Digital Commons Network^™

Gain-Of-Function Chromatin Remodeling Activity Of Oncogenic Foxl2c134w Reprograms Glucocorticoid Receptor Occupancy To Drive Granulosa Cell Tumors, Thomas Welte, Veena K Vuttaradhi, Eleonora Y Khlebus, Allison Brodsky, Alejandra Flores Legarreta, Joseph Celestino, Reid T Powell, Clifford C Stephan, Nghi Nguyen, Jian Li, Shiro Takamatsu, Katherine Calzoncinth, Anil K Sood, David M Gershenson, P Andrew Futreal, Barrett Lawson, R Tyler Hillman

Faculty, Staff and Student Publications

Adult type ovarian granulosa cell tumors (AGCT) are rare malignancies with the near universal c.C402G (p.Cys134Trp) somatic mutation in FOXL2, a forkhead box family transcription factor important for ovarian function. Relapsed AGCT is incurable, but the mechanism of the unique FOXL2 mutation could confer therapeutic vulnerabilities. To identify FOXL2C134W-dependent pharmacologic synergies, we created and characterized endogenous FOXL2 isogenic AGCT cells and an AGCT tumoroid biobank. A drug screen identified that glucocorticoids promote FOXL2C134W-dependent AGCT growth. Epigenetic investigation revealed that the Cys134Trp mutation exposes latent DNA sequence-specific chromatin remodeling activity in FOXL2. FOXL2C134W-dependent chromatin remodeling activity redirected glucocorticoid receptor chromatin occupancy …

Intouch Week Of March 3, 2025, New York Medical College

InTouch

• Fawaz Al-Mufti, M.D., Leads Stroke Trial Exploring Cognitive Benefits of Thrombectomy
• Faculty Spotlight: From Pupil to Professor: Adam Karp, M.D. '19
• Student Spotlight: Janice Fung’s Quest to Combat Plague Through Vaccine Innovation
• Alumni Spotlight: The Extraordinary Life of Donald Doyle, M.D. ‘67

Antibody-Drug Conjugates Targeting The Egfr Ligand Epiregulin Elicit Robust Antitumor Activity In Colorectal Cancer, Joan Jacob, Yasuaki Anami, Peyton C High, Zhengdong Liang, Shraddha Subramanian, Sukhen C Ghosh, Solmaz Aghaamiri, Cara Guernsey-Biddle, Ha Tran, Julie Rowe, Ali Azhdarinia, Kyoji Tsuchikama, Kendra S Carmon

Faculty, Staff and Student Publications

As colorectal cancer remains a leading cause of cancer-related death, identifying therapeutic targets and approaches is essential to improve patient outcomes. The EGFR ligand epiregulin (EREG) is highly expressed in RAS wild-type (WT) and mutant colorectal cancer, with minimal expression in normal tissues, making it an attractive target for antibody-drug conjugate (ADC) development. In this study, we produced and purified an EREG mAb, H231, which had high specificity and affinity for human and mouse EREG. H231 also internalized to lysosomes, which is important for ADC payload release. ImmunoPET and ex vivo biodistribution studies showed significant tumor uptake of zirconium-89-labeled H231, …

Social Fiction: Leavy Pioneers A Genre, Christine Sleeter

The Qualitative Report

In this article Sleeter details how Patricia Leavy pioneered the genre of social fiction. She details the method and the publication of the landmark Social Fictions book series, the first and only series of its kind. Sleeter reviews a handful of Leavy’s acclaimed novels, her own fiction, and other titles in the series. She explains how and why social fiction is significant for the qualitative research community.

A Full-Fat Remix Of Low-Fat Love Stories, Tabitha Chilton, Gioia Chilton

The Qualitative Report

Low-Fat Love Stories is a book coauthored by Patricia Leavy and Victoria Scotti. The book is a collection of short stories and visual arts based directly on women’s interview transcripts. In this article, the authors respond to Low-Fat Love Stories through text and visual art. The authors show how artistic analysis inspires personal reflection.

The Impact Of Patricia Leavy’S Sociological Fiction, J. E. Sumerau

The Qualitative Report

This article examines the impact of Patricia Leavy’s Sociological Fiction upon students, professors, and other readers. Utilizing examples from over seven years teaching and writing sociological fiction works at a private liberal arts university in the southeastern United States, I illustrate and discuss some ways Leavy’s works facilitate (1) students finding themselves and sociology as a field of study; (2) professors navigating personal and professional questions during the life course; and (3) readers, regardless of identity, navigating self-development, reflection, and sociological inquiry as a potential interest or commitment. In so doing, I suggest examples of sociological fiction by Leavy and …

Patricia Leavy’S Spark As A Novel And Metaphor For Creative Interdisciplinary Research, Ashleigh Watson

The Qualitative Report

Spark by Patricia Leavy follows Sociology Professor Peyton Wilde as she travels to remote Iceland to participate in a mysterious scholarly seminar. Set in a moody grand manor with an enigmatic host and an eclectic cast of characters, the story blends intellectual intrigue with personal discovery and highlights the strength of Leavy’s social fiction: her characterisation, her use of motifs, and her attention to questions at the heart of scholarly work. This article reflects on the research tensions, interpersonal differences and everyday materialities that animate the story and raise valuable questions for interdisciplinary collaboration. For those interested in fiction and …

Targeted Normoxemia And Supplemental Oxygen-Free Days In Critically Injured Adults: A Stepped-Wedge Cluster Randomized Clinical Trial, David J Douin, John D Rice, Erin L Anderson, Conner L Jackson, Alex C Cheng, Mengli Xiao, Jessica Cwik, Laurel E Beaty, Jessica L Wild, Mohamud R Daya, Pratik B Doshi, Shannon C Eastham, Michael D Goodman, Scott R Gunn, Jason S Haukoos, Jessica A Hudson, Jan O Jansen, Jason T Mcmullan, Julie A Rizzo, Martin A Schreiber, Wesley H Self, Matthew W Semler, Aimee Steinwand, Nicole Werner, Vikhyat S Bebarta, Steven G Schauer, Adit A Ginde

Faculty, Staff and Student Publications

Importance: Supplemental oxygen is fundamental to caring for critically injured adults but can expose them to excess inspired oxygen.

Objective: To determine the safety and effectiveness of targeting normoxemia in critically ill trauma patients.

Design, setting, and participants: This multicenter, stepped-wedge, cluster randomized clinical trial compared targeted normoxemia (defined as a peripheral oxygen saturation [Spo2] of 90% to 96%) with usual care among adult trauma patients admitted to an intensive care unit (ICU) at 8 level I trauma centers across the US. These trauma centers were randomized at 3-month intervals when they crossed over from usual care to targeting normoxemia. …

Accumulation Of Cd38 In Hybrid Epithelial/Mesenchymal Cells Promotes Immune Remodeling And Metastasis In Breast Cancer, Tanvi H Visal, Recep Bayraktar, Petra Den Hollander, Michael A Attathikhun, Tieling Zhou, Jing Wang, Li Shen, Corina-Elena Minciuna, Meng Chen, Elizve Barrientos-Toro, Harsh Batra, Maria Gabriela Raso, Fei Yang, Edwin R Parra, Aysegul A Sahin, George A Calin, Sendurai A Mani

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a highly metastatic subtype of breast cancer. The epithelial-to-mesenchymal transition is a nonbinary process in the metastatic cascade that generates tumor cells with both epithelial and mesenchymal traits known as hybrid EM cells. Recent studies have elucidated the enhanced metastatic potential of cancers featuring the hybrid EM phenotype, highlighting the need to uncover molecular drivers and targetable vulnerabilities of the hybrid EM state. Here, we discovered that hybrid EM breast tumors are enriched in CD38, an immunosuppressive molecule associated with worse clinical outcomes in liquid malignancies. Altering CD38 expression in tumor cell impacted migratory, invasive, …

Sustainable Well-Being For Young Adults: An Online Course To Build Ecological And Psychological Flourishing In A Changing Climate, Jeremy Stanley Bekker

Theses and Dissertations

Sustainable well-being is "happiness that contributes to individual, community and/or global well-being without exploiting other people, the environment or future generations" (O'Brien, 2010, p. 2). Sustainable well-being education may encourage environmentally sustainable behavior while also teaching people how to live meaningful lives. However, there is currently a lack of research-based disseminable courses for teaching sustainable well-being. We hypothesized that taking the course would result in lower eco-anxiety and higher well-being, as well as increased pro-environmental self-efficacy and pro-environmental values. We used a randomized crossover repeated measures research design to assess pre and post effects. Quantitative results indicated that participating in …

Epigenetic Insights Into Substance Use Disorder And Associated Psychiatric Conditions, Ambrose Loc Ngo, Christopher M. Ahmad, Niki Gharavi Alkhansari, Linda Nguyen, Huiping Zhang

Student Publications

Background: Substance use disorder (SUD) is closely associated with epigenetic modifications that significantly impact mental health outcomes. Alcohol and drug misuse induce widespread changes in the epigenome and transcriptome of the central nervous system, disrupting critical processes such as reward signaling and emotional regulation. These alterations in epigenetic regulation and gene expression often persist even after substance cessation, potentially contributing to the onset or worsening of psychiatric conditions, including schizophrenia, depression, stress, and anxiety.

Summary: This review delves into key epigenetic mechanisms underlying SUD and its comorbid psychiatric disorders, with a focus on DNA methylation, histone modifications, and noncoding RNA …

Environmental Hygiene Strategies To Combat Antimicrobial Resistance In Healthcare Settings, Mary Morgan Lee, Caroline A O'Neil, Lucy Vogt, Jennie H Kwon

2020-Current year OA Pubs

In this manuscript, we highlight current literature on environmental hygiene techniques to combat reservoirs of antibiotic resistant organisms in the healthcare environment. We discuss several topics for each strategy, including mechanism of action, assessment of effectiveness based on studies, cost, and real-world translatability. The techniques and topics summarized here are not inclusive of all available environmental hygiene techniques but highlight some of the more popular and investigated strategies. We focus on the following: Ultraviolet radiation, hydrogen peroxide vapor, copper-coated surfaces, phages, interventions involving sinks, and educational initiatives.

Environmental Injustice At Toxic Appalachian Prisons, Molly Baker

Immigration and Human Rights Law Review

In the United States, both federal and state governments continue to build prisons at toxic locations despite the serious health and safety hazards for prisoners. This Article discusses how the convergence of destructive and toxic mining operations with the rural prison boom in the Appalachian Mountain region has resulted in grave human rights violations at the hands of government actors. “Toxic prison siting,” the practice of constructing new prisons at toxic former mining sites, in Appalachia continues to violate the right to the highest attainable standard of physical and mental health as laid out in the International Covenant on Economic, …

Appraisal Of Community Awareness Of Water Conservation And The Importance Of Greywater As One Of The Solutions To Reduce Water Wastage In The Kingdom Of Saudi Arabia, Ahmed A. Alghamdi

Yanbu Journal of Engineering and Science

The Kingdom of Saudi Arabia depends mainly on desalinating seawater for its potable water needs due to the scarcity of natural water resources such as rainwater, rivers and lakes. With the high cost involved in the water desalination process and the state bearing a high percentage of these costs, it becomes a great necessity for the general community to be aware of the importance of water conservation. Reusing grey water in agriculture, industry, or even for potable water production has become an acceptable solution in many countries. Greywater reclamation and reuse have long been considered a favored strategy to overcome …

Transitioning To Alternative Fuels: A Study On The Feasibility Of Synthetic Fuels In Saudi Arabia’S Road Transport Sector, Elaf N. Mahrous, Syed Yousufuddin, Muhammad Saleem

Yanbu Journal of Engineering and Science

Researchers are exploring alternative fuels to transition away from conventional fuels, driven by the need to reduce carbon emissions and dependence on fossil fuels. The transportation sector is a significant consumer of fuels, making it a crucial area for alternative fuel adoption. This study is an expansion on earlier works by recognizing the potential for synfuels derived from fossil fuels to compete with fuels derived from renewable sources. Study illustrating possible transition scenarios in the road transport sector to replace gasoline and diesel in fossil fuel-dependent economies, including Saudi Arabia. The study highlights the potential of alternative fuels like ethanol …

A Comprehensive Analysis Of The Application Of Gis And Rs Technologies In Flood Prediction And Risk Assessment, With A Focus On Wadi Baysh Dam In The Jazan Region. Ksa, Mahmoud Abdelrahim Abdelgiom

Yanbu Journal of Engineering and Science

This study uses GIS spatial analysis and open-source data based on flood hazards formulas to provide a thorough analysis and forecast of floods using Geographic Information Systems (GIS) and Remote Sensing (RS). The Wadi Baysh Dam overflowed with water in 2016 as a result of the torrential downpour that hit the dam, its streams, and the surrounding surroundings results the increasing the storage capacity. In terms of water reserves, it is the dam that is thought to be the biggest in the Kingdom. Some settlements in Baysh, which are under siege since their highways are blocked off, suffered greatly as …

Optimization Of Diesel Engine Performance And Emission Characteristics Employing Hybrid Taguchi-Gtma-Utility Technique, Syed Yousufuddin, Naseeb Khan, Muhammad Saleem

Yanbu Journal of Engineering and Science

With the advent of employing bio-fuels along with the diesel in compression ignition engines the study of performance and emission characteristics have occupied the prominence, owing to diversified multi responses. As the limited information is available about the application of Taguchi based GTMA process to maximize the overall performance and emission characteristics of diesel engine, in the present work the investigation was carried out to maximize the overall utility by employing the Taguchi based GTMA process. By following the user preference rating, weights for the response characteristics namely brake thermal efficiency, brake specific fuel consumption, carbon monoxide and oxides of …

Grid-Connected Pv System Statistics And Evaluation; Review, Mohamed I. Mosaad

Yanbu Journal of Engineering and Science

Today, the grid-connected photovoltaic (PV) power system plays a significant role in generating electrical energy by making use of the sun’s rays, then converting it into usable electrical energy and connecting it to the electrical grid. This process can be done by connecting the PV panel to the DC/DC converter then there will be a controlled DC/AC inverter. This paper discusses a literature review about the PV system, types, advantages, and disadvantages, generating level ratings and levels, statistics, and comparisons between countries worldwide. In addition, a review of the control method presented in PV systems.

Estimating The Energy Recovery Potential From Municipal Solid Waste In Ha’Il Region (Kingdom Of Saudi Arabia), Noureddine Elboughdiri, Muhammad Imran Khan, Takwa Missaoui

Yanbu Journal of Engineering and Science

In the Kingdom of Saudi Arabia (KSA), the need of an agile solid waste management (SWM) system is vital to control safely the rapid growth of its municipal solid waste (MSW) with minimal environment toll. Further, the domestic energy production in KSA is thriving and putting a tremendous pressure on its reserves of fossil oil. Waste-to-energy (WTE) plants provides an excellent opportunity, even if MSW mitigation and energy production are usually considered separately. Energy recovery (ER) from waste is not a new field of study; however, its implementation remains a challenge in KSA. Although there is abundance of useful waste …

Meme Generation Using Deep Neural Network To Engage Viewers On Social Media, Gasim Othamn Alandjani, Altaf Hussain Bouk

Yanbu Journal of Engineering and Science

In today’s technological era, most new generations are using memes because the phenomenon of memes is rapidly gaining in popularity. In addition, various modifications and parodies use social and cultural phenomena to transform an original idea into another. Virus memes are sometimes called virus scripts and are the most widespread on the Internet. However, there is little scientific evidence for this assumption. This paper presents an innovative method to generate memes using machine learning algorithms that match the users’ humorous and relevant captions. The VGG16 network is used to return the embedded image. We have collected feedback from citizens of …

Movie Genre Classification From Rgb Movie Poster Image Using Deep Feed-Forward Network, Mushtaque Ahmed Korai, Altaf Hussain Bouk, Abdul Hameed Sindhi

Yanbu Journal of Engineering and Science

A movie poster image is one of the important media in the filmmaking process, providing valuable information about the movie, such as movie titles, characters, and genres. Identifying a movie genre from a poster can be a daunting task, as it can relate to multiple genres. To solve this problem, this paper uses a deep feedforward neural network to classify movie genres from movie poster images. In this regard, we used and trained a state-of-the-art InceptionV3 deep neural network. The network is trained on our dataset consisting of 36,423 movie poster images taken from the IMDB website, which is categorized …

Development Of An Optimal Path Planning Using Elite Opposition Based Bat Algorithm For A Mobile Robot, Zaharudeen Haruna, Muhammad B. Mu'azu Mu'azu, Prosper Oyibo, Salawuden A. Tijani

Yanbu Journal of Engineering and Science

This research work presents the development of an optimal path planning using elite opposition based bat algorithm (EOBA) for mobile robot, such that the robot avoids obstacle(s) without making contact with them. The bat algorithm (BA) is a nature. inspired meta-heuristic algorithm that works on the basis of the echolocation behavior of bat. It, however, has a poor exploration capability leading to it easily getting stuck in local optima. The EOBA is developed by modifying the BA with the elite opposition-based learning (EOBL) so as to diversify the solution search space and the inertial weight in order to balance its …

A Novel Bio-Coagulant Aid To Treat High Turbid Water Containing Humic Acids, Hossam Altaher, Tarek E. Khalil, Reda Abubeah

Yanbu Journal of Engineering and Science

In general, the production of potable water from raw water sources involves the coagulation or flocculation process to remove turbidity. Alum has been widely used as a coagulant; however, there is a concern about its associated risk of Alzheimer's disease. As a result, there has been considerable interest in the development of natural coagulants and coagulant aids in order to reduce the dose of alum. This study aimed at evaluating the use of Corchorus Olitorius L. (COL), a leafy vegetable grown in Africa and the Middle East, as a novel coagulant aid over other synthetic coagulant aids. It is a …

“Hippo” Law Law And The Biodiversity Crisis Of Habitat Loss, Invasive Species, Pollution, Population, And Overharvesting, Andrew W. Torrance, Bill Tomlinson

UC Law SF International Law Review

This article explores the critical issue of biodiversity loss through the lens of the “HIPPO” acronym coined by Edward O. Wilson: Habitat loss, Invasive species, Pollution, Population, and Overharvesting. It examines the ecological and social ramifications of declining biodiversity and assesses existing legal frameworks aimed at mitigating these threats. Furthermore, the article proposes innovative legal mechanisms to address each HIPPO factor, offering a legal approach that spans many different domains. By integrating comparative legal analysis and suggesting forward-looking legal reforms, this work aims to contribute to the conservation efforts essential for sustaining biodiversity in the face of escalating environmental challenges.

Cal Poly Humboldt Library Digest, March 2025, Cal Poly Humboldt Library

Library Publications

No abstract provided.

Fourth Sunday Of Easter - 11 May 2025, Errol Lobo

Pastoral Liturgy

No abstract provided.

Resistance, Adaptation, And Assimilation: Native American Responses To Christianization In The Great Lakes Region, 1800-1900, Noah S. Danforth

HS 390 Primary Research Papers

Analysis of the relationship between Native Americans and missionaries shifted from an early broad, sweeping praise of the missionaries, to overwhelming condemnation of their actions in the post Civil Rights political climate. Since the time of European contact, histories often fell into Hagiography; extolling the virtues of the missionaries, and their God-ordained work to save the soul of the perceived heathen Native. In the mind of many, the conversion of the Native was merely a natural result of the superiority of European-descended American culture. However, as a result of the Civil Rights Movement, a pivot away from lauditive analysis took …

Life, Liberty And Property: Property As A Weapon Utilized Against Native Peoples And As A Tool To Strengthen Native Sovereignty In The Upper Midwest, Jacob R A Ludwig

HS 390 Primary Research Papers

While many Americans today recognize the continuing paternalism of the federal government towards Tribal governments, much still remains unknown to the public regarding the specific laws, policies and treaties that have provided the continuing legal authority for this paternalism. Throughout American history, the relationship between the federal government and Native American tribes can be seen through the use of violence both in law, and outside of it. Treaties, the basis for removal, have been used by both the federal government and subsequently tribal governments to assert their authority over land. In the Upper Midwest, various Anishinaabe tribes signed several treaties …

The Mathematical Experience Museum: Breathing Life Into Theorems And Formulas, Jin Akiyama, Jude Buot, Mark Anthony C. Tolentino

Mathematics Faculty Publications

No abstract provided.

Using Stable Isotope Analysis To Investigate The Trophic Ecology Of Aquatic Insects, Shelby Ann Medlock

Master's Theses

Despite their abundance on the landscape, ponds and associated macroinvertebrate assemblages have largely been underrepresented in scientific studies, which usually focus on lakes or streams. Similar to other waterbodies, ponds can harbor high levels of invertebrate biodiversity, which is important as aquatic insects are experiencing declines due to habitat destruction, pollution, climate change, and invasive species introductions. To evaluate how these threats impact pond insects and the ecosystem services they may provide, a thorough understanding of their ecology is essential. However, significant knowledge gaps remain, especially regarding trophic levels and species-specific diets. To address these knowledge gaps, I used carbon …