Digital Commons Network^™

A Case Of Milkweed Poisoning In Cattle In Colorado, Raye Walck, Brett Webb, Steve Ensley, Daniel Cook

Poisonous Plant Research (PPR)

Milkweeds, Asclepias spp., are herbaceous perennials of the Apocyanaceae family. Milkweeds contain several cardiac glycosides, cardenolides, that are toxic. Clinical signs associated with milkweed toxicity are generalized weakness, difficulty in breathing, rapid weak pulse, bloating, violent spasms, paralysis, and death. Here we report a clinical case of milkweed toxicity in cattle due to contaminated hay. Clinical signs observed in the poisoned animals were consistent with cardenolide toxicity. Milkweed was detected in the rumen contents of the poisoned cow using DNA metabarcoding. In summary, multiple lines of corroborative evidence were used to make the diagnoses of milkweed poisoning in this case.

2025-03-28 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of March 28, 2025, which includes the meeting minutes of the meeting held on February 7, 2025.

Studies On Cell Cycle Regulation And Ecm Modification During Tubular Organ Formation In Drosophila Embryos, Jeffrey Matthew

LSU Doctoral Dissertations

The formation of tubular organs—such as the heart and kidneys—is a complex developmental process that requires the precise coordination of tissue remodeling with dynamic changes in cellular behavior. Key processes including cell proliferation, apoptosis, and extracellular matrix (ECM) formation must be tightly synchronized with mechanisms that generate and transmit physical forces, transforming a flat epithelial sheet into a three-dimensional organ. Disruptions in the homeostasis of these processes during organogenesis can lead to congenital defects, such as pulmonary atresia and renal hypoplasia.

To investigate the mechanisms underlying epithelial morphogenesis, the Chung laboratory employs the Drosophila embryonic salivary gland (SG) as a …

Voices Of Heritage And Resilience: A Performance Guide To Soprano Arias Celebrating The Black Experience In Opera, Imani S. Francis

LSU Doctoral Dissertations

Voices of Heritage and Resilience: A Performance Guide for Soprano Arias Celebrating the Black Experience explores a selection of soprano arias that illuminate the depth, complexity, and resilience of Black identity through opera. This study provides historical context, musical style, and vocal performance strategies for works that center around the African American experience, spanning both traditional and contemporary repertoire.

By examining the relations between text, music, and historical significance, this dissertation highlights how these arias convey themes of struggle, conflict, oppression, love, and perseverance. It also supplies guidance to the singer through the use of vocal methods, interpretation, and stylistic …

Desistance, Emancipation, Empathy, And Pedagogy: The Incarcerated Teaching Artist’S Approach To Poetry, Ghostwrite Mike

Journal of Prison Education Research

The Art of Recovery and Therapy (ART) leisure time activity group at Valley State Prison (VSP) in Chowchilla, California, is a resident-led arts and humanities-based self-help forum that has been available to carceral state residents for more than a decade and is administered in collaboration with full-time, non-custody, civil servant facility staff (CDCR site, n.d.). ART is among the California Department of Corrections and Rehabilitation’s (CDCR) longest running and most autonomous creator habitats founded and facilitated entirely by resident practitioners. ART wields a codified state regulatory authority to function and fundraise (Cal. Code Regs. § 3233-3237, 3240) as well as …

Stable Heteroclinic Channels As A Decision-Making Model: Overcoming Low Signal-To-Noise Ratio With Mutual Inhibition, Natasha A. Rouse

Faculty Scholarship

Bio-inspired robot controllers are becoming more complex as we strive to make them more robust to, and flexible in, noisy, real-world environments. A stable heteroclinic network (SHN) is a dynamical system that produces cyclical state transitions using noisy input. SHN-based robot controllers enable sensory input to be integrated at the phase-space level of the controller, thus simplifying sensor-integrated, robot control methods. In this work, we investigate the mechanism that drives branching state trajectories in SHNs. We liken the branching state trajectories to decision-splits imposed into the system, which opens the door for more sophisticated controls-all driven by sensory input. This …

Application Of Quantum Entanglement To Explain The Healing Mechanism By Highly Diluted Homoeopathic Medicines, Bijay Krishna Chaudhuri, Biswadeep Chaudhuri

Indian Journal of Research in Homoeopathy

Background: The healing mechanism of highly diluted homoeopathic medicines (DHM) is not yet very clear.

Objectives: Our objective is to apply the concepts of entropy, information, and quantum mechanical principle of entanglement to find a model for explaining the healing mechanism of DHM.

Methodology: All living or non-living things are composed of dynamic microscopic quantum particles (electrons, protons, ions, etc.) which follow the basic properties of quantum mechanics such as quantum entanglement, superposition of quantum states and coherent interaction among these particles. The continuous change of thermodynamic entropies of the dynamic living cells leads to information change for cellular communication …

Effect Of Individualised Homoeopathic Intervention In Dyslipidaemia: An Open-Label, Randomised, Controlled, Exploratory Trial, Roja Varanasi, Rupali Bhalerao, Raveendar Ch, Raju Kolli, Ravi Sardala, R.V.R. Prasad, Paul Sumithran, M. Prakash Rao, Ramesh Dubashi, Kiranmayee R.G.R, S. Rajeeva, V. Sarathy, P.A. Rajakumari, Priyanka Srivastava, Anupriya Chaudhary, Gnnana Prakasham, P. Prasad, Arvind Kumar, Viqar A. Siddiqui, Praveen Oberai, Raj K. Manchanda

Indian Journal of Research in Homoeopathy

Background: Dyslipidaemia, the derangement of one or many of the lipoproteins is a major cause of cardiovascular events, causing 2.6 million deaths per year globally.

Objectives: This study evaluated the efficacy of individualised homoeopathic medicines with lifestyle modification in the management of dyslipidaemia.

Materials and Methods: This multicentric, open-label, randomised controlled exploratory trial was conducted at seven study sites under the Central Council for Research in Homoeopathy. Participants fulfilling the eligibility criteria were enrolled. The primary outcome was to evaluate changes in Low-Density Lipoprotein cholesterol at months 3 and 6. Secondary outcomes were to evaluate changes in total cholesterol, triglyceride, …

The Emergence Of Human Primordial Germ Cell-Like Cells In Stem Cell-Derived Gastruloids, Jitesh Neupane, Gabriele Lubatti, Theresa Gross-Thebing, Mayra Luisa Ruiz Tejada Segura, Richard Butler, Sargon Gross-Thebing, Sabine Dietmann, Antonio Scialdone, M Azim Surani

2020-Current year OA Pubs

Most advances in early human postimplantation development depend on animal studies and stem cell-based embryo models. Here, we present self-organized three-dimensional human gastruloids (hGs) derived from embryonic stem cells. The transcriptome profile of day 3 hGs aligned with Carnegie stage 7 human gastrula, with cell types and differentiation trajectories consistent with human gastrulation. Notably, we observed the emergence of nascent primordial germ cell-like cells (PGCLCs), but without exogenous bone morphogenetic protein (BMP) signaling, which is essential for the PGCLC fate. A mutation in the

Immersive Mixed-Reality Anatomy Lab, Cassidy Norkett

Honors Theses

The Mixed Reality Heart Anatomy Lesson was created to address the WMU Homer Stryker M.D. School of Medicine’s need for an interactive and dynamic laboratory lesson. The application allows for a more efficient way for medical students to learn and comprehend the material. The design and development of a mixed reality application running on smart glasses provides students with a situation aware, fully engaged, and immersive learning experience. The Apple Vision Pro device allows medical students to complete their labs by merging physiology and anatomy concepts through 3D models, object detection, self-assessments, and an artificial intelligence chatbot. There can be …

Research Highlights, Shruti Jain Vij, Charu Sehgal

Indian Journal of Research in Homoeopathy

Research Highlights

Brain-Targeted Reactive Oxygen Species In Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, And Novel Therapeutic Pathways, Renjun Wang, Min Wang, Dongshu Du, Zhiying Shan, Lanrong Bi, Qing-Hui Chen

Michigan Tech Publications

Hypertension (HTN) is a complex disease with significant global health implications, driven by neural and oxidative mechanisms. Reactive oxygen species (ROS), once considered mere metabolic byproducts, are now recognized as one of the key contributors to dysfunction of the autonomic nerve system, which involves the onset and progression of HTN. This review highlights the dynamic roles of ROS in neuronal signaling, subcellular compartmentalization, and brain-immune interactions, focusing on their impacts on synaptic remodeling, neuroinflammation, and epigenetic modifications within key autonomic regions such as the paraventricular nucleus and rostral ventrolateral medulla. We discuss novel ROS sources, including microglia-derived and endoplasmic reticulum …

Systemic Antitumor Immune Response Of Doped Yttria Nanoscintillators Under Low-Dose X-Ray Irradiation, Onur Sahin, Yuri Mackeyev, Geraldine V Vijay, Soumyabrata Roy, Ashokkumar Meiyazhagan, Yasmin Zahra, Okan Tezcan, Valeria Gonzalez, Belal Abousaida, Holden R Wagner, Pearl Fernandes, Riaz Mowzoon-Mogharrabi, Bhanu P Venkatesulu, Cheng-En Hsieh, Joseph B K Kim, Subhiksha Raghuram, Xiang Zhang, Kristen A Miller, Guanhui Gao, Pankaj K Singh, Sang Hyun Cho, Rao V L Papineni, Pulickel M Ajayan, Sunil Krishnan

Faculty, Staff and Student Publications

Inadequate light penetration in tissues restricts photodynamic therapy to treating only superficial tumors. To enable x-ray-excited photodynamic therapy (XPDT) that targets deep-seated tumors, we synthesized a nanoscintillator-photosensitizer complex containing 5% Eu-doped Y2O3 fluorescing at 611 nanometers and decorated with SiO2 containing the scintillation-coupled photosensitizer methylene blue and a polyethylene glycol coating [PEGylated Y2O3:Eu@SiO2-methylene blue (pYSM)]. When irradiated, pYSMs generate singlet oxygen species in vitro, causing cytotoxicity with hallmarks of immunogenic cell death (calreticulin translocation to the cell membrane). Intravenously administered pYSMs home passively to pancreatic tumor xenografts and, upon 10 gray irradiation, cause significant tumor regression (P < 0.01). On combining XPDT with anti-PD1 immunotherapy, a distant nonirradiated tumor also regresses via an increase in intratumoral activated CD8+ cytotoxic T cells. Collectively, we advance a systemically delivered XPDT strategy that mediates an antitumor effect in both irradiated and nonirradiated (abscopal) tumors when coupled with immunotherapy, converting an immunologically "cold" tumor to an immunologically "hot" tumor.

Sitc Strategic Vision: Prevention, Premalignant Immunity, Host And Environmental Factors, Sasha E Stanton, Kristin G Anderson, Tullia C Bruno, Christian M Capitini, Mary L Disis, Jennifer Mcquade, Laszlo Radvanyi, Claire Vanpouille-Box, Jennifer Wargo, Kelly J Baines, Megan M Y Hong, Adnan Rajeh, Raymond H Kim, Phillip Awadalla, Lauren K Hughes, Saman Maleki Vareki

Faculty, Staff and Student Publications

Cancer immunotherapy has improved the survival of a subset of patients by harnessing the power of the immune system to find and destroy malignant cells. The immune system also protects the host by destroying developing premalignant and malignant tumors. Advancing our knowledge of premalignant immunity and immune changes seen in lesions that develop into invasive cancer versus those that regress offers an exciting opportunity to leverage the immune system for immune prevention and immune interception of premalignancy. Understanding the immune environment of premalignant lesions and how chronic inflammation plays a central role in the evolution of premalignancy is essential for …

Bridging Gaps In Cancer Care: Utilizing Large Language Models For Accessible Dietary Recommendations, Julia A. Logan, Sriya Sadhu, Cameo Hazlewood, Melissa Denton, Sara Burke, Christina A. Simone-Soule, Caroline Black, Corey Ciaverelli, Jacqueline Stulb, Hamidreza Nourzadeh, Yevgeniy Vinogradskiy, Amy Leader, Adam Dicker, Wookjin Choi, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Background/Objectives: Weight management is directly linked to cancer recurrence and survival, but unfortunately, nutritional oncology counseling is not typically covered by insurance, creating a disparity for patients without nutritional education and food access. Novel ways of imparting personalized nutrition advice are needed to address this issue. Large language models (LLMs) offer a promising path toward tailoring dietary advice to individual patients. This study aimed to assess the capacity of LLMs to offer personalized dietary advice to patients with breast cancer. Methods: Thirty-one prompt templates were designed to evaluate dietary recommendations generated by ChatGPT and Gemini with variations within …

Dnajb6: A Potent Dnajb Chaperone In Regulating Tau Proteostasis, Abigail R. Esquivel

USF Tampa Graduate Theses and Dissertations

Neurodegenerative diseases often feature the pathological buildup of misfolded proteins, and tau is a principal culprit in multiple tauopathies. One chaperone of emerging interest is DnaJB6b, a member of the Hsp40/DnaJ family, which exhibits potent anti-aggregation activity against several disease-related proteins. Recent investigations highlight its unique capacity to recognize and neutralize aggregation-prone forms of tau. DnaJB6b appears potent against multiple variants of tau and may be acting against tau, in part, by directing misfolded tau toward proteasomal clearance. The first lines of evidence come from systematic chaperone screens, where DnaJB6b repeatedly emerged as a strong suppressor of tau seeding. Further …

Investigating The Proviral And Immunogenic Effects Of Sars-Cov-2 Accessory Protein 7a, Grant Michael Hawkins

Dissertations

SARS-CoV-2 and related sarbecoviruses encode a set of accessory proteins (3a, 3b, 6, 7a, 7b, 8, 9b, and 10) that control host responses to infection and promote virus growth. Of these accessory proteins, 7a is set apart by its intracellular localization near coronavirus (CoV) budding sites and its incorporation into secreted virions. Initial studies utilizing a virus-like particle (VLP) system identified significant proviral effects mediated by 7a, but the system lacked the context of an actual CoV infection. To investigate 7a functions during CoV infections, we constructed recombinant Mouse Hepatitis Viruses (rMHV strain A59) that express 7a genes. Comparative infections …

Refinement Of Megakaryocyte Lineage Commitment In Hematopoietic Stem And Progenitor Cells During Postnatal And Adult Hematopoiesis, Ryan Michael Mack

Dissertations

Mammalian hematopoiesis ensures the continuous production of specialized blood cells, yet the mechanisms that govern megakaryocyte/erythroid (MK/E) bifurcation remain incompletely understood. While HSPCs sustain all blood lineages, how transient waves of progenitors arise and adapt from fetal to adult stages is less clear. This gap in knowledge limits our capacity to precisely manipulate platelet and red blood cell outputs in both developmental and therapeutic contexts. Using refined gating strategies and various bulk- and single-cell transcriptomics, we dissected the traditional “common myeloid progenitor” and Multipotent Progenitor (MPP) compartment into multiple functionally distinct subsets (C1, C2, C3). Within C1, an ESAM⁺ fraction …

Effects Of Prebiotic Phytocompound Administration In Gestational Diabetic Dams And Its Influence On Offspring Cognitive Outcomes, Gayathri Jagadeesan, Tushar K Das, Jennifer M Mendoza, Ghalya Alrousan, Maria P Blasco-Conesa, Parimelazhagan Thangaraj, Bhanu Priya Ganesh

Faculty, Staff and Student Publications

Gestational diabetes mellitus (GD)-induced gut dysbiosis in pregnant mothers may increase the risk of cognitive impairment and neurological disorders in both the mother and offspring as they age. Restoring gut balance could improve cognitive outcomes for both. Despite advancements in GD treatment, side effects have increased, and long-term neurocognitive impacts on offspring born to GD mothers remain underexplored. This study uses a GD mouse model, inducing pancreatic dysfunction in 3-month-old pregnant C57BL/6J mice with Streptozotocin. The efficacy and mechanism of the prebiotic phytocompound green leaf extract (

Assessing Cancer Therapeutic Efficacy In Vivo Using [2h7]Glucose Deuterium Metabolic Imaging, Mario C Chang, Vinay R Malut, Rohit Mahar, Anna Rushin, Marc A Mcleod, Geraldine L Pierre, Indu R Malut, Stephen J Staklinski, Max E Glanz, Mukundan Ragavan, Gaurav Sharma, Manoj Madheswaran, Arshee Badar, Aparna D Rao, Brian K Law, Michael S Kilberg, James H P Collins, Vikram D Kodibagkar, James A Bankson, Ralph J Deberardinis, Matthew E Merritt

Faculty, Staff and Student Publications

Metabolic imaging produces powerful visual assessments of organ function in vivo. Current techniques can be improved by safely increasing metabolic contrast. The gold standard, 2-[18F]fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging, is limited by radioactive exposure and sparse assessment of metabolism beyond glucose uptake and retention. Deuterium magnetic resonance imaging (DMRI) with [6,6-2H2]glucose is nonradioactive, achieves tumor metabolic contrast, but can be improved by enriched contrast from deuterated water (HDO) based imaging. Here, we developed a DMRI protocol employing [2H7]glucose. Imaging 2H-signal and measuring HDO production in tumor-bearing mice detected differential glucose utilization across baseline tumors, tumors treated with vehicle control or …

Deep Learning (Cnn) For Detecting Road Infrastructure In Old Mosul City Using High-Resolution Aerial Imagery, Mustafa Ismat Abdulrahman, Muntadher Aidi Shareef, Alyaa Abbas Al-Attar

Baghdad Science Journal

Road networks and transportation infrastructure play a crucial role in many applications such as urban planning and environmental assessment. Remote sensing provides multispectral data that can be used to identify, extract, and map roads. However, accurate mapping of road networks from aerial imagery poses challenges due to the complexity of real-world road patterns. The aim of this study was to develop deep learning techniques for automated road extraction from aerial photographs. The study evaluated several convolutional neural network (CNN) architectures were including a hybrid spectral-spatial network (HybridSN). Models were assessed on a dataset of urban aerial images with lidar-derived ground …

Medicinal Plant Leaf Classification Using Deep Learning And Vision Transformers, Shahriar Hossain, Rizbanul Hasan, Jia Uddin

Baghdad Science Journal

Identification of medicinal plant leaves is very crucial as their cultivation and production are essential for the medicine industry. Many different classes of medicinal leaves look identical but serve different purposes in the medicine industry and have different remedies for different diseases. Hence it is imperative to use methods that are automated, faster, and produce good accuracy. Cutting-edge models have been trained to discern the subtle distinctions between various species of leaves, accounting for a myriad of factors such as leaf texture, shape, and color variations, which are often imperceptible to the human eye. In this research, Transfer learning (TL) …

Patient Selection, Ventricular Tachycardia Substrate Delineation, And Data Transfer For Stereotactic Arrhythmia Radioablation: A Clinical Consensus Statement Of The European Heart Rhythm Association Of The European Society Of Cardiology And The Heart Rhythm Society, Katja Zeppenfeld, Clifford Robinson, Et Al.

2020-Current year OA Pubs

Stereotactic arrhythmia radioablation (STAR) is a novel, non-invasive, and promising treatment option for ventricular arrhythmias (VAs). It has been applied in highly selected patients mainly as bailout procedure, when (multiple) catheter ablations, together with anti-arrhythmic drugs, were unable to control the VAs. Despite the increasing clinical use, there is still limited knowledge of the acute and long-term response of normal and diseased myocardium to STAR. Acute toxicity appeared to be reasonably low, but potential late adverse effects may be underreported. Among published studies, the provided methodological information is often limited, and patient selection, target volume definition, methods for determination and …

Characterization Of Hepatic Pathology During Azoxymethane-Induced Acute Liver Failure, Shadikchhya Maya Bhattarai, Ashwin Jhawer, Gabriel Frampton, Eleonora Troyanovskaya, Sharon Demorrow, Matthew Mcmillin

Faculty, Staff and Students Publications

Background: Acute liver failure (ALF) is a loss of liver function due to a severe hepatic insult. Studies utilizing the azoxymethane (AOM) mouse model of ALF, which also generates hepatic encephalopathy, have primarily focused on development of neurological deficits. However, the molecular processes that generate liver damage have not been fully characterized. Therefore, a more comprehensive characterization of the hepatic consequences of AOM toxicity is needed to better understand this disease model.

Aim: To identify molecular pathology contributing to hepatic injury during the progression of AOM-induced ALF.

Methods: C57BL/6 mice were injected with AOM to produce ALF and hepatic encephalopathy. …

An In Vivo Screen Identifies Nat10 As A Master Regulator Of Brain Metastasis, Jocelyn F Chen, Peng Xu, Wesley L Cai, Huacui Chen, Emily Wingrove, Xiaojian Shi, Wenxue Li, Giulia Biancon, Meiling Zhang, Amer Balabaki, Ethan D Krop, Elianna Asare, Yangyi Zhang, Mingzhu Yin, Toma Tebaldi, Jordan L Meier, Thomas F Westbrook, Stephanie Halene, Yansheng Liu, Hongying Shen, Don X Nguyen, Qin Yan

Faculty, Staff and Students Publications

Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis, the major cause of cancer-related deaths. Here, we conducted an in vivo screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis. Knockdown of NAT10 restrains cancer cell proliferation and migration in vitro and tumor growth and brain metastasis in vivo. The poorly characterized RNA helicase domain of NAT10 is critical for cell growth in vitro, while both RNA helicase and NAT domains are essential for primary tumor growth and brain metastasis in vivo. Mechanically, NAT10 promotes the …

"The Letting Of Blood": Evolutionary Perspectives On Violence In Cormac Mccarthy’S Western Worlds, Nicholas Adam Pankewycz

Electronic Theses and Dissertations Archive

Abstract: Pankewycz, Nicholas Adam. PhD. The University of Memphis. December 2024. “the letting of blood”: Evolutionary Perspectives on Violence in Cormac McCarthy’s Western Worlds. Theron Britt PhD. Through a close analysis of Cormac McCarthy's Western oeuvre, the dissertation examines how his depiction of violence reflects fundamental aspects of human nature, suggesting that the aggressive behaviors portrayed are inherent and shaped by environmental and evolutionary pressures. McCarthy's unflinching narratives provide insight into the darker facets of humanity, depicting scenes of brutality that challenge readers to confront the pervasive nature of violence in both American history and the human species. By situating …

Data Collection And Field Research Opportunities And Problems In India, A. K. Chakravarti

The Geographical Bulletin

There are few countries in the world which can provide such a wide range of problems for field study as India. For both macro and micro level studies, spatial variations in physical, cultural, economic and political conditions within a short distance may be phenomenal and provide a complex matrix for analysis. India is divided into linguistic states. A linguistic state in turn may contain tertiary subcultures, each with a different set of conditions within its boundaries. On a linguistic state may be superimposed three distinct areas of tertiary subcultures, viz., urban, rural-and tribal, each with different levels of education, standard …

Astronomical Geography: An Examination Of The Early American Literature, James W. Vining

The Geographical Bulletin

Judging from textbooks in geography, there must be educational value in starting with the general and proceeding to the specific, an application of the deductive approach. It is not uncommon today for introductory physical geography and earth science textbooks to precede the examination of the planet's interior, land-water surface, and atmosphere with a brief survey of the fundamentals of astronomy. Not only is this true today, it has been true from the beginnings of American geography, as this study documents. Specifically, this paper examines the information on astronomy in geography school books published before 1850 for the purposes of determining …

The Shorthorn: May 16, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.

The Shorthorn: May 02, 1933

The Shorthorn Newspaper Collection: 1930s

No abstract provided.