Digital Commons Network^™

Redesigning The Hospital Environment To Improve Restfulness, Caellagh D Catley, Kayla Paynter, Kendall Jackson, Ashley Huggins, Jenny Ji, Sai Anusha Sanka, Michelle Simkins, Thomas M Maddox, Patrick G Lyons

2020-Current year OA Pubs

IMPORTANCE: Hospital wards are often not conducive to patient sleep, negatively affecting patient health and experience.

OBJECTIVES: To assess determinants of in-hospital restfulness and to design and test rest-promoting interventions on the wards in partnership with clinicians, staff, and patients.

DESIGN, SETTING, AND PARTICIPANTS: This rapid-sequential mixed-methods quality improvement study was performed at a large urban academic hospital in St Louis, Missouri, from May 1, 2021, to December 31, 2022, with follow-up through hospitalization. Mixed-methods activities involved purposively selected hospitalized adults on the wards, nurses, hospitalists, and hospital staff. Interventions included all adult hospitalizations on the study wards.

INTERVENTIONS: Sequential …

Heterozygous Btnl8 Variants In Individuals With Multisystem Inflammatory Syndrome In Children (Mis-C), Evangelos Bellos, Erica G Schmitt, Et Al.

2020-Current year OA Pubs

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.2, 95% CI: 3.5-5.3, P < 10-6). BTNL8 encodes an intestinal epithelial regulator of Vγ4+γδ T cells implicated in regulating gut homeostasis. Enrichment was exclusive to MIS-C, being absent in patients with COVID-19 or bacterial disease. Using an available functional test for BTNL8, rare variants from a larger cohort of MIS-C patients (n = 835) were tested which identified eight variants in 18 patients (2.2%) with impaired engagement of Vγ4+γδ T cells. Most of these variants were in the B30.2 domain of BTNL8 implicated in sensing epithelial cell status. These findings were associated with altered intestinal permeability, suggesting a possible link between disrupted gut homeostasis and MIS-C-associated enteropathy triggered by SARS-CoV-2.

Vps13b Is Localized At The Interface Between Golgi Cisternae And Is A Functional Partner Of Fam177a1, Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R Mcadow, Catherine Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf, Pietro De Camilli

2020-Current year OA Pubs

Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacent membranes, cause Cohen syndrome. VPS13B is known to be concentrated in the Golgi complex, but its precise location within this organelle and thus the site(s) where it achieves lipid transport remains unclear. Here, we show that VPS13B is localized at the interface between proximal and distal Golgi subcompartments and that Golgi complex reformation after Brefeldin A (BFA)-induced disruption is delayed in VPS13B KO cells. This delay is phenocopied by the loss of FAM177A1, a Golgi complex protein of unknown function reported to be a …

Concomitant Epidural And Longitudinal Anterior Spinal Artery Contrast Spread In A Lumbar Transforaminal Epidural Steroid Injection (Tfesi), Philip J. Koehler Iii, Paul M. Kitei, David S. Stolzenberg, Elaine H. Hatch

Rothman Institute Papers

A 78-year-old female with a remote history of L3-4 decompression and fusion presented with several months of low back and radicular leg pain. MRI revealed moderate L2-L3 spinal canal stenosis, ligamentum flavum infolding, moderate bilateral foraminal stenosis, and a grade I retrolisthesis. A right sided L2-L3 TFESI was performed using multiplanar fluoroscopic imaging with a subpedicular supraneural approach. During live iodinated contrast injection, imaging revealed concomitant epidural and central arterial contrast spread. The needle was retracted and repeat live fluoroscopic imaging demonstrated no vascular uptake. Desired epidural and nerve root contrast spread remained in place with repeat still imaging. Dexamethasone …

Lost Roots, Graziela Larroca

Theses

Lost Roots is an interactive 2.5D exploration game where players unite spirits by growing an underground network of roots. With a limited amount of roots to grow, players must unlock memories of the deceased and navigate through a cemetery in order to advance. The game serves as a unique take on the idea of purgatory, where the soul is essentially stuck and the player must find their own way out. The player first awakens underneath a tombstone with no memories of the past. Their only ability is to navigate through the dirt as a singular root, navigating around obstacles to …

For The Greater Good, Hannah Craft

Theses

The body of work included in my thesis exhibition explores how craft mediums can be used to create sculptural work motivated by narrative. Each piece presents a freeze-frame sculptural vignette in the instant before death occurs.

A Grounded Theoretic Analysis Of College Students’ Attitudes Regarding Indoor Plants And Pets As Moderators Of Daily Stressors, Lydia Dill

Honors Projects

This study explores college students' attitudes toward indoor plants and pets, and how this may impact college students’ experience with stress. Through in-depth interviews and grounded theory methodology, three key themes emerged: Plant Ownership as a Method of Establishing Structure, Plants as Ornamentation, and Pets as a Source of Comfort. Plant ownership helps students create routines and emotional stability, while plants also enhance living spaces aesthetically. Pets provide emotional support, offering companionship and support, particularly during academic pressures. The study builds on previous research by examining both indoor plants and pets together, highlighting how each fulfills unique emotional, psychological, and …

Applications Of Neural Networks In Parkinson’S Disease Diagnosis, Saladin Minhaaj

Theses

Parkinson's disease (PD) is a complex and debilitating neurodegenerative disorder that affects millions of people worldwide. Early and accurate diagnosis is crucial for effective treatment and management of PD. This thesis explores the application of neural networks in PD diagnosis, leveraging their ability to learn patterns from large datasets and make accurate predictions.

Thesis provides an overview of PD, including its symptoms, diagnosis, and current challenges in diagnosis. We then delve into the fundamentals of neural networks, including supervised learning, mathematical interpretations, and parametric models. This research focuses on the development of neural network models that can accurately diagnose PD …

A Comparison Of Vestibular Function In Young Adult Musicians And Non-Musician Peers, Alexandria W. Greene, Ashley G. Flagge, Nicholas S. Stanley

Ashley Flagge Publications

Purpose: The majority of college-level musicians exceed the daily recommended noise dose level during instrumental practices and performances, although less than one-third report wearing hearing protection while playing their instruments. Although the hazardous effects of music on the auditory system have been established, even in young adult musicians still early in their musical careers, the effects of music on the vestibular system are still unclear. The purpose of the present study was to examine vestibular/balance differences between young adult musicians and non-musicians to determine the effects of music exposure on the vestibular system.

Method: Young adult participants aged 18-27 years …

Birthday Girl, Makayla Tappin

Master's Projects

The lives of four friends plummet into chaos after a dead friend from college seemingly resurfaces – alive.

Built For Two, David Miller

Master's Projects

Built for Two is an original romantic comedy screenplay that I wrote during my time at Kennesaw State University.

Prenatal Tobacco Exposure, Brain Subcortical Volumes, And Gray-White Matter Contrast, Troy B. Puga, Gaelle E. Doucet, Grace Thiel

Student Publications

Importance Maternal tobacco use during pregnancy (MTDP) remains a major public health challenge. However, the complete spectrum of effects of MTDP is not fully understood.

Objectives To examine the longitudinal associations of MTDP and children’s brain morphometric subcortical volume and gray-white matter contrast (GWC) development.

Design, Setting, and Participants Cohort study of children aged 9 to 10 years at wave 1 (October 2016 to October 2018) and at a 2-year follow-up (wave 2; August 2018 to January 2021; aged 11-12 years) across 21 US sites in the Adolescent Brain Cognitive Development (ABCD) Study. Data were analyzed from October 2023 to …

A Review On Ethnomedical Use Of Tephrosia Vogelii Hook.F. And Its Potentiality Towards The Development Of Antimicrobial Agents And Pesticides, Stephano Hanolo Mlozi, Juma Mmongoyo, Musa Chacha

Tanzania Journal of Science

Fish bean, Tephrosia vogelii Hook.f is among of potential medicinal plant species in the genus Tephrosia. It has been traditionally used to cure human and animal ailments including fungal and bacterial diseases though not exhaustively scientifically reported. Similarly, its extracts have been locally used to control vectors and pests in small scale farming though the drug development from its extracts and phytochemicals is not reported. Thus, this review focused to unveil its ethnomedical and pharmaceutical potentiality with emphasis towards development of antimicrobial agents and pesticides. Data collection for the review was based on the published paper searched globally in several …

Understanding Orthopaedic Infections: A Conceptual Approach, Gregory Laborde, Christopher Bloise, George Karam

School of Medicine Faculty Publications

BACKGROUND: Memorizing mounds of facts without having an effective conceptual framework to store them is often an unsuccessful learning style because memory frequently fails without understanding. To accomplish this goal, we offer a framework of ideas called "concept maps". Of the many strategies for metacognition (that is, thinking about thinking), concept mapping is proven to improve meaningful and independent learning. We used this approach to guide understanding of common orthopaedic infections. This paper is not meant to serve as an approach on how to treat, but rather as a storage system with the ability to assist in understanding orthopaedic infections. …

Tourism: A Bridge Between Religions, Deša Karamehmedović

International Journal of Religious Tourism and Pilgrimage

Interreligious dialogue is crucial for cultural, economic, and social progress, fostering cultural development through activities like tourism. To address misunderstandings and biases, continuous development and promotion of interreligious dialogue is essential. This two-way process emphasises the importance of ‘listening and telling’, while respecting differences. Religious tourism serves as a valuable tool for encounters and understanding among diverse communities. This paper tries to address the question of whether there are for interreligious dialogue in tourism that have yet to be applied and could be implemented? The findings from tourism theory indicate that religious encounters primarily take place in sacred places, sacred …

Substance Use Disorder Civil Commitment And Association With Post-Commitment Treatment Retention Among Adult Women, Lydie Ultimo

Walden Dissertations and Doctoral Studies

The effects of substance abuse are a public health challenge, as evidenced by the prevalence of drug-related overdoses since the year 2000. Involuntary civil commitment (ICC) denotes a legal basis to mandate treatment for people at imminent risk of harm due to substance use disorders (SUD). Grounded on the transtheoretical model stages of change, this quantitative retrospective cohort study analyzed the relationship between mental disorder history, medication for addiction treatment (MAT), and voluntary retention in SUD treatment post-ICC, controlling for age, race/ethnicity, drugs used, housing status, and Department of Children and Families services. Secondary data from the Massachusetts Department of …

Effectiveness Of Eucalyptus For Pain Management: An Integrative Review, Taylor Stone, Jennifer Tran

Master's Projects

This integrative review examines eucalyptus essential oil effectiveness for pain, particularly as an alternative to opioids. An extensive literature search was conducted across multiple databases, including Joanna Briggs Institue, Cochrane, CINAHL, PubMed, and Scopus, focusing on studies examining eucalyptus oil’s analgesic properties, along with its effectiveness when used alone or in conjunction with complementary therapies like massage and acupuncture. Analysis identified three key themes: (1) the effectiveness of eucalyptus oil in pain reduction across various acute and chronic pain conditions, (2) its role in potentially reducing reliance on pharmaceutical pain relief, and (3) its capacity to enhance the effectiveness of …

Inherited Retinal Degenerations And Non-Neovascular Age-Related Macular Degeneration: Progress And Unmet Needs, Jacque L Duncan, Angela Bowman, Amy Laster, Claire Gelfman, David G Birch, Shannon E Boye, Stephen P Daiger, Lucian Del Priore, Donald J Zack, James T Handa

Faculty, Staff and Student Publications

Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD. The article outlines opportunities to address gaps and unmet needs that should lead to additional progress toward the development of treatments …

Systemic Administration Of A Site-Targeted Complement Inhibitor Attenuates Chronic Stress-Induced Social Behavior Deficits And Neuroinflammation In Mice, Amit Kumar Madeshiya, Brandi Quintanilla, Carl Whitehead, Stephen Tomlinson, Anilkumar Pillai

Faculty, Staff and Student Publications

Chronic stress, a risk factor for many neuropsychiatric conditions, causes dysregulation in the immune system in both humans and animal models. Additionally, inflammation and synapse loss have been associated with deficits in social behavior. The complement system, a key player of innate immunity, has been linked to social behavior impairments caused by chronic stress. However, it is not known whether complement inhibition can help prevent neuroinflammation and behavioral deficits caused by chronic stress. In this study, we investigated the potential of a site-targeted complement inhibitor to ameliorate chronic stress-induced changes in social behavior and inflammatory markers in the prefrontal cortex …

Chagos Archipelago, Claire Collins, David J. Curnick, Tom Letessier, Joanna Harris

School of Biological and Marine Sciences

No abstract provided.

Myeloid Activation Clears Ascites And Reveals Il27-Dependent Regression Of Metastatic Ovarian Cancer, Brennah Murphy, Taito Miyamoto, Bryan S Manning, Gauri Mirji, Alessio Ugolini, Toshitha Kannan, Kohei Hamada, Yanfang P Zhu, Daniel T Claiborne, Lu Huang, Rugang Zhang, Yulia Nefedova, Andrew Kossenkov, Filippo Veglia, Rahul Shinde, Nan Zhang

Faculty, Staff and Student Publications

Patients with metastatic ovarian cancer (OvCa) have a 5-year survival rate of < 30% due to the persisting dissemination of chemoresistant cells in the peritoneal fluid and the immunosuppressive microenvironment in the peritoneal cavity. Here, we report that intraperitoneal administration of β-glucan and IFNγ (BI) induced robust tumor regression in clinically relevant models of metastatic OvCa. BI induced tumor regression by controlling fluid tumor burden and activating localized antitumor immunity. β-glucan alone cleared ascites and eliminated fluid tumor cells by inducing intraperitoneal clotting in the fluid and Dectin-1-Syk-dependent NETosis in the omentum. In omentum tumors, BI expanded a novel subset of immunostimulatory IL27+ macrophages and neutralizing IL27 impaired BI efficacy in vivo. Moreover, BI directly induced IL27 secretion in macrophages where single agent treatment did not. Finally, BI extended mouse survival in a chemoresistant model and significantly improved chemotherapy response in a chemo-sensitive model. In summary, we propose a new therapeutic strategy for the treatment of metastatic OvCa.

Rna Shielding Of P65 Is Required To Potentiate Oncogenic Inflammation In Tet2-Mutated Clonal Hematopoiesis, Nana Adjoa Ben-Crentsil, Wazim Mohammed Ismail, Maria E Balasis, Hannah Newman, Ariel Quintana, Moritz Binder, Traci Kruer, Surendra Neupane, Meghan C Ferrall-Fairbanks, Jenna Fernandez, Terra L Lasho, Christy M Finke, Mohammed L Ibrahim, Kathy L Mcgraw, Michael Wysota, Amy L Aldrich, Christopher B Ryder, Christopher T Letson, Joshua Traina, Amy F Mclemore, Nathalie Droin, Aditi Shastri, Seongseok Yun, Eric Solary, David A Sallman, Amer A Beg, Li Ma, Alexandre Gaspar-Maia, Mrinal M Patnaik, Eric Padron

Faculty, Staff and Student Publications

This work identifies MALAT1 as a requisite downstream effector of oncogenic feedforward inflammatory circuits necessary for the development of TET2-mutated CH and fulminant myeloid malignancy. We elucidate a novel mechanism by which MALAT1 "shields" p65 from dephosphorylation to potentiate this circuit and nominate MALAT1 inhibition as a future therapeutic strategy.

Functional Role Of Myosin-Binding Protein H In Thick Filaments Of Developing Vertebrate Fast-Twitch Skeletal Muscle, Andrew F Mead, Marilyn J Cipolla, Aaron N Johnson, Christina A Gurnett, Et Al.

2020-Current year OA Pubs

Myosin-binding protein H (MyBP-H) is a component of the vertebrate skeletal muscle sarcomere with sequence and domain homology to myosin-binding protein C (MyBP-C). Whereas skeletal muscle isoforms of MyBP-C (fMyBP-C, sMyBP-C) modulate muscle contractility via interactions with actin thin filaments and myosin motors within the muscle sarcomere "C-zone," MyBP-H has no known function. This is in part due to MyBP-H having limited expression in adult fast-twitch muscle and no known involvement in muscle disease. Quantitative proteomics reported here reveal that MyBP-H is highly expressed in prenatal rat fast-twitch muscles and larval zebrafish, suggesting a conserved role in muscle development and …

Inside Outsider Art: Challenges And Opportunities For A Marginalized Genre, Lucas Lynn

Duke Law Journal

Outsider art encompasses the work of artists, typically self-taught, who experience some form of marginalization and do not proactively participate in the mainstream art world. Adored in part for the biographies of the artists and in part for the quality of the art, the genre has become increasingly popular in secondary markets and museums over the last half century. However, buyers of outsider art still find it difficult to authenticate and attribute works. This Note examines the challenges inherent in outsider art and proposes three opportunities that can help address the challenges with authentication and provenance in outsider art while …

Major Depressive Disorder And Driving Behavior Among Older Adults, Ganesh M Babulal, Ling Chen, Jean-Francois Trani, David C Brown, David B Carr, Beau M Ances, Eric J Lenze, Drives Project

2020-Current year OA Pubs

IMPORTANCE: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.

OBJECTIVE: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).

DESIGN, SETTING, AND PARTICIPANTS: A prospective longitudinal cohort study was conducted among older adults (≥65 years) from the Driving Real-World In-Vehicle Evaluation System Project collected from July 1, 2021, to December 30, 2023. The sample included 85 participants with MDD and 310 participants without. Neurological, clinical, mood, and neuropsychological …

Onset And Progression Of Disease In Nonhuman Primates With Pde6c Cone Disorder, Monica Ardon, Lily Nguyen, Rui Chen, Jeffrey Rogers, Tim Stout, Sara Thomasy, Ala Moshiri

Faculty, Staff and Students Publications

PURPOSE: The California National Primate Research Center contains a colony of rhesus macaques with a homozygous missense mutation in PDE6C (R565Q) which causes a cone disorder similar to PDE6C achromatopsia in humans. The purposes of this study are to characterize the phenotype in PDE6C macaques in detail to determine the onset of the cone phenotype, the degree to which the phenotype progresses, if heterozygote animals have an intermediate phenotype, and if rod photoreceptor function declines over time.

METHODS: We analyzed spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and electroretinography (ERG) data from 102 eyes of 51 macaques (aged 0.25 …

Neurofeedback: New Territories And Neurocognitive Mechanisms Of Endogenous Neuromodulation, James Sulzer, T Dorina Papageorgiou, Rainer Goebel, Talma Hendler

Faculty, Staff and Students Publications

Neurofeedback (NF) is endogenous neuromodulation of circumscribed brain circuitry. While its use of real-time brain activity in a closed-loop system is similar to brain-computer interfaces, instead of controlling an external device like the latter, the goal of NF is to change a targeted brain function. In this special issue on NF, we present current and future methods for extracting and manipulating neural function, how these methods may reveal new insights about brain function, applications, and rarely discussed ethical considerations of guiding and interpreting the brain activity of others. Together, the articles in this issue outline the possibilities of NF use …

Integrating Natural Product Research Laboratory With Artificial Intelligence: Advancements And Breakthroughs In Traditional Medicine, Jai-Sing Yang, Shih-Chang Tsai, Yuan-Man Hsu, Da-Tian Bau, Chia-Wen Tsai, Wen-Shin Chang, Sheng-Chu Kuo, Sheng-Chu Kuo, Chien-Chih Yu, Yu-Jen Chiu, Fuu-Jen Tsai

BioMedicine

The Natural Product Research Laboratory (NPRL) of China Medical University Hospital (CMUH) was established in collaboration with CMUH and Professor Kuo-Hsiung Lee from the University of North Carolina at Chapel Hill. The laboratory collection features over 6,000 natural products worldwide, including pure compounds and semi-synthetic derivatives. This is the most comprehensive and fully operational natural product database in Taiwan. This review article explores the history and development of the NPRL of CMUH. We then provide an overview of the recent applications and impact of artificial intelligence (AI) in new drug discovery. Finally, we examine advanced powerful AI-tools and related software …

Transformative Interventions In Cell Biology: The Development And Use Of Instructor/Student-Interactive Demonstrations Of Key Cell Biology Concepts, Prashanth Rao, Ashok Upadhyaya, Meera Nanjundan

International Journal of Teaching and Learning in Higher Education

In Cell Biology, a sophomore/junior undergraduate-level high-enrollment core course, students are expected to develop a broad and detailed understanding of the functioning of eukaryotic cells. For example, some of the more challenging biological concepts include machinery involved in the replication and translational processes, protein trafficking/orientation in membranes, as well as both G protein-coupled receptor and receptor tyrosine kinase signal transduction pathways. In this instructional article, we describe prior published reports of the use of interactive demonstrations of several of these key biological concepts in the classroom. Furthermore, we narrate our efforts to integrate several of these disparate evidence-based techniques (EBTs) …

Fostering Active Learning And Metacognitive Skills In A Cognitive-Science Based Math Course, Sheila Tabanli

International Journal of Teaching and Learning in Higher Education

There is a large body of research on how to improve student learning through active learning and metacognition. However, without well-structured guidelines, students do not tend to actively engage with the taught material, peers, and the instructor at a desirable metacognitive level (Deslauriers et al., 2019). To address this problem, a research-driven assessment structure is integrated into a nontraditional course called “Methods for Mathematical Problem Solving” (M2PS). Methods for Mathematical Problem Solving was designed by the author to teach students effective study principles stemming from cognitive science. The assessments include synchronous check for understanding (CFU) assignments to further investigate the …