shihab, Jalal Hameed Hamza, William Serson, Andre Amakobo Diatta, Martin Battaglia, Maythem Al-Amery, Hail Z Rihan

Baghdad Science Journal

Drought stress is considered a limiting factor during the early growth stages of sorghum. An experiment was conducted under field conditions during the fall seasons of 2017 and 2018. The objective was to improve the growth of sorghum seedlings and their chemical properties to tolerate drought stress. Three variables were investigated: first factor cultivars (Inqath, Rabeh, and Buhoth70), second factor seed priming (primed and unprimed seed). Seeds were primed by soaking for 12 hours in a solution containing 300 mg L−1 + 70 mg L−1 of gibberellic (GA3) and salicylic (SA) acids, respectively, and third factor drought stress represented by …

On Some Separation Axioms In Soft Lattice Topological Spaces, Sandhya S. Pai, Baiju T

Baghdad Science Journal

In the realm of topology, various constraints are frequently imposed on the types of topological spaces under examination and these constraints are defined by what are known as separation axioms. Also, the separation axioms can be seen as additional conditions that may be incorporated into the definition of topological spaces. Separation axioms serve various purposes in lattice theory. They provide tools for classifying and comparing different lattices, revealing their structural and topological properties. While traditional separation axioms like T0, T1, T2, etc., still play a role, their interpretation and implications differ in the context of soft sets and lattice structures. …

Synthesis, Characterization And Antioxidant Study Of Some Metal Ion Complexes With Azo 1-(2,4,6-Trihydroxy-3-((3-Hydroxyphenyl) Diazenyl) Phenyl) Ethan-1-One., Areeg Malek Fadhel, Abbas Ali Salih Al Hamdani, Saad G. Mohamed

Baghdad Science Journal

During a diazotization coupling reaction, an azo dye-ligand (H4L) was formed by combining 3-aminophenol and 2,4,6-trihydroxyacetophenone. This ligand was then allowed to react with several different metal ions (Mo (VI), Fe (III), Co (II), Cr (III), Ru (III) and Rh (III)), forming stable metal complexes with various geometries. The binding of the azo-dye group to the metal ions was detected through the M-N and M-O absorption bands in Fourier-transform-infrared, which indicated the involvement of nitrogen and oxygen. LC-MS spectra confirmed the molecular weights of the ligand and its complexes, and elemental analysis was also conducted. Electronic spectra were used to …

Some Outcomes Involving A Specific Class Of Functions Over Differential Subordination And Superordination, Mustafa I. Hameed, Shaheed Jameel Al-Dulaimi, Kayode Oshinubi, Hussaini Joshua, Ali F. Jameel, Israa A. Ibrahim

Baghdad Science Journal

This work investigates several aspects of differential subordination and superordination, leading to the inclusion of a specific class within the domain of univalent meromorphic functions in a perforated open unit disc and deriving a few sandwich theorems. The purpose of this article is to look into a few of the characteristics of variation subordination for analytic univalent functions over a perforated unit disc. It additionally aims to shed insight into geometric characteristics like coefficient inequality, Hadamard product characteristics, and the Komatu integral operator. A few interesting findings have been discovered for variations in subordination as well as superordination in analytic …

Carbon Footprint For Industry -Al-Rasheed Vegetable Oil Factory, Elham M. Al-Bayati, Jinan S. Al-Hassan

Baghdad Science Journal

This is a comprehensive study to calculate the carbon footprint of the Al-Rasheed vegetable oil factory in gaining a clear understanding of the environmental impact and identifying opportunities for emission reduction and sustainability improvement and to provide an overview of the key elements and objectives of the current study. Utilizing industry-standard calculation methodologies and emission factors specific to Al-Rasheed Factory and geographic location, we analyzed the collected data to quantify Al-Rasheed carbon emissions across only scope 1(Direct GHG Emissions via the burning of fossil fuels) measured by using the latest IPCC 2021 version 1.02 GHG Protocol and the SimaPro version …

Nadaraya-Watson Estimation Of A Circular Regression Model On Peak Systolic Blood Pressure Data, Rana Sadiq Nazer, Omar Abdulmohsin Ali

Journal of Economics and Administrative Sciences

Purpose: The research aims to estimate models representing phenomena that follow the logic of circular (angular) data, accounting for the 24-hour periodicity in measurement. Theoretical framework: The regression model is developed to account for the periodic nature of the circular scale, considering the periodicity in the dependent variable y, the explanatory variables x, or both. Design/methodology/approach: Two estimation methods were applied: a parametric model, represented by the Simple Circular Regression (SCR) model, and a nonparametric model, represented by the Nadaraya-Watson Circular Regression (NW) model. The analysis used real data from 50 patients at Al-Kindi Teaching Hospital in Baghdad. Findings: The …

Immunopeptidomic Mhc-I Profiling And Immunogenicity Testing Identifies Tcj2 As A New Chagas Disease Mrna Vaccine Candidate, Leroy Versteeg, Rakesh Adhikari, Gonteria Robinson, Jungsoon Lee, Junfei Wei, Nelufa Islam, Brian Keegan, William K Russell, Cristina Poveda, Maria Jose Villar, Kathryn Jones, Maria Elena Bottazzi, Peter Hotez, Edwin Tijhaar, Jeroen Pollet

Faculty, Staff and Students Publications

Trypanosoma cruzi is a protozoan parasite that causes Chagas disease. Globally 6 to 7 million people are infected by this parasite of which 20-30% will progress to develop Chronic Chagasic Cardiomyopathy (CCC). Despite its high disease burden, no clinically approved vaccine exists for the prevention or treatment of CCC. Developing vaccines that can stimulate T. cruzi-specific CD8+ cytotoxic T cells and eliminate infected cells requires targeting parasitic antigens presented on major histocompatibility complex-I (MHC-I) molecules. We utilized mass spectrometry-based immunopeptidomics to investigate which parasitic peptides are displayed on MHC-I of T. cruzi infected cells. Through duplicate experiments, we identified an …

A New Ex Vivo Model System To Analyze Factors Affecting The Integrity Of Fetal Membranes In Fetoscopic Surgery, Serjosha Robmann, Raoul Hopf, Costanza Giampietro, Lukas Moser, Alexandra Dolder, Magdalena Sanz Cortes, Martin Ehrbar, Nicole Ochsenbein, Jan Deprest, Edoardo Mazza

Faculty, Staff and Students Publications

We developed an ex vivo model system to analyze the influence of relevant environmental and mechanical factors potentially affecting the integrity of fetal membranes during fetoscopic surgery. The set-up exposes amniochorion membranes to insufflation at predefined levels of gas pressure, flow, humidity, and temperature. Change in fetal membranes stiffness is quantified during the phase mimicking surgery through measurement of membranes' strain in response to cyclic overpressure. The trocar induced perforation creates a mechanical weakness whose stability is assessed by increasing the insufflation pressure until membrane rupture. Damage of the epithelial cells lining the amnion is assessed through live-dead staining. Initial …

Fournier's Gangrene Severity Index And Charlson Comorbidity Index Predict Mortality, Intensive Care Unit Admission, And Length Of Hospital Stay In Patients With Fournier's Gangrene: An Analysis Of 264 Consecutive Patients, Nicholas Hauser, Chenlin Huang, Girija Vaidya, Timothy Chrusciel, Krithika Narayana Kumarasan, John Culhane, Sameer Siddiqui

Faculty, Staff and Students Publications

Introduction: Fournier’s gangrene (FG) is a rapidly progressing necrotizing fasciitis. The Fournier's Gangrene Severity Index (FGSI), in conjunction with the Charlson Comorbidity Index (CCI), has been used as a mortality predictor during hospitalization. Patients with diabetes have also been shown to be at an increased risk for the development of FG. This study explores the potential of using FGSI, CCI, and patient diabetes status in predicting more extensive patient outcomes, including intensive care unit (ICU) admission and length of hospital stay.

Methods: From 2013 to 2023, inpatient admissions with the diagnosis of FG were selected from the EPIC Clarity database …

Brief Of First Amendment And Internet Law Professors As Amici Curiae In Support Of Petitioners, Tiktok Inc. V. Garland, No. 24-656 (U.S. 2025)., Shubhangi Agarwalla, Enrique Armijo, Kevin Bankston, Susan Benesch, Ashutosh Bhagwat, Stuart N. Brotman, Ryan Calo, Anupam Chander, Erwin Chemerinsky, Alan K. Chen, David Craig, Eric Goldman, Gregory Gondwe, James Grimmelmann, Nikolas Guggenberger, G.S. Hans, Robert A. Heverly, Thomas E. Kadri, David Kaye, Heidi Kitrosser, Vivek Krishnamurthy, Edward Lee, Mark A. Lemley, David S. Levine, Yvette Joy Liebesman, Gregory P. Magarian, Jess Miers, Sean O’Brien, Mary-Rose Papandrea, Kermit Roosevelt, Jennifer Safstrom, Pamela Samuelson, Madhavi Sunder, Christopher Jon Sprigman, Jordi Weinstock

Con Law Center Amicus Briefs

“Without freedom of thought, there can be no such thing as wisdom, and no such thing as public liberty, without freedom of speech.” Benjamin Franklin, Silence Dogwood, No. 8 (July 9, 1722). For this reason, the U.S. Constitution makes clear that the Government cannot abridge free speech based on its content or viewpoint absent compelling and narrowly tailored grounds. Indeed, the protection of all speech is foundational to American democracy. See United States v. Schwimmer, 279 U.S. 644, 654–55 (1929) (Holmes, J., dissenting) (“[I]f there is any principle of the Constitution that more imperatively calls for attachment than any other …

Hemodynamic And Clinical Outcomes With Balloon-Expandable Valves Versus Self-Expanding Valves In Patients With Small Aortic Annulus Undergoing Transcatheter Aortic Valve Replacement: A Meta-Analysis Of Randomized Controlled Trials And Propensity Score Matched Studies, Mushood Ahmed, Areeba Ahsan, Shehroze Tabassum, Irra Tariq, Eeshal Zulfiqar, Mahnoor Farooq Raja, Asma Mahmood, Raheel Ahmed, Farhan Shahid, Syed Khurram M Gardezi, Mahboob Alam, Rodrigo Bagur, Mamas A Mamas

Faculty, Staff and Students Publications

Transcatheter aortic valve replacement (TAVR) is considered more effective than surgical aortic valve implantation for patients with a small aortic annulus (SAA), however, the comparative efficacy of different transcatheter heart valves (THVs) remains uncertain. A literature search was performed across databases from their inception until June 2024 to identify eligible randomized controlled trials (RCTs) and propensity-score matched (PSM) studies. Clinical outcomes were evaluated using a random-effects model to pool risk ratios (RRs) with 95 % confidence intervals (CIs). The analysis included 10 studies with 2,960 patients. BEVs were associated with a significantly smaller indexed effective orifice area (MD: -0.18, 95 …

Beyond Boundaries: Governance Considerations For Climate-Driven Habitat Shifts Of Highly Migratory Marine Species Across Jurisdictions, Bianca S. Santos, Elliott L. Hazen, Heather Welch, Nerea Lezama-Ochoa, Barbara A. Block, Daniel P. Costa, Scott A. Shaffer, Larry B. Crowder

Faculty Research, Scholarly, and Creative Activity

The mobile nature of migratory marine animals across jurisdictional boundaries can challenge the management of biodiversity, particularly under global environmental change. While projections of climate-driven habitat change can reveal whether marine species are predicted to gain or lose habitat in the future, geopolitical boundaries and differing governance regimes may influence animals’ abilities to thrive in new areas. Broad geographic movements and diverse governance approaches elicit the need for strong international collaboration to holistically manage and conserve these shared migratory species. In this study, we use data from the Tagging of Pacific Predators program to demonstrate the feasibility of using climate-driven …

Impact Of Pegylated Liposomes On Cytotoxicity Of Tamoxifen And Piperine On Mcf-7 Human Breast Carcinoma Cells, Klaudi K. Vaiphei, A Prabakaran, Singh Snigdha, Satyajit Laxman Murkute, Purusottam Mohapatra, Rakesh Kumar Sahoo, Sanya Batheja, Umesh Gupta, Anu Puri, Upal Roy

Health & Biomedical Sciences Faculty Publications

Tamoxifen (TMF) is an anticancer agent used for managing estrogen receptor-positive breast cancer. It has limited therapeutic efficacy against breast cancer, which could be enhanced by the coadministration of herbal drugs like piperine (PIP). However, the hydrophobic nature of TMF and PIP restricts their therapeutic application. Therefore, the present study focuses on the impact of the anticancer activity of TMF in combination with PIP and after entrapping them into liposomes (TMF-PIP-LPs and TMF-PIP-PEG-LPs). The liposomes were prepared using the thin film hydration method. In addition, the morphology of the prepared liposomes was found spherical after SEM and TEM analyses. Further, …

Anaplasma Phagocytophilum’S Effect On Gopher Tortoises Of South East Florida, Elena Tonkin

Harriet L Wilkes Honors College Theses 2020 - Present

Recent studies have revealed Anaplasma phagocytophilum as a new pathogen that has started to affect gopher tortoise populations throughout Florida. This study investigated how the pathogen, A. phagocytophilum, has potentially begun to spread amongst the gopher tortoises in the Abacoa Greenway and the Florida Atlantic University Preserve (FAUP). To investigate these tortoises, blood samples were taken from multiple specimens from Range VI of the Greenway and FAUP. DNA isolated from these samples were then analyzed for the presence of A.phagocytophilum utilizing PCR and gel electrophoresis, followed by Sanger sequencing. This research demonstrated that A.phagocytophilum has not made its way …

Compact Solar-Powered Plasma Water Generator: Enhanced Germination Of Aged Seed With The Corona Dielectric Barrier Discharger, Yiting Xiao, Yang Tian, Haizheng Xiong, Ainong Shi, Jun Zhu

Biological and Agricultural Engineering Faculty Publications and Presentations

Seed aging adversely affects agricultural productivity by reducing germination rates and seedling vigor, leading to significant costs for seed banks and companies due to the need for frequent seed renewals. This study demonstrated the use of plasma-activated water (PAW), generated by a solar-powered corona dielectric barrier discharger, to enhance germination rates of spinach seeds that had been stored at 4 °C for 23 years. Treating seeds with PAW at 17 kV for 15 min improved germination (by 135%) and seedling growth compared to untreated seeds. Through detailed analysis, beneficial PAW properties for seed development were identified, and a molecular mechanism …

The Impact Of Early Axial Interfragmentary Motion On The Fracture Healing Environment: A Scoping Review, Griffin R Rechter, Ryan Tyler Anthony, Justin Rennard, James F Kellam, Stephen J Warner

Faculty, Staff and Student Publications

Purpose: The initial interfragmentary motion (IFM) at a fracture site determines the mode of fracture healing. Understanding the impact of orthopaedic interventions on the fracture environment is essential to advancing our knowledge of fracture healing. The purpose of this scoping review is to analyze the orthopaedic literature to assess our understanding of the effects of early axial IFM on fracture healing outcomes.

Methods: PubMed, OVID, and Scopus databases were queried to identify all studies from inception until June 2023 assessing axial IFM on fracture healing outcomes in animal and human subjects. We collected information regarding the amount of IFM, osteotomy/fracture …

Redox Regulation Of Proteostasis, Long Duy Duong, James D West, Kevin A Morano

Faculty, Staff and Student Publications

Oxidants produced through endogenous metabolism or encountered in the environment react directly with reactive sites in biological macromolecules. Many proteins, in particular, are susceptible to oxidative damage, which can lead to their altered structure and function. Such structural and functional changes trigger a cascade of events that influence key components of the proteostasis network. Here, we highlight recent advances in our understanding of how cells respond to the challenges of protein folding and metabolic alterations that occur during oxidative stress. Immediately after an oxidative insult, cells selectively block the translation of most new proteins and shift molecular chaperones from folding …