Digital Commons Network^™

Paano Nga Ba Ang Peta Play (O Ano Nga Ba Ang Isang Play Na Matatawag Na Petang-Peta), Manuel D. Pambid

Kritika Kultura

In telling the story of PETA, or the Philippine Educational Theater Association, this article reflects on the distinct characteristics that PETA plays have acquired in the more than 40 years it has served as the people’s theater—from the martial law years to the present, for the continuous expression of Filipino culture and heritage. The article shows the variety of PETA plays and the people behind their collaborative production, and ends with the present challenges of PETA as it reaches out to a younger generation of audience.

The Aesthetics Of Poverty: A Rationale In Designing For Philippine People's Theater 1973-1986, Brenda V. Fajardo

Kritika Kultura

This article will discuss the production design approaches and techniques used in plays by the Philippine Educational Theater Association (PETA) from 1973-1986, using the principles of “aesthetics of poverty.” The “aesthetics of poverty” came about in consideration of the poverty situation of the Philippines and is really an attitude more than anything else, appropriate for the social conditions of Philippine society. This was also the period when there was very limited budget for productions, the result of which was creating with one’s imagination and clear imaging for meanings and symbolic representation.

Fostering Conceptual Roles For Change: Identity And Agency In Esea Teacher Preparation, Brian Morgan

Kritika Kultura

English Changing, the theme and title of the 2009 ESEA conference held in Manila, raises specific challenges for language teacher education: To what extent do we prepare teachers to be passive recipients of the social, cultural, and economic changes that align with the global spread of English? Alternatively, how might we encourage teachers to become active participants—“agents of change”—through their mediation and implementation of language curricula and pedagogy? The author addresses such questions by first reflecting on his own personal and professional development in EFL and EAP teaching contexts. These experiences are then related to the growing research literature in …

Radical Remembering: Contaminating Memory In The Works Of Martin Lynch, Tom Maguire

Kritika Kultura

Martin Lynch has been prominent in the practice of community theatre in Northern Ireland through works like The Stone Chair and The Wedding Community Play and his role as founding Chair of Belfast’s Community Arts Forum. This essay argues, however, that in his work as a playwright engaged in staging the remembered histories of Belfast’s working class, it is possible to regard him as a radical playwright. Locating Lynch in the tradition of John McGrath’s popular theatre allows his work to be seen as both recovering working class experience and, crucially, probing mythologies that have justified and perpetuated political violence. …

The Collected Poems Of J.R.R. Tolkien (2024), Edited By Christina Scull And Wayne G. Hammond., John R. Holmes

Journal of Tolkien Research

Book review, by John R. Holmes, of The Collected Poems of J.R.R. Tolkien (2024), edited by Christina Scull and Wayne G. Hammond

Coastal Marine Heatwaves In The Santa Barbara Channel: Decadal Trends And Ecological Implications, Kit Yu Karen Chan, L. Kui, A. M. Mcdonald, A. L. Ritger, G. E. Hofmann

Biology Faculty Works

Marine heatwaves (MHWs) are of increasing concern due to the emerging ecological and socioeconomic impacts on coastal ecosystems. Leveraging the data of the Santa Barbara Coastal Long-Term Ecological Research project, we analyzed the MHW event metrics observed in the kelp forest ecosystem and across Santa Barbara Channel, CA, USA. Not only was there a significant positive trend in the number of MHWs recorded, their duration and intensity were also increasing over time. MHWs were detected year-round, suggesting that marine organisms have exposure risks regardless of their phenology. Exposure at one life history stage could have a legacy effect on the …

Tnf Prevents Establishment Of Anti-Tumor Immunity And Elucidates Toxicities Following Myxoma Virus Based Oncolytic Virotherapy, Miriam Beatriz Valenzuela Cardenas

Biomedical Sciences ETDs

Tumor Necrosis Factor Alpha (TNF) can lead to tumor regression through its direct cytolytic activity, yet it has also been implicated to facilitate tumor progression. This scenario complicates the efficacy and applicability of TNF based therapeutics as treatment for malignancies. In the context of oncolytic virotherapy (OV) which uses replicating viruses to treat tumors and acts by triggering production of pro-inflammatory cytokines, exploring such mechanisms is vital. Here we show that a Myxoma based oncolytic virus (vPD1/IL12) can induce large amounts TNF. The presence of TNF in the context of vPD1/IL12 plays a detrimental role both for tumor regression by …

Investigating Tumor Growth And Regulation In Supratentorial Ependymomas; The Impact Of Dlk1 And Egr1 Knockout, Om Sinojia

Honors Scholar Theses

Ependymomas (EPNs) are primary brain tumors that often arise from radial glial cells lining the ventricular system. Supratentorial ependymomas (ST-EPNs) are particularly aggressive, and understanding the molecular factors driving their growth is critical for developing targeted therapies. This study investigates the roles of DLK1 and EGR1, key regulators in cellular differentiation and tumorigenesis, in the development of ST-EPNs. We utilized genetically engineered mouse models to induce postnatal knockouts of DLK1 and EGR1 and evaluated tumor growth using histological and imaging techniques. Tumor area was quantified across multiple brain sections from both male and female mice. DLK1 knockout brains exhibited consistent …

Corneal Transplants And Their Impact, Bianca Estrada

Honors Capstones

A corneal transplant, also called keratoplasty or corneal grafting, is a type of surgery where damaged or diseased corneal tissue is replaced by a healthy donor cornea. The first successful corneal transplant was performed in 1905 by Dr. Eduard Zirm, but since then, surgical advancements have developed greatly, leading to more beneficial outcomes. Corneal blindness is a major form of reversible blindness that is manageable with healthy donor cornea transplantation. Other recipients or possible candidates for corneal transplantation include those with keratoconus, Fuchs’ dystrophy, eye infections, or eye injuries. This remarkable surgery is now one of the most common transplant …

Gad314.1 Example 1, Sae University College

Exemplars

A submisson for GAD314.1 - Portfolio for the period of 24T3 of high quality to serve as an exemplar for future trimesters

Gad314.1 Portfolio Example 1, Sae University College

Exemplars

An example of GAD314.1 - Portfolio of high quality and work to serve as an exemplar for future trimesters.

Targeting Myeloid Cell Iron Metabolism In Salmonella-Induced Colitis, Mariella Arcos Padilla

Biomedical Engineering ETDs

Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality.

Previous studies have shown that mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating bacterial infections remains unclear.

Here, we found that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also …

New Trends In The Study Of Haredi Culture And Society, David N. Myers, Nechumi Malovicki-Yaffe

The Jewish Role in American Life: An Annual Review

Who are Haredim? And why are they the source of both increasing attention and continuing misunderstanding? New Trends in the Study of Haredi Culture and Society draws on the innovative research of leading scholars from a variety of disciplines—including history, religious studies, demography, linguistics, and geography—to trace the growing prominence of Haredi (often called ultra-Orthodox) Jews in Jewish life. Haredi Jews are committed to preserving a measure of segregation from the rest of society consistent with the guiding principles of their forebears; yet increasingly, they are appearing more visibly and assertively in public spaces. Demographic analysis suggests that they will …

Testing Vivo-Morpholino Mediated Gene Knockdown Of Stat6, Spi1b, And Hnf4Α In Adult Threespine Stickleback, Stella Dipippo

Honors Scholar Theses

The fibrotic immune response to the cestode parasite, Schistocephalus solidus, varies among threespine stickleback populations. Fibrosis suppresses parasite growth but has costly effects on the fish. Previous genomic studies in stickleback have suggested potential roles of Spi1b, STAT6, and HNF4α in modulating fibrosis severity, but there is presently no evidence for this in-vivo. We used antisense vivo-morpholino oligonucleotides (MOs) to attempt to knockdown the expression of each gene in the liver, spleen, and intestine of adult stickleback. Vivo-MOs have been proven effective in other species of teleost fish, as well as in mice and humans, but …

Non-Conformity As Queerness: The Phenomenology Of Gender Identity Beyond The Binary, Gretl Josselyn

Honors Scholar Theses

Gender non-conformity is a defiance of fixed binary ideas of gender identity and expression which are enforced within societies. The phenomenological concept of breaking free from expectations based on one’s gender assigned at birth allows freedom of expression and an acceptance of non-conformity. Building on the works of Judith Butler, Sara Ahmed, María Lugones, and Iria Marion Young, among others, the act of performance and queering one’s identity and actions are explored. Gender identity is constantly evolving, and each expectation of what one’s gender expression should look like is a performance put on to conform. Individuals are not born with …

Impact Of Site-Specific Conjugation Strategies On The Pharmacokinetics Of Antibody Conjugated Radiotherapeutics, Ábel Nagy, David Ulmert, Wahed Zedan, Claire M Storey, Julie Park, Susanne Geres, Katharina Lückerath, Kjell Sjöström, Hadis Westin, Norbert Peekhaus, Daniel Lj Thorek, Amelie Eriksson Karlström, Mohamed Altai

2020-Current year OA Pubs

Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been developed in recent years for toxin- and fluorophore-mAb conjugates. In this study, we studied two site-specific labelling strategies for the conjugation of the macrocyclic chelating agent, DOTA, to the anti-Leucine Rich Repeat Containing 15 (LRRC15) mAb DUNP19. Specifically, one approach utilized a DOTA-bearing peptide (FcIII) with a strong affinity for the fragment …

Top Ten Epilepsy Research Priorities: A Uk Priority Setting Partnership, Rohit Shankar

Peninsula Medical School

Purpose: Research into epilepsy has experienced decades of chronic underfunding compared to other neurological conditions despite its prevalence and seriousness. To evidence the need for greater investment, the Epilepsy Research Institute (formerly Epilepsy Research UK) funded, led and managed a James Lind Alliance (JLA) Priority Setting Partnership (PSP). This “industry standard” methodology brings together healthcare professionals, patients, carers and patient group representatives to identify and prioritise research uncertainties within a defined area of health or care.Methods: The UK Epilepsy PSP is a once-in-a-generation, national consensus that collated and ranked the research priorities of the UK epilepsy and associated condition community. …

Biomedical Potential Of Natural Products From Selected Tanzanian Flora: A Review, Stephen S. Nyandoro, Joan J.E. Munissi

Tanzania Journal of Science

Natural products have been used for treatment of various diseases for thousands of years and served as sources of drug lead compounds for the improvement of livelihood. This paper presents a review on the biomedical potentials of selected natural products isolated from eight plant species indigenous to Tanzania. The review covers research work published between 2010 and 2023, and identifies 33 natural products with different pharmacological properties from Tanzanian plants. These bioactive natural products are discussed with other similar compounds isolated elsewhere from the same or different plant species to get further insights on the potential application in modern medicine …

Disclose By Law, Obfuscate By Strategy: A Corpus-Based Analysis Of Patent Filings, Katherine Ireland, W. Michael Schuster, Tim R. Samples

BYU Law Review

The patent system encourages dissemination of technical information by granting inventors exclusive rights to their inventions in exchange for public disclosure of their technology. The American Inventors Protection Act (AIPA), enacted in 1999, advanced this goal by increasing the scope and speed of disclosure. Previously, filings were published only if and when a patent was granted, but under the AIPA most applications are published eighteen months after filing. The sum of those changes amplified a fundamental tradeoff between protection and exposure. Although patents offer protection, competitors can exploit disclosures by integrating the innovations into their own research and development efforts. …

In Silico-Predicted Cytokeratin Fragment 21-1 (Cyfra 21-1) Immunogenic Epitopes For The Early Detection Of Nasopharyngeal Carcinoma, Brian Umbu Rezi Depamede, Bachti Alisjahbana, Sulaiman Ngongu Depamede, Sanny Hafidhoh, Siti Nururrohmah, Ilham Ngongu Tryawan, Muhammad Yusuf

Chimica et Natura Acta

Nasopharyngeal Carcinoma, an aggressive cancer in the head and neck region is mostly diagnosed at an advanced stage and thus has a poor prognosis. Cytokeratin Fragment 21-1 (CYFRA 21-1) is one of the oncomarkers discovered in saliva. For developing a diagnostic kit, CYFRA 21-1 antibodies and immunogens are needed. Natural CYFRA 21-1 immunogen is difficult to obtain, so it must be made in-silico using bioinformatics. We aim to predict CYFRA 21-1 immunogenic epitope to produce antibodies polyclonal against CYFRA 21-1, which can be used to develop NPC diagnostics. The immunogenic epitopes were predicted and chosen based on antigenicity, surface accessibility, …

Working Paper No. 85, Alexis De Tocqueville And The American Wealth Gap, Chloe Kneedler

Working Papers in Economics

This inquiry seeks to establish that French lawyer and scholar, Alexis de Tocqueville, observed as early as the 1830s, what would later emerge as the American wealth gap. After a nine-month journey that included his traveling through different parts of the nascent United States, Tocqueville wrote a two-volume book titled: Democracy in America [1835]. Over the length of his two volumes, Tocqueville reflects upon his experiences and observations drawn from the American nation in its fifth decade. Throughout this book, Tocqueville described the democratic structure of this country as emblematic of what could be expected from this “New World,” and …

The Microrna Mir-223 Constrains Colitis-Associated Tumorigenesis By Limiting Myeloid Cell Infiltration And Chemokine Expression, Ciara L Flynn, Gary E Markey, Viola Neudecker, Charlotte Farrelly, Glenn T Furuta, Holger K Eltzschig, Joanne C Masterson, Eóin N Mcnamee

Faculty, Staff and Student Publications

Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression is observed in CAC, it is also unclear how myeloid-specific microRNAs impact the inflammatory process that underpins the continuum from ulcerative colitis to tumorigenesis. In this study, we report that miR-223 acts to limit myeloid-driven inflammation in the azoxymethane (AOM)-dextran sodium sulfate (DSS) model of CAC in mice. In this model, miR-223-/y mice present with significantly larger tumors with an enhanced proliferative signature. Immunoprofiling showed that …

Farmers’ Decision Processes About Biocontrol Innovation Adoption: Dynamics Surrounding Push-Pull Technology In Western Kenya, Olufemi Samson Adesina, Stephen Whitfield, Susannah M. Sallu, Steven M. Sait, Jimmy Pittchar

All Peer-Reviewed Publications

Smallholder farmers in sub-Saharan Africa (SSA) face increasing challenges from pests and climate change, among other issues. In response to these challenges, international agricultural research for development (R4D) investment is often focused on developing and scaling up techniques and technologies that bolster resilience. However, such approaches are often technocentric and follow linear assumptions of innovation diffusion and adoption, which overlook the complex realities that influence smallholder farmers’ dynamic decisions and engagement with novel techniques. This study used qualitative ethnographic methods to explore the experiences, knowledge construction, motivations, and decision-making of farmers in Western Kenya regarding the extensively researched push-pull technology …

Global Impact Of Aging On The Hemodynamic Response Function In The Gray Matter Of Human Cerebral Cortex, Nooshin J Fesharaki, Amanda Taylor, Keisjon Mosby, Ruosha Li, Jung Hwan Kim, David Ress

Faculty, Staff and Students Publications

In functional magnetic resonance imaging, the hemodynamic response function (HRF) is a stereotypical response to local changes in cerebral hemodynamics and oxygen metabolism due to briefly (< 4 s) evoked neural activity. Accordingly, the HRF is often used as an impulse response with the assumption of linearity in data analysis. In cognitive aging studies, it has been very common to interpret differences in brain activation as age-related changes in neural activity. Contrary to this assumption, however, evidence has accrued that normal aging may also significantly affect the vasculature, thereby affecting cerebral hemodynamics and metabolism, confounding interpretation of fMRI cognitive aging studies. In this study, use was made of a multisensory task to evoke the HRF in ~87% of cerebral cortex in cognitively intact adults with ages ranging from 22 to 75 years. This widespread activation enabled us to investigate age trends in the spatial distributions of HRF characteristics within the majority of cortical gray matter, which we termed as global age trends. The task evoked both positive and negative HRFs, which were characterized using model-free parameters in native-space coordinates. We found significant global age trends in the distributions of HRF parameters in terms of both amplitudes (e.g., peak amplitude and contrast-to-noise ratio) and temporal dynamics (e.g., full-width-at-half-maximum). Our findings offer insight into how age-dependent changes affect neurovascular coupling and show promise for use of HRF parameters as non-invasive indicators for age-related pathology.

A Practical Clinical Approach To Navigate Pulmonary Embolism Management: A Primer And Narrative Review Of The Evolving Landscape, Kevin Benavente, Bradley Fujiuchi, Hafeez Ul Hassan Virk, Pavan K Kavali, Walter Ageno, Geoffrey D Barnes, Marc Righini, Mahboob Alam, Rachel P Rosovsky, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Advances in imaging, pharmacological, and procedural technologies have rapidly expanded the care of pulmonary embolism. Earlier, more accurate identification and quantification has enhanced risk stratification across the spectrum of the disease process, with a number of clinical tools available to prognosticate outcomes and guide treatment. Direct oral anticoagulants have enabled a consistent and more convenient long-term therapeutic option, with a greater shift toward outpatient treatment for a select group of low-risk patients. The array of catheter-directed therapies now available has contributed to a more versatile and nuanced armamentarium of treatment options, including ultrasound-facilitated thrombolysis and mechanical thrombectomy. Research into supportive …

A Practical Clinical Approach To Navigate Pulmonary Embolism Management: A Primer And Narrative Review Of The Evolving Landscape, Kevin Benavente, Bradley Fujiuchi, Hafeez Ul Hassan Virk, Pavan K Kavali, Walter Ageno, Geoffrey D Barnes, Marc Righini, Mahboob Alam, Rachel P Rosovsky, Chayakrit Krittanawong

2020-Current year OA Pubs

Advances in imaging, pharmacological, and procedural technologies have rapidly expanded the care of pulmonary embolism. Earlier, more accurate identification and quantification has enhanced risk stratification across the spectrum of the disease process, with a number of clinical tools available to prognosticate outcomes and guide treatment. Direct oral anticoagulants have enabled a consistent and more convenient long-term therapeutic option, with a greater shift toward outpatient treatment for a select group of low-risk patients. The array of catheter-directed therapies now available has contributed to a more versatile and nuanced armamentarium of treatment options, including ultrasound-facilitated thrombolysis and mechanical thrombectomy. Research into supportive …

The Structure And Function Of A Coastal State Aquaculture Plan, C. R. Fong, C. M. Gonzales, M. Rennick, H. J. Lahr, L. D. Gardner, B. S. Halpern, H. E. Froehlich

Faculty Research, Scholarly, and Creative Activity

Aquaculture contributes approximately half of all global aquatic food production and will be critical in addressing future seafood demand, including the United States (U.S.). Many states, territories, and countries are developing and updating aquaculture specific policy in an effort to plan for, and better manage the expansion of aquaculture in their territorial waters. The U.S. has considerable potential to sustainably expand aquaculture production, which has been a focus in both federal and state policy. State aquaculture plans have been used for over 40 years to help plan and coordinate aquaculture development, with a growing emphasis on sustainability. Here, we located …

Effect Of Temperature And Rhenium Content In Precipitates On Dispersion Hardening Of Tungsten, Yulia R. Sharapova, Arseny M. Kazakov, Elena A. Korznikova, Alexandr Zinovev, Dmitry Terentyev, Sergey V. Dmitriev

Karbala International Journal of Modern Science

Tungsten (W) is being developed as a plasma-facing material for fusion reactors, where it is subjected to MeV neutron irradiation, low-energy helium isotope particles, and high temperatures. These conditions lead to the formation of point defects, dislocation loops, voids, and transmutation into rhenium (Re) and osmium (Os), which form precipitates that significantly impact dislocation motion and increase hardness. This study uses molecular dynamics modeling to examine the interaction between an edge dislocation and Re-rich particles of various stoichiometries, specifically coherent bcc-phase particles and noncoherent σ-phase precipitates. Results show that shear stress increases by approximately 20-40% with larger particle size (3-5 …

Alanine Supplementation Enhancing Cordycepin Production In Cordyceps Militaris Via Upregulation Of Cns2 And Cns3 Genes Expression Levels, Wenbin Yu, Zeying Zhao, Bin Zeng, Yayi Tu, Bin He

Journal of Food and Drug Analysis

Cordycepin, a key bioactive compound produced by Cordyceps militaris, faces the challenge of low productivity forcommercial use. In this study, alanine supplementation in Cordyceps militaris boosted cordycepin production, peakingat 3 mg/g with 12 g/L concentration. Transcriptome analysis revealed 1711 differentially expressed genes, Pathwayanalysis indicates that protein processing in the endoplasmic reticulum was the most affected pathway. In addition, thetranscriptome showed that adenylosuccinate lyase is essential for the synthesis of cordycepin. The modulation of fourgenes (Cns1-4) points to a regulatory mechanism that could increase cordycepin biosynthesis, offering a strategy to overcome low productivity for commercial applications.

Cinnamic Acid Lowers Blood Pressure And Reversesvascular Endothelial Dysfunction In Rats, Abdul Jabbar Shah, Hafiz Misbah-Ud-Din Qamar, Umme Salma, Taous Khan

Journal of Food and Drug Analysis

Cinnamic acid (CA) possesses important cardiovascular effects such as cardioprotective, antiatherogenic, anti-hyperlipidemic and antioxidant, which predicts its potential role in the treatment of hypertension. The study wasexecuted to investigate the antihypertensive potential of CA in Sprague Dawley (SD) rats followed by evaluation indiverse vascular preparations. Invasive blood pressure monitoring technique was used in normotensive and hyper-tensive rats, under anesthesia. Isolated aortic rings from rat and rabbit, Langendorrf's perfused isolated rabbit heart and guinea-pig right atria were used to probe the underlying mechanisms. The responses were recorded with pressure andforce transducers connected to PowerLab Data Acquisition System. Intravenous administration of CA …