Digital Commons Network^™

Nh 4-H Presents Evaluation Demonstration Exhibits, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Biophysical Response Of A Coastal Woodland To Extreme Water Deficit During A Year Of Record-Breaking Heat, Caitlin E. Moore, Sally E. Thompson, Jason Beringer, Wesley Cooper, Simone Gelsinari, Hoang Long Nguyen, Huanhuan Wang, Qiaoyun Xie, Richard P. Silberstein

Research outputs 2022 to 2026

Global terrestrial and ocean surface temperatures continue to reach record levels, resulting in heat waves, drought, and prolonged heat stress experienced by vegetation in many regions. In 2023-2024, coastal terrestrial ecosystems in Western Australia were particularly affected, experiencing their driest and hottest summer since observations began in the early 1900s. Banksia woodlands are a threatened ecological community in this region that are endangered by the cumulative impacts of climate change, clearing and changing groundwater regimes, the last of which is strongly influenced by the dual use of groundwater resources by the ecosystem and by the ∼2 million people in the …

Pilbara Fat-Tailed Macropods: Using Multivariate And Morphometric Analyses To Explore Spatial And Stylistic Variability, Shiqin He, Syed Zulqarnain Gilani, Patrick Morrison, Michael Hughes, Jo Mcdonald

Research outputs 2022 to 2026

This paper presents a pioneering analysis of a distinctive engraved motif from the Pilbara region: the fat-tailed macropod (kangaroo). This stylistic analysis has used a combination of conventional qualitative and multivariate techniques with less commonly deployed geometric morphometrics analysis (GMA). Focusing on a distinctive engraved motif in Australia’s northwest, this study has quantified the stylistic characteristics of the fat-tailed macropod depictions by identifying the significant attributes that contribute to this motif’s schema. By using both multivariate analysis and GMA software, we have developed a more nuanced understanding of the synchronic and diachronic dimensions of this deep-time indigenous artistic tradition. Differing …

Regulating Hidden Ai Authorship, Jacob Noti-Victor

Articles

With the rapid emergence of high-quality generative artificial intelligence (“AI”), some have advocated for mandatory disclosure when the technology is used to generate new text, images, or video. But the precise harms posed by nontransparent uses of generative AI have not been fully explored. While the use of the technology to produce material that masquerades as factual (“deepfakes”) is clearly deceptive, this Article focuses on a more ambiguous area: the consumer’s interest in knowing whether works of art or entertainment were created using generative AI. In the markets for creative content—fine art, books, movies, television, music, and the like—producers have …

4-H Presents 2025 Multimedia Pilot, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Nh 4-H Presents Evaluation Public Speaking, Demonstration And Action Exhibits, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Nh 4-H Presents Evaluation Poster Exhibits, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

2025 Belknap And Carroll Counties 4-H Presents Event Packet, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Test 2025 Belknap And Carroll Counties 4h Presents Event Packet, Mikayla Cerney

UNH Cooperative Extension

No abstract provided.

Workshop Descriptions, Christine Whiting

UNH Cooperative Extension

No abstract provided.

The Basics Of Calf Nutrition: Post Colostrum To Weaning, Sarah Allen, Peter S. Erickson

UNH Cooperative Extension

No abstract provided.

Environmental Costs Of The West Philippine Sea Dispute In Light Of Catholic Social Teaching, Teofilo Giovan S. Pugeda Iii

Loyola Papers

This paper is an analytical reflection on the insights Catholic Social Teaching (CST) has to offer on the West Philippine Sea Dispute. It discusses (1) an overview of the maritime dispute, mainly from the Philippine perspective, (2) the disputed legal status of the West Philippine Sea in local and international law, (3) the state of coral reefs in the South China Sea, particularly in the West Philippine Sea, (4) CST on the environment, especially concerning water, and (5) some practical and conceptual avenues to enrich the conversation.

Ukrainian Internally Displaced Persons And Their Journey Of Christian Hope, Pamela A. Tuason

Loyola Papers

This paper examines eighteen narratives of Ukrainian internally displaced persons (IDPs) during the ongoing war and interprets them through the lens of Christian hope as articulated by Jürgen Moltmann. Using Paul Ricoeur’s threefold mimetic theory—prefiguration, configuration, and refiguration—the study analyzes how personal stories reveal theological meanings embedded in experiences of suffering, trauma, and displacement. The narratives highlight the role of history in displacement, the capacity of traumatized persons to reinterpret suffering through hope, and the longing to regain home. The study also proposes a model for the theological study of migrant narratives, contributing to migration theology and to discussions on …

Protective Effects Of Nerolidol On Thrombotic Events, Systemic Inflammation, Oxidative Stress, And Dna Damage Following Pulmonary Exposure To Diesel Exhaust Particles, Naserddine Hamadi, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Alreem Alderei, Maha Alfalahi, Shamma Alhefeiti, Dana Alnaqbi, Salama Alshamsi, Abderrahim Nemmar

All Works

Background/Objectives: Inhalation of environmental particulate air pollution has been reported to cause pulmonary and systemic events including coagulation disturbances, systemic inflammation, and oxidative stress. Nerolidol, a naturally occurring sesquiterpene alcohol, has effective antioxidant and anti-inflammatory effects. Hence, the aim in the present investigation was to evaluate the potential ameliorative effects of nerolidol on the coagulation and systemic actions induced by pulmonary exposure to diesel exhaust particles (DEPs). Methods: Nerolidol (100 mg/kg) was given to mice by oral gavage one hour before the intratracheal instillation of DEPs (0.5 mg/kg), and 24 h later various markers of coagulation and systemic toxicity were …

Testing The Proteus Effect In Autistic And Neurotypical Participants, Chris Fullwood, Liam Cross, Gray Atherton, Darren Chadwick

School of Psychology

This study examined the Proteus effect in autistic and neurotypical participants via the video game, The Sims. Thirty-two participants (16 autistic, 16 neurotypical) participated in a free-play session of The Sims, playing as either an attractive or unattractive avatar. In line with predictions, participants who had played as the attractive avatar negotiated for a significantly larger share of a fictional pot of money during a post-play economic game. Further, participants who had used the attractive avatar engaged in significantly more exercise activities in-game and flirted more often with nonplayable characters. While there was some evidence to suggest that autistic people …

Comparison Of Deep Learning And Traditional Machine Learning Models For Predicting Mild Cognitive Impairment Using Plasma Proteomic Biomarkers, Kesheng Wang, Donald A. Adjeroh, Wei Fang, Suzy M. Walter, Danqing Xiao, Ubolrat Piamjariyakul, Chun Xu

Health & Biomedical Sciences Faculty Publications

Mild cognitive impairment (MCI) is a clinical condition characterized by a decline in cognitive ability and progression of cognitive impairment. It is often considered a transitional stage between normal aging and Alzheimer’s disease (AD). This study aimed to compare deep learning (DL) and traditional machine learning (ML) methods in predicting MCI using plasma proteomic biomarkers. A total of 239 adults were selected from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort along with a pool of 146 plasma proteomic biomarkers. We evaluated seven traditional ML models (support vector machines (SVMs), logistic regression (LR), naïve Bayes (NB), random forest (RF), k-nearest neighbor …

Spotting And Responding To Health Misinformation And Disinformation, Michael J. Mcgee, Jean-Philippe Berteau

Open Educational Resources

Three one-hour lessons. In these lessons students will learn to identify health misinformation which spreads rapidly through social media, search engines, and online platforms. By generating false health news stories with AI and critically analyzing them, students will develop essential skills for public health literacy and ethical responsibility. These activities equip future health professionals with the tools to discern evidence-based information from deceptive content and provide guidance to ensure accurate and authentic communication in the field.

Unraveling Algerian Bat Coronaviruses: From Initial Detection To Genome Recovery And Co-Infection Discovery, Safia Zeghbib, Zsófia Tauber, Tamás Görföl, Karimane Malek Zeghbib, Mourad Ahmim, Gábor Kemenesi

School of Biomedical Sciences

IntroductionBats, known as main reservoirs for coronaviruses such as SARS-CoV and SARS-CoV-2, carry these viruses asymptomatically thanks to their unique immune systems. These viruses can spill over to humans through direct contact or intermediate hosts, as observed in the cases of SARS and COVID-19. Despite the significant public health implications, research on bat-related viral zoonoses remains inadequate in Algeria due to insufficient surveillance and funding. Additionally, the ecological diversity of Algerian bats is still largely unexplored, resulting in knowledge gaps. Therefore, investigating bat coronaviruses within the One Health framework in Algeria provides a holistic approach to understanding and mitigating the …

Convergence On Camk4: A Key Modulator Of Autism-Associated Signaling Pathways In Neurons, Jacqueline Kaiser, Alana Risteska, Abbey G Muller, Haoxiong Sun, Bethany Lei, Kevin Nay, Anthony R Means, Margot A Cousin, David H Drewry, Jonathan S Oakhill, Bruce E Kemp, Anthony J Hannan, Michael Berk, Mark A Febbraio, Andrew L Gundlach, Elisa L Hill-Yardin, John W Scott

Faculty, Staff and Students Publications

Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For many people living with profound autism, this genetic heterogeneity has impeded the identification of common biological targets for therapy development for core and comorbid traits that include significant impairments in social communication and repetitive and restricted behaviors. A substantial number of genes associated with autism encode proteins involved in signal transduction and synaptic transmission that are critical for brain development and function. CAMK4 is an emerging risk gene for autism spectrum disorder that encodes the CaMK4 (calcium/calmodulin-dependent …

The Glu86 Residue In Tbx4 Proves Critical For Human Lung Development, Przemyslaw Szafranski, Tomasz Gambin, Gail Deutsch, Salma A Nassef, Mary Clay Bailey, Debra L Kearney, Paweł Stankiewicz

Faculty, Staff and Students Publications

T-box transcription factors are a group of evolutionarily conserved T-box-containing regulators of mesoderm specification and development. Heterozygous single nucleotide variants (SNVs) or copy-number variant (CNV) deletions involving dosage-sensitive TBX4 have been associated with pulmonary arterial hypertension (PAH), ischiocoxopodopatellar syndrome with or without PAH, and lethal lung developmental disorders (LLDDs), including acinar dysplasia (AcDys), congenital alveolar dysplasia (CAD), and other unspecified primary pulmonary hypoplasias. Loss- and gain-of-function variants have been proposed to cause pediatric PAH and LLDDs, and adult forms of PAH, respectively. Of more than 50 missense SNVs scattered across the entire TBX4, only three have been reported in patients …

Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin And Epithelial Disruption, Jennifer M Mccracken, Gisele A Calderon, Felipe Rivas, Dorothea Erxleben, Taylor Moseley, Lishore A Kumar, Daniel E Kennedy, Swathi Balaji, Adam Hall, Julie C E Hakim

Faculty, Staff and Students Publications

Vaginal fibrosis induced by cancer therapy continues to take a physical and psychoemotional burden. To advance the efforts to generate a reproducible and cost-effective animal model, we tested the effect of repeated bleomycin instillations with mucosal layer disruption on induction of vaginal fibrosis. Tissue samples collected at various time points were analyzed for fibrosis-related gene expression changes and collagen content. Low (1.5 U/kg) and high-dose (2.5 U/kg) bleomycin instillations alone did not induce fibrosis, but when high-dose bleomycin was combined with epithelial disruption, increased profibrotic gene expression and trichrome staining were observed. To evaluate spatial and temporal changes in the …

Exploration Of Cytokines And Microbiome Among Males And Females With Diarrhea-Predominant Irritable Bowel Syndrome, Li Juen Chen, Anna M Plantinga, Robert Burr, Kevin Cain, Pamela Barney, Tor Savidge, Robert J Shulman, Margaret Heitkemper, Kendra Kamp

Faculty, Staff and Students Publications

Background: Whether pathophysiological factors differ between males and females with irritable bowel syndrome-diarrhea (IBS-D) remains to be tested. To better understand potential sex differences, males with IBS-D were compared to naturally cycling females and to females with IBS-D taking hormonal contraception on plasma levels of cytokines and gut microbiome characteristics.

Methods: Males and females with Rome III IBS-D completed questionnaires and kept a daily symptom diary for 28 days. Blood and stool samples were collected between days 3 and 8 of the daily diary (estrogen-dominant days in naturally cycling females). Blood samples were analyzed for lipopolysaccharide (LPS)-stimulated and unstimulated cytokine …

Early Life Epigenetics And Childhood Outcomes: A Scoping Review, Srirupa Hari Gopal, Theresa Alenghat, Mohan Pammi

Faculty, Staff and Students Publications

Epigenetics is the study of changes in gene expression, without a change in the DNA sequence that are potentially heritable. Epigenetic mechanisms such as DNA methylation, histone modifications, and small non-coding RNA (sncRNA) changes have been studied in various childhood disorders. Causal links to maternal health and toxin exposures can introduce epigenetic modifications to the fetal DNA, which can be detected in the cord blood. Cord blood epigenetic modifications provide evidence of in-utero stressors and immediate postnatal changes, which can impact both short and long-term outcomes in children. The mechanisms of these epigenetic changes can be leveraged for prevention, early …

Modeling The Kinetics Of Interorgan Arginine Metabolism During Bacterial Sepsis In Swine, Caitlin Vonderohe, Douglas Burrin

Faculty, Staff and Students Publications

No abstract provided.

Building A Geospatial Archive Of Species Loss As Response To Local Caribou Extinction, Jack Kredell, Chris Lamb, Devin Becker

Student Publications [Scholarly]

This article offers a critical assessment of Storying Extinction: Responding to the Loss of North Idaho’s Mountain Caribou, a public-facing digital environmental humanities project produced by a team of University of Idaho Library researchers following the 2019 extirpation of mountain caribou from the South Selkirk Mountains of the Inland Northwest (the last caribou to inhabit the contiguous United States). The project has been conceptualized as a community response to the specific species loss, and it takes the form of a deep map, or geospatial archive, where users can inhabit and explore the region’s multispecies landscape in the aftermath of caribou …

Multi-Omics Delineate Growth Factor Network Underlying Exercise Effects In An Alzheimer’S Mouse Model, Xin Li, Chaozhong Liu, Wenbo Li, Guantong Qi, Yanwan Dai, Chaohao Gu, Yuxiang Sun, Wenjun Zhou, Veronica C Ciliberto, Jing Liang, Udhaya Kumar S, Dongyin Guan, Zhaoyong Hu, Hui Zheng, Zhandong Liu, Hu Chen, Ying-Wooi Wan, Zheng Sun

Duncan NRI Faculty and Staff Publications

Introduction: Physical exercise is a primary defense against age-related cognitive decline and Alzheimer's disease (AD).

Methods: We conducted single-nucleus transcriptomic and chromatin accessibility analyses (snRNA-seq and snATAC-seq) on the hippocampus of mice carrying mutations in the amyloid precursor protein gene (APPNL-G-F) following prolonged voluntary wheel-running exercise.

Results: Exercise mitigates amyloid-induced changes in transcriptome and chromatin accessibility through cell type-specific regulatory networks converging on growth factor signaling, particularly the epidermal growth factor receptor (EGFR) signaling. The beneficial effects of exercise on neurocognition can be blocked by pharmacological inhibition of EGFR and its downstream PI3K signaling. Exercise leads to elevated levels of …

Tekotok’S Digital Satire And Public Sentiment In Response To The Realities Of Work In Indonesia, Ahmad Farid Fanani

Jurnal Politik

Inequities within Indonesia's labor system remain a prominent issue, particularly in terms of fair access and protection for all segments of the workforce. As digital media continues to evolve, critiques of labor policy are increasingly expressed through new mediums, including satirical animations. This study aims to explore how the satirical animated videos from the YouTube channel Tekotok represent critiques of labor policy using Critical Discourse Analysis (CDA) and public sentiment analysis. A mixed-methods approach is employed, combining Fairclough’s three-dimensional model for narrative analysis with the IndoBERT model to classify sentiment in 875 YouTube comments. The results demonstrate that Tekotok’s animations …

Reevaluating Anti-Inflammatory Therapy: Targeting Senescence To Balance Anti-Cancer Efficacy And Vascular Disease, Bernardo Casso-Chapa, Norma Alicia Vazquez González, Nhat-Tu Le, Nicolas L Palaskas, Kevin T Nead, Lydia P Eutsey, Venkata S K Samanthapudi, Abigail M Osborn, Jonghae Lee, Gilbert Mejia, Oanh Hoang, Steven H Lin, Anita Deswal, Joerg Herrmann, Guangyu Wang, James L Kirkland, Sunil Krishnan, Xander H T Wehrens, Eduardo N Chini, Syed Wamique Yusuf, Cezar A Iliescu, Abhishek Jain, Jared K Burks, Erin Seeley, Philip L Lorenzi, Khanh M Chau, Keila C Ostos-Mendoza, Isabella M Grumbach, Paul S Brookes, Nordin M J Hanssen, Menno P J De Winther, Laurent Yvan-Charvet, Sivareddy Kotla, Keri Schadler, Jun-Ichi Abe

The Brown Foundation: Institute of Molecular Medicine

Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease, mitigating immune responses can decrease inflammation and slow atherosclerosis progression. Anti-inflammatory therapy, therefore, presents a unique dilemma for cancer survivors: while it may decrease cardiovascular risk, it might also promote cancer growth and metastasis by suppressing the immune response. Senescence presents a potentially targetable solution to this challenge; senescence increases the risk of both cancer therapy resistance and vascular disease. Exercise, notably, shows promise in delaying this premature senescence, potentially …

Quantitative Profiling Ph Heterogeneity Of Acidic Endolysosomal Compartments Using Fluorescence Lifetime Imaging Microscopy, Dinghuan Deng, Youchen Guan, Ayse Sena Mutlu, Baiping Wang, Shihong Max Gao, Hui Zheng, Meng C Wang

Center on Aging Staff Publications

The endolysosomal system plays a crucial role in maintaining cellular homeostasis and promoting organism fitness. The pH of its acidic compartments is a crucial parameter for proper function, and it is dynamically influenced by both intracellular and environmental factors. Here, we present a method based on fluorescence lifetime imaging microscopy (FLIM) for quantitatively analyzing the pH profiles of acidic endolysosomal compartments in diverse types of primary mammalian cells and in live organism Caenorhabditis elegans. This FLIM-based method exhibits high sensitivity in resolving subtle pH differences, thereby revealing heterogeneity within a cell and across cell types. This method enables rapid …

Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3): A Biomarker Of Coronary Artery Disease Induced Myocardial Ischaemia, Jacqui A Lee, Jessika Wise, Sara D Raudsepp, Louise N Paton, Jan Powell, Kieran Jina, Sally Aldous, Richard W Troughton, Philip D Adamson, A Mark Richards, W Frank Peacock, James L Januzzi, Noah Erceg, Luca Koechlin, Jasper Boeddinghaus, Pedro Lopez-Ayala, Christian Mueller, Martin P Than, John W Pickering, Chris J Pemberton

Faculty, Staff and Students Publications

Aims: Among individuals presenting to the emergency department (ED) with chest pain, clinical uncertainty surrounds the appropriate identification of non-myocardial infarction (MI) individuals who would most benefit from objective functional/anatomical testing (e.g. imaging). We applied a proteomic biomarker discovery approach to identify novel candidates reflecting coronary artery disease (CAD) induced ischaemia that could translate to measurement in clinical samples.

Methods and results: Mass spectroscopy (MS) of perfusate from an isolated rat heart model of cardiac ischaemia identified >100 novel protein biomarkers. A prominent candidate, insulin-like growth factor binding protein (IGFBP-3), was then interrogated for its ability to identify CAD-related ischaemia …