Digital Commons Network^™

Genome-Wide Profiling Of Trna Modifications By Induro-Trnaseq Reveals Coordinated Changes, Yuko Nakano, Howard Gamper, Henri Mcguigan, Sunita Maharjan, Jiatong Li, Zhiyi Sun, Erbay Yigit, Sebastian Grünberg, Keerthana Krishnan, Nan-Sheng Li, Joseph Piccirilli, Ralph Kleiner, Nicole Nichols, Brian Gregory, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. The critical barrier is the difficulty of readthrough of modifications by reverse transcriptases (RTs). Here we use Induro-a new group-II intron-encoded RT-to map and quantify genome-wide tRNA modifications in Induro-tRNAseq. We show that Induro progressively increases readthrough over time by selectively overcoming RT stops without altering the misincorporation frequency. In a parallel analysis of Induro vs. a related RT, we provide comparative datasets to facilitate the prediction of each modification. We assess tRNA modifications across five human cell lines and …

Development And Characterization Of Cd44-Targeted X-Aptamers With Enhanced Binding Affinity For Cancer Therapeutics, Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G Gorenstein

Faculty, Staff and Student Publications

CD44, a pivotal cell surface molecule, plays a crucial role in many cellular functions, including cell-cell interactions, adhesion, and migration. It serves as a receptor for hyaluronic acid and is involved in lymphocyte activation, recirculation, homing, and hematopoiesis. Moreover, CD44 is a commonly used cancer stem cell marker associated with tumor progression and metastasis. The development of CD44 aptamers that specifically target CD44 can be utilized to target CD44-positive cells, including cancer stem cells, and for drug delivery. Building on the primary sequences of our previously selected thioaptamers (TAs) and observed variations, we developed a bead-based X-aptamer (XA) library by …

The Right To Receive Information: Conceptual Problems, Shrutanjaya Bhardwaj Mr

Indian Journal of Law and Technology

This article studies the “right to receive information” or the “right to know”, a judicially-recognised right under Article 19(1)(a) of the Constitution. It attempts to show, through an analysis of judgments of the Supreme Court and High Courts, that the right rests on a shaky philosophical foundation and that there are inconsistencies in how the right is judicially treated in terms of its structure and content.

First, the article questions the logic that the “right to know” is implicit in Article 19(1)(a) merely because it makes the exercise of free speech more meaningful. Such a logic was authoritatively rejected by …

Social Jetlag Alters Markers Of Exercise-Induced Mitochondrial Adaptations In The Heart, Michael B. Dial, Elias M. Malek, Austin R. Cooper, Greco A. Neblina, Nikoleta I. Vasileva, Graham Mcginnis

Kinesiology and Nutrition Sciences Faculty Research

Social jetlag (SJL) represents the behavioral misalignment of sleep and wake times on work days and free days, and potently disrupts the circadian rhythm. SJL affects up to 70% of the population worldwide and is associated with increased risk for many cardiometabolic diseases. Animal models of acute SJL have shown disruption in locomotor activity and expression of clock genes in select tissues, its impact on the heart remains unclear. The purpose of this study was to investigate the effects of prolonged SJL (6 weeks), on activity rhythms, and the impact on exercise-induced adaptations in the heart. Male mice (n …

Efektivitas Full Body Stretching Dan Edukasi Manual Handling Digital Terhadap Keluhan Musculoskeletal Disorders Pekerja Yantek, Nadia Rosalinda, Anita Sulistyorini, Marji Marji, Supriyadi Supriyadi, Tika Dwi Tama

National Journal of Occupational Health and Safety

Occupational Diseases (PAK) in the form of pain complaints in the skeletal system that cause the work process are called Musculoskeletal Disorders (MSDs). PT. PLN Yantek workers are at risk of experiencing MSDs complaints because the work is done manually and the work posture is less ergonomic. This study aimed to analyze the effect of implementing full-body stretch and digital-based manual handling education and to assess its effectiveness on MSDs. The study used a quasi-experimental method with a one-group pretest-posttest design involving 26 Yantek workers. The intervention was given at 10 meetings, MSDs complaints were measured using the Nordic Body …

Walking Through The Aristotelian Lane: Amartya Sen On Rational Choice, Barada Laxmi Panda

Comparative Philosophy

The term ‘rational choice’ has great impact on the life of a rational agent. Rational choice helps the agent to understand her capability of making choice and the intentional involvement for working on a particular aspect considering certain circumstances. At the same time, this creates a lot of dilemmas in terms of understanding the freewill of the agent while being committed for a work. Following this, Amartya Sen’s discussion on this subject seems relevant where Sen very prominently reflects on the point that rational choice involves freedom, rationality, and normativity. These three features are coherent with each other and with …

A Constructive Dialogue Between Confucianism And Transcendentalism Of Ralph Waldo Emerson, Yuedi Liu

Comparative Philosophy

Ralph Waldo Emerson, an American Transcendentalist, is known as “the American Confucius”. He is also deeply influenced by the Confucianism from Confucius to Mencius, moreover, there is a constructive dialogue and engagement between them. However, it can not be inferred that Confucianism is also transcendentalism. First, Confucianism is based on “One-worldness”. Second, Confucianism is a kind of Guanxi-ism (relationism), so it is not individualism. Third, Confucianism is not intuitionism, but has the“structure of emotion-reason”. Fourth, Confucianism is not focus on “Oversoul”, but towards a pan-aestheticism based on the integration of Rites and Music. However, there are many similarities between American …

The Economics And Productivity Of Us Cow-Calf Production, Richard Nehring, Hannah Shear, Kelvin L. Leibold, Andrew Swanson

Journal of Applied Farm Economics

We explore US beef cow-calf production in 2018 and estimate net returns, returns to scale, and technical efficiency associated with backgrounding versus nonbackgrounding by size and production system. We determine the relative profitability of cow-calf operations by type, region, and size. Results, using both stochastic production frontier analysis and data envelopment analysis, indicate that larger operations tend to be more scale and technically efficient than smaller operations. While larger operations may be more scale and technically efficient and have lower variable costs per cow, off-farm income helps smaller operations become competitive. The availability of detailed cost of production information in …

Financial Impact Of Beef Cow Culling: Canadian Analysis, Heidi R. Johnson, Eric T. Micheels, Kathy A. Larson

Journal of Applied Farm Economics

Culling decisions within beef production systems are not reversible, and as such, data can help decision-makers double-check heuristics to avoid costly mistakes. In this essay, we use financial methods to examine cow culling decisions, evaluating their impact on overall herd profitability. To do so, we use production and financial data from 16 “typical farms” within the Canadian Cow-Calf Cost of Production Network to explore the financial impact of different culling strategies. This essay builds on prior literature by using Canadian data, as there may be differences in costs and productivity across production regions. We identify four culling scenarios that vary …

Children's Rights Debates, Revisited, Martha Minow

Florida Law Review

A Dunwody distinguished lecture in law that reflects on children's rights.

Risk: A Weak Element In U.S. Strategy Formulation, Frank Hoffman

Joint Force Quarterly

Strategic risk is an inherent element of national security decisionmaking, yet it is often insufficiently incorporated into U.S. strategy formulation. Frank Hoffman argues that risk analysis should be a routine and continuous component of strategic planning rather than an exercise conducted primarily during implementation. Drawing on joint doctrine and case studies involving the Iraq War, Operation Neptune Spear, and the U.S. withdrawal from Afghanistan, the article illustrates how assumptions, institutional biases, and inconsistent approaches to risk can shape strategic outcomes. Hoffman calls for a broader, shared understanding of strategic risk across the national security community and recommends developing an interagency …

Joint Force Quarterly, Issue 116, 1st Quarter 2025, National Defense University Press

Joint Force Quarterly

Joint Force Quarterly 116 explores key challenges and innovations in military strategy, operations, and global security. The Forum section examines how the U.S. approaches risk in its strategy, the impact of nonstrategic nuclear weapons, and the importance of using data-driven methods in planning military operations.

In JPME Today, articles focus on how joint military campaigns succeed, the role of storytelling and persuasion in operations, and the urgent need to modernize professional military education.

The Commentary section highlights Ireland's strategic role in securing Europe’s western flank and evaluates whether China’s military overestimates the potential of artificial intelligence.

The Features section dives …

The New Pornography Wars, Julie Dahlstrom

Florida Law Review

The world’s largest online pornography conglomerate, MindGeek, has come under fire for the publishing of “rape videos,” child pornography, and nonconsensual pornography on its website, Pornhub. In response, as in the “pornography wars” of the 1970s and 1980s, lawyers and activists have turned to civil remedies and filed creative anti-trafficking lawsuits against MindGeek and third parties, like payment processing company, Visa. These lawsuits seek not only to achieve legal accountability for online sex trafficking but also to reframe a broader array of online harms as sex trafficking. This Article explores what these new trafficking lawsuits mean for the future regulation …

Centella Asiatica: Recent Cosmeceutical Uses For Treatment Of Skin Diseases, Iman I. Soliman, Nouran Medhat, Huda Saleh, Mai El Halawany

Bulletin of Faculty of Pharmacy Cairo University

Centella asiatica is one of the well-known herbal species used in traditional medicine across Asia such as India, Indonesia, and China. It had been used as a medicinal plant for hundreds of years. Besides its general pharmacological activities such as neuroprotection, anti-cancer and anti-diabetes. It demonstrated effective dermatological actions as being a potent anti-inflammatory, antioxidant, healing and moisturizing properties. The major constituents responsible for these effects were triterpenoids. Triterpenoids included asciaticoside which was reported to induce collagen synthesis. Madecassoside was known for its wound healing properties. It was well known for its efficiency in improving the treatment of hypertrophic wounds. …

The Beacon, January 24, 2025, Beacon Staff

The Beacon, 2024-2025

Unsung Hero: Lori Bonnema; Come enjoy a night of dancing; Zendaya and Holland spark online frenzy; "Wicked" lives up to Broadway original; 2025 fashion throwbacks and throwaways; Heritage Singers present Madrigal Dinners; Comfort to those from far away; Unsung Hero: Lori Bonnema; Diaper drive at local church; Latin dance night; The sad reality of New Year's resolutions; You should try failure; Van Kalsbeek takes down 20-uear-old record; Track and field begins 2025 season; Wrestling charging through 2024-25 season; MLK chapel is moving to many; We all know the BINGO event is not getting old;

The Bison, January, 24, 2025

The Bison Newspapers

No abstract provided.

Frsc 480-002: Forensic Microscopy, David Fisher

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Ypfs Lessons Learned Oral History Project: An Interview With Pedro Machado, Pedro Machado, Mercedes Cardona

Documents

No abstract provided.

Volume Cxliv, Number 10, January 24, 2025, Lawrence University

The Lawrentian

No abstract provided.

Review Of New Treatment Options For Toxoplasmosis, Kiley Roman

D.U.Quark

Toxoplasmosis is an infectious disease caused by the parasite, Toxoplasma Gondii. The parasite is often carried in cats and contaminated food and water. Toxoplasmosis is not serious most of the time but can be harmful to immunocompromised people, pregnant women, and their fetuses or babies. Treatments are commonly given to the immunocompromised. However, there are problems with the current treatments, in which they only treat active parasites and cannot remove the cysts created by disease progression. Due to the treatments’ inability to remove cysts, an infected person may not fully recover from the infection. This review evaluated the new …

Some Contradictions Of The Welfare State: Revisited, Chris O'Ralaigh

Research Outputs: 2025-Present

It is now 40 years since the publication of Claus Offe's classical paper, Some Contradictions of the Modern Welfare State. Much change has occurred to the form and content of welfare states over the intervening years, yet in addition to change, continuities are very much evident, and it is this constellation of developments – alongside anniversarial convenience – which has motivated a re-examination of Offe's seminal work on the contradictions of welfare states. This anniversary article re-introduces and provides a critique of the original paper before moving on to a historical comparison of the major political economic and societal differences …

Single-Chain Variable Fragments: Targeting Snake Venom Phospholipase A2 And Serine Protease, Ying Jia, Ariane Garcia, Elizabeth Reyes

School of Integrative Biological & Chemical Sciences Faculty Publications

Snakebite is a critical global public health issue, causing substantial mortality and morbidity, particularly in tropical and subtropical regions. The development of innovative antivenoms targeting snake venom toxins is therefore of paramount importance. In this study, we adopted an epitope-directed approach to design three degenerate 15-mer peptides based on amino acid sequence alignments of snake venom phospholipase A2s (PLA2s) and snake venom serine proteases (SVSPs) from snake (Crotalus atrox). By leveraging their immunogenic and inhibitory profiles, these peptides were specifically designed to target the Asp49 and Lys49 variants of PLA2 and SVSP toxins. Groups of five mice were immunized with …

Co-Option Of Mitochondrial Nucleic Acid-Sensing Pathways By Hsv-1 Ul12.5 For Reactivation From Latent Infection, Patryk A. Krakowiak, Matthew E. Flores, Sean R. Cuddy, Abigail L. Whitford, Sara A. Dochnal, Aleksandra Babnis, Tsuyoshi Miyake, Marco Tigano, Daniel A. Engel, Anna R. Cliffe

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Although viruses subvert innate immune pathways for their replication, there is evidence they can also co-opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus-1 (HSV-1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune-sensing pathways and reduces productive replication in nonneuronal cells. HSV-1 establishes latency in neurons and can reactivate to cause disease. We found that UL12.5 is required for HSV-1 reactivation in neurons and acts to directly promote viral lytic gene expression during initial exit from latency. Further, the direct activation of innate immune-sensing pathways triggered …

Tug Of War Between Opt-In And Opt-Out Organ Donation Systems, Amna Cehaja

DePaul Journal of Health Care Law

The demand for organ transplants is far greater than the supply of transplantable organs. Every day, twenty people in the United States die as they await an organ transplant; this equates to roughly 7,300 people annually. Whilst organ donation can be highly effective for prospective patients, not all individuals want to take part in such an action. A person’s decision not to partake in organ donation can stem from their ethics, morality, religion, and much more. For individuals that live in the United States and do not want to donate their organs upon death, they do not have to take …

Remote Sensing In Iberá Wetlands, Argentina: Uncrewed Aircraft Systems And Service Learning Supporting Environmental Resilience, James Tyler Deal

Student Research Symposium (SRS)

Mapping wetland regions is challenging. Uncrewed aircraft systems (UAS) have inherent abilities to sense rapidly and efficiently remotely difficult to access locations. Wetland regions around the world are under pressure due to increasing human presence and climate change. Iberá Wetlands in Argentina provides an example of a region that rebounded from detritus effects of human activity. Although the Iberá Wetlands suffered great environmental degradation causing large animals to be driven from the area, visitors today see a biologically diverse region bearing the fruit of restoration. It serves as a prime location for demonstrating the ability of UAS to efficiently collect …

The Impact Of Light Pollution On The Erau Campus, Myles Curtis, Ahnika Gee

Student Research Symposium (SRS)

The 1-meter telescope at the Embry-Riddle Aeronautical University Daytona Beach campus is the largest university-based research telescope in Florida. However, the light pollution from facilities and outdoor light fixtures greatly interferes with these resources, the quality of student life, and ecological systems in the area. Our team works to identify the greatest contributors to light pollution on campus so that we can develop cost effective and accessible solutions. A Unihedron Sky Quality Meter (SQM) is used to measure the amount of light being emitted from various sources of light. We are taking empirical and quantitative data, using the SQM, in …

Assessing Human Impact On The Soil Of Jekyll Island, Georgia, Hannah Lyons, Astrid Senko, Ryan Paulson, Megan Neumann, Ava Messmer

Student Research Symposium (SRS)

Jekyll Island has been one of Georgia’s top vacation spots since the late 1800s, but its dependence on tourism has the potential to affect its ecosystem. While prior studies have examined erosion and native flora, little is known about how recreation impacts the island’s soil composition. This study collected soil samples from areas with varying levels of human traffic. A commercially available soil probe was used to collect soil. The samples were analyzed for pH, nitrogen, phosphorus, and potassium using a LAMOTTE Model EM soil testing kit. Preliminary soil results showed that high-foot traffic areas averaged a pH of 6.5, …

Seeking The Divine: A Proposed Methodology Of Religion To Resolve Adjudications Over The Nexus Inquiry In Religious Asylum Claims, Saloni S. Jaiswal

University of Chicago Legal Forum

What is religion, and should immigration courts seek to define religion in the context of asylum claims? Under the Immigration and Nationality Act (INA), individuals who have experienced past persecution or fear future persecution because of their religious beliefs can apply for asylum in the United States. Although individuals are afforded these protections under the statutory provisions of the INA, there is a fundamental problem in the way courts have treated religious asylum claims. Rather than holistically considering religion, courts have instead focused on religion’s fragmentary aspects. This fragmentary understanding of religion has contributed to another legal problem among the …

Adjusting Immunity For Unconstitutional Torts, Liam Grah

University of Chicago Legal Forum

Sovereign immunity protects the government from liability arising in suits brought against it by citizens. Though lacking a firm constitutional basis, sovereign immunity has been justified as protecting the public fisc and maintaining the sense of sovereign dignity. The Federal Tort Claims Act (FTCA) broadly waives sovereign immunity for tort claims against the United States. The discretionary function exception maintains immunity for tortious acts committed by employees acting within the valid bounds of their discretion. There is a circuit split about whether the discretionary function exception immunizes tortious conduct that is also unconstitutional. Circuits in the majority side of the …

Climatizing National Security, Mark Nevitt

University of Chicago Legal Forum

Is climate change a national security issue? Human security? Ecological security? This Article addresses the growing nexus between climate change and various conceptions of security with a particular emphasis on climate change's national security impacts. This Article argues that there is a growing connection between national security and climate change and a corresponding need to address the normative implications of "climatizing national security." This connection can be observed through three lenses: mitigation (reducing greenhouse gas emissions from military and national security sources); adaptation (investing in climate resilient infrastructure in an effort to prepare for climate impacts), and response (addressing climate-exacerbated …