Digital Commons Network^™

Maternal Dietary Dha And Epa Supplementation Ameliorates Adverse Cardiac Outcomes In Thc-Exposed Rat Offspring., Kendrick Lee, Mohammed H Sarikahya, Samantha L Cousineau, Ken K-C Yeung, Amica Lucas, Kara Loudon, Thane Tomy, Gregg T Tomy, David R C Natale, Steven R Laviolette, Daniel B Hardy

Physiology and Pharmacology Publications

Cannabis use in pregnancy is associated with low birthweight outcomes. Recent preclinical data suggests that maternal Δ9-tetrahydrocannabinol (THC) exposure leads to decreases in birthweight followed by early cardiac deficits in offspring. Currently, no studies have explored an intervention for these maternal THC-induced deficits. Omega-3 fatty acids have been shown to exhibit cardioprotective effects. In this present study, we demonstrated that maternal dietary supplementation of omega-3 fatty acids ameliorates both THC-induced fetal growth and postnatal cardiac deficits in offspring. Our data indicates this may be underpinned by alterations in cardiac and hepatic fatty acids and reduction in markers of cardiac collagen …

Applied Leadership Principles In Multiracial/Multiethnic Churches, Steffon Arrington

Doctor of Ministry Projects and Theses

We would all be a lot wiser, and a lot smarter if we had a looking glass to see what life holds in store every five to ten years. Upon reflection on our lives, we can discern the transformations, and in some instances, we may recognize the guiding influence of God’s providence. I’m often reminded of the words from the prophet Jeremiah: “For I know the plans I have for you, says the LORD, plans for welfare and not for evil, to give you a future and a hope” (Jeremiah 29:11). As I look back on my life, I see …

A Case Of Turmeric-Induced Hepatotoxicity With Hyperferritinemia, Nina R. Spitofsky, Albert A. Huang, Aria Jalalian, Stefanie Gallagher, Scott Fink

Department of Medicine Faculty Papers

Introduction: We present the first published case of turmeric-associated drug-induced liver injury (DILI) accompanied by significant ferritin elevation. Case Presentation: Our patient, a 59-year-old female with DILI caused by long-term ingestion of oral turmeric supplements, presented with painless jaundice on an annual exam. The patient’s liver function tests exhibited a hepatocellular pattern and hyperferritinemia (>2,000 ng/dL). Additional testing was negative except for heterozygosity for the H63D allele associated with hemochromatosis. A liver biopsy indicated acute hepatitis without fibrosis or stainable iron. Conclusion: Upon discontinuation of the supplement, liver enzymes normalized within a month. This case highlights the potential for …

A Journey Of Innovation In Mitral Transcatheter Edge-To-Edge Repair: Lessons From The Repair Registry, Gilbert H L Tang, Syed Zaid

Faculty, Staff and Students Publications

No abstract provided.

Garnet & Black: Spring 2025, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.

Whale Sentience & Scientific Serendipity, Andrew Rowan Dphil

WellBeing News

Whales exhibit advanced cognitive functions, including intricate social behaviors and communication skills, indicative of high intelligence and sentience. Understanding these traits is crucial for informing ethical considerations and enhancing conservation strategies for these majestic marine mammals.

To Declaw Or Not To Declaw?, Andrew Rowan Dphil, Kathleen Rowan

WellBeing News

Declawing cats, known medically as onychectomy, involves amputating the last bone of each toe to remove the claws. While some pet owners consider it a solution to prevent property damage or reduce the risk of relinquishment to shelters, the procedure is associated with significant pain, potential behavioral changes such as increased biting and litterbox avoidance, and ethical debates regarding animal welfare. Alternatives like providing appropriate scratching surfaces, regular nail trimming, and using nail caps are recommended to address unwanted scratching behaviors without resorting to declawing.

Pets And Politics, Andrew Rowan Dphil

WellBeing News

The article explores how politicians leverage pet ownership to enhance their public image, noting that over 90% of U.S. presidents have had pets in the White House. It also examines studies highlighting pets' role as social catalysts and discusses regional variations in pet ownership across the United States.

Predicting Precipitation And Ndvi Utilization Of The Multi-Level Linear Mixed-Effects Model And The Ca-Markov Simulation Model, Fatima Belhaj, Hlila Rachid, Ouallali Abdessalam, Aqil Tariq, Belkendil Abdeldjalil, Beroho Mohamed, Hassan Alzahrani, Hajra Mustafa, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

The current work intends to reconstruct the spatiotemporal evolution of precipitation and the Normalized Differentiate Vegetation Index (NDVI) in the Loukkos watershed and provide scenarios for their recent and future evolution, therefore determining the degree of association. We conducted a study on the time series data of precipitation and NDVI from 1999 to 2019. The NDVI prediction is conducted using the CA-Markov model and the linear mixed-effects multi-level model (LME) with precipitation data from 2019 to 2040. The CA-Markov model was employed to predict the vegetation indices for 2029 and 2040 using 1999, 2009, and 2019 data. The model simulates …

Individualized Peep Can Improve Both Pulmonary Hemodynamics And Lung Function In Acute Lung Injury, Mayson L A Sousa, Luca S Menga, Annia Schreiber, Mattia Docci, Fernando Vieira, Bhushan H Katira, Mariangela Pellegrini, Sebastian Dubo, Ghislaine Douflé, Eduardo L V Costa, Martin Post, Marcelo B P Amato, Laurent Brochard

2020-Current year OA Pubs

RATIONALE: There are several approaches to select the optimal positive end-expiratory pressure (PEEP), resulting in different PEEP levels. The impact of different PEEP settings may extend beyond respiratory mechanics, affecting pulmonary hemodynamics.

OBJECTIVES: To compare PEEP levels obtained with three titration strategies-(i) highest respiratory system compliance (C

METHODS: Experimental studies in two porcine models of acute lung injury: (I) bilateral injury induced in both lungs, generating a highly recruitable model (n = 37); (II) asymmetrical injury, generating a poorly recruitable model (n = 13). In all experiments, a decremental PEEP titration was performed monitoring P

MEASUREMENTS AND MAIN RESULTS: PEEP …

Nad+ Prevents Chronic Kidney Disease By Activating Renal Tubular Metabolism, Bryce A. Jones, Sanjay Jain, Et Al.

2020-Current year OA Pubs

Chronic kidney disease (CKD) is associated with renal metabolic disturbances, including impaired fatty acid oxidation (FAO). Nicotinamide adenine dinucleotide (NAD+) is a small molecule that participates in hundreds of metabolism-related reactions. NAD+ levels are decreased in CKD, and NAD+ supplementation is protective. However, both the mechanism of how NAD+ supplementation protects from CKD, as well as the cell types involved, are poorly understood. Using a mouse model of Alport syndrome, we show that nicotinamide riboside (NR), an NAD+ precursor, stimulated renal PPARα signaling and restored FAO in the proximal tubules, thereby protecting from CKD in both sexes. Bulk RNA-sequencing showed …

The Free Press Vol. 56, Issue 10, 03-10-2025, Chris Tiner, Cayley Bowman

Free Press, The

Husky Hero--ICE Raids Nationwide--Unhoused Found Dead--Project 2025--Gun Violence in Maine--Mayo Street Arts Play--Book Review--Indoor Track and Field LEC Champions--USM Parking Update

Cloning And Expression Of Scamp3 In Escherichia Coli Bl21(De3) With In Silico Sequence-Based Cancer Epitopes Prediction, Selly Setiati Rajagukguk, Sabar Pambudi, Astari Dwiranti, Doddy Irawan Setyo Utomo, Anom Bowolaksono

Makara Journal of Science

Secretory carrier membrane protein 3 (SCAMP3) is a crucial membrane protein involved in intracellular vesicle traffick-ing and exocytosis. The SCAMP3 expression has been observed in diverse cancer types, such as melanoma, glioma, hepatocellular and breast cancer. Increased SCAMP3 expression has been reported in certain cancer cells relative to that in normal cells, suggesting the potential role of SCAMP3 in cancer development or progression. In this study, we successfully cloned and expressed SCAMP3 in Escherichia coli strain BL21(DE3). SCAMP3 was amplified and insert-ed directionally into the prokaryotic expression vector pET21d(+). The transformation of recombinant plasmid into E. coli BL21(DE3) cells were …

The Echo: March 10, 2025, Taylor University

2024-2025 (Volume 112)

No abstract provided.

A Phase I/Ii Trial Of Avelumab Combinations With Ivuxolimab, Utomilumab, And Radiation Therapy In Patients With Advanced Gastrointestinal Malignancies, Jibran Ahmed, Anne Knisely, Carlos Torrado, Bettzy Stephen, Yali Yang, Juhee Song, Anas Alshawa, Abdulrazzak Zarifa, Anuja Jhingran, Eugene J Koay, Van Karlyle Morris, Milind Javle, Robert A Wolff, Funda Meric-Bernstam, Shubham Pant, Jordi Rodon, Aung Naing

Faculty, Staff and Student Publications

Background: Checkpoint agonists utomilumab (4-1BB agonist) and ivuxolimab (OX40 agonist) enhance Teffector cell function. Preclinical studies suggest that combining these drugs with avelumab (anti-PD-L1 antibody) can potentially synergize this effect. In addition, tissue abscopal effects of radiation therapy may improve antigen presentation, complementing PD-L1 blockade. We conducted a single institution, open-label, multi-arm, non-randomized, phase 1/2 clinical trial of avelumab in combination with ivuxolimab, with or without utomilumab, and radiation therapy in patients with advanced solid tumors. Herein, we present a subgroup analysis in patients with gastrointestinal (GI) tumors (pancreatic, colon, gastric, and hepatocellular).

Methods: The primary objectives of this study …

Suppression Of Stress Granule Formation Is A Vulnerability Imposed By Mutant P53., Elizabeth A. Thoenen, Atul Ranjan, Alejandro Parrales, Shigeto Nishikawa, Dan A. Dixon, Sugako Oka, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Missense mutations in the TP53 (p53) gene have been linked to malignant progression. However, our in-silico analyses reveal that hepatocellular carcinoma (HCC) patients with mutant p53 (mutp53) have better overall survival compared to those with p53-null (p53^null) HCC, unlike other cancer types. Given the historical use of sorafenib (SOR) monotherapy for advanced HCC, we hypothesize that mutp53 increases sensitivity to SOR, a multikinase inhibitor that induces endoplasmic reticulum (ER) stress. Here we show that mutp53 inhibits stress granule (SG) formation by binding to an ER stress sensor, PKR-like ER kinase (PERK), and a key SG component, GAP SH3 …

Advances In Extracellular Matrix-Associated Diagnostics And Therapeutics, Morten Karsdal, Thomas R Cox, Amelia L Parker, Nicholas Willumsen, Jannie Marie Bülow Sand, Gisli Jenkins, Henrik H Hansen, Anouk Oldenburger, Kerstin E Geillinger-Kaestle, Anna Thorsø Larsen, Darcey Black, Federica Genovese, Alexander Eckersley, Andrea Heinz, Alexander Nyström, Signe Holm Nielsen, Lucas Bennink, Lars Johannsson, Anne-Christine Bay-Jensen, Dana E Orange, Scott Friedman, Mads Røpke, Vincent Fiore, Detlef Schuppan, Florian Rieder, Benjamin Simona, Lee Borthwick, Mark Skarsfeldt, Haakan Wennbo, Paresh Thakker, Ruedi Stoffel, Graham W Clarke, Raghu Kalluri, Darren Ruane, Faiez Zannad, Joachim Høg Mortensen, Dovile Sinkeviciute, Fred Sundberg, Molly Coseno, Christian Thudium, Adam P Croft, Dinesh Khanna, Michael Cooreman, Andre Broermann, Diana Julie Leeming, Ali Mobasheri, Sylvie Ricard-Blum

Faculty, Staff and Student Publications

The extracellular matrix (ECM) is the common denominator of more than 50 chronic diseases. Some of these chronic pathologies lead to enhanced tissue formation and deposition, whereas others are associated with increased tissue degradation, and some exhibit a combination of both, leading to severe tissue alterations. To develop effective therapies for diseases affecting the lung, liver, kidney, skin, intestine, musculoskeletal system, heart, and solid tumors, we need to modulate the ECM's composition to restore its organization and function. Across diverse organ diseases, there are common denominators and distinguishing factors in this fibroinflammatory axis, which may be used to foster new …

Do Universities Choose The Right Strategies For X Engagement? The Case Of Six Universities In Thailand, Mathupayas Thongmak

Higher Learning Research Communications

Objective: The purpose of this study is to understand how Thai public universities engage their stakeholders on X (the social media platform previously known as Twitter). This article answers the following research questions: 1) What are the X message strategies of six public universities? 2) Do they choose the most effective strategies to drive X engagement in terms of favorites and reposts?

Method: Data was automatically collected using anX analytic tool, and the potential variables were extracted semi-automatically using tools appropriate to text mining, sentiment analysis, word cloud, and so on. Posts from six universities in Thailand were investigated.

Results: …

A Robust Skin Cancer Classification Using Deep Learning, Abdelrahman Abbas, Hussam Elbehiery

Sustainable Machine Intelligence Journal

In the medical field, detecting skin cancer from pictures can be difficult. Skin cancer identification is a laborious process in modern medicine that could eventually result in patient death. Early detection of skin cancer is essential to the effectiveness of full treatment. It is difficult to diagnose skin cancer effectively. Consequently, there are not enough qualified dermatologists around the globe to meet the demands of modern healthcare. Data imbalance problems are caused by the wide diversity in data from several healthcare industry categories. Deep learning models are frequently trained in one category more than others due to issues with data …

Augmented Expression Of Superoxide Dismutase 2 Mitigates Progression And Rupture Of Experimental Abdominal Aortic Aneurysm, Huimin Yan, Ying Hu, Yang Lyu, Antonina Akk, Angela C Hirbe, Samuel A Wickline, Hua Pan, Elisha D O Roberson, Christine T N Pham

2020-Current year OA Pubs

No abstract provided.

Antibacterial Activity Of Endophytic Actinobacteria Isolated From Ziziphus Mauritiana Against Multidrug-Resistant Strains, Hafifatunil Khairani, Jepri Agung Priyanto, Muhammad Eka Prastya, Dwi Retnowati

Makara Journal of Science

Increasing resistance to existing antibiotics has led to a need for new alternative sources. Among the possibilities that need to be explored is the endophytic actinobacteria associated with Ziziphus mauritiana. The present study aimed to evaluate the antibacterial activity of endophytic actinobacteria isolated from Z. mauritiana against five multidrug-resistant bacterial strains. Thirty actinobacteria isolates were obtained from the roots, stem, and leaves of the plant using the serial dilution technique. Using a double-layer agar test, we found that colonies from five of the 30 isolates (16%) exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and the M18 strain of Bacillus …

Assessment Of Fish Biodiversity Of The Cimandiri Watershed, West Java, Indonesia, Rudhy Gustiano, Haryono Haryono, Gema Wahyudewantoro, Krismono Krismono, Rusdianto Rusdianto, Firman M. Nur

Makara Journal of Science

Information on the fish biodiversity of the Cimandiri Watershed is incomplete, and human activities and anthropogen-ic impacts pose a significant threat to this biodiversity. The purpose of this study was to assess the biodiversity of fish in the Cimandiri Watershed. The results indicated that fish biodiversity in the area included 104 species belonging to 49 families. There were 26 species in the upstream area, 47 species in the middle area, and 61 species in the downstream area. Forty-three species were native to Indonesia, and 7 of the native fish were endemic to the area. There were 11 introduced species belonging …

A Role For The Actin Cytoskeleton And Plastin-3 In Osteoblast Mineralization And Mechanosensation, Samantha Meagan Chin

Arts & Sciences Graduate Student Theses and Dissertations

The great diversity in actin network architectures and dynamics is exploited by cells to drive fundamental biological processes including cell migration, intracellular trafficking, and cell division. One such system that relies on the actin cytoskeleton to fulfill its physiological function are osteoblasts, which are mesenchymal lineage bone cells that promote bone formation through depositing a collagen scaffold and subsequently promoting mineralization of this matrix. A number of factors are known to drive osteogenic differentiation of pre-osteoblast cells including extracellular matrix cues such as substrate stiffness, which are primarily detected via mechanosensitive machinery linked to the actin cytoskeleton. Disruptions to β-actin, …

Creating Sustainable School And Home Gardens: Using Drones To Enhance Garden Projects, Douglas Weber, Rita Hagevik, Kathy Cabe Trundle

All Current Publications

This fact sheet explores using drones to enhance garden projects at home and in schools. It covers the benefits of drones, such as monitoring garden health, planning layouts, and assessing plant conditions through advanced imaging technologies. Additionally, it outlines essential factors to consider when selecting a drone, including cost, battery life, camera quality, and local regulations. Tips for safe operation and effective usage are also provided, as well as fun facts about drones.

Creating Sustainable School And Home Gardens: Organic Pest Management, Ruby Mohr, Kathy Cabe Trundle, Rita Hagevik

All Current Publications

This fact sheet on organic pest management outlines sustainable gardening practices that promote ecological balance and biodiversity. It defines organic pest management as a proactive method, using natural insecticides like sulfur and neem oil, along with unique pest control strategies such as beer traps and cinnamon repellents. Additionally, it highlights plants like mint and marigolds that repel harmful pests while attracting beneficial insects. By implementing these approaches, gardeners can protect crops sustainably, enhance soil health, and reduce reliance on synthetic pesticides, thus supporting a healthier food system.

Apobec3a Drives Ovarian Cancer Metastasis By Altering Epithelial-Mesenchymal Transition, Jessica M. Devenport, Thi Tran, Brooke R. Harris, Dylan Fingerman, Rachel A. Deweerd, Lojain H. Elkhidir, Danielle Lavigne, Katherine Fuh, Lulu Sun, Jeffrey J. Bednarski, Ronny Drapkin, Mary M. Mullen, Abby M. Green

2020-Current year OA Pubs

High-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive histological subtype of ovarian cancer and often presents with metastatic disease. The drivers of metastasis in HGSOC remain enigmatic. APOBEC3A (A3A), an enzyme that generates mutations across various cancers, has been proposed as a mediator of tumor heterogeneity and disease progression. However, the role of A3A in HGSOC has not been explored. We observed an association between high levels of APOBEC3-mediated mutagenesis and poor overall survival in primary HGSOC. We experimentally addressed this correlation by modeling A3A expression in HGSOC, and this resulted in increased metastatic behavior of HGSOC …

Volume 1, Issue 1, Authors Listed Within Journal Issue

NEBO: A Literary Journal

Nebo, Volume 1, Issue 1 (Spring 1983), marks the beginning of a new era for Arkansas Tech University’s literary journal, as it transitions from its former identity as The Five Cent Cigar to Nebo. Published biannually by the English Department, Nebo takes its name from both the Chaldean god of writing and the iconic Arkansas landmark, Mount Nebo, symbolizing the journal’s dedication to creative expression and literary excellence.

This inaugural issue showcases poetry and fiction from both emerging and established writers, featuring works by Howard Nemerov, Dana Gioia, and Lily Peter, among others. With this transition, Nebo affirms …

Difficulties And Challenges Facing Use Of Interactive Multimedia Applications (Imms) To Develop The Skills Of Reading And Writing In English From The Visually Impaired Students' Points Of View At The Syrian Governmental Universities, Hala Muhammad Sulieman, Nadim Badie Mustafa

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

The article aimed to identify the challenges and difficulties associated with the use of interactive multimedia applications (IMMs) for developing the skills of reading and writing in EFL (English as a foreign language) from the perspective of visually impaired students at the Syrian governmental universities, considering their gender and academic year as variables, on which the article problem relies on. The researcher developed a questionnaire of 43 questions, and divided them into three sections and two main themes. After the validity of the questionnaire had been verified, and its stability had been calculated as well, it was applied to gather …

Transmedia Edutainment For Sustainable Advocacy: How Narrative Engagement And Counterarguments Influence Generation Z’S Response To Sustainable Development Messages, Aya Shata, Michelle Seelig, Nick Carcioppolo

Hank Greenspun School of Journalism and Media Studies Faculty Research

Media convergence has created new forms of storytelling, such as transmedia edutainment (TE-E), which can serve as an innovative communication strategy for promoting pro-environmental attitudes and behaviors. Because of the limited evidence about the persuasive outcomes of narrative TE-E, this research investigates the role of TE-E as a novel communication approach that advocates for sustainable development among Generation Z. Drawing on narrative persuasion theories, we conducted an experiment (N = 441) that examined the narrative mechanisms of TE-E, focusing on narrative engagement and counterargument, and assessed the narrative outcomes of different single formats—including video, game, and comic—compared with TE-E. Findings …

A Standards Perspective On Genomic Data Reusability And Reproducibility, Ishi Keenum, Scott A. Jackson, Emiley Eloe-Fadrosh, Lynn M. Schriml

Michigan Tech Publications

Genomic and metagenomic sequence data provides an unprecedented ability to re-examine findings, offering a transformative potential for advancing research, developing computational tools, enhancing clinical applications, and fostering scientific collaboration. However, effective and ethical reuse of genomics data is hampered by numerous technical and social challenges. The International Microbiome and Multi’Omics Standards Alliance (IMMSA, https://www.microbialstandards.org/) and the Genomic Standards Consortium (GSC, https://gensc.org) hosted a 5-part seminar series “A Year of Data Reuse” in 2024 to explore challenges and opportunities of data reuse and reproducibility across disparate domains of the genomic sciences. Addressing these challenges will require a multifaceted approach, including common …