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Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt Jan 2025

Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt

The Science Journal of the Lander College of Arts and Sciences

This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …

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Full Issue: Volume 19, Number 1, Fall 2025 Jan 2025

Full Issue: Volume 19, Number 1, Fall 2025

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 19, Number 1 of The Science Journal of the Lander College of Arts and Sciences. Published Fall 2025.

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Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert Jan 2025

Does Chronic Stress Play A Role In The Genesis Of Neurodegenerative Diseases?, Rachelle Halpert

The Science Journal of the Lander College of Arts and Sciences

Chronic stress has been increasingly recognized as a major contributor to the onset and progression of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. This paper explores the correlation between chronic stress and neurodegeneration by reviewing population, clinical, and animal studies. Studies show that long-term stress disrupts the hypothalamic-pituitary-adrenal (HPA) axis, impairs hippocampal function, increases oxidative stress, and promotes neuroinflammation. These processes are all implicated in cognitive decline. The mechanisms through which these processes occur are discussed including elevated glucocorticoid levels, shortened telomeres, mitochondrial dysfunction, and the activity of pro-inflammatory microglia. Lastly, potential interventions are reviewed, including lifestyle modifications such …

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Can Deadly Toxins Become Tools For Medicine?, Esther Gross Jan 2025

Can Deadly Toxins Become Tools For Medicine?, Esther Gross

The Science Journal of the Lander College of Arts and Sciences

Natural toxins, long feared as deadly poison, are increasingly being harnessed as powerful medicine. This paper explores the growing role of animal and plant toxins in modern medicine, tracing their use from ancient remedies to cutting-edge biomedical science. Through a study of their biochemical mechanisms, therapeutic applications, and clinical case histories, this paper draws attention to the remarkable specificity and potency of toxin-derived compounds for disease treatment in diabetes, chronic pain, cancer, cardiovascular disease, etc. This paper also investigates the scientific and practical barriers to the universal clinical application of toxins, such as issues of toxicity, cost, stability, and ethical …

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Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer Jan 2025

Should Crispr Be Available As A Widespread Gene Therapy For Humans?, Mirel Leifer

The Science Journal of the Lander College of Arts and Sciences

The CRISPR/Cas gene editing tool was discovered in 2012 and since then has been researched extensively. It has many applications in the research and medical world and has been the topic of many discussions since its discovery. This paper describes several of the advantages of CRISPR; what it has been used for and the potential that it contains. Among those advantages are sickle cell treatment, Alzheimer’s treatment, coupling CRISPR with induced pluripotent stem cells(iPSCs), and the cancer battle. Also discussed in this paper are number of concerns that surround this new gene therapy. Among those are medical concerns and ethical …

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Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh Jan 2025

Does Prenatal Stress Have Prenatal And Life-Long Effects?, Miriam Lavizadeh

The Science Journal of the Lander College of Arts and Sciences

Maternal prenatal stress (MPS) has a unique impact on the developing fetus and the child’s life post birth. Pregnancy is a highly anxious time for a lot of women. Many have pregnancy related concerns as well as overall stress from environmental and societal factors. However, this takes a toll on the fetus’s development which can later cause different cognitive and health outcomes in the child. During a time of stress, one’s HPA axis gets activated causing the release of various hormones, particularly cortisol and catecholamines. These hormones can cross the placental barrier called HSD11B2-11β-hydroxysteroid dehydrogenase 2, exposing the sensitive and …

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The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss Jan 2025

The Role Of The Gut–Brain Axis In Irritable Bowel Syndrome, Malky Weiss

The Science Journal of the Lander College of Arts and Sciences

The gastrointestinal (GI) system and the brain share a highly integrated relationship mediated by the gut–brain axis, with implications across a range of medical disciplines. Irritable bowel syndrome (IBS) is the most prevalent disorder of gut brain interaction (DGBI) which affects a significant portion of the global population, yet its pathophysiology has historically been poorly understood. This review examines the development and maintenance of IBS, drawing on literary sources to explore the gut–brain axis and disease expression which occurs as a result of its dysfunction. Common pathological features of IBS include visceral hypersensitivity, altered serotonin signaling, inappropriate immune activation, and …

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Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt Jan 2025

Implant Alternatives: The Advancements Of Stem Cells In Regenerative Dentistry, Akiva Goldschmidt

The Science Journal of the Lander College of Arts and Sciences

This research paper explores the potential of mesenchymal stem cells (MSCs) within the realm of dentistry, focusing particularly on their ability to repair tissues and regenerate entire teeth. MSCs are significant as they can send differentiation signals to nearby cells and release growth factors such as TGF-β and VEGF, which promote cellular activities necessary for dental repair and regeneration. The paper discusses the traditional methods of dental restoration, such as fillings and implants, and their inherent limitations. It then transitions to exploring innovative strategies that utilize MSCs to overcome these challenges and regenerate tooth structures including enamel, dentin, and periodontal …

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Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen Jan 2025

Novel Pharmacotherapies For Treatment-Resistant Depression: Lysergic Acid Diethylamide (Lsd), Eliana Cohen

The Science Journal of the Lander College of Arts and Sciences

Treatment Resistant Depression has become extremely prevalent with 30% of depression cases being unresolvable. Psychedelics specifically Lysergic Acid Diethylamide has been a newfound unconventional approach that has demonstrated significant benefits for depression. LSD is a hallucinogenic drug mainly acting on the serotonin receptors that leads to altered sensory and perception affecting mood. This research paper comprehensively examines animal and human studies on LSD’s healing properties and enduring effects. The studies find that LSD induces neuroplasticity, and alters gene expressions associated with synaptogenesis and neurogenesis. Additionally LSD affects the activity of different neurotransmitters in the central nervous system enhancing mood. Lastly …

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Cumulative Environmental Impacts In Thailand : A Legal Appraisal Of The Eia Regime Under Neqa, Leila Kenza Cherkaoui Jan 2025

Cumulative Environmental Impacts In Thailand : A Legal Appraisal Of The Eia Regime Under Neqa, Leila Kenza Cherkaoui

Chulalongkorn University Theses and Dissertations (Chula ETD)

This Research examines the limitations of Thailand’s Environmental Impact Assessment (EIA) framework under the Enhancement and conservation of National Environmental Quality Act B.e. 2535 (1992) (NEQA), with a focus on its failure to address cumulative environmental impacts in tourism-intensive regions such as Phuket, Koh Samui, and Chiang Mai. While EIA was originally introduced to ensure that environmental risks are considered before project approval, in practice Thailand’s system remains narrowly projectbased, overlooking the combined effects of multiple small and medium scale development that together exceed ecological carrying capacity. This has contributed to serious environmental degradation, including coral reef decline, freshwater depletion, …

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The Moderating Role Of Investor Sentiment Regimes On The Impact Of Flow Types On Capital Structure Decisions (Evidence From Thailand), Shiva Sachaphimukh Jan 2025

The Moderating Role Of Investor Sentiment Regimes On The Impact Of Flow Types On Capital Structure Decisions (Evidence From Thailand), Shiva Sachaphimukh

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study analyzes how foreign and domestic capital flows influence the leverage of SET100 Thai non-financial firms, considering investor sentiment regimes and firm cyclicality (2013–2023). It contrasts fundamental foreign portfolio flows with speculative domestic trading turnover. Sentiment regimes powerfully amplify flow effects. Bullish domestic sentiment and high domestic turnover significantly increase leverage (sentiment-exploitation). Conversely, deteriorating sentiment and foreign outflows intensify debt reliance (stress-compensation). Domestic flows have stronger, more immediate leverage effects than foreign flows, revealing a behavioral asymmetry. Cyclical firms respond aggressively to domestic factors and sentiment, while non-cyclical firms prioritize foreign capital stability.The findings highlight the critical role of …

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The Influence Of Butterbear Mascot Attractiveness On Brand Attitude, Huyen Phuong Do Jan 2025

The Influence Of Butterbear Mascot Attractiveness On Brand Attitude, Huyen Phuong Do

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research examines the influence of mascot’s perceived attractiveness on the brand attitude towards Butterbear. Data were collected via online survey from 220 male and female respondents (aged 18-26) residing in Bangkok, who had been exposed to content from Butterbear brand within the past three months. Overall, participants perceived Butterbear mascot as highly attractive (M = 4.39) and reported positive attitudes towards the Butterbear brand (M = 4.30). Furthermore, the findings revealed that all six dimensions underlying mascot attractiveness (Brand Impact, Brand Expertise, Mascot Uniqueness, Mascot Anthropomorphism, Mascot Intimacy, and Mascot Consistency) showed statistically significant correlations with the brand attitude. …

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Social Media Use And Personal Branding Identity Of Myanmar Freelancers, Lin Htet Thway Jan 2025

Social Media Use And Personal Branding Identity Of Myanmar Freelancers, Lin Htet Thway

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study examined social media use, self-expression, professionalism, self-efficacy, self-disclosure, and personal branding identity among Myanmar freelancers, and investigated how these factors influence their personal branding identity on social media. An online survey of 200 freelancers aged 18 to 45 years was conducted. Respondents reported high levels of social media use (M = 4.07), self-expression (M = 4.13), professionalism (M = 4.16), self-efficacy (M = 4.17), personal branding identity (M = 4.30), and a moderately high level of self-disclosure (M = 3.95). Regression results showed that the five variables together explained 24.4 percent of the variance in personal branding identity …

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นวัตกรรมการถ่ายทอดองค์ความรู้สู่เกษตรกรเพื่อการทำนาอย่างยั่งยืนภายใต้มาตรการกีดกันทางการค้าด้านสิ่งแวดล้อม, ธัญธร โกวิทยะวงศ์ Jan 2025

นวัตกรรมการถ่ายทอดองค์ความรู้สู่เกษตรกรเพื่อการทำนาอย่างยั่งยืนภายใต้มาตรการกีดกันทางการค้าด้านสิ่งแวดล้อม, ธัญธร โกวิทยะวงศ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้มุ่งพัฒนาแนวทางการถ่ายทอดองค์ความรู้สู่เกษตรกรเพื่อการทำนาข้าวแบบยั่งยืน ภายใต้บริบทที่มาตรการกีดกันทางการค้าด้านสิ่งแวดล้อมของนานาประเทศมีแนวโน้มเข้มงวดขึ้นอย่างต่อเนื่อง การศึกษานี้อาศัยการสัมภาษณ์เชิงลึกจากผู้เชี่ยวชาญ ผู้นำเกษตรกรที่ประสบผลสำเร็จ และเกษตรกรทั่วไป เพื่อทำความเข้าใจปัญหา อุปสรรค และพฤติกรรมการรับรู้ของผู้ปฏิบัติงานในพื้นที่ ซึ่งพบว่าเกษตรกรมักปรับเปลี่ยนพฤติกรรมได้ดีเมื่อมีโอกาสเห็นผลจริงในแปลงนา เข้าใจขั้นตอนแบบง่าย ไม่ซับซ้อน และมองเห็นประโยชน์เชิงเศรษฐกิจอย่างเด่นชัด ทั้งในมิติการลดต้นทุน การใช้น้ำอย่างมีประสิทธิภาพ ไปจนถึงโอกาสในการขายผลผลิตในตลาดที่ให้ราคาที่สูงขึ้น จากผลดังกล่าว จึงพัฒนาแนวทางการถ่ายทอดความรู้ที่เน้นการสาธิตในพื้นที่จริง การใช้ผู้นำเกษตรกรเป็นต้นแบบ การสื่อสารด้วยภาษาที่ตรงประเด็น และการนำเสนอคุณค่าทางเศรษฐกิจของการทำนาแบบยั่งยืนควบคู่กับทิศทางการค้าโลกที่ให้ความสำคัญต่อมาตรฐานด้านสิ่งแวดล้อม แนวทางนี้ช่วยให้การถ่ายทอดองค์ความรู้เข้าถึงเกษตรกรได้มากขึ้น เกิดการปรับเปลี่ยนพฤติกรรมอย่างเป็นรูปธรรม และยกระดับความพร้อมของประเทศไทยในการรับมือกับมาตรการกีดกันทางการค้าด้านสิ่งแวดล้อม รวมถึงเสริมความสามารถในการแข่งขันการค้าข้าวไทยในระยะยาว

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Functional Characterization Of Vago In Black Tiger Shrimp Penaeus Monodon Ikk-Nf-Κb Signaling Pathway Against Viral Infection, Zittipong Nanakorn Jan 2025

Functional Characterization Of Vago In Black Tiger Shrimp Penaeus Monodon Ikk-Nf-Κb Signaling Pathway Against Viral Infection, Zittipong Nanakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cytokines serve as key regulators in innate antiviral defense. In crustaceans, research on cytokine-mediated immunity remains limited. A previous study in Penaeus monodon has demonstrated that PmVago proteins exhibit cytokine-like function by acting through the inhibitor of kappa B kinase-nuclear factor κB (IKK-NF-κB) cascade to defend against white spot syndrome virus (WSSV). In this study, five PmVago isoforms were identified, each showing differential transcriptional responses to pathogen challenges. Among them, PmVago1 and PmVago4 exhibited strong antiviral responses against WSSV infection. RNA interference of PmVago1 and PmVago4 increased shrimp susceptibility to WSSV infection with enhanced viral replication. Their suppression also disrupted …

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Immunoinformatics-Based Design And In Vitro Expression Analysis Of A Multi-Epitope Vaccine Against African Swine Fever Virus, Dhithya Venkateswaran Jan 2025

Immunoinformatics-Based Design And In Vitro Expression Analysis Of A Multi-Epitope Vaccine Against African Swine Fever Virus, Dhithya Venkateswaran

Chulalongkorn University Theses and Dissertations (Chula ETD)

African swine fever (ASF) is a lethal haemorrhagic disease affecting domestic and wild pigs, causing severe economic losses globally. The absence of an effective vaccine has hindered ASF control, as traditional approaches are challenged by the virus’s genetic complexity and immune evasion mechanisms. In this study, we employed immunoinformatics to design a multi-epitope vaccine (MEV) against African Swine Fever Virus (ASFV), targeting conserved viral proteins—B646L (p72), CP204L (p30), E183L (p54), and EP402R (CD2v). Antigenic and non-allergenic BL and HL epitopes were selected and assembled with appropriate adjuvant and linkers to construct the MEV. No CTL epitopes were included, as they …

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Canine Uterine Fibrosis Associated With Age And Pyometra, Maulida Selma Hanim Jan 2025

Canine Uterine Fibrosis Associated With Age And Pyometra, Maulida Selma Hanim

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigated whether aging and uterine pathology drive fibrosis in the canine uterus by quantifying collagen deposition in endometrial and myometrial compartments. Uterine samples from 55 small-sized, intact, nulliparous bitches were classified into five groups according to age and pathological conditions. Healthy group divided into juvenile, young adult, old adult, and the pathological group included cystic endometrial hyperplasia (CEH), and pyometra. Fibrosis was assessed using Masson’s trichrome staining; collagen proportion was quantified with ImageJ and analysed in SAS. Across healthy age groups, collagen proportions in the endometrial stroma, circular myometrium, and longitudinal myometrium did not differ significantly (P > 0.05). …

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Expression Of Peroxisome Proliferator-Activated Receptor Alpha In Feline Mammary Carcinomas, Ngoc Anh Van Pham Jan 2025

Expression Of Peroxisome Proliferator-Activated Receptor Alpha In Feline Mammary Carcinomas, Ngoc Anh Van Pham

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to investigate the expression patterns of peroxisome proliferator-activated receptor alpha (PPARα) in normal tissue and feline mammary carcinomas. Thirty feline mammary carcinomas (FMCs) and eight normal mammary tissues were used in this study. In the same FMC cats, tissues were collected from 2 regions which are the neoplastic tissue and the adjacent non-neoplastic tissues. The study was composed of three parts: (1) clinical data collection and histopathological diagnosis; (2) Immunohistochemistry (IHC) evaluation of PPARα, Ki-67, and proliferating cell nuclear antigen (PCNA); and (3) Western blot analysis of PPARα isoforms. The results revealed no significant differences in PPARα …

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Diagnostic Approaches And Therapeutic Evaluation In Canine Benign Prostatic Hyperplasia: An Integrated Analysis Of Prostatic Volume, Serum Canine Prostatic Specific Esterase (Cpse) Levels, And Proteomic Profiles, Panthipa Borikappakul Jan 2025

Diagnostic Approaches And Therapeutic Evaluation In Canine Benign Prostatic Hyperplasia: An Integrated Analysis Of Prostatic Volume, Serum Canine Prostatic Specific Esterase (Cpse) Levels, And Proteomic Profiles, Panthipa Borikappakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Benign prostatic hyperplasia (BPH) is a highly prevalent condition in intact male dogs. However, its diagnosis and clinical management remain limited by the lack of clear thresholds for clinically significant prostatic enlargement, insufficient biomarkers to monitor treatment response, and an incomplete understanding of the molecular mechanisms driving disease progression. To address these gaps, this thesis integrated ultrasonographic, biochemical, and proteomic approaches across three complementary studies. First, the actual to expected normal prostatic volume ratio was evaluated to establish a clinically meaningful cutoff distinguishing subclinical from clinical BPH, providing an imaging-based indicator for early recognition of clinically relevant enlargement. Building on …

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Community Ecology Of Domestic Animals And Wildlife At Solid Waste Disposal Sites Near Dong Phayayen – Khaoyai Forest Complex And Its Impacts On Zoonotic Diseases, Paisin Lekcharoen Jan 2025

Community Ecology Of Domestic Animals And Wildlife At Solid Waste Disposal Sites Near Dong Phayayen – Khaoyai Forest Complex And Its Impacts On Zoonotic Diseases, Paisin Lekcharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Solid waste disposal sites (SWS) at forest edges represent critical zoonotic transmission hotspots where wildlife, domestic animals, and humans converge. This study characterized host community structure, pathogen circulation, and network topology at SWS adjacent to the Dong Phayayen-Khao Yai Forest Complex, Thailand. Three study phases (2021-2023) comprised: (1) camera trapping at five SWS (3,907 trap-nights); (2) small mammal trapping across four habitats (1,420 individuals, 12 species), ectoparasite collection (20,560 chiggers, 14 species), and molecular pathogen detection; and (3) network analysis of connectivity among habitat, host, chigger, and pathogen. Domestic dogs dominated communities (88.3%), creating simplified assemblages. Potential transmission operated through …

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Optimization Of Artificial Insemination In Swine Through Gnrh Agonist Application In Boar Semen With Special Emphasis On Epithelial Penetration And Pharmacokinetics, Preechaphon Taechamaeteekul Jan 2025

Optimization Of Artificial Insemination In Swine Through Gnrh Agonist Application In Boar Semen With Special Emphasis On Epithelial Penetration And Pharmacokinetics, Preechaphon Taechamaeteekul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Induction of ovulation in pigs is a widely applied technique in commercial swine farms, using hormonal treatments to improve reproductive efficiency and productivity. The GnRH agonist buserelin acetate is widely used to induce ovulation and can be administered via intramuscular or intravaginal routes. However, the success of ovulation induction via the intravaginal route still depends on several factors, and information regarding the pharmacokinetics and tissue permeation of buserelin remains limited. This thesis aimed to investigate the pharmacokinetic profile, endometrial permeability, and reproductive effects of buserelin to develop an effective and practical ovulation control strategy for commercial swine production. This thesis …

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Surveillance And Genetic Characterization Of Atypical Porcine Pestivirus (Appv) In Central Thailand, Sana Shahid Jan 2025

Surveillance And Genetic Characterization Of Atypical Porcine Pestivirus (Appv) In Central Thailand, Sana Shahid

Chulalongkorn University Theses and Dissertations (Chula ETD)

Atypical Porcine Pestivirus (APPV) is an emerging swine pathogen associated with congenital tremor (CT) Type A-II, a neurological condition characterized by tremors of the head, body, and limbs, as well as poor growth in piglets. From September 2023 to August 2025, nasal and blood samples were collected from 181 pigs from four commercial pig farms in Central Thailand, and APPV was detected in 17 samples. Notably, all APPV-positive samples come from one farm. A follow-up study was conducted at the infected farm to assess APPV persistence and its association with age groups and clinical signs. In total, 275 pigs were …

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Genomic Characterization Of Streptococcus Agalactiae And Streptococcus Suis Isolated From Diseased Snakeskin Gourami (Trichopodus Pectoralis), Surawit Chueahiran Jan 2025

Genomic Characterization Of Streptococcus Agalactiae And Streptococcus Suis Isolated From Diseased Snakeskin Gourami (Trichopodus Pectoralis), Surawit Chueahiran

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigates severe, recurrent mortality outbreaks in farmed snakeskin gourami (Trichopodus pectoralis) in central Thailand between 2021 and 2023. Characterized by exophthalmos and systemic hemorrhage, these incidents prompted an investigation to identify causative agents, assess antimicrobial resistance (AMR), and explore genomic adaptation. Bacterial isolates from moribund fish in Samut Sakhon province were identified via MALDI-TOF MS and 16S rRNA sequencing, followed by whole-genome sequencing (Illumina HiSeq) and comparative pan-genomic analysis. Two primary pathogens, Streptococcus agalactiae and Streptococcus suis, were confirmed as causative agents of acute bacterial septicemia, occurring in both single and co-infections. Phylogenetic analysis revealed that S. suis …

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Expression Patterns Of Alpha-Fetoprotein And Phosphodiesterase 4d In Canine Mammary Tumors, Thi Kieu Trinh Mai Jan 2025

Expression Patterns Of Alpha-Fetoprotein And Phosphodiesterase 4d In Canine Mammary Tumors, Thi Kieu Trinh Mai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Canine mammary tumors (CMTs) represent one of the most common neoplasms in female dogs, with a substantial proportion exhibiting malignant behavior and aggressive progression. Despite their clinical importance and relevance to comparative oncology, the molecular mechanisms underlying CMT development remain incompletely understood. This study aimed to evaluate the expression patterns of alpha-fetoprotein (AFP) and phosphodiesterase 4D (PDE4D) in canine mammary tissues, and to investigate their correlations with Ki-67, a standard marker of cell proliferation. A total of 50 dogs were included in this study (40 diagnosed with CMTs and 10 without CMTs), yielding 90 FFPE tissue samples for protein analysis …

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A Comparative Case Study Of Face-To-Face Vs Virtual Fortune Telling In Bangkok In The Aftermath Of Covid-19 : Relevance And Adaptation, Jade Evalyn Di Donato Jan 2025

A Comparative Case Study Of Face-To-Face Vs Virtual Fortune Telling In Bangkok In The Aftermath Of Covid-19 : Relevance And Adaptation, Jade Evalyn Di Donato

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study explores the adaptation of Thai fortune telling practices, specifically astrology and tarot card reading, in response to increasing digitization and the impact of the Covid-19 pandemic. While the practice has been traditionally rooted in face-to-face interactions, it has transformed in recent years with the growing prevalence of online consultations. Utilizing Catherine Bell's theory of ritualization alongside the Transfer of Ritual theory, this research analyzes how the ritual meaning and symbolism of Thai fortune telling are preserved across digital and physical spaces, especially in a post-pandemic world. Relying on a comparative case study of two female fortune tellers—one who …

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Comparative Study Of Chinese And Korean Webcomic Industries From The Perspective Of Platformization And Copyright Governance : Lessons From The Success Of Korean Webtoons, Jiayi Wang Jan 2025

Comparative Study Of Chinese And Korean Webcomic Industries From The Perspective Of Platformization And Copyright Governance : Lessons From The Success Of Korean Webtoons, Jiayi Wang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Research Objectives: This study aims to comparatively analyze the divergent development paths of the Chinese and Korean webtoon industries, focusing on the synergistic mechanisms of platformization and copyright governance. It seeks to diagnose the root causes of China's "localization failure" and propose a viable ecosystem reconstruction pathway. Methodology: Employing a qualitative comparative case study approach, this research examines primary platforms (Naver, Kakao, Kuaikan, Tencent) through the lens of an integrated theoretical framework combining platformization, media political economy, and copyright governance. Data is triangulated from industry reports, financial disclosures, and academic literature. Findings: The research finds that Korea's success is built …

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Investigation Of Lipid Binding Regions In Phospholipase (Ves A 1) From Vespa Venom By Computational Study, Nawanwat Chainuwong Pattaranggoon Jan 2025

Investigation Of Lipid Binding Regions In Phospholipase (Ves A 1) From Vespa Venom By Computational Study, Nawanwat Chainuwong Pattaranggoon

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigated the structural behavior, membrane adhesion mechanism, and inhibition mechanism of Ves a 1, the primary phospholipase A1 enzyme from the venom of the Thai banded tiger wasp (\textit{Vespa affinis}). The main objective was to discover an inhibitor for Ves a 1 from this species. From a database of 2,056 FDA-approved drugs, voxilaprevir was found to bind well to the main catalytic site of Ves a 1, exhibiting a binding free energy (Delta GBindSIE) of approximately -11 to -10 kcal/mol, whereas DMPC, used as a positive control, had a binding energy of approximately -9 to -7 kcal/mol. Analysis …

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Evaluation Of Leptospirosis Vaccine Efficacy After Modifications Of N-Linked Glycosylation In Liga Mrna Vaccines., Rampapat Phaetthayanan Jan 2025

Evaluation Of Leptospirosis Vaccine Efficacy After Modifications Of N-Linked Glycosylation In Liga Mrna Vaccines., Rampapat Phaetthayanan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospirosis, caused by pathogenic Leptospira species, is a widespread zoonotic disease, particularly prevalent in developing countries in tropical areas. Commercially available bacterins have several limitations. A previous study developed a messenger RNA (mRNA) vaccine encoding the carboxy-terminal domain 7-13 of LigA (LigAc) that was expressed with glycosylation in mammalian cells and elicited high humoral immune response in a hamster model but failed to provide protection against lethal challenge. To improve the protective efficacy, this study aimed to develop LigAc-mRNA vaccines with minimal glycosylation. Three mRNA constructs were developed based on two strategies: modifying the potential N-glycosylation sites (from asparagine to …

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Comparison Of Vat Exemptions In Korea And Thailand, Youngun Lim Jan 2025

Comparison Of Vat Exemptions In Korea And Thailand, Youngun Lim

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Value Added Tax (VAT) is a relatively recent innovation compared to traditional taxes such as income and property taxes. Nevertheless, it has been rapidly adopted across jurisdictions worldwide due to its efficiency and revenue-generating capacity. As a general consumption tax, VAT is levied on most goods and services. However, exemptions are commonly granted in many jurisdictions for reasons of social equity, economic policy, or administrative simplicity. This study conducts a comprehensive comparative analysis of VAT exemption regimes in two major Asian economies—South Korea and Thailand—both of which have established mature VAT systems. The research focuses on examining each country’s …

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The Popularity Of The Untamed In Thailand And I Told Sunset About You In China : Reciprocal Fandom And Cultural Diplomacy, Yuanwei Gao Jan 2025

The Popularity Of The Untamed In Thailand And I Told Sunset About You In China : Reciprocal Fandom And Cultural Diplomacy, Yuanwei Gao

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to explore cross-cultural fan interactions between China and Thailand and their influence on cultural diplomacy. In recent years, television dramas from both China and Thailand have gained remarkable popularity in the respective countries. Among various types of dramas, BL (Boys’ Love) dramas stand out as a typical case of transnational fan interaction due to their large cross-border audience and highly active online and offline interaction. Among them, the Chinese TV drama The Untamed (Chen Qing Ling) has received wide attention in Thailand, and the Thai TV drama I Told Sunset About You (แปลรักฉันด้วยใจเธอ) has sparked heated discussions …

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