Digital Commons Network^™

Cams In Command: Aging Brain Macrophages Fine-Tune Stroke Immune Responses, Rodney M Ritzel, Danye Jiang, Louise D Mccullough

Faculty, Staff and Student Publications

Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.

Therapeutic Perspectives For Prion Diseases In Humans And Animals, Rebeca Benavente, Rodrigo Morales

Faculty, Staff and Student Publications

No abstract provided.

Addressing Inference Time Of Machine Learning Models In Embedded Systems, Samuel Black

UNLV Theses, Dissertations, Professional Papers, and Capstones

Embedded Systems are used for a wide range of specialized computing purposes including surveyal, safety, security, and quality of life. Many areas that embedded systems are used in require the use of machine learning models. Constraints can be placed on embedded systems. Timeliness of execution, user satisfaction, security, power, and resource limitations must be considered when designing for embedded systems. Neural networks excel at complex tasks that are otherwise intractable, but their relatively high computational cost poses a challenge for inclusion in embedded systems. Neural network architectures should be optimized to reduce the total number of operations performed while maintaining …

Mtor Maintains Endothelial Cell Integrity To Limit Lung Vascular Injury, Michelle Warren Millar, Rauf A Najar, Spencer A Slavin, Mohammad Shadab, Imran Tahir, Zahra Mahamed, Xin Lin, Jun-Ichi Abe, Terry W Wright, David A Dean, Fabeha Fazal, Arshad Rahman

Faculty, Staff and Student Publications

The functional and structural integrity of the endothelium is essential for vascular homeostasis. Loss of barrier function in quiescent and migratory capacity in proliferative endothelium causes exuberant vascular permeability, a cardinal feature of many inflammatory diseases including acute lung injury (ALI). However, the signals governing these fundamental endothelial cell (EC) functions are poorly understood. Here, we identify mechanistic target of rapamycin (MTOR) as an important link in preserving the barrier integrity and migratory/angiogenic responses in EC and preventing lung vascular injury and mortality in mice. Knockdown of MTOR in EC altered cell morphology, impaired proliferation and migration, and increased endocytosis …

Radiation-Induced Macrovessel/Microvessel Disease, Jun-Ichi Abe, Bryan G Allen, Andreas M Beyer, David Lewandowski, Kranti A Mapuskar, Vikram Subramanian, Michelle R Tamplin, Isabella M Grumbach

Faculty, Staff and Student Publications

Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers. Moreover, radiation at various sites can lead to peripheral vascular disease. An aspect of radiation-induced injury that has received little attention is microvascular injury, which typically results from …

Ras-Mutant Leukaemia Stem Cells Drive Clinical Resistance To Venetoclax, Junya Sango, Saul Carcamo, Maria Sirenko, Abhishek Maiti, Hager Mansour, Gulay Ulukaya, Lewis E Tomalin, Nataly Cruz-Rodriguez, Tiansu Wang, Malgorzata Olszewska, Emmanuel Olivier, Manon Jaud, Bettina Nadorp, Benjamin Kroger, Feng Hu, Lewis Silverman, Stephen S Chung, Elvin Wagenblast, Ronan Chaligne, Ann-Kathrin Eisfeld, Deniz Demircioglu, Dan A Landau, Piro Lito, Elli Papaemmanuil, Courtney D Dinardo, Dan Hasson, Marina Konopleva, Eirini P Papapetrou

Faculty, Staff and Student Publications

Cancer driver mutations often show distinct temporal acquisition patterns, but the biological basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of acute myeloid leukaemia, upon progression or relapsed/refractory disease1-6. Here, by using human leukaemogenesis models, we first show that RAS mutations are obligatory late events that need to succeed earlier cooperating mutations. We provide the mechanistic explanation for this in a requirement for mutant RAS to specifically transform committed progenitors of the myelomonocytic lineage (granulocyte-monocyte progenitors) harbouring previously acquired driver mutations, showing that advanced leukaemic clones can originate from a different cell type …

Artificial Intelligence And Machine Learning In Cancer Pain: A Systematic Review, Vivian Salama, Brandon Godinich, Yimin Geng, Laia Humbert-Vidan, Laura Maule, Kareem A Wahid, Mohamed A Naser, Renjie He, Abdallah S R Mohamed, Clifton D Fuller, Amy C Moreno

Faculty, Staff and Student Publications

Background/objectives: Pain is a challenging multifaceted symptom reported by most cancer patients. This systematic review aims to explore applications of artificial intelligence/machine learning (AI/ML) in predicting pain-related outcomes and pain management in cancer.

Methods: A comprehensive search of Ovid MEDLINE, EMBASE and Web of Science databases was conducted using terms: "Cancer," "Pain," "Pain Management," "Analgesics," "Artificial Intelligence," "Machine Learning," and "Neural Networks" published up to September 7, 2023. AI/ML models, their validation and performance were summarized. Quality assessment was conducted using PROBAST risk-of-bias andadherence to TRIPOD guidelines.

Results: Forty four studies from 2006 to 2023 were included. Nineteen studies used …

Grant Writing: The Essentials, Jayme Renfro

Faculty Book Gallery

Welcome to the exciting and impactful world of grant writing! Whether you are a student embarking on a career in nonprofit management, a budding researcher eager to secure funding for your projects, or a professional looking to hone your grant writing skills, this textbook is designed to guide you through every step of the grant writing process. Grant writing is not just about securing funds; it's about crafting a story, building relationships, and making a tangible impact on communities and fields of study. This book aims to equip you with the knowledge, skills, and insights needed to excel in this …

Imipridones Inhibit Tumor Growth And Improve Survival In An Orthotopic Liver Metastasis Mouse Model Of Human Uveal Melanoma, Chandrani Chattopadhyay, Janos Roszik, Rajat Bhattacharya, Md Alauddin, Iqbal Mahmud, Sirisha Yadugiri, Mir Mustafa Ali, Fatima S Khan, Varun Vijay Prabhu, Philip L Lorenzi, Bo Wei, Elizabeth Burton, Rohini R Morey, Rossana Lazcano, Michael A Davies, Sapna P Patel, Elizabeth A Grimm

Faculty, Staff and Student Publications

Background: Uveal melanoma (UM) is a highly aggressive disease with very few treatment options. We previously demonstrated that mUM is characterized by high oxidative phosphorylation (OXPHOS). Here we tested the anti-tumor, signaling and metabolic effects of imipridones, which are CLPP activators, which inhibit OXPHOS indirectly and have demonstrated safety in patients.

Methods: We assessed CLPP expression in UM patient samples. We tested the effects of imipridones (ONC201 and ONC212) on the growth, survival, signaling and metabolism of UM cell lines in vitro, and for therapeutic efficacy in vivo in UM liver metastasis models.

Results: CLPP expression was detected in primary …

Issue 41

The Synapse: Intercollegiate science magazine

No abstract provided.

Digging Up A New Era In Fertilizer: Investigating The Potential Of Electron Bifurcation In Ammonia Synthesiss, Ella Wurtzbacher

The Synapse: Intercollegiate science magazine

No abstract provided.

This Land Is Your Land, This Land Is My Land, Alexia Liu

The Synapse: Intercollegiate science magazine

No abstract provided.

The Statue: Representing Queerness In Myth And Fairytale Through Animation, Alana Mcanulty

Postgraduate

There is a preexisting overlap of myth and fairytale, queer representation, and animated film. Many of the earliest animated films were adaptations of fairy tales, and those adaptations often included queer-coded villains. This is usually where the combination of all three of these elements ends, often falling short of meaningful representation (Baker, 2010). Fairytale and animation are synonymous in our modern cultural understanding (Holiday and Sergeant, 2018) after all, the first full length animated feature film was an adaptation of Snow White and the Seven Dwarfs (1937). Queer representation within the fairytale and mythology genre is not a new area …

The Dark Cloud : A Creative Exploration Of Anxiety Through 3d Animation, James Applegate

Postgraduate

Fear and anxiety are mundane and innately human experiences, and ones that everyone struggles with on occasion. However, approximately a third to a quarter of all adults will suffer from clinical anxiety disorders at some point in their lives. Of these, many will go undiagnosed, and of those that do, only a fraction receive proper treatment.

An Animation Production Extension Of Spirit Spider, Jayden Abbott

Postgraduate

The Spirit Spider project comprises two components, a creative work called Spirit Spider and this accompanying exegesis. This project exemplifies a deep exploration of the animation process, emphasizing the iterative nature of creative development over the interpretation of the final product. Through each phase, from initial storyboarding to overcoming technical challenges and refining skills in Blender, the project has adhered to a methodology that prioritizes creative problem-solving and adaptability.

This exegesis has examined the careful selection of tools, such as Blender, and the integration of newly learned techniques that continuously shaped the project’s direction. By dedicating focused time to both …

Development Of A Surface-Mounted Strong Post For The Midwest Guardrail System, Gnyarienn Selva Kumar

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

This research investigated the development of a surface-mounted strong post for the Midwest Guardrail System (MGS), designed to replicate the behavior of the standard MGS post, a W6 x8.5, 72-in. long post embedded 40 in. into strong soil. The MGS is a strong post, W-beam guardrail system that has been successfully evaluated in many applications using crashworthiness criteria described in the American Association of State Highway and Transportation Officials (AASHTO) Manual for Assessing Safety Hardware (MASH). However, in some locations, conventional soil-embedded posts are impossible to install due to subgrade obstructions like concrete slabs, mow strips, utilities, and limited right-of-way. …

Chronic Illness Education 2024: Resources To Help Mitigate The Effect Of Stress On Adult Obesity, Alexander Saleski, Alexander Weiss, Alexandra Turfe, Ananya Murali, Baraa Mohammed, Marley Sternberg

Patient Education Projects

No abstract provided.

Increasing The Impact Of Dietary Fiber From Grains On Human Health Through Gut Microbiome, Sujun Liu

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The relationship between dietary fiber intake and human health has gained significant attention due to its potential in preventing chronic diseases and promoting gut health. Grains are a primary source of dietary fiber; however, the health impact of grain fibers is often limited because they are incompletely metabolized by gut bacteria. This dissertation explores innovative strategies to enhance the concentration and of dietary fiber from grains and its utilization by gut bacteria. By investigating various treatments, this research aims to maximize the health benefits of grain-derived dietary fibers, thereby contributing to a healthier society.

This dissertation is organized into four …

Survival And Occupancy Of Red-Bellied Woodpeckers In A Fragmented Forested Landscape In North-Central Ohio, 1995-2005, David A. Zuwerink, James S. Marshall

North American Bird Bander

No abstract provided.

Recent Literature, Claire Stuyck

North American Bird Bander

No abstract provided.

A New Angle On Using Mist-Nets To Capture Wintering Grassland Birds, John A. Muller, Erin H. Strasser, Nuwanthika Nagode, Jeremy D. Ross

North American Bird Bander

No abstract provided.

Anouncements And Report On The 2024 Annual Meeting, David Cimprich

North American Bird Bander

No abstract provided.

Exploring Students' Computer-Supported Collaborative Argumentation With Socio-Scientific Issues, Wenli Chen, Yiting Han, Jesmine Tan, Aileen Siew Cheng Chai, Qianru Lyu, Lyna

Research Collection Lee Kong Chian School Of Business

Background: This study examined the effect of computer-supported collaborative argumentation (CSCA) on secondary school students' understanding of socio-scientific issues (SSI). Engaging students in collaborative argumentation is known to help with deepening their understanding of SSI. Methods: In this study, a mixed-method design is used to investigate 84 students' collaborative argumentation processes and outcomes. The statistical analysis, epistemic network analysis and qualitative uptake analysis results showed that CSCA was effective in supporting secondary school students' evidence-based argumentation skills on SSI. Findings and Conclusion: Several cases were presented to show how students engaged in CSCA to explore meaningful learning opportunities and how …

Pathobiology Of Myocardial And Cardiomyocyte Injury In Ischemic Heart Disease: Perspective From Seventy Years Of Cell Injury Research, L Maximilian Buja

Faculty, Staff and Student Publications

This review presents a perspective on the pathobiology of acute myocardial infarction, a major manifestation of ischemic heart disease, and related mechanisms of ischemic and toxic cardiomyocyte injury, based on advances and insights that have accrued over the last seventy years, including my sixty years of involvement in the field as a physician-scientist-pathologist. This analysis is based on integration of my research within the broader context of research in the field. A particular focus has been on direct measurements in cardiomyocytes of electrolyte content by electron probe X-ray microanalysis (EPXMA) and Ca2+ fluxes by fura-2 microspectrofluorometry. These studies established that …

Outcomes Of Lateralized Reverse Total Shoulder Arthroplasty Versus Latissimus Dorsi Transfer For External Rotation Deficit: A Systematic Review And Meta-Analysis, Keegan M Hones, Caroline T Gutowski, Taylor R Rakauskas, Victoria E Bindi, Trevor Simcox, Jonathan O Wright, Bradley S Schoch, Thomas W Wright, Jean-David Werthel, Joseph J King, Kevin A Hao

Faculty, Staff and Student Publications

Background: To compare clinical outcomes following lateralized reverse shoulder arthroplasty (RSA) versus RSA with latissimus dorsi transfer (LDT) in patients with poor preoperative active external rotation (ER).

Methods: We performed a systematic review per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We queried PubMed/Medline, Embase, Web of Science, and Cochrane databases to identify articles reporting clinical outcomes of RSA with LDT or lateralized RSA alone performed in patients with preoperative ER ≤0°. Our primary outcomes were active ER, active forward elevation (FE), Constant score, and the incidence of complications.

Results: We included 12 RSA with LDT studies …

Wirelessly Actuated Microfluidic Pump And Valve For Controlled Liquid Delivery In Dental Implants, Yilan Xu, Honglu Lin, Boyang Xiao, Hutomo Tanoto, Joel Berinstein, Alend Khoshnaw, Simon Young, Yuxiao Zhou, Xiaoguang Dong

Faculty, Staff and Student Publications

Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (< 65 mT), are reported. A magnet-screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant-bone interface, a region traditionally difficult to access. On-demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long-term and targeted delivery of therapeutic agents in various bioengineering applications.

Engineering Immunity: Bacterial Delivery Of Cancer Neoantigen Vaccines, Christopher D Johnston, Jennifer A Wargo

Faculty, Staff and Student Publications

In the battle against cancer, researchers are exploring the use of engineered bacteria as living medicines. Redenti and colleagues demonstrate that Escherichia coli Nissle 1917 (EcN) can be engineered to deliver cancer neoantigen payloads, stimulating antigen-specific CD4+ and CD8+ T cells and mediating antitumor immunity in preclinical models of colorectal cancer and melanoma.

Socio-Ecological Drivers Of Anthropogenic Marine Debris Effects On Coral Reef Communities In The Florida Keys, Usa, Tokea Payton

All Dissertations

The Florida Keys reef tract has rapidly shifted from a structurally complex, hard coral-dominated reef to a less rugose, soft coral-dominated reef. Persistent anthropogenic stressors facilitate ecological transitions by including recreational and commercial fishing and increased anthropogenic marine debris. These artificial structures are becoming habitats for small marine taxa known as cryptofauna. Cryptofauna are among the most essential yet understudied reef taxa where little is known about their fate considering degrading coral reefs and increasing anthropogenic disturbance. With increased anthropogenic stressors on the marine environment, the SCUBA diving community has initiated extensive marine debris removal efforts to assist in cleaning …

Exploring The Contribution Of Mobile Money To The Well-Being Of Rural Tanzanian Villagers And Assessing Their Readiness To Adopt A Similar Model To Advance Their Healthcare Access An Exploratory Study, Sr. Magdalena P. Chubwa

Seton Hall University Dissertations and Theses (ETDs)

Background: Healthcare for rural villages in Tanzania has always been rudimentary. Lack of the infrastructure and poverty are among the many obstacles facing this population’s access to healthcare. While, the rise of telehealth has improved access to healthcare in many parts of the world, its use in rural Tanzania has been extremely limited to poor internet access. However, given the availability of non-internet connected mobile phones in rural Tanzania, the potential to use this devise to improve healthcare access exists. Individuals using mobile phones for financial transactions may be motivated to access healthcare via telehealth by using their non-internet connected …

Integrating Social And Ecological Insights In The Management Plan For An Emerging Conservation Landscape: Kanha-Pench Corridor, Hrishita Negi

All Dissertations

Since its inception in 1973, Project Tiger, which laid the groundwork for India's tiger conservation program, has grown from 9 to 53 intensively monitored and managed tiger reserves. With an increase in tigers' permanent occupancy outside of designated tiger reserves, one of the many challenges confronting India's tiger conservation has been managing its success, with a particular emphasis on this spillover population that ranges extensively in human-dominated, multi-use forest landscapes. This research illustrates the application of a participatory modeling approach to integrate human dimensions with ecological knowledge about tigers in a previously identified forest corridor in Central India. Key dimensions …