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The Winter Issue 2024, Destiny Dehart, Tifanee Mask, Crystal Walker, Lili Debarbier, Oliver La Barbrea Dec 2024

The Winter Issue 2024, Destiny Dehart, Tifanee Mask, Crystal Walker, Lili Debarbier, Oliver La Barbrea

Fonds and Feathers

This issue, edited by Destiny DeHart, features “An Archival Dichotomy: Is a Digital Collection or Physical Collection Best?” by Tifanee Mask Jackson, “Bringing Virtual Escape Rooms to the Library” by Crystal Walker, “Digitization and Natural History: Collections: Impact on Museum Educators and K-12 STEM Education Collections” by Lili DeBarbieri, “Preservation of Queer History in Texas” by Oliver La Barbrea, “Is Misinformation an Epidemic?: Digital literacy, who is she?” by Destiny DeHart, “Interview with Digital Historian Dr. Stephanie Seal Walters” by Destiny DeHart, and the poem “Cain & Abel” by Tifanee Mask Jackson. In addition, upcoming conferences are listed. A list …


Dante’S Pilgrimage: Transformation As A ‘Web Of Belief’, Stephen F. Haller Dec 2024

Dante’S Pilgrimage: Transformation As A ‘Web Of Belief’, Stephen F. Haller

International Journal of Religious Tourism and Pilgrimage

In Dante’s allegorical pilgrimage to hell and back, he travels through three stages of transformation that are illustrated in his paradigmatic example of identity transformation; namely, Dante’s Divine Comedy. As a pilgrim, he starts out in a state of ‘unease’ (or ‘sin’). Next, there is a ‘solution’ to his psychological disarray, which results in the religious experience of joy. William James has persuasively argued that these are the common features of all religious experiences (1901). Dante is in a stage of his life when he can no longer be reached by argument. This state of mind is described, by the …


The Impact Of Prophet Ibrahim’S Supplications In The Qur’An On The Flourishing Of Islamic Pilgrimage, Tariq H. M. Elhadary, Razaq Raj Dec 2024

The Impact Of Prophet Ibrahim’S Supplications In The Qur’An On The Flourishing Of Islamic Pilgrimage, Tariq H. M. Elhadary, Razaq Raj

International Journal of Religious Tourism and Pilgrimage

The supplications of Prophet Ibrahim (pbuh) in the Qur’an have had a significant impact on the flourishing of Islamic Pilgrimage and have also provided spiritual guidance for those who visit these sacred sites. Through his supplications, Prophet Ibrahim (pbuh) expressed his love for the sacred places associated with the Islamic faith. His prayers for both the visitors and residents of these places, are believed to invoke divine blessings and protection upon them. Prophet Ibrahim’s supplications in the Qur’an also encouraged Muslim pilgrims (often referred to as religious tourists) to visit these holy sites by reminding them of the great rewards …


To Read Or Not To Read: How Book Censorship Affects Students And Undermines Different Worldviews, Jordyn L. Bailey Dec 2024

To Read Or Not To Read: How Book Censorship Affects Students And Undermines Different Worldviews, Jordyn L. Bailey

Honors Theses

The past five years have seen an unprecedented growth in book challenges across the nation. The American Library Association announced in March 2024 that 2023 saw a ninety-two percent increase in challenged titles, making it a record year for book bans and challenges (American Library Association 2024). States are seeing increased government inference into these issues. Namely, Florida remains a leader in book challenges with over forty percent of all book bans in the 2022-2023 school year (Meehan 2023). This project examines the effect of book challenges and bans on adolescent readers, with an emphasis on how frequently challenged books, …


Sustainable Carbon Footprint Growth Mechanism In Forest Systems Under Patterns Ofglobal Climate Change, Wenbo Zhang, Guangxu Liu Dec 2024

Sustainable Carbon Footprint Growth Mechanism In Forest Systems Under Patterns Ofglobal Climate Change, Wenbo Zhang, Guangxu Liu

Turkish Journal of Agriculture and Forestry

Forests play a crucial role in regulating the global carbon cycle, but there are few existing studies on measuring the carbonfootprint of forest systems and analyzing the driving factors for sustained growth. This study investigated the carbon footprint of forestsystems, examined the driving factors behind their sustained growth under patterns of global climate change, and developed a researchmethodology to understand this sustained growth mechanism. To determine the carbon footprint and carbon-carrying capacity offorest systems, this study began with the impact of cities on forest systems and constructed a carbon footprint account for forest systems.Based on a relative growth model and …


Comparing Metabolism And Hypoxia Tolerance Of Native And Non-Native Florida Freshwater Fishes In Climate Change Scenarios, Benjamin A. Share Dec 2024

Comparing Metabolism And Hypoxia Tolerance Of Native And Non-Native Florida Freshwater Fishes In Climate Change Scenarios, Benjamin A. Share

All HCAS Student Capstones, Theses, and Dissertations

As climate change brings rising water temperatures and lower dissolved oxygen (DO) concentrations to freshwater bodies, it has become increasingly important to understand how this will affect ecosystems with established non-native or invasive species. Fishes of the family Cichlidae are the most pervasive non-native fishes in the Everglades and may increase their range further north under a changing climate. To better understand potential invasibility and competition with native fishes, the metabolism and hypoxia tolerance of non-native Blue Tilapia Oreochromis aureus was compared to native Bluegill Lepomis macrochirus when acclimated across a range of seasonal and projected temperatures. Intermittent-flow respirometry was …


Interspecific Associations Of Mesopredators In Western Tennessee: I. A Review Of Mesopredator Associations From The Scientific Literature; Ii. Mesopredator Associations Determined From Long-Term Scent-Station Data; Iii. Spatial And Temporal Patterns Of Interspecific Associations Of Mesopredators From Camera-Trap Data., Colten Taunton Snyder Dec 2024

Interspecific Associations Of Mesopredators In Western Tennessee: I. A Review Of Mesopredator Associations From The Scientific Literature; Ii. Mesopredator Associations Determined From Long-Term Scent-Station Data; Iii. Spatial And Temporal Patterns Of Interspecific Associations Of Mesopredators From Camera-Trap Data., Colten Taunton Snyder

Electronic Theses and Dissertations Archive

The goal of this study was to assess the interspecific associations of mesopredators (raccoon, Procyon lotor; Virginia opossum, Didelphis virginiana; coyote, Canis latrans; bobcat, Lynx rufus) in western Tennessee using long-term scent-station data and camera-trapping methods. First, a review of past literature regarding interspecific relationships of the species was completed. Spatial associations were evaluated using 11 years of scent-station data from Milan Army Ammunition Plant (Carroll and Gibson counties, Tennessee). Results of the study showed an association between raccoons and Virginia opossums (positive) and between Virginia opossums and coyotes (negative). Spatial and temporal associations were assessed using camera traps at …


Species Interactions Between Two Cavity-Nesting Songbirds Under The Threat Of Brood Parasitism And Nest Depredation, Shelby Green Dec 2024

Species Interactions Between Two Cavity-Nesting Songbirds Under The Threat Of Brood Parasitism And Nest Depredation, Shelby Green

Electronic Theses and Dissertations Archive

Interspecies interactions are strong drivers of natural selection, but their combined effects in nature are poorly understood. Here I investigate the breeding ecology of wild populations of Carolina Wrens and Prothonotary Warblers – species breeding in sympatry and occupying similar ecological niches but with contrasting life-histories. Wrens are, for example, noisy and aggressive when defending their nests and territories from potential threats and are far less likely than warblers to experience brood parasitism but more likely to experience nest depredation, especially when the density of nesting pairs increases. I hypothesize that the migratory warblers derive a fitness benefit from nesting …


The Purification, Characterization, And Inhibition Profile Of Some Herbicides Ofglutathione S-Transferase From Broccoli, Hacer Erdem Kiziltunç, Hali̇s Şaki̇roğlu, Mi̇ne Aksoy Dec 2024

The Purification, Characterization, And Inhibition Profile Of Some Herbicides Ofglutathione S-Transferase From Broccoli, Hacer Erdem Kiziltunç, Hali̇s Şaki̇roğlu, Mi̇ne Aksoy

Turkish Journal of Agriculture and Forestry

Herbicide selectivity is determined by the variability of herbicide degradation processes in weeds and crops. GlutathioneS-transferases (GSTs) have been widely studied in plants because of their role in herbicide metabolism. GSTs metabolize herbicides bycatalyzing reduced glutathione (GSH) conjugation. The significance of GSTs in herbicide metabolism has been understood by examiningGST in some plants. In this study, a GST enzyme was purified from broccoli using an affinity chromatography (glutathione agarose)method to contribute to the elucidation of plant GSTs. A characterization of the purified broccoli GST enzyme was then carried out.In the last step, the inhibition profiles of some selected types of …


Physicochemical, Bioactive, Microbial, And Sensory Characteristics Of Homemade Vinegar Produced With A Local Apple Variety Using A Traditional Method, Hasan Kiliçgün, Fi̇li̇z Yangilar Dec 2024

Physicochemical, Bioactive, Microbial, And Sensory Characteristics Of Homemade Vinegar Produced With A Local Apple Variety Using A Traditional Method, Hasan Kiliçgün, Fi̇li̇z Yangilar

Turkish Journal of Agriculture and Forestry

Apple is one of the most widely grown fruits in the world and can be found fresh in the market throughout the whole yeardue to its excellent storage ability. In addition to fresh consumption, apples are processed into a variety of products including fruitjuice, vinegar, jams, and pies. In this study, the bioactive contents and microbial, physicochemical, and sensory properties of sevenvinegars traditionally produced using a local apple variety, Kara Sakı, with different yeast materials (Saccharomyces cerevisiae, chickpea,buckwheat, barley, whey, natural home apple vinegar, and commercial apple cider vinegar) were assessed. The results indicated significantdifferences among vinegar samples for dry …


In Silico Analysis Of Three-Amino Acid Loop Extension (Tale) Proteins In Phaseolusvulgaris L. And Investigation Of Their Transcript Levels In Response To Drought Stress, Fatma Nur Avci, Tarik Kirlioğlu, Aybüke Okay, Emi̇ne Sümer Aras, İlker Büyük Dec 2024

In Silico Analysis Of Three-Amino Acid Loop Extension (Tale) Proteins In Phaseolusvulgaris L. And Investigation Of Their Transcript Levels In Response To Drought Stress, Fatma Nur Avci, Tarik Kirlioğlu, Aybüke Okay, Emi̇ne Sümer Aras, İlker Büyük

Turkish Journal of Agriculture and Forestry

Drought represents a major global threat to the environment, thus leading to food insecurity. Transcription factors (TFs) have a significant role in regulating the expression of stress-related genes. TALE genes, a type of TF, are known to regulate important biological processes like the maintenance of shoot apical meristems and root formation in plants. In this study, 35 TALE genes were identified and they were found to be categorized into KNOX-like homeodomain (KNOX) and BLH/BELL-like subfamilies in Phaseolus vulgaris according to the phylogenetic analysis. The detailed characterization of PvTALE genes using in silico analyzes further showed that segmental duplications predominate in …


Grafting Success And Quality Of Hazelnut Plants: Impact Of Grafting Methods, Clones And Bonding Materials, Sava Džankić, Sandra Bijelić, Borivoje Bogdanović, Goran Jaćimović, Hülya Ünver Dec 2024

Grafting Success And Quality Of Hazelnut Plants: Impact Of Grafting Methods, Clones And Bonding Materials, Sava Džankić, Sandra Bijelić, Borivoje Bogdanović, Goran Jaćimović, Hülya Ünver

Turkish Journal of Agriculture and Forestry

Despite favourable agro-ecological conditions, there is a significant gap between the real demand for hazelnut fruits and the state of production in the Republic of Serbia. However, over the past few decades, hazelnut production has been significantly enhanced through establishing orchards with grafted seedlings. As hazelnut grafting has predominantly relied on the whip and tongue method until recently, there has been a need to explore other grafting methods of Corylus avellana L. on generative rootstocks of Corylus colurna L. The aim of this study was to comparatively investigate the grafting of three clones of C. avellana using four grafting methods, …


Landscape Of Kidney Replacement Therapy Provision In Low- And Lower-Middle Income Countries: A Multinational Study From The Isn-Gkha, Victoria Nkunu, Somkanya Tungsanga, Hassane M. Diongole, Abdulshahid Sarki Dec 2024

Landscape Of Kidney Replacement Therapy Provision In Low- And Lower-Middle Income Countries: A Multinational Study From The Isn-Gkha, Victoria Nkunu, Somkanya Tungsanga, Hassane M. Diongole, Abdulshahid Sarki

Open Access archive

In low- and lower-middle-income countries (LLMICs), delivering equitable kidney care presents substantial challenges, resulting in significant disparities in disease management and treatment outcomes for people with kidney failure. This comprehensive report leveraged data from the International Society of Nephrology-Global Kidney Health Atlas (ISN-GKHA), to provide a detailed update on the landscape of kidney replacement therapy (KRT) in LLMICs. Among the 65 participating LLMICs, reimbursement for KRT (publicly funded by the government and free at the point of delivery) was available in 28%, 15%, and 8% for hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT), respectively. Additionally, while 56% and …


Sympathetic Innervation Of Interscapular Brown Adipose Tissue Is Not A Predominant Mediator Of Ot-Elicited Reductions Of Body Weight Gain And Adiposity In Male Diet-Induced Obese Rats, Edwards, Ha Nguyen, Andrew Dodson, Adam Herbertson, Mackenzie Honeycutt, Jared Slattery, June Rambousek, Edison Tsui, Tami Wolden-Hansen, Tomasz Wietecha, James Graham, Geronimo Tapia, Carl Sikkema, Kevin O'Brien, Thomas Mundinger, Elaine Peskind, Vitaly Ryu, Peter Havel, Arshad Khan, Gerald Taborsky, James Blevins Dec 2024

Sympathetic Innervation Of Interscapular Brown Adipose Tissue Is Not A Predominant Mediator Of Ot-Elicited Reductions Of Body Weight Gain And Adiposity In Male Diet-Induced Obese Rats, Edwards, Ha Nguyen, Andrew Dodson, Adam Herbertson, Mackenzie Honeycutt, Jared Slattery, June Rambousek, Edison Tsui, Tami Wolden-Hansen, Tomasz Wietecha, James Graham, Geronimo Tapia, Carl Sikkema, Kevin O'Brien, Thomas Mundinger, Elaine Peskind, Vitaly Ryu, Peter Havel, Arshad Khan, Gerald Taborsky, James Blevins

Departmental Papers (Biology)

Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing energy expenditure (EE). Previous studies in our lab have shown that  administration of OT into the fourth ventricle (4V; hindbrain) elicits weight loss and stimulates interscapular brown adipose tissue temperature (TIBAT) in DIO rats. We hypothesized that OT-elicited stimulation of sympathetic nervous system (SNS) activation of IBAT contributes to its ability to activate BAT and reduce BW in DIO rats. To test this, we determined the effect of disrupting SNS activation of IBAT on …


Neurofeedback: New Territories And Neurocognitive Mechanisms Of Endogenous Neuromodulation, James Sulzer, T Dorina Papageorgiou, Rainer Goebel, Talma Hendler Dec 2024

Neurofeedback: New Territories And Neurocognitive Mechanisms Of Endogenous Neuromodulation, James Sulzer, T Dorina Papageorgiou, Rainer Goebel, Talma Hendler

Faculty, Staff and Students Publications

Neurofeedback (NF) is endogenous neuromodulation of circumscribed brain circuitry. While its use of real-time brain activity in a closed-loop system is similar to brain-computer interfaces, instead of controlling an external device like the latter, the goal of NF is to change a targeted brain function. In this special issue on NF, we present current and future methods for extracting and manipulating neural function, how these methods may reveal new insights about brain function, applications, and rarely discussed ethical considerations of guiding and interpreting the brain activity of others. Together, the articles in this issue outline the possibilities of NF use …


Understanding Bigeye Scad (Selar Crumenophthalmus) In Southeast Florida: Age-Growth, Reproduction, And Diet, Mariah France Dec 2024

Understanding Bigeye Scad (Selar Crumenophthalmus) In Southeast Florida: Age-Growth, Reproduction, And Diet, Mariah France

All HCAS Student Capstones, Theses, and Dissertations

In southeastern Florida, the bigeye scad (Selar crumenophthalmus) is highly regarded as a baitfish for targeting billfish and other large sportfishes, often commanding market prices as live bait exceeding $180 per dozen. Despite its economic significance, there is limited knowledge regarding the species within the Atlantic Ocean, especially the population that occurs in Florida. Bigeye scad were collected monthly from local bait shops in Pompano Beach, Miami, and Islamorada to assess age-growth, reproductive behaviors, and dietary habits. Specimens from May to August had the highest values for length-weight relationships and gonadsomatic index, indicative of a spawning season during …


Oregon State Rank Assessment For Wolverine (Gulo Gulo), Misty Nelson, Eleanor P. Gaines Dec 2024

Oregon State Rank Assessment For Wolverine (Gulo Gulo), Misty Nelson, Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for wolverine (Gulo gulo) using NatureServe methodology, 2024.


Formulasi Sediaan Hair Tonic Dari Kombinasi Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Dan Ekstrak Lidah Buaya (Aloe Vera), Sjamsiah Sjamsiah, Titik Andriani, Ekha Irmawati, Kurnia Ramadani Dec 2024

Formulasi Sediaan Hair Tonic Dari Kombinasi Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Dan Ekstrak Lidah Buaya (Aloe Vera), Sjamsiah Sjamsiah, Titik Andriani, Ekha Irmawati, Kurnia Ramadani

Chimica et Natura Acta

Sediaan penumbuh rambut alami telah menjadi pilihan paling populer karena diolah dari berbagai bahan alami dan mempunyai banyak manfaat dan efek samping yang relatif kecil. Tanaman obat seperti daun sirsak dan lidah buaya merupakan bahan-bahan alami yang dapat digunakan dalam pembuatan sediaan tonik rambut alami. Tujuan penelitian ini adalah untuk mengidentifikasi karakteristik tonik rambut dari berbagai ekstrak dan untuk mengetahui pengaruh ekstrak tonik rambut kombinasi ekstrak daun sirsak lidah buaya terhadap efektivitas pertumbuhan rambut pada hewan uji kelinci dengan menggunakan metode uji organoleptik, homogenitas, uji pH, uji berat jenis, uji viskositas dan uji ANOVA. Hasil penelitian menunjukkan bahwa karakteristik tonik …


Different Irrigation Strategies Affect Proximate Composition And Fatty Acid Profiles Of Grape Seeds Under Semi-Arid Conditions, Mehmet İlhan Odabaşioğlu Dec 2024

Different Irrigation Strategies Affect Proximate Composition And Fatty Acid Profiles Of Grape Seeds Under Semi-Arid Conditions, Mehmet İlhan Odabaşioğlu

Turkish Journal of Agriculture and Forestry

Grapevine (Vitis vinifera) is one of the most widely cultivated horticultural plants with high socioeconomic value, and itis extensively appreciated for its colorful berries and the wines made from its berries. Variations in the phytochemical compoundsof different tissues of grape berries under different cultural practices have been explored in numerous studies in recent years. In thisstudy, variations in the physical, proximate, and fatty acid compositions of grape (Vitis vinifera L. ‘Red Globe’) seeds under differentpartial root-zone drying and deficit irrigation treatments were investigated. The results showed that different irrigation treatments andirrigation levels affected the vitality, moisture, and oil contents of …


Combined Physiological And Biochemical Analysis And Molecular Biotechnology For Atrazine Residue Reduction In Soybeans, Fenglan Hu, Yan Ding Dec 2024

Combined Physiological And Biochemical Analysis And Molecular Biotechnology For Atrazine Residue Reduction In Soybeans, Fenglan Hu, Yan Ding

Turkish Journal of Agriculture and Forestry

To address the problem of atrazine residue in soybeans affecting the ecological environment and human health, in the presentstudy it is proposed to combine the bioorganic fertilizer DNBF10 and the highly efficient degrading bacterial strain AT-b3 with themagnetic biochar carrier MBC to form a novel DMBC-P bioremediation technology. The results indicated that the DMBC-P technologycould effectively reduce the residual amount of atrazine in soybeans and significantly enhance their growth and physiological indexes bypromoting atrazine degradation and phosphorus utilization and reducing oxidative stress. At the physiological and biochemical levels,DNBF10 significantly alleviated atrazine-induced oxidative stress, reducing the IBRv2 values to 1.84 and …


Bioethanol Yield Of The Sorghum × Sudangrass Hybrid Under Arid And Semiaridconditions: Nitrogen Dose Effects, Orthogonal Comparisons, And Component Analyses, Hali̇t Tutar Dec 2024

Bioethanol Yield Of The Sorghum × Sudangrass Hybrid Under Arid And Semiaridconditions: Nitrogen Dose Effects, Orthogonal Comparisons, And Component Analyses, Hali̇t Tutar

Turkish Journal of Agriculture and Forestry

The sorghum x sudangrass hybrid is highly significant as a biofuel crop due to its high biomass production, drought tolerance, ability to adapt to various climatic conditions, and high sugar content in its stems. This research aimed to determine the effects of six different nitrogen dose treatments on ethanol yield, yield parameters, and fertilizer use relationships in sorghum x sudangrass hybrid plants at two locations in 2021 and 2022. The experiment was established according to the randomized block design with three replicates. Nitrogen treatments were applied as N0 (0 kg da-1), N5 (5 kg da-1), N10 (10 kg da-1), N15 …


Healing In Ashes, November 2023, Kristin Mattson Dec 2024

Healing In Ashes, November 2023, Kristin Mattson

The North Meridian Review

No abstract provided.


The Bridge, Renesha Dhanraj Dec 2024

The Bridge, Renesha Dhanraj

The North Meridian Review

No abstract provided.


Mifepristone Is Safe, Pray For The Culture Warriors, And Rossastroscuro, Johnny Byutorie Dec 2024

Mifepristone Is Safe, Pray For The Culture Warriors, And Rossastroscuro, Johnny Byutorie

The North Meridian Review

No abstract provided.


Review: Crocodile Tears Didin't Cause The Flood, Chris Heisserer Dec 2024

Review: Crocodile Tears Didin't Cause The Flood, Chris Heisserer

The North Meridian Review

No abstract provided.


Oregon State Rank Assessment For Camas Pocket Gopher (Thomomys Bulbivorus), Eleanor P. Gaines Dec 2024

Oregon State Rank Assessment For Camas Pocket Gopher (Thomomys Bulbivorus), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Camas pocket gopher (Thomomys bulbiforus) using NatureServe methodology, 2024.


Redesigning The Hospital Environment To Improve Restfulness, Caellagh D Catley, Kayla Paynter, Kendall Jackson, Ashley Huggins, Jenny Ji, Sai Anusha Sanka, Michelle Simkins, Thomas M Maddox, Patrick G Lyons Dec 2024

Redesigning The Hospital Environment To Improve Restfulness, Caellagh D Catley, Kayla Paynter, Kendall Jackson, Ashley Huggins, Jenny Ji, Sai Anusha Sanka, Michelle Simkins, Thomas M Maddox, Patrick G Lyons

2020-Current year OA Pubs

IMPORTANCE: Hospital wards are often not conducive to patient sleep, negatively affecting patient health and experience.

OBJECTIVES: To assess determinants of in-hospital restfulness and to design and test rest-promoting interventions on the wards in partnership with clinicians, staff, and patients.

DESIGN, SETTING, AND PARTICIPANTS: This rapid-sequential mixed-methods quality improvement study was performed at a large urban academic hospital in St Louis, Missouri, from May 1, 2021, to December 31, 2022, with follow-up through hospitalization. Mixed-methods activities involved purposively selected hospitalized adults on the wards, nurses, hospitalists, and hospital staff. Interventions included all adult hospitalizations on the study wards.

INTERVENTIONS: Sequential …


Heterozygous Btnl8 Variants In Individuals With Multisystem Inflammatory Syndrome In Children (Mis-C), Evangelos Bellos, Erica G Schmitt, Et Al. Dec 2024

Heterozygous Btnl8 Variants In Individuals With Multisystem Inflammatory Syndrome In Children (Mis-C), Evangelos Bellos, Erica G Schmitt, Et Al.

2020-Current year OA Pubs

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.2, 95% CI: 3.5-5.3, P < 10-6). BTNL8 encodes an intestinal epithelial regulator of Vγ4+γδ T cells implicated in regulating gut homeostasis. Enrichment was exclusive to MIS-C, being absent in patients with COVID-19 or bacterial disease. Using an available functional test for BTNL8, rare variants from a larger cohort of MIS-C patients (n = 835) were tested which identified eight variants in 18 patients (2.2%) with impaired engagement of Vγ4+γδ T cells. Most of these variants were in the B30.2 domain of BTNL8 implicated in sensing epithelial cell status. These findings were associated with altered intestinal permeability, suggesting a possible link between disrupted gut homeostasis and MIS-C-associated enteropathy triggered by SARS-CoV-2.


Vps13b Is Localized At The Interface Between Golgi Cisternae And Is A Functional Partner Of Fam177a1, Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R Mcadow, Catherine Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf, Pietro De Camilli Dec 2024

Vps13b Is Localized At The Interface Between Golgi Cisternae And Is A Functional Partner Of Fam177a1, Berrak Ugur, Florian Schueder, Jimann Shin, Michael G Hanna, Yumei Wu, Marianna Leonzino, Maohan Su, Anthony R Mcadow, Catherine Wilson, John Postlethwait, Lilianna Solnica-Krezel, Joerg Bewersdorf, Pietro De Camilli

2020-Current year OA Pubs

Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacent membranes, cause Cohen syndrome. VPS13B is known to be concentrated in the Golgi complex, but its precise location within this organelle and thus the site(s) where it achieves lipid transport remains unclear. Here, we show that VPS13B is localized at the interface between proximal and distal Golgi subcompartments and that Golgi complex reformation after Brefeldin A (BFA)-induced disruption is delayed in VPS13B KO cells. This delay is phenocopied by the loss of FAM177A1, a Golgi complex protein of unknown function reported to be a …


Concomitant Epidural And Longitudinal Anterior Spinal Artery Contrast Spread In A Lumbar Transforaminal Epidural Steroid Injection (Tfesi), Philip J. Koehler Iii, Paul M. Kitei, David S. Stolzenberg, Elaine H. Hatch Dec 2024

Concomitant Epidural And Longitudinal Anterior Spinal Artery Contrast Spread In A Lumbar Transforaminal Epidural Steroid Injection (Tfesi), Philip J. Koehler Iii, Paul M. Kitei, David S. Stolzenberg, Elaine H. Hatch

Rothman Institute Papers

A 78-year-old female with a remote history of L3-4 decompression and fusion presented with several months of low back and radicular leg pain. MRI revealed moderate L2-L3 spinal canal stenosis, ligamentum flavum infolding, moderate bilateral foraminal stenosis, and a grade I retrolisthesis. A right sided L2-L3 TFESI was performed using multiplanar fluoroscopic imaging with a subpedicular supraneural approach. During live iodinated contrast injection, imaging revealed concomitant epidural and central arterial contrast spread. The needle was retracted and repeat live fluoroscopic imaging demonstrated no vascular uptake. Desired epidural and nerve root contrast spread remained in place with repeat still imaging. Dexamethasone …