Digital Commons Network^™

Tifab Modulates Metabolic Pathways In Kmt2a::Mllt3-Induced Aml Through Hnf4a, Yang Wang, Yan Xiu, Qianze Dong, Jinming Zhao, Kelao Neumbo, Masaru Miyagi, Nicholas Borcherding, Lin Fu, Havana De Celis, Nicolas Pintozzi, Daniel T Starczynowski, Chen Zhao

2020-Current year OA Pubs

Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein with forkhead-associated domain B (TIFAB), an inhibitor of NF-κB signaling, plays critical roles in hematopoiesis, myelodysplastic neoplasms, and leukemia. We previously demonstrated that Tifab enhances KMT2A::MLLT3-driven acute myeloid leukemia (AML) by either upregulating Hoxa9 or through ubiquitin-specific peptidase 15-mediated downregulation of p53 signaling. In this study, we show that Tifab deletion in KMT2A::MLLT3-induced AML impairs leukemia stem/progenitor cell (LSPC) engraftment, glucose uptake, and mitochondrial function. Gene set enrichment analysis reveals that Tifab deletion downregulates MYC, HOXA9/MEIS1, mTORC1 signaling, and genes involved in glycolysis and oxidative phosphorylation. By comparing genes upregulated in TIFAB-overexpressing …

Atp-Sensitive Potassium Channels Alter Glycolytic Flux To Modulate Cortical Activity And Sleep, Nicholas J Constantino, Caitlin M Carroll, Holden C Williams, Hemendra J Vekaria, Carla M Yuede, Kai Saito, Patrick W Sheehan, J Andy Snipes, Marcus E Raichle, Erik S Musiek, Patrick G Sullivan, Josh M Morganti, Lance A Johnson, Shannon L Macauley

2020-Current year OA Pubs

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decreased ISF lactate is required for sleep. ATP-sensitive potassium (K

Academic Senate - Minutes, 2/25/2025, Academic Senate

Academic Senate Minutes

No abstract provided.

Ultrasound-Triggered Release Of Vancomycin From A Novel Spinal Device: Antibiotic Release And Efficacy In Vivo, Lauren J. Delaney, Priscilla Machado, Ji-Bin Liu, Rachel Evans, Asia Winslow, Neil Zhao, Christopher K. Kepler, Rajkishen Narayanan, Teeto Ezeonu, Viren Soni, Gagan Kaushal, Rachel Hilliard, Thomas P. Schaer, Noreen J. Hickok, Flemming Forsberg

Department of Orthopaedic Surgery Faculty Papers

Post-surgical spinal infection occurs in up to 20 % of patients, despite aggressive peri-operative antibiotic treatments. To improve prophylaxis, we have designed and evaluated an ultrasound-activated prophylactic antibiotic release system to combat post-surgical bacterial survival. Polylactic acid (PLA) clips (1 cm³) were 3D-printed with an interior reservoir (0.8 cm³) for carrying drug payload, specifically vancomycin (VAN). Under IACUC approval, clips were surgically implanted into the spines of sheep (n = 9) and swine (n = 2) by removing the spinous process at several levels of the lumbar spine. In the sheep, clips were insonated and the …

The Diamond, February 25, 2025, Dordt University

Dordt Diamond

• Front Page:Defender Swim Team Takes on First KCAC Conference Meet; Math Professor Creates Website for Christian Educators; The Search to Lift School Spirit
• News: Dordt University's Joel Penner Named "Frosty Westering Coach of the Year"; Dordt Men's Volleyball Stays Positive Despite Season Ups & Downs
• Feature: Senior Spotlight; Wayside Chapel: A Beacon of Faith at the Side of the Road
• Arts & Entertainment: Concert Choir Presents a Night of Songs and Sweets; The Return of "The Show"
• Politics: Defining Fair Play: A Local Look on "No Men in Women's Sports"; DOGE Wreaks Havoc in Dordt …

Atp-Sensitive Potassium Channels Alter Glycolytic Flux To Modulate Cortical Activity And Sleep, Nicholas J. Constantino, Caitlin M. Carroll, Holden C. Williams, Hemendra J. Vekaria, Carla M. Yuede, Kai Saito, Patrick W. Sheehan, J. Andy Snipes, Marcus E. Raichle, Erik S. Musiek, Patrick G. Sullivan, Josh M. Morganti, Lance A. Johnson, Shannon L. Macauley

Physiology Faculty Publications

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decreased ISF lactate is required for sleep. ATP-sensitive potassium (K_ATP) channels couple glucose-lactate metabolism with excitability. Using mice lacking K_ATP channel activity (e.g., Kir6.2^−/− mice), we explored how changes in glucose utilization affect cortical electroencephalography (EEG) activity and sleep/wake homeostasis. In the brain, Kir6.2^−/− mice shunt glucose toward glycolysis, reducing neurotransmitter biosynthesis and dampening cortical EEG activity. Kir6.2^−/− mice spent more time …

Let’S Be Cool About It: Anticipating Proper, Whole-Human Cryopreservation And The Necessary Oversight For Adequate Consumer Protection, Peter Lyon

Minnesota Journal of Law, Science & Technology

No abstract provided.

Plant-Based, Fast-Food, Western-Contemporary, And Animal-Based Dietary Patterns And Risk Of Premature Aging In Adult Survivors Of Childhood Cancer: A Cross-Sectional Study, Tuo Lan, Mei Wang, Annalynn M Williams, Matthew J Ehrhardt, Jennifer Q Lanctot, Shu Jiang, Kevin R Krull, Gregory T Armstrong, Melissa M Hudson, Graham A Colditz, Leslie L Robison, Kirsten K Ness, Yikyung Park

2020-Current year OA Pubs

BACKGROUND: Although premature aging is a significant concern in adult survivors of childhood cancer, little is known about the role of diet in premature aging in this vulnerable population. Therefore, we examined whether dietary patterns specific to childhood cancer survivors are associated with premature aging.

METHODS: This cross-sectional study included 2904 adult survivors of childhood cancer (mean age = 31 years, SD = 8 years) in the St. Jude Lifetime Cohort. Diet was assessed using a food frequency. Four dietary patterns were identified: (1) plant-based diet pattern high in whole grains, fruit, and vegetables; (2) fast-food diet pattern high in …

Agouti And Bmp Signaling Drive A Naturally Occurring Fate Conversion Of Melanophores To Leucophores In Zebrafish, Delai Huang, Emaan H. Kapadia, Yipeng Liang, Leah P. Shriver, Shengkun Dai, Gary J. Patti, Bruno M. Humbel, Vincent Laudet, David M. Parichy

2020-Current year OA Pubs

No abstract provided.

Better Generalization Through Distraction? Concurrent Load Reduces The Size Of The Inverse Base-Rate Effect, Lenard Dome, Andy J. Wills

School of Psychology

The inverse base-rate effect (IBRE) is an irrational phenomenon in predictive learning. It occurs when people try to generalize what they have experienced to novel and ambiguous events. This irrational generalization manifests as a preference for rare, unlikely outcomes in the face of ambiguity. At least two formal mathematical models of this irrational preference (EXIT, NNRAS) lead to a counter-intuitive prediction: the effect reduces under concurrent load. We tested this prediction across two experiments (N1 = 72, Mage = 20.12; N2 = 160, Mage = 20.88). We confirm the prediction, but only when participants were under an obvious time constraint. …

Loss Of Mucin 2 And Mhc Ii Molecules Causes Rare Resistance To Murine Rv Infection, Carolyn Bomidi, Faith M Sawyer, Noah Shroyer, Margaret Conner, Mary K Estes, Sarah E Blutt

Faculty, Staff and Students Publications

Enteric pathogen rotavirus (RV) primarily infects mature enterocytes at the tips of the intestinal villi; however, the role of secretory Paneth and goblet cells in RV pathogenesis remains unappreciated. Atoh1 knockout mice (Atoh1cKO) were used to conditionally delete Paneth, goblet, and enteroendocrine cells in the epithelium to investigate the role of secretory cells in RV infection. Unexpectedly, the number of infected enterocytes and the amount of RV shedding in the stool were greatly decreased following secretory cell deletion. Resistance to RV infection persisted for 7 days after virus inoculation, and Atoh1 knockout mice co-housed with infected wild-type mice were uninfected, …

Mapping Snorna-Target Rna Interactions In An Rna-Binding Protein-Dependent Manner With Chimeric Eclip, Zhuoyi Song, Bongmin Bae, Simon Schnabl, Fei Yuan, Thareendra De Zoysa, Maureen V Akinyi, Charlotte A Le Roux, Karine Choquet, Amanda J Whipple, Eric L Van Nostrand

Faculty, Staff and Students Publications

Background: Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and spliceosomal RNA (snRNA). However, many orphan snoRNAs remain uncharacterized, with unidentified or unvalidated targets, and studies on additional snoRNA-associated proteins are limited.

Results: We adapted an enhanced chimeric eCLIP approach to comprehensively profile snoRNA-target RNA interactions using both core and accessory snoRNA-binding proteins as baits. Using core snoRNA-binding proteins, we confirmed most annotated snoRNA-rRNA and snoRNA-snRNA interactions in mouse and human cell lines and called novel, high-confidence interactions for orphan snoRNAs. While …

Integration Of Metabolomic And Transcriptomic Analyses Reveals Regulatory Functions Of The Chrebp Transcription Factor In Energy Metabolism, Jie An, Inna Astapova, Guofang Zhang, Andrew L Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J Muehlbauer, Tabitha George, Joseph Brozinick, Mark A Herman, Christopher B Newgard

Faculty, Staff and Students Publications

The transcription factor carbohydrate response element binding protein (ChREBP) activates genes of glucose, fructose, and lipid metabolism in response to carbohydrate feeding. Integrated transcriptomic and metabolomic analyses in rats with GalNac-siRNA-mediated suppression of ChREBP expression in liver reveal other ChREBP functions. GalNac-siChREBP treatment reduces expression of genes involved in coenzyme A (CoA) biosynthesis, with lowering of CoA and short-chain acyl-CoA levels. Despite suppression of pyruvate kinase, pyruvate levels are maintained, possibly via increased expression of pyruvate and amino acid transporters. In addition, expression of multiple anaplerotic enzymes is decreased by GalNac-siChREBP treatment, affecting TCA cycle intermediates. Finally, GalNAc-siChREBP treatment suppresses …

Clostridioides Difficile Colonization Is Not Mediated By Bile Salts And Utilizes Stickland Fermentation Of Proline In An In Vitro Model, Xiaoyun Huang, April E Johnson, Joshua N Brehm, Thi Van Thanh Do, Thomas A Auchtung, Hugh C Mccullough, Armando I Lerma, Sigmund J Haidacher, Kathleen M Hoch, Thomas D Horvath, Joseph A Sorg, Anthony M Haag, Jennifer M Auchtung

Faculty, Staff and Students Publications

Treatment with antibiotics is a major risk factor for Clostridioides difficile infection, likely due to depletion of the gastrointestinal microbiota. Two microbiota-mediated mechanisms thought to limit C. difficile colonization include the conversion of conjugated primary bile salts into secondary bile salts toxic to C. difficile growth and competition between the microbiota and C. difficile for limiting nutrients. Using a continuous flow model that simulates the nutrient conditions of the distal colon, we investigated how treatment with 6 clinically used antibiotics influenced susceptibility to C. difficile infection in 12 different microbial communities cultivated from healthy individuals. Antibiotic treatment reduced microbial richness; …

The Hao-Fountain Syndrome Protein Usp7 Regulates Neuronal Connectivity In The Brain Via A Novel P53-Independent Ubiquitin Signaling Pathway, Hao Chen, Cole J Ferguson, Dylan C Mitchell, Isabel Risch, Amanda Titus, Joao A Paulo, Andrew Hwang, Loren K Beck, Tsen-Hsuan Lin, Sheng-Kwei Song, Carla M Yuede, Hiroko Yano, Obi L Griffith, Malachi Griffith, Steven P Gygi, Azad Bonni, Albert H Kim, Et Al.

2020-Current year OA Pubs

Mutation or deletion of the deubiquitinase USP7 causes Hao-Fountain syndrome (HAFOUS), which is characterized by speech delay, intellectual disability, and aggressive behavior and highlights important unknown roles of USP7 in the nervous system. Here, we conditionally delete USP7 in glutamatergic neurons in the mouse forebrain, triggering disease-relevant phenotypes, including sensorimotor deficits, impaired cognition, and aggressive behavior. Although USP7 deletion induces p53-dependent neuronal apoptosis, most behavioral abnormalities in USP7 conditional knockout mice persist following p53 loss. Strikingly, USP7 deletion perturbs the synaptic proteome and dendritic spinogenesis independent of p53. Integrated proteomics and biochemical analyses identify the RNA splicing factor Ppil4 as …

Investigating Overtourism Approaches In National Wildlife Refuges: The Case Of New Jersey, Zachary Lorenz, Noel Criscione-Naylor

ICHRIE Research Reports

The COVID-19 pandemic of 2020 has had rippling effects on a plethora of industries, with outdoor tourism being one of the greatest examples. As United States citizens left their homes, they yearned for their natural resources, leading to a palpable uptake in visitation as public parks reopened. While there is municipal, county, state, and federal lands accessible to visitation, the following commentary is focused specifically on National Wildlife Refuges (Federal). New Jersey is an appropriate case to demonstrate the pros and cons of shared resources, which have been impacted by anthropogenic factors. Additionally, Wildlife Refuges planning, and practices were examined …

The Role Of A Mother In 2022 America, Hannah Wellens

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

Familial roles, household work distribution, and opinions concerning the operation of a household have been a popular topic of discussion within recent years. Many people push for fathers and mothers to take on equal amounts of housework and childcare duties, but previous research suggests that this often fails to happen. This paper uses 2022 survey data to investigate how demographic characteristics can predict who does the chores in the home, and how an individual believes a home should operate. Chi-Square tests, Fisher’s Exact tests, and logistic regression models show evidence that sex does still influence who is responsible for household …

Numerical Simulation Of Airflow Properties Of The Naca 6420 Airfoil Using The Transition Rans K-Ε Model, Oluwaseyi O. Alabi, Saidat A. Salisu, Oyeyemi T. Aforolagba -Balogun, Temitope A. Ladigbolu, Ayotunde O. Fasina, Anas Bala

Al-Bahir

This study investigates the airflow properties around the airfoil using numerical simulation, addressing the longstanding challenge of accurately predicting transition phenomena in turbulent flows. The importance of this research lies in its potential to improve the design and performance of airfoils in various engineering applications, such as wind turbines, and aircraft. A custom 2-dimensional airfoil model was created using Airfoil instruments, featuring a 6% maximum curvature, 40% curvature position, and 20% thickness. COMSOL Multiphysics software performed computations at a velocity of over 19 hours, with data analyzed at 60-minute intervals. The Transition turbulent model was employed to simulate the airflow …

He Is The Master Of Wood, Water, And Hill: Is Tom Bombadil The True Key Keeper Of The Old Forest?, Noelia Ramos

Journal of Tolkien Research

Tom Bombadil, with his iconic singing―”Hey! Come merry doll! Derry doll and merry-o!―has captivated scholars worldwide, due to the enigmatic nature Tolkien intentionally left unexplained. This deliberate mystery has fuelled extensive debate, leading many to explore possible mythological and cultural frameworks that might decode Bombadil’s origins. Among these hypotheses, a Celtic interpretation has often been dismissed despite its potential relevance. This paper, thereby, seeks to analyse Bombadil’s function within the Old Forest and his interactions with the hobbits during their forest episode, presenting fresh insights into his role as a Celtic-inspired guide and druidic figure.

To support this analysis, primary …

Extraterritorial Act Versus The Indigenous People Protection: An Analysis Of The European Union Deforestation-Free Regulation, Aartje Tehupeiory, Putu George Matthew Simbolon

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

At first glance, indigenous people and international trade appear to be two separate issues. However, this perception does not apply in the case of European Regulation 2023/1115. This study aims to provide an understanding of how Indonesia should respond to the EU DFR, which has affected Indonesia’s national interests in protecting indigenous people. This study applied a normative method through doctrinal and conceptual approaches to achieve the objective. The study covers two main discussions. The first explains how due diligence under the EU DFR has indirectly pushed Indonesia to become an EU trading partner and provide more excellent protection for …

Creativity And Innovation In The Age Of Artificial Intelligence: A Copyright Dilemma, S. M. Aamir Ali, Anuttama Ghose, Shashikant Saurav, Sachin Deshmukh

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

No abstract provided.

Democracy Crisis And The Rise Of Datacracy, Widodo Dwi Putro

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

There is no permanent constitutional and political-legal system. Scientists also predict that the phenomenon of the rise of datacracy with big data and algorithms will replace the democratic system. In this research, the author aims to answer the following questions: (i) Why is democracy bound to be replaced by datacracy? (ii) what alternative options can be proposed to bridge the legal and political implications that might occur if datacracy replaces democracy? The author uses literature studies and an interdisciplinary approach to critique and offer ideas in this study. It is proposed, among other things, that datacracy will not eliminate people's …

Human Genetic Engineering: Should Indonesia Regulate It?, Hari Sutra Disemadi

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Human genetic engineering raises pros and cons. Despite the potential to contribute to the health sector, it can cause several problems. While, in theory, it goes against nature and against other conservative beliefs, human genetic engineering gains important support from Transhumanism—a philosophy promoting the scientific evolution of the human race. This study determines the relevancy regulation of human genetic engineering on a global scope and how it affects the prospects of regulating human genetic engineering in Indonesia. The study aims to provide consideration for Indonesia in determining the legality status of human genetic engineering, through analyses of legal constructions surrounding …

Port Denials And Restrictions Policies During Covid-19 Pandemic Based On International Law, Angela Jessica Desmonda

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

As a public facility, port has a significant potential to be cluster of the Covid-19 spread. Many states have implemented policies of denials and restriction of port access to protect people’s health. This study aims to analyze port denials and restrictions policies settings based on international law. In addition, this study is to analyze whether the status of state of emergency will affect state’s obligations based on international law. This study was conducted by analyzing associated international treaty law and customary law. The study concludes that no international treaty law and customary law prohibit port denials and restrictions because port …

An Endless Struggle Of Fighting Discrimination In The Name Of Human Rights Protection, Hernadi Affandi, Tarsisius Murwadji

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

The Incident of George Floyd’s death reminds people of the peril of discrimination that still exists within the American society. The incident has triggered worldwide reactions from people who feel sympathy for the victim and reject racism. To eliminate racial discrimination, every modern society needs to remove any negative paradigm towards intergroup relation. In the context of the United States, the American Government has the responsibility to protect the rights of citizens from any forms of discrimination. That includes racial discrimination. In addition, people have to be reminiscent of the danger of racial discrimination in the modern era. The danger …

New Face Of International Law From Western To Global Construct, Atip Latipulhayat

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

The modern international law, not only imitates, but the substance is truly the European values and traditions. The European nations produce the norm of international law with a clear objective is to divide the world into "selves" (European nations) and "others" (non-European nations). This is exacerbated by European colonialism and imperialism, which allow their values and traditions to become hegemonic norms that ultimately produce the paradigm of "otherness" in international law. Non-European nations are "others", which are considered only as users of the European values. The “otherness” paradigm in international law is resulted from the universal claim of the European …

Critical Review Of Indonesian Government Legal Policies On The Conversion Of Protected Forests And Communal Lands Of The Indigenous Batak People Around Lake Toba, Imamulhadi Imamulhadi, Nia Kurniati

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

The Development Plan of Sibisa Lake Toba Tourism Area as The National Strategic Area for Tourism by performing a land conversion on protected forests and communal lands had stirred up a problem dilemma regarding the resistance from indigenous people around Toba Lake. It is crucial to be questioned, whether the conversion policy of protected forests and communal lands by the Indonesian Government to develop Sibisa Danau Toba Tourism Area is in accordance with related laws and regulations? As the answer, it can be concluded that the mentioned policy opposes: Article 18b of the 1945 Constitution; Article 15 of the Law …

Dampak Ketiadaan Pengaturan Kuota Ekspor Hiu Tikus (Alopias Ssp.) Di Indonesia, Wahyu Hardiningsih, Hari Purwadi, Emmy Latifah

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Kuota ekspor merupakan salah satu mekanisme perlindungan ekosistem laut. Banyaknya perburuan Ikan Hiu Tikus (Alopias Ssp.) di Indonesia saat ini karena permintaan pasar yang tinggi, khususnya dari luar negeri. Tingginya permintaan menyebabkan ikan jenis ini masuk ke dalam daftar Convention on International Trade in Endanger Species of Wild Fauna and Flora (CITES) Appendiks II pada tahun 2016. Jika Ikan Hiu Tikus yang merupakan predator puncak pada rantai makanan di laut ini sampai terancam punah, maka ekosistem laut akan mengalami kerusakan parah. Hasil penelitian menunjukkan bahwa Indonesia belum memiliki perangkat hukum yang memadai terkait dengan penentuan komponen-komponen kuota ekspor …

The Rise Of The Spirit Of National Interest And The Existence Of World Trade Organization Agreement: A Case Study Of Indonesia, I Gusti Ngurah Parikesit, I Gusti Ngurah Wairocana

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

There has been an anxiety over the rise of the spirit of national interest on the existence of World Trade Organization. This spirit that has been reflected from domestic trade policy, to some extent, has undermined trade negotiation process under the WTO as shown by the failure of the Doha Round to conclude significant trade deals. Countries also started concluding bilateral and regional trade agreements instead of the WTO. This article aimed to analyze whether the rise of the spirit of national interest has threaten the existence of the WTO agreements, putting Indonesia as a case study. This article is …

Status Hukum Sumber Daya Alam Di Luar Jurisdiksi Nasional Dan Posisi Negara Maju Di Bidang Keantariksaan, Mardianis Mardianis

Padjadjaran Jurnal Ilmu Hukum (Journal of Law)

Abstrak

Pengaturan kepemilikan dan penggunaan sumber daya alam di luar jurisdiksi nasional selalu menjadi perebutan dan perdebatan antara negara maju dan negara berkembang. Sampai saat ini sudah disahkan tiga rezim hukum internasional khusus yang berlaku untuk tiga wilayah sumber daya alam, yaitu Antartika, Laut Bebas khusus Dasar Laut Dalam, dan Antariksa khususnya Bulan. Ketiga rezim tersebut menggunakan konsepsi ‘common heritage of mankind/warisan bersama umat manusia’ sebagai prinsip utama pengaturannya. Tulisan ini dengan menggunakan metode penelitian normatif dan komparatif akan meneliti secara rinci variasi penerapan prinsip tersebut serta posisi negara maju di bidang keantariksaan terkait pemberlakuan rezim tersebut. Pada …