Digital Commons Network^™

We Know About The Right To Bear Arms, But What About The Rights Of Bears Ears, Brandon Andrews

LSU Journal of Energy Law and Resources

No abstract provided.

The Case Against E-Waste In The Bayou State: Proposing E-Waste Recycling Legislation In Louisiana, Elizabeth Bueche

LSU Journal of Energy Law and Resources

No abstract provided.

America Runs On Biodiesel: Implementation Of A New Federal Mandate For Increased Renewable Energy Fuel, Asia Jackson

LSU Journal of Energy Law and Resources

No abstract provided.

The Rider (2025-02-17), Rebeca Salinas

The Rider Archives

Vol. 10, No. 19

Recent Developments In Heterologous Expression Of Cellulases Using The Pichia Pastoris Expression System: A Comprehensive Literature Review, Nazish Muzaffar, Abdur Raziq, Muhammad Waseem Khan, Niaz Muhammad Khan, Bushra Shahid, Anbareen Gul, Hayat Ullah

Biological Engineering Student Research

Cellulosic biomass is considered an important and sustainable source of renewable energy, which needs a complex mixture of different enzymes for its degradation. After amylase, cellulases are the second most important enzymes, gain more importance due to their broad range of applications at the industrial level, and are considered more economical and environmentally friendly; researchers have focused more on the production of cellulase with its higher expression rate and low cost. Pichia pastoris, a methylotrophic yeast strain, has a more effective and well-established system for the production of heterologous proteins, particularly for industrial enzymes. Moreover, its readily achievable high-density …

Rna Methyltransferase Spout1/Cenp-32 Links Mitotic Spindle Organization With The Neurodevelopmental Disorder Spadmiss, Avinash V Dharmadhikari, Maria Alba Abad, Sheraz Khan, Reza Maroofian, Tristan T Sands, Farid Ullah, Itaru Samejima, Yanwen Shen, Martin A Wear, Kiara E Moore, Elena Kondakova, Natalia Mitina, Theres Schaub, Grace K Lee, Christine H Umandap, Sara M Berger, Alejandro D Iglesias, Bernt Popp, Rami Abou Jamra, Heinz Gabriel, Stefan Rentas, Alyssa L Rippert, Christopher Gray, Kosuke Izumi, Laura K Conlin, Daniel C Koboldt, Theresa Mihalic Mosher, Scott E Hickey, Dara V F Albert, Haley Norwood, Amy Feldman Lewanda, Hongzheng Dai, Pengfei Liu, Tadahiro Mitani, Dana Marafi, Hatice Koçak Eker, Davut Pehlivan, Jennifer E Posey, Natalie C Lippa, Natalie Vena, Erin L Heinzen, David B Goldstein, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nouriya Abbas Al-Sannaa, Mina Zamani, Saeid Sadeghian, Reza Azizimalamiri, Tahere Seifia, Maha S Zaki, Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Lama Alabdi, Fowzan Sami Alkuraya, Heba Dawoud, Aya Lofty, Peter Bauer, Giovanni Zifarelli, Erum Afzal, Faisal Zafar, Stephanie Efthymiou, Daniel Gossett, Meghan C Towne, Raey Yeneabat, Belen Perez-Duenas, Ana Cazurro-Gutierrez, Edgard Verdura, Veronica Cantarin-Extremera, Ana Do Vale Marques, Aleksandra Helwak, David Tollervey, Sandeep N Wontakal, Vimla S Aggarwal, Jill A Rosenfeld, Victor Tarabykin, Shinya Ohta, James R Lupski, Henry Houlden, William C Earnshaw, Erica E Davis, A Arockia Jeyaprakash, Jun Liao

Faculty, Staff and Students Publications

SPOUT1/CENP-32 encodes a putative SPOUT RNA methyltransferase previously identified as a mitotic chromosome associated protein. SPOUT1/CENP-32 depletion leads to centrosome detachment from the spindle poles and chromosome misalignment. Aided by gene matching platforms, here we identify 28 individuals with neurodevelopmental delays from 21 families with bi-allelic variants in SPOUT1/CENP-32 detected by exome/genome sequencing. Zebrafish spout1/cenp-32 mutants show reduction in larval head size with concomitant apoptosis likely associated with altered cell cycle progression. In vivo complementation assays in zebrafish indicate that SPOUT1/CENP-32 missense variants identified in humans are pathogenic. Crystal structure analysis of SPOUT1/CENP-32 reveals that most disease-associated missense variants are …

The Role Of Urinary Microbiome Analysis In The Diagnostic Approach And Management Of Urinary Incontinence: A Systematic Review, Pouyan Shaker, Zohreh Roshani, Ehsan Timajchi, Zahra Sharifi, Sarah Nikzadfar Goli, Behrooz Broumand, Mohammad Ali Shafiee

Student Publications

Urinary incontinence (UI) is a significant global health issue that impacts mainly middle-aged women, severely affecting their quality of life. Emerging research highlights the urinary microbiome's complex role in the etiology and management of UI, with microbial dysbiosis potentially influencing symptom severity and treatment outcomes. This systematic review aimed to evaluate the current evidence on the urinary microbiome's role in diagnosing and managing UI, focusing on variations in microbial composition across UI subtypes. We identified 21 studies, mostly employing 16S rRNA sequencing to characterize urinary microbiota and their associations with various UI subtypes, including urgency urinary incontinence (UUI), overactive bladder …

Small Molecule-Mediated Inhibition Of The Oxidoreductase Ero1a Restrains Aggressive Breast Cancer By Impairing Vegf And Pd-L1 In The Tumor Microenvironment, Ersilia Varone, Jaehyung Cho, Et Al.

2020-Current year OA Pubs

Cancer cells adapt to harsh environmental conditions by inducing the Unfolded Protein Response (UPR), of which ERO1A is a mediator. ERO1A aids protein folding by acting as a protein disulfide oxidase, and under cancer-related hypoxia conditions, it favors the folding of angiogenic VEGFA, leading tumor cells to thrive and spread. The upregulation of ERO1A in cancer cells, oppositely to the dispensability of ERO1A activity in healthy cells, renders ERO1A a perfect target for cancer therapy. Here, we report the upregulation of ERO1A in a cohort of aggressive triple-negative breast cancer (TNBC) patients in which ERO1A levels correlate with a higher …

Impulsivity Facets And Substance Use Involvement: Insights From Genomic Structural Equation Modeling, Laura Vilar-Ribó, Alexander S Hatoum, Andrew D Grotzinger, Travis T Mallard, 23andme Research Team, Sarah Elson, Pierre Fontanillas, Abraham A Palmer, Daniel E Gustavson, Sandra Sanchez-Roige

2020-Current year OA Pubs

BACKGROUND: Impulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear.

METHODS: We used genomic structural equation modeling and genome-wide association studies (

RESULTS: We found that the SU and SUD factors were strongly genetically inter-correlated (

CONCLUSIONS: Our findings show that specific impulsivity facets confer risk for distinct stages of substance use involvement, with potential implications for SUDs prevention and treatment.

Criminal Responsibilities Arising From Artificial Intelligence Crimes, Sahar Fouad Majeed Al-Najjar

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

The digital revolution that emerged in the twentieth century had a radical impact on various aspects of life, especially in the economic industry, which included three forms (Artificial Intelligence (AI), the Internet of Things, and Big Data. With regard to artificial intelligence, it was discovered in the mid-fifties of the last century, and its real birth was at the conference organized in the United States of America by the scientists John McCarthy and Marvin Minsky. Over the years, artificial intelligence techniques have developed rapidly until some applications have reached the ability to self-learn from the situations that they encounter and …

Leagal Adaptation Of The Container And Its Delivery Contract In The Field Of Cargo Transportation, Haifaa Mezher Falhi, Shatha Abdul – Jabbar Khandan

Imam Ja'afar Al-Sadiq University Journal of Legal Studies

The study of the legal nature of the container and the contract for its presentation in the field of transporting goods is one of the issues that aroused the interest of jurisprudence, legislation and the judiciary because of the problems and difficulties it reflects, the solution of which requires identifying the party providing the container, the nature of the contract concluded in its regard, and the fact that the container provided by the shipper is called the description of the goods, or it A first-degree packaging means, and the contract concluded in respect of it is often a lease contract …

Western Australia’S Marine Heatwave Update - 16 February 2025, Department Of Primary Industries And Regional Development, Western Australia

Marine Heatwave Notification Reports

No abstract provided.

Sustainable Model For Analyzing The Impact Of Social Media On Customer Buying Behavior: A Case Study, Bshair Alharthi, Mohammed A. Farsi

Sustainable Machine Intelligence Journal

In today's digital landscape, chatbots have become widely used across various applications, particularly in systems that provide intelligent assistance to users. To enhance user experience, these systems are often equipped with chatbots capable of processing user inquiries and delivering accurate, timely responses. This study proposes a structured framework for evaluating the impact of social media on customer buying behavior through a case study focused on selecting the most suitable Online Chatbot Platform (OCP). The selection of an optimal OCP is a complex multi-criteria decision-making (MCDM) problem, involving multiple interdependent and often conflicting factors. One of the key challenges in this …

Three Walks Along Wascana Creek, Ken Wilson

The Goose

"Three Walks Along Wascana Creek" recalls the author's walking along Wascana Creek in Regina, Saskatchewan, in June 2021.

A New Dictionary Of Archives Terminology, Jody Baltessen

The Goose

Poetry by Jody Baltessen.

"A Fate For Fire”: A Review Of Knife On Snow By Alice Major, Kate Rogers

The Goose

A review of Knife on Snow, by Alice Major.

Review Of Earth To Tables Legacies: Multimedia Food Conversations Across Generations And Cultures By Deborah Berndt, Lauren E. Baker, And Alexandra Gelis With The Earth To Table Legacies Collaborators, Daniel Coleman

The Goose

Book review of Review of Earth to Tables Legacies: Multimedia Food Conversations across Generations and Cultures by Deborah Berndt, Lauren E. Baker, and Alexandra Gelis with the Earth to Table Legacies Collaborators.

Found: Three Trashed Poems, Tanis Macdonald

The Goose

Three poems about garbage, what is leftover and found.

Video Poem: What Remains, Edie Steiner

The Goose

What Remainsis a three-minute poetry film I created to address the issue of “becoming-with” (Wright 2014). In the film, I document two large-scale, public-art spectacles I witnessed in Toronto, as historical markers of collective becoming-with. I contrast super-8mm film footage of the 1984 outdoor public performance “Shibola” at the Bell Trinity Square building in Toronto, by the Japanese Butoh dance group Sankai Juku, with digital video of “A Tribute to Toronto,” Judy Chicago’s 2022 Smoke Sculpture on the Toronto waterfront. I then intercut these images with digital recordings of ruins and relics, both ancient and modern, merging as …

Review Of Ecologies Of A Storied Planet In The Anthropocene By Serpil Oppermann, Mailyn Abreu Toribio

The Goose

A review of Ecologies of a Storied Planet in the Anthropocene, by Serpil Oppermann.

We Are All Strays Now (Now), Grace Moore

The Goose

Drawing on ideas of kinship and straying, this piece of creative non-fiction considers my relationship with a "neighbourhood cat," dying from a coronavirus, just prior to the beginning of the Covid-19 pandemic. It addresses how we make kin with strays, and the ways in which animals insert themselves into human lives.

Mining Waste In The Himalayas, Leslie Leong

The Goose

Materiality is a key aspect of the fourteen artworks I created over one month as Artist-in-Residence at Sagarmatha Next, the experience centre for sustainable tourism in the Khumbu region of Nepal. My intention with the residency is to create work from the human discards that accumulate in the area around Mount Everest, known as Sagarmatha in Nepali. The artwork I created during this residency are deeply rooted in the materiality of their components and serve as powerful commentaries on environmental issues, the passage of time, and the potential for transformation inherent in discarded materials. Through the deliberate use of waste, …

My Art Is Garbage, Beth Shepherd

The Goose

In “My Art is Garbage,” I describe three recent art projects where garbage is both a theme and an artistic medium used to critique the overuse of and inability to reuse or safely dispose of plastics we use every day. The first work, Untitled (Plastic Film Balls), uses non-recyclable single-use household plastic made to form an installation of shimmering balls and alludes to the environmental footprint of the artworld. Plastic Shores, a series of monotype prints, reminds us that plastics in the environment are deleterious to species that we see every day. Finally Plastic Pests, a series …

Beach Finds, Gina M. Granter

The Goose

This photo series, Beach Finds, is all from the beach of my hometown in Rocky Harbour, Newfoundland, from walks I took in the early spring of 2021. Particularly after storms, there would be an abundance of garbage washed ashore. I found a stick from a Buried Treasure ice cream treat that I had not seen since the 1980s; fabric flowers that had blown from the town’s seaside cemeteries into the water and back to land; hand-woven fishing nets that were now grounded; a tampon applicator that reminded me of the first one I ever saw as a child, on …

Antisense Oligonucleotide-Mediated Tra2Β Poison Exon Inclusion Induces The Expression Of A Lncrna With Anti-Tumor Effects., Nathan Leclair, Mattia Brugiolo, Sunghee Park, Maeva Devoucoux, Laura M Urbanski, Brittany Lynn Angarola, Marina Yurieva, Olga Anczuków

Faculty Research 2025

Upregulated expression of the oncogenic splicing factor TRA2β occurs in human tumors partly through decreased inclusion of its autoregulatory non-coding poison exon (PE). Here, we reveal that low TRA2β-PE inclusion negatively impacts patient survival across several tumor types. We demonstrate the ability of splice-switching antisense oligonucleotides (ASOs) to promote TRA2β-PE inclusion and lower TRA2β protein levels in pre-clinical cancer models. TRA2β-PE-targeting ASOs induce anti-cancer phenotypes and widespread transcriptomic alterations with functional impact on RNA processing, mTOR, and p53 signaling pathways. Surprisingly, the effect of TRA2β-PE-targeting ASOs on cell viability are not phenocopied by TRA2β knockdown. Mechanistically, we find that the …

Review Essay: Anthony Valerio's Writer's Life And The Truth Of Distortion, George Guida

Publications and Research

No abstract provided.

The Dog Dies At The Beginning Of This Paper: Issuing Victims Protective Orders As A Result Of An Abuser’S Intentional Destruction Of Property, Brighton Frost

Texas A&M Journal of Property Law

Domestic violence is a prevailing issue in the United States for both men and women, growing exponentially during COVID-19. In the law, there are two approaches to remedy this issue. The first being a criminal conviction of the abuser, which requires witness testimony and is held to a higher burden of proof than the other. The other approach is for the victim to obtain a protective order against the abuser. However, in many states, protective orders are only available to victims once the abuser physically attacks them, despite there being reliable signs of abuse before physical violence occurs. Thus, this …

Trichosporon Asahii And Candida Guilliermondii As A Source Of Orbital Infection In An Immunocompromised Individual, David Morcos, Kevin Hardy, Anthony Makovec, Morgan Schill, John Foxworth

School of Medicine Faculty Publications

A 47-year-old male with a history of immunosuppression and recent intensive care unit admission presented with progressive orbital swelling and pain. Blood cultures grew Trichosporon asahii and Candida guilliermondii, with matching positive cultures from peripheral and central venous samples. Given his fungemia and worsening orbital involvement, induction therapy with amphotericin B and isavuconazole was initiated. Within weeks, clinical improvement was noted, prompting a transition to long-term consolidation therapy with oral posaconazole and isavuconazole. At follow-up, the patient demonstrated sustained clinical stability with no recurrence of infection. Orbital involvement from fungemia due to T. asahii and C. guilliermondii is rare, and …

Single-Cell Rna Sequencing Identifies Molecular Biomarkers Predicting Late Progression To Cdk4/6 Inhibition In Patients With Hr+/Her2- Metastatic Breast Cancer, Linjie Luo, Peng Yang, Sofia Mastoraki, Xiayu Rao, Yan Wang, Nicole M Kettner, Akshara Singareeka Raghavendra, Debasish Tripathy, Senthil Damodaran, Kelly K Hunt, Jing Wang, Ziyi Li, Khandan Keyomarsi

Faculty, Staff and Student Publications

Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) in combination with endocrine therapy are the standard treatment for patients with hormone receptor-positive, HER2-negative metastatic breast cancer (mBC). Despite the efficacy of CDK4/6is, intrinsic resistance occurs in approximately one-third of patients, highlighting the need for reliable predictive biomarkers.

Methods: Single-cell RNA sequencing analyzed metastatic tumors from HR+/HER2- mBC patients pre-CDK4/6i treatment at baseline (BL) and/or at disease progression. BL samples were from CDK4/6i responders (median progression-free survival [mPFS] = 25.5 months), while progressors were categorized as early-progressors (EP, mPFS = 3 months) and late-progressors (LP, mPFS = 11 months). Metastatic sites included liver, …

Copyright Law And Metaverse: A Comparative Study Of Challenges And Opportunities Of The Egyptian Copyright Law Entering The Virtual Era, Ayat Khalaf

Theses and Dissertations

Metaverse invokes legal challenges of Intellectual Property Rights in a limitless world of imagination for both entertainment and business aspects. The virtual world requires special devices and technologies to be accessed such as VR (virtual reality) and AR (augmented reality) appliances. The creation and protection of these devices cannot operate without patents. Besides, the protection of their software and platforms goes through copyright protection. Moreover, this imposes a non-traditional sense of trademark protection for new categories of goods and services. The peculiarities of copyright in the metaverse lie in two main challenges: firstly, copyright in the virtual world is usually …