Digital Commons Network^™

Bridging The Gap: Fostering Open Dialogue On Resource Access And Service Needs, Cameron Castillo

Capstone Projects and Master's Theses

This project investigates whether there are additional resources desired by clients or are needed to better support said clients in their recovery at the Interim, Inc. organization. This agency is a nonprofit organization whose sole purpose is to build community connections through providing services to individuals facing mental health and substance use challenges. While there is a wide range of programs available, there may still be clients with unmet needs. The purpose of this project was to identify any service gaps by conducting separate surveys of clients and staff members. Through the use of open-ended questions, the expectation of receiving …

Impact Of Place Based Learning On Community Engagement And Ownership, Alexis Mendez

Capstone Projects and Master's Theses

Place-based learning (PBL) offers an educational approach that emphasizes local history, environments, and communities, allowing students to engage with relevant content through the expertise gained from lived experiences. By utilizing their immediate surroundings, students are able to absorb educational material and foster a sense of place that can encourage civic engagement, environmental stewardship, and community ownership. This senior capstone research project explores the potential to enhance community ownership and engagement in Salinas, California through a Problem-Based Learning (PBL) approach. This project integrates the local geological and cultural history of California, Monterey Bay, and the Salinas Valley, alongside hands-on water quality …

Parenting With Grace, Eva Nelson Cole

Capstone Projects and Master's Theses

Parents are often caught off guard by the upheaval of adding children to their lives. Feelings of guilt, shame, isolation, and depression can arise when parents are faced with the demands and stressors that come along with having children. Studies have shown that children who have distressed parents endure lasting negative outcomes that can extend into the primary school years (Mihelic et al., 2018). Educating parents and giving them some awareness about what to expect can make a real difference. To have these conversations, I created a two-part parenting workshop for new parents at Parents’ Place in Pacific Grove, CA. …

Targeting The Glutamine-Arginine-Proline Metabolism Axis In Cancer, Di Wang, Jiang-Jie Duan, Yu-Feng Guo, Jun-Jie Chen, Tian-Qing Chen, Jun Wang, Shi-Cang Yu

Faculty, Staff and Student Publications

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline axis is an important node of cancer metabolism and plays a major role in amino acid metabolism. This axis also acts as a scaffold for the synthesis of other nonessential amino acids and essential metabolites. In this paper, we briefly review (1) the glutamine addiction exhibited by tumour cells with accelerated glutamine transport and metabolism; (2) the methods regulating extracellular glutamine entry, intracellular glutamine synthesis and the fate of intracellular glutamine; (3) the glutamine, proline and arginine metabolic pathways and their interaction; and (4) the research progress in tumour therapy …

Genetic Ablation Of The Isoform Γ Of Pi3k Decreases Antidepressant Efficacy Of Ketamine In Male Mice, Gabriela N Vaz, Flávia C Turcato, Isabel A V Lima, Franciele F Scarante, Melissa R Araújo, Tamires A V Brigante, Livia C M Rodrigues, Francisco S Guimarães, Jaime E C Hallak, Jose A Crippa, Antonio L Teixeira, Antonio C P De Oliveira, Alline Cristina Campos

Faculty, Staff and Student Publications

About one-third of major depressive disorder (MDD) patients demonstrate unresponsiveness to classic antidepressants, and even the clinical efficacy of fast-acting drugs such as ketamine varies significantly among patients with treatment-resistant depression. Nevertheless, the lack of suitable animal models that mimic a possible ketamine-resistant phenotype challenges the understanding of resistance to drug treatment. In this study, we showed that PI3Kγ knock-out (KO) mice do not respond to classical doses of ketamine and classical antidepressants. PI3Kγ KO mice were unresponsive to both the rapid and sustained antidepressant-like effects of a single dose of ketamine in the forced swimming test. Additionally, they were …

A119: Intermittent Hypoxic Training Promotes Whole-Body Hif-1Α Expression To Improve Exercise Capacity, Yuepeng Li, Lan Zheng

International Journal of Physical Activity and Health

Research Context: It has been shown that a hypoxic environment induces up-regulation of HIF-1α and changes in its downstream gene sequences, and that exercising under hypoxic conditions improves athletes' sprint performance. However, there is more controversy regarding the effects of exercise under hypoxic conditions on exercise capacity, and the molecular mechanisms have been less well studied. Therefore, the aim of this study was to investigate the link between HIF-1α expression and exercise capacity under hypoxic conditions of exercise, and to provide a realistic theoretical basis for intermittent hypoxic training to improve exercise capacity.

Research Methodology: A total of 480 wild-type …

A150: Analysis Of The Mechanism Of Resveratrol's Action On Myocardial Energy Metabolism In Exercise-Induced Fatigue Rats, Shang Xu, Jinru Cai, Yulong Hu

International Journal of Physical Activity and Health

Background/Purpose: Promotional effects of resveratrol on myocardial mitochondrial energy metabolism in exercise-induced fatigue rats were investigated by network pharmacology and animal experiments.

Method: In the present study, the effects of resveratrol on myocardial energy metabolism were assessed using network pharmacology with enrichment analysis. Forty-eight healthy male SD rats of 6–8 weeks of age were selected and randomly divided into blank control group (C), resveratrol administration group (R), exercise fatigue group (E), and exercise fatigue + resveratrol administration group (ER) with 12 rats in each group. Rats in E group and the exercise fatigue + ER group were weight-bearing 5% swimming …

2024 Personal-Sized Seedless Watermelon Cultivar Evaluation In Indiana, Wenjing Guan

Midwest Vegetable Trial Reports

The annual watermelon cultivar evaluation trial is conducted at Southwest Purdue Agricultural Center (SWPAC) in Vincennes, Indiana. It evaluates yield, fruit quality, and overall plant performance of commercial watermelon cultivars and advanced breeding lines. Purdue Extension and seed companies financially support the trial. The 2024 personal-sized triploid watermelon cultivar trial evaluated 18 cultivars.

“A Frail Wish On Human Morality” Versus “A Life-And-Death Question For Humanity”, Yeomin Yoon

KAUPA Letters

No abstract provided.

Patterns In Gray Wolf Pup Survival And Recruitment In Northern Minnesota, Andrea Hynes

All NMU Master's Theses

Knowledge of how and why the vital rates of wildlife populations change through and over time is crucial for understanding wildlife population dynamics. Because estimating gray wolf pup survival is challenging, our understanding of pup survival and the factors influencing survival and recruitment is limited. I used a combination of litter counts and video observations from a large remote camera array to estimate annual wolf pup survival and recruitment and to evaluate intra-annual patterns in pup survival and recruitment within the Greater Voyageurs Ecosystem, MN, USA. Mean annual pup survival during 2019–2023 was 0.24, and the mean annual recruitment rate …

At Least, We Should Try, Semoon Chang

KAUPA Letters

No abstract provided.

Mesoporous Silica Administration As A New Strategy In The Management Of Warfarin Toxicity: An In-Vitro And In-Vivo Study, Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose:

Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. Warfarin overdose, whether intentional or unintentional, can cause life-threatening bleeding. Here, we present a novel warfarin adsorbent based on mesoporous silica that could serve as an antidote to warfarin toxicity.

Methods:

Amino-functionalized mesoporous silica (MS-NH2) was synthesized based on the co-condensation method through a soft template technique followed by template removal. The prepared structure and functional group were studied by Fourier transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) checked the morphology. The …

Beyond Boundaries: Governance Considerations For Climate-Driven Habitat Shifts Of Highly Migratory Marine Species Across Jurisdictions, Bianca S. Santos, Elliott L. Hazen, Heather Welch, Nerea Lezama-Ochoa, Barbara A. Block, Daniel P. Costa, Scott A. Shaffer, Larry B. Crowder

Faculty Research, Scholarly, and Creative Activity

The mobile nature of migratory marine animals across jurisdictional boundaries can challenge the management of biodiversity, particularly under global environmental change. While projections of climate-driven habitat change can reveal whether marine species are predicted to gain or lose habitat in the future, geopolitical boundaries and differing governance regimes may influence animals’ abilities to thrive in new areas. Broad geographic movements and diverse governance approaches elicit the need for strong international collaboration to holistically manage and conserve these shared migratory species. In this study, we use data from the Tagging of Pacific Predators program to demonstrate the feasibility of using climate-driven …

Pacific Rxtracts - December 2024, Pacific Rxtracts

Pacific RxTracts

Articles

• Attruby: A Promising Treatment for Transthyretin Amyloid Cardiomyopathy
• Triple Threat: GMRx2, An Emerging Low-Dose Triple Pill For Hypertension
• New Treatment for Hemophilia A or B
• Breaking the Placebo Barrier: FDA Review Challenges Effectiveness of Popular Decongestant
• Exploring Bempedoic Acid: Potential Benefits for Statin-Intolerant Patients and Liver Health
• The Flu Vaccine: Meeting You Where You Are
• Unique Application of Statins for Radiotherapy-Induced Cardiotoxicity
• One Shot, Two Solutions: How Semaglutide Combats Obesity and Knee Osteoarthritis

Brief Of First Amendment And Internet Law Professors As Amici Curiae In Support Of Petitioners, Tiktok Inc. V. Garland, No. 24-656 (U.S. 2025)., Shubhangi Agarwalla, Enrique Armijo, Kevin Bankston, Susan Benesch, Ashutosh Bhagwat, Stuart N. Brotman, Ryan Calo, Anupam Chander, Erwin Chemerinsky, Alan K. Chen, David Craig, Eric Goldman, Gregory Gondwe, James Grimmelmann, Nikolas Guggenberger, G.S. Hans, Robert A. Heverly, Thomas E. Kadri, David Kaye, Heidi Kitrosser, Vivek Krishnamurthy, Edward Lee, Mark A. Lemley, David S. Levine, Yvette Joy Liebesman, Gregory P. Magarian, Jess Miers, Sean O’Brien, Mary-Rose Papandrea, Kermit Roosevelt, Jennifer Safstrom, Pamela Samuelson, Madhavi Sunder, Christopher Jon Sprigman, Jordi Weinstock

Con Law Center Amicus Briefs

“Without freedom of thought, there can be no such thing as wisdom, and no such thing as public liberty, without freedom of speech.” Benjamin Franklin, Silence Dogwood, No. 8 (July 9, 1722). For this reason, the U.S. Constitution makes clear that the Government cannot abridge free speech based on its content or viewpoint absent compelling and narrowly tailored grounds. Indeed, the protection of all speech is foundational to American democracy. See United States v. Schwimmer, 279 U.S. 644, 654–55 (1929) (Holmes, J., dissenting) (“[I]f there is any principle of the Constitution that more imperatively calls for attachment than any other …

Equine-Assisted Learning: An Analysis Of Path Intl. Programs, Gretchen Schulz

Boise State University Theses and Dissertations

Equine-Assisted Learning (EAL) is an expanding field within Equine-Assisted Services (EAS). Following in the steps of other EAS professional organizations, The Professional Association of Therapeutic Horsemanship, International, (PATH Intl.) launched an EAL certification program for facilitators in 2023. Previously published research has identified a number of positive outcomes among EAL participants, such as increased motivation and positive attitudes towards reading, increased tolerance for ambiguity, lower perceptions of burnout, improved well-being, decreased depression and anxiety, increased self-efficacy, and greater self-awareness and reflection. As the field of EAL and the number of trained EAL facilitators grows, data on programs across the country …

Predictors In Help-Seeking Intentions For Friends With Eating Disorders, Allie M. Robb

Honors Theses

Emotional intelligence is a significant factor in one’s well-being as high emotional intelligence predicts sound mental well-being and a better quality of life as one can accurately understand emotions (Kulkarni & Velhal, 2023). However, low emotional intelligence has also been found to be a predictor not only of the development of mental health disorders but also have the lowest intentions to seek help (Ciarrochi et. al., 2002; Kulkarni & Velhal, 2023). Because they are unlikely to seek help, it is important for others who see the potential cause to help intervene. The purpose of this study is to investigate the …

Swinging On Windmills Of Love, Life, And Law: The Quixotic Pursuits Of Upendra Baxi (Book Review Of 'Of Law And Life: Upendra Baxi In Conversation With Arvind Narrain, Lawrence Liang, Sitharamam Kakarala, And Sruti Chaganti'), Amita Dhanda

National Law School Journal

This book review begins by elaborating on the melange of forms adopted by Of Law and Life: Upendra Baxi in Conversation with Arvind Narrain, Lawrence Liang, Sitharamam Kakarala, and Sruti Chaganti (Orient BlackSwan 2024). It then reflects on the different themes emerging from this narrative on Baxi’s life and work. The review next dwells on the book’s pedagogic possibilities. Since the book is not a comprehensive but a selective narrative of Baxi’s ‘law and life’, there are matters that have not been included in it—the author concludes the review by giving voice to these silences.

The Role Of Christianity In Shaping Agrarian Policies And Environmental Interactions: A Comparative Analysis Of The Uk And The Netherlands, Grace N. Brimble

University Honors Theses

This thesis explores the enduring influence of Protestant Christianity on agrarian practices and environmental policies in the UK and the Netherlands, focusing on how historical religious values shape modern ecological and political landscapes. Despite increasing secularism, Protestant ethics--emphasising stewardship, diligence, and moral responsibility--persist culturally, influencing debates on sustainability, rural identity, and land use. Using case studies such as nitrogen policy protests in the Netherlands and post-Brexit agricultural transitions in the UK, this analysis highlights the symbolic role of Christian values in framing resistance and adaptation to contemporary challenges. The research combines discourse analysis and ethnographic perspectives to uncover the interplay …

What Is The Evidence? Updates In The Use Of Antenatal Corticosteroids For Patients At Risk Of Preterm Birth, Moti Gulersen, Cynthia Gyamfi-Bannerman

Department of Obstetrics and Gynecology Faculty Papers

Antenatal corticosteroids have long been considered one of the most important antenatal therapies available for pregnant patients at risk of preterm birth based on the associated reduction of neonatal morbidity and mortality following their administration. However, despite decades of research since their incorporation into routine clinical practice, a number of key questions related to antenatal corticosteroid use remain. These include evaluating the impact of antenatal corticosteroids at gestational ages outside of the previously recommended window of 24 0/7–33 6/7 weeks of gestation, determining factors associated with optimal steroid timing in order to reduce unnecessary exposure, alterations in its dosing regimen, …

Effect Of Fathers In Preemie Prep For Parents (P3) Program On Couple’S Preterm Birth Preparedness, Mir A. Basir, Siobhan M. Mcdonnell, Ruta Brazauskas, U. Olivia Kim, Sheikh Iqbal Ahamed, Jennifer J. Mcintosh, Kris Pizur-Barnekow, Michael B. Pitt, Abbey Kruper, Steven R. Leuthner, Kathryn E. Flynn

Computer Science Faculty Research and Publications

Objective

Evaluate the effect of fathers’ participation in the Preemie Prep for Parents (P3) program on maternal learning and fathers’ preterm birth knowledge.

Methods

Mothers with preterm birth predisposing medical condition(s) enrolled with or without the baby’s father and were randomized to the P3 intervention (text-messages linking to animated videos) or control (patient education webpages). Parent Prematurity Knowledge Questionnaire assessed knowledge, including unmarried fathers’ legal neonatal decision-making ability.

Results

104 mothers reported living with the baby’s father; 50 participated with the father and 54 participated alone. In the P3 group, mothers participating with the father (n = 33) had greater …

Demonstrating Feasibility Of Ultrasound-Sensitive Microbubbles Delivery To Treat Disruptions In The Blood Brain Barrier Endothelium, Rubens Jourdain

Theses and Dissertations

Vascular cognitive impairment and dementia (VCID) is one of the main causes of dementia. VCID is caused by age and other genetic factors that lead to disruptions in the blood brain barrier (BBB) and allow blood components to enter the brain. The currently available treatments of VCID include opening the BBB with high-frequency-ultrasound to deliver drugs to the brain. However, this only treats the already developed disease. Consequently, we developed a new drug delivery system whose goal is to restore the brain capillary endothelial cells (BCEC) lining the blood vessel. The objective of this study was to demonstrate the feasibility …

Machine Learning Methods For Quantification Of Glacier Variations Through Satellite Imagery, Robert D. Breininger

Theses and Dissertations

Glaciers around the world have experienced a trend of recession within the past century. Quantification of glacier variations using satellite imagery is of great interest due to the importance of glaciers as freshwater resources and as indicators of climate change. The potential methods to quantify glacier variations with increasing complexity include detecting the terminus location, quantifying the glacier surface area, and measuring glacier volume. Although there are methods in literature designed purposefully for glacier area segmentation that have achieved acceptable results, they are often localized to the region where their training data were acquired and further rely on training sets …

Demand For Milk And Milk Products In The Rural Household Of Bangladesh: A Panel Data Analysis, Eshrat Jahan Mahfuza, Mohammad Jahangir Alam, Andrew M. Mckensie

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Milk is considered an essential source of protein for people of all ages. However, Bangladeshi people, particularly those living in rural areas, tend to consume less milk and milk products than necessary. Therefore, this study aims to investigate the demand for milk and milk products among rural consumers and the factors affecting their consumption habits. The study utilizes balanced panel data from three waves of the Bangladesh Integrated Household Survey: 2011–12, 2015, and 2018–19, collected by the International Food Policy Research Institute. Both the Almost Ideal Demand System (AIDS) and Fixed Effects Model were employed. The expenditure elasticity for liquid …

Uniting Science And Society: The Role Of Leadership Studies, Scientific, And Political Leaders In Combating Science Polarization, Kathryn E. Reda

Interdisciplinary Journal of Leadership Studies

This commentary discusses the recent political polarization of scientific research and how this polarization threatens the neutrality of science in American society. It contends further that leadership studies, along with scientific studies, have become a contentious battleground themselves, particularly on topics like climate change, energy policy, and the COVID-19 pandemic. This is exacerbated by mass media misinformation and declining public trust. Science polarization poses a significant challenge for leadership as it erodes informed decision making, making it crucial for leaders to bridge rather than deepen ideological divides. Leadership studies as a discipline has a responsibility to explore the causes of …

Carceral Apartheid: Centering State Responsibility For The Racial Order, Ion Meyn

Cardozo Law Review

Racial harms are often attributed to private ordering. But the power of White communities to subordinate communities of color is not a constellation of private acts independent of state violence. When scrutinized, acts of racial exclusion, segregation, and violence persist to the extent they are aligned with the political order and backed by the state’s violent guarantee. The knowledge that any resistance to these acts will be met with state retribution bristles in the background.

There are different ways in which state violence produces and reproduces the racial order: (1) direct violence; (2) a violent guarantee backing communal acts of …

Comparison Of Statistical And Machine Learning Genomic Prediction Methods In Plant Breeding: Case Studies In Maize And Soybean, Igor Kuivjogi Fernandes

Graduate Theses and Dissertations

Plant breeding is essential to increase genetic gain and food production worldwide. This study was conducted to evaluate new ways to use machine learning (ML) to tackle plant breeding challenges, where two ideas were tested — the first chapter focuses on how to combine genetic and environmental data using ML to improve the prediction of maize grain yield in multi-environment trials, while the second chapter centers on how to couple feature selection of molecular markers with ML to enhance prediction of yield in soybean, and, in both cases, ML approaches were compared to well-established statistical methods greatly adopted by the …

Bird's Eye View-A Guide To Bird Behavior, Oliver Spencer

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Oliver Spencer is a senior writing major from Fort Wayne, Indiana. He loves writing in many genres, but especially creative nonfiction, magical realism, and horror. He is planning on going to graduate school for a degree in library science. Oliver loves birds, theater, and researching.

Vol. 37 Iss. 1 [Full Issue], - -

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

No abstract provided.

Portrait Of The Church On Fire, Abigail Fathauer

A Midwestern Review: A Magazine of the Arts and Issues at DePauw University

Abigail Fathauer is a Senior English Literature major with minors in Art History and World Literature. When she’s not writing papers or reading the next book on her TBR, she’s working at the local animal shelter and not shutting up about it. In another life, she was a medieval scribe.