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Contributions To The Knowledge Of The Biology Of The Arabian Abalone Haliotis Mariae Wood, 1828, J. Stirn, K. A. Ai-Hashmi Apr 2025

Contributions To The Knowledge Of The Biology Of The Arabian Abalone Haliotis Mariae Wood, 1828, J. Stirn, K. A. Ai-Hashmi

Journal of Agricultural and Marine Sciences

The Arabian abalone occur in the Arabian Sea’s rocky coastal zone in association with conspicuous macrolgal communities in which it represents the dominant herbivorous component. Despite such ecological importance and although the commercial exploitation of abalone presents a considerable contribution to Omani fisheries, almost nothing is known about the biology of this species. This report presents results of research carried out in the field and with laboratory cultures, and draws general conclusions related also to the fisheries management of these possibly overexploited abalone populations, Cobort observations in the field and measured increments of cultured specimens showed a growth rate significantly …

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Improvement Of Animal Production By Altering The Environment Of The Animal, D. V. Armstrong Apr 2025

Improvement Of Animal Production By Altering The Environment Of The Animal, D. V. Armstrong

Journal of Agricultural and Marine Sciences

Hot weather causes heat stress in dairy cattle. The resultant decrease in milk production and reproductive efficiency ca be offset by implementation of a program consisting of cooling through shades, ventilation , evaporative coolers and spray and fans. Corral shade would be consistent to be essential to reduce stress. Feed line shade will improve dry matter intake and milk production. Holding pen cooling with spray and fans is cost effective, even in moderate climate. Shade cooling using evaporative or spray and fans is cost effective, if milk price is competitive to world price. The economic benefit should be determined before …

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Animal Breeding Considerations For Improved Animal Performance In Hot Environments, J. W. Fuquay Apr 2025

Animal Breeding Considerations For Improved Animal Performance In Hot Environments, J. W. Fuquay

Journal of Agricultural and Marine Sciences

A variety of options are available for improved performance including altering genotype with genetic improvement of indigenous breeds through selective breeding; upgrading through crossbreeding of indigenous females with semen from genetically superior exotic males with a possible goal of developing a new breed; and introduction of new breeds through transfer of embryos from genetically superior exotic breeds into indigenous females or importation of exotic animals of the desired breeding. Each option has its advantages and disadvantages. The most rapid gains mightbe possible new environment can be a problem. In the interest of adaptation and survival, systems that utilize the maternal …

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Livestock Environment Prospects For The 90'S, W. W. Thatcher Apr 2025

Livestock Environment Prospects For The 90'S, W. W. Thatcher

Journal of Agricultural and Marine Sciences

When projecting livestock environmental prospects for the 1990's. it is critical to recognize the multidimensional nature of managing livestock species under hot environments. This paper identifies potential critical physiological windows during the life cycle of the animal that are sensitive to heat stress and responsive to environmental modification. Ovarian follicular development appears to be sensitive to heat stress leading to reductions in intensity of oestrus and subsequent fertility. Periods of follicular development that are sensitive to heat stress have not been defined. With current improved systems to alter the microenvironment of animals. the period of embryonic sensitivity to heat stress …

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Animal Health In The Tropics, M.R. Jainudeen, A. R. Sheikh-Omar Apr 2025

Animal Health In The Tropics, M.R. Jainudeen, A. R. Sheikh-Omar

Journal of Agricultural and Marine Sciences

Most developing countries in Africa and Asia are located in the tropics (23° north and south of the equator). The poor productivity of ruminants in these countries is mostly due to inadequate nutrition, infectious diseases, low rates of reproduction, poor genotype, high ambient temperatures and socioeconomic constraints. In addition to infectious diseases which have long since been eradicated or brought under control in developed countries, there are diseases unique to the tropical environment. In the past, the diagnosis of most diseases was based on serological tests. The enzyme-linked immunosorbent assay (ELISA), a rapid method of identifying viral and bacterial infections, …

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Sheep And Goat Production In Hot Climates, L. Reynolds Apr 2025

Sheep And Goat Production In Hot Climates, L. Reynolds

Journal of Agricultural and Marine Sciences

This paper discusses the reasons for keeping small ruminants and investigates the areas in which technological improvements are likely to have most impact in increasing the output from sheep and goat enterprises in hot climates. The most important areas in which biological manipulation can raise productivity lie in the areas of improved nutrition and increased survival of young animals. Nutritional studies of animals receiving diets of natural tropical grazing and browse may not reflect the rations actually consumed due to the ability of animals to select high quality forage from what is on offer. One suggestion is made as to …

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Role Of Biotechnology In Animal Production Systems In Hot Climates, P. J. Hansen Apr 2025

Role Of Biotechnology In Animal Production Systems In Hot Climates, P. J. Hansen

Journal of Agricultural and Marine Sciences

Developments in the biological sciences in the last three decades have revolutionized mankind's ability to manipulate the genetics, cell biology and physiology of biological organisms. These techniques, collectively termed biotechnology, create the opportunity for modifying domestic animals in ways that markedly increase the efficiency of production. Among the procedures being developed for animal production systems are marker-assisted selection of specific alleles of a gene that are associated with high production, production of transgenic animals , super ovulation and embryo transfer, in vitro fertilization, embryo sexing and cloning, production of large amounts of previously-rare proteins through use of genetically -engineered bacteria …

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Optimizing Production Of Heat Stressed Broilers, R. G. Teeter Apr 2025

Optimizing Production Of Heat Stressed Broilers, R. G. Teeter

Journal of Agricultural and Marine Sciences

Broiler chickens are highly susceptible to heat stress during the time at which their growth rates ought to be highest. In order to overcome the deleterious effect of heat stress, consideration has to be given to ways in which the heat production of the bird and its ability to dissipate heat are brought into balance whilst still permitting the birds to eat and grow rapidly. Methods for adjusting this balance include changes in the micro environment of the birds, alterations to heat output by variations in the timing, quantity and quality of food and enabling the bird to maximize its …

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Validity And Relevancy Analysis: An Approach To The Admissions Of Experimental Evidence, Maine Law Review Apr 2025

Validity And Relevancy Analysis: An Approach To The Admissions Of Experimental Evidence, Maine Law Review

Maine Law Review

Rules of evidence in the common law system were developed to serve the fundamental purpose of minimizing erroneous factual conclusions by the jury. In pursuit of this goal, two guiding principles have been followed: first, that the jury should be provided with the most accurate and trustworthy information possible; second, that the flow of information to the jury should be controlled to exclude evidence which is irrelevant or otherwise misleading. Since the earliest cases in which the results of experiments were offered as evidence, American courts have treated experiments as a unique form of evidence but have found it difficult …

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Aqueous Extracts Of Zingiber Officinale Rhizomes And Hibiscus Sabdariffa Leaves Enhanced Plasmodium Berghei-Infected Mice's Hematological Parameters., Fatimah Aluko Abubakar, Raliat Abimbola Aladodo, Aremu Abubakar Apr 2025

Aqueous Extracts Of Zingiber Officinale Rhizomes And Hibiscus Sabdariffa Leaves Enhanced Plasmodium Berghei-Infected Mice's Hematological Parameters., Fatimah Aluko Abubakar, Raliat Abimbola Aladodo, Aremu Abubakar

Al-Bahir

Malaria remains a global health challenge, leading to severe hematological complications. Natural alternatives such as Zingiber officinale and Hibiscus sabdariffa, known for their antioxidant and bioactive properties, are being investigated for their therapeutic potential. This study examines the hematological benefits of Z. officinale and H. sabdariffa in mice infected with the common malaria research model, NK65 chloroquine-sensitive Plasmodium berghei. Forty-two albino mice, averaging 24.5 ± 1.23g, were randomly divided into six groups. Mice in group A were uninfected which served as the normal control group. Mice in groups B, C, D, E, and F were inoculated intraperitoneally with P. …

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Weekend Trip To Brisbane, Caley Haydu Apr 2025

Weekend Trip To Brisbane, Caley Haydu

2024-25 Postcards

Postcard from Caley Haydu, during the Linfield University Semester Abroad Program at Deakn University in Melbourne, Australia.

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The Curse Of El Dorado: How The Californnia Gold Rush Shaped The History Of Hawai'i, Ernesto Coronado Apr 2025

The Curse Of El Dorado: How The Californnia Gold Rush Shaped The History Of Hawai'i, Ernesto Coronado

Theses and Dissertations

In the discourse of Western historiography, we fail to account for the importance of the Hawai’ian Islands. American imperialism did not stop with the occupation of the Pacific Coast but continued into the Pacific. In the mid-nineteenth century, Hawai’i and its monarch, King Kamehameha III, stood at the center of a dispute between Britain, France, and the United States. King Kamehameha III used the California Gold Rush and Hawai’i’s location to his advantage to garner capital and prevent the imperial powers from annexing his kingdom. However, even he knew he could not stop the mass wave of Hawai’ians leaving the …

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Rewilding: Native Gardening For The Pacific Northwest And North Coast, Peter Haggard, Jane Monroe Apr 2025

Rewilding: Native Gardening For The Pacific Northwest And North Coast, Peter Haggard, Jane Monroe

Textbooks and Manuals Series

Think of this book as a tool that will guide you through the journey of transforming your yard or lawn into a resilient garden landscape filled with vibrant native plants and endemic wildlife. Dig into a new way of gardening—one that nurtures not just your plants, but the planet. This book is for gardeners who want to get their hands dirty while creating thriving habitats for native wildlife. Whether you’re replacing bird feeders with natural food sources, growing your own produce while boosting biodiversity, or transforming urban and suburban spaces into havens for indigenous species, this guide will inspire you …

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Alex Willoughby Full Interview Transcript, Urban Green Lab, Tennessee State University Apr 2025

Alex Willoughby Full Interview Transcript, Urban Green Lab, Tennessee State University

Hear from Alex Willoughby - Nashvillian in the Tornado's Path

No abstract provided.

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Cyber Physical Emulation Of Power Grids: Co-Simulation Of Exata Cps And Hypersim, Mckayla Snow Apr 2025

Cyber Physical Emulation Of Power Grids: Co-Simulation Of Exata Cps And Hypersim, Mckayla Snow

Electrical and Computer Engineering ETDs

This thesis explores the use of cyber-physical emulation of power grids to analyze the impact of different types of cyberattacks. It outlines the co-simulation process of HYPERSIM and EXata CPS within the OPAL-RT real-time digital simulator, demonstrating various cyberattacks on two power system models. The first model is a simple communication-focused testbed for easy demonstration of co-simulation setup, while the second is a power system model of a secondary network used to assess the cybersecurity of network protector units in low-voltage networks through a hardware-in-the-loop (HIL) testbed. Using this testbed, the cybersecurity of the direct transfer trip (DTT) scheme is …

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Dairy And Food Science Student Newsletter, April 08, 2025, Department Of Dairy And Food Science Apr 2025

Dairy And Food Science Student Newsletter, April 08, 2025, Department Of Dairy And Food Science

Dairy and Food Science Student Newsletter

No abstract provided.

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Genetic Variation Modulates Susceptibility To Aberrant Dna Hypomethylation And Imprint Deregulation In Naive Pluripotent Stem Cells., C Parikh, R A Glenn, Y Shi, K Chatterjee, K Kasliwal, Emily Swanzey, S Singer, S C Do, Y Zhan, Y Furuta, M Tahiliani, E Apostolou, A Polyzos, R Koche, J G Mezey, T Vierbuchen, M Stadtfeld Apr 2025

Genetic Variation Modulates Susceptibility To Aberrant Dna Hypomethylation And Imprint Deregulation In Naive Pluripotent Stem Cells., C Parikh, R A Glenn, Y Shi, K Chatterjee, K Kasliwal, Emily Swanzey, S Singer, S C Do, Y Zhan, Y Furuta, M Tahiliani, E Apostolou, A Polyzos, R Koche, J G Mezey, T Vierbuchen, M Stadtfeld

Faculty Research 2025

Naive pluripotent stem cells (nPSCs) frequently undergo pathological loss of DNA methylation at imprinted gene loci, posing a hurdle for biomedical applications and underscoring the need to identify underlying causes. We show that nPSCs from inbred mouse strains exhibit strain-specific susceptibility to locus-specific deregulation of imprinting marks during reprogramming and upon exposure to a mitogen-activated protein kinase (MAPK) inhibitor, a common approach to maintain naive pluripotency. Analysis of genetically diverse nPSCs from the Diversity Outbred (DO) stock confirms the impact of genetic variation on epigenome stability, which we leverage to identify trans-acting quantitative trait loci (QTLs) that modulate DNA methylation …

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Successful Leadership Strategies For Reducing Staff Turnover In Clinical Research Organizations, Tamala Burden Apr 2025

Successful Leadership Strategies For Reducing Staff Turnover In Clinical Research Organizations, Tamala Burden

Walden Dissertations and Doctoral Studies

High employee turnover in clinical research organizations (CROs) disrupts research continuity, increases operational costs, and threatens the timely execution of clinical trials. High employee turnover is a critical concern to CRO leaders, as excessive employee attrition can delay developing and delivering new patient therapies and threaten organizational performance. Grounded in social exchange theory, the purpose of this qualitative pragmatic inquiry was to identify and explore employee-focused strategies that CRO leaders use to reduce employee turnover successfully. Data collection included semistructured interviews with six purposively selected CRO leaders, supplemented by publicly available records to triangulate findings. Following Braun and Clarke’s 6-step …

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The Cardiovascular Care Of The Pediatric Athlete, Eli Friedman Apr 2025

The Cardiovascular Care Of The Pediatric Athlete, Eli Friedman

All Publications

Sports cardiology broadly encompasses the cardiovascular care of individuals who place a high premium on habitual exercise, sports performance, and/or sports competition. Some of the essential aspects within sports cardiology include the preparticipation cardiac evaluation and the management of cardiac diseases in athletes. Although most sports cardiology practitioners are trained in adult cardiology, a significant number of individuals who participate in sports are pediatric-aged, < 18 years old. Up to two-thirds of children in middle and high school participate in organized sports or are involved in nonorganized recreational sports. The cardiovascular care of pediatric-aged athletes can be challenging because many of the classic tenets and principles in adult sports cardiology do not fully generalize to pediatrics, and there is a lack of the evidence base that may be present for adult athletes. The epidemiology, presentation, and progression of cardiovascular diseases can be significantly different between pediatric and adult athletes. The evaluation of potential diseases and management considerations may also differ between pediatric and adult athletes. Similar to adults, there are "gray zones" where it is difficult to differentiate between normal exercise-induced cardiac remodeling and true cardiac pathology, but the additional lack of normative standards further complicates assessments in pediatric athletes. Management decisions for pediatric athletes are generally based on limited data but carry substantial short- and long-term implications. Thus, shared decision-making as part of the determination of clinical management strategies and for sports participation is critical and requires the participation of the parents or guardian(s). In this state-of-the-art review, key differences between pediatric and adult-aged athletes are highlighted. Specifically, how to define the "pediatric athlete," consider cardiovascular adaptations observed among pediatric athletes, determine preparticipation screening options and optimal symptom-driven evaluations in children, and consider best practices for pediatric athletes with several key cardiac conditions are detailed. The purpose of this document is to represent the first primary reference available to providers who care for pediatric athletes with cardiovascular concerns.

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Tumor-Derived Arachidonic Acid Reprograms Neutrophils To Promote Immune Suppression And Therapy Resistance In Triple-Negative Breast Cancer, Liqun Yu, Keziah Liebenberg, Yichao Shen, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Ling Wu, Weijie Zhang, Hilda L Chan, Bo Wei, Philip L Lorenzi, Yang Gao, Igor Bado, Luis Becerra-Dominguez, Charlotte Helena Rivas, Sergio Aguirre, Bradley C Pingel, Yi-Hsuan Wu, Yunfeng Ding, Jun Liu, David G Edwards, Livia S Eberlin, Xiang H-F Zhang Apr 2025

Tumor-Derived Arachidonic Acid Reprograms Neutrophils To Promote Immune Suppression And Therapy Resistance In Triple-Negative Breast Cancer, Liqun Yu, Keziah Liebenberg, Yichao Shen, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Ling Wu, Weijie Zhang, Hilda L Chan, Bo Wei, Philip L Lorenzi, Yang Gao, Igor Bado, Luis Becerra-Dominguez, Charlotte Helena Rivas, Sergio Aguirre, Bradley C Pingel, Yi-Hsuan Wu, Yunfeng Ding, Jun Liu, David G Edwards, Livia S Eberlin, Xiang H-F Zhang

Faculty, Staff and Students Publications

The combination of immune checkpoint blockade and chemotherapies is the standard of care for triple-negative breast cancer (TNBC). However, initially, responsive tumors can still develop recurrences, suggesting acquired resistance mechanisms that remain poorly understood. Herein, we discover that TNBC cells surviving anti-programmed cell death protein-1 (anti-PD-1) and chemotherapy treatment accumulate neutral lipids. Disrupting lipid droplet formation in cancer cells reverses resistance and mitigates the immunosuppressive microenvironment. Single-cell RNA sequencing reveals a subset of neutrophils exhibiting a lipid-laden phenotype similar to adjacent tumor cells. Mechanistically, tumor-derived extracellular vesicles carrying lipids, including arachidonic acid (AA), mediate neutrophil reprogramming. Blocking dietary intake of …

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Protpen: A Pipeline That Combines Sequence- And Structure-Based Approaches To Predict Protein Functions, Diya Mathai Apr 2025

Protpen: A Pipeline That Combines Sequence- And Structure-Based Approaches To Predict Protein Functions, Diya Mathai

Theses

Proteins of unknown function represent a significant gap in our understanding of biological processes, with many organisms, especially prokaryotes, harboring large portions of their proteomes that remain uncharacterized. For example, in Pseudomonas aeruginosa, a major human pathogen, a large proportion of proteins are categorized as unknown or hypothetical in function. The precise number varies across species, but studies have shown that up to 30–50% of proteins in bacterial proteomes can lack functional annotations. Addressing this gap is critical to understanding the biology and pathogenicity of such organisms. Recent advancements in computational tools, particularly those in sequence and structure-based prediction, offer …

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Protecting Global Health Partnerships In The Era Of Destructive Nationalism, Maya Adam, Desiree Labeaud, Nokwanele Mbewu, Jennifer Gates, Randall Waechter, Mercy Borbor-Cordova, Lydiah Kibe, Sonia Alvarez, Annie Dori, Anil Bilimale, Meggie Mwoka, Jessica Deffler, Michele Spring, Avriel Diaz, Rachael Farquhar, Willy Dunbar, Comfort Phiri, Valerie Luzadis, Nicole Redvers, Cristina Alonso, Rosemary Rochford, Rachel Lowe, Kareem Coomansingh, Moses Laman, Rebeca Sultana, Sadie Ryan, Amaya Bustinduy, Anita Hargrave-Bouagnon, Shazia Ruybal-Pesántez, Zebedee Kerry, Trevor Kelebi, Samuel Mcewen, Leanne Robinson, Maritza Salazar Campo, Till Bärnighausen Apr 2025

Protecting Global Health Partnerships In The Era Of Destructive Nationalism, Maya Adam, Desiree Labeaud, Nokwanele Mbewu, Jennifer Gates, Randall Waechter, Mercy Borbor-Cordova, Lydiah Kibe, Sonia Alvarez, Annie Dori, Anil Bilimale, Meggie Mwoka, Jessica Deffler, Michele Spring, Avriel Diaz, Rachael Farquhar, Willy Dunbar, Comfort Phiri, Valerie Luzadis, Nicole Redvers, Cristina Alonso, Rosemary Rochford, Rachel Lowe, Kareem Coomansingh, Moses Laman, Rebeca Sultana, Sadie Ryan, Amaya Bustinduy, Anita Hargrave-Bouagnon, Shazia Ruybal-Pesántez, Zebedee Kerry, Trevor Kelebi, Samuel Mcewen, Leanne Robinson, Maritza Salazar Campo, Till Bärnighausen

Department of Family & Community Medicine Faculty Papers

No abstract provided.

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The Unconstitutional Impact Of Anti-Transgender Legislation On Native Hawaiians, Aaliah Moi-Matsumoto Apr 2025

The Unconstitutional Impact Of Anti-Transgender Legislation On Native Hawaiians, Aaliah Moi-Matsumoto

Seattle Journal for Social Justice

No abstract provided.

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Gpat4 Sustains Endoplasmic Reticulum Homeostasis In Endocardial Cells And Safeguards Heart Development, Tianyang Zhao, Kuipei Jin, Xiaodong Wang, Xiong Su, Youjun Wang, Mingming Gao, Wen Luo, Hongyuan Yang, Zhongzhou Yang Apr 2025

Gpat4 Sustains Endoplasmic Reticulum Homeostasis In Endocardial Cells And Safeguards Heart Development, Tianyang Zhao, Kuipei Jin, Xiaodong Wang, Xiong Su, Youjun Wang, Mingming Gao, Wen Luo, Hongyuan Yang, Zhongzhou Yang

Faculty, Staff and Student Publications

The endocardium plays a pivotal role in governing myocardial development, and understanding the intrinsic regulatory insights will help apprehend pathological cardiomyopathy. Glycerol-3-phosphate acyltransferase 4 (GPAT4) is an endoplasmic reticulum (ER) membrane anchored protein. While the role of GPAT4 in glycerophospholipid biosynthesis is well established, its function in the ER is less explored. Here, we generate Gpat4 global and tissue-specific knockout mice and identify the essential role of GPAT4 in endocardial development. Deficiency of GPAT4 provokes endocardial ER stress response and enhances ER-mitochondrial (ER-mito) communications, leading to mitochondrial DNA (mtDNA) escape. As a result, the cGAS-STING pathway is triggered to stimulate …

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"In Art Things Are Either Necessary Or Superfluous", Fernando Zóbel De Ayala Apr 2025

"In Art Things Are Either Necessary Or Superfluous", Fernando Zóbel De Ayala

Perspectives in the Arts and Humanities Asia

No abstract provided.

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Molecular Subtyping Of Hypertensive Disorders Of Pregnancy, Michal Elovitz, Elaine Gee, Nathaniel Delaney-Busch, Alison Moe, Mitsu Reddy, Arkady Khodursky, Johnny La, Ilma Abbas, Kay Mekaru, Hunter Collins, Farooq Siddiqui, Rory Nolan, Rupsa Boelig, Daniel Kiefer, Pamela Simmons, George Saade, Antonio Saad, Ebony Carter, Thomas Mcelrath, Stephen Quake, Mark Depristo, Carrie Haverty, Manfred Lee, Eugeni Namsaraev, Vincenzo Berghella, Ai-Ris Collier, Antonia Frolova, Esther Park-Hwang, Luis Pacheco, Elizabeth Sutton, Maneesh Jain, Kara Rood, William A Grobman, Joseph Biggio, Cynthia Gyamfi-Bannerman, Arun Jeyabalan, Morten Rasmussen Apr 2025

Molecular Subtyping Of Hypertensive Disorders Of Pregnancy, Michal Elovitz, Elaine Gee, Nathaniel Delaney-Busch, Alison Moe, Mitsu Reddy, Arkady Khodursky, Johnny La, Ilma Abbas, Kay Mekaru, Hunter Collins, Farooq Siddiqui, Rory Nolan, Rupsa Boelig, Daniel Kiefer, Pamela Simmons, George Saade, Antonio Saad, Ebony Carter, Thomas Mcelrath, Stephen Quake, Mark Depristo, Carrie Haverty, Manfred Lee, Eugeni Namsaraev, Vincenzo Berghella, Ai-Ris Collier, Antonia Frolova, Esther Park-Hwang, Luis Pacheco, Elizabeth Sutton, Maneesh Jain, Kara Rood, William A Grobman, Joseph Biggio, Cynthia Gyamfi-Bannerman, Arun Jeyabalan, Morten Rasmussen

Department of Obstetrics and Gynecology Faculty Papers

Hypertensive disorders of pregnancy (HDP), including preeclampsia, affect 1 in 6 pregnancies, are major contributors to maternal morbidity and mortality, yet lack precision medicine strategies. Analyzing transcriptomic data from a prospectively-collected diverse cohort (n = 9102), this study reveals distinct RNA subtypes in maternal blood, reclassifying clinical HDP phenotypes like early/late-onset preeclampsia. The placental gene PAPPA2 strongly predicts the most severe forms of preeclampsia in individuals without pre-existing high risk factors, months before symptoms, and its overexpression correlates with earlier delivery in a dose-dependent manner. Further, molecular subtypes characterized by immune genes are upregulated in less severe forms of HDP. …

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Incorporating A Sustainable Eportfolio Model Within The Curriculum For Enhanced Professional Development: Building Bridges In Pharmacy Technician Education, Tao Zhang, Seána Hogan, Kathryn Young, Mary Therese Mcgrath, Jill Barrett, Julie Dunne Apr 2025

Incorporating A Sustainable Eportfolio Model Within The Curriculum For Enhanced Professional Development: Building Bridges In Pharmacy Technician Education, Tao Zhang, Seána Hogan, Kathryn Young, Mary Therese Mcgrath, Jill Barrett, Julie Dunne

Research Outputs: 2025-Present

No abstract provided.

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The Lynmouth Flood Disaster As A ‘Rural Enterprise Metabolic Rift’ And Securitising Rural Regions Against Future Hazards Of Planetary Collapse, Orlando Goodall Apr 2025

The Lynmouth Flood Disaster As A ‘Rural Enterprise Metabolic Rift’ And Securitising Rural Regions Against Future Hazards Of Planetary Collapse, Orlando Goodall

School of Law, Humanities and Social Sciences

This article advances a novel synthesis of two critical theoretical positions to reinterpret the Lynmouth flood disaster of 1952 – an event which caused the deaths of 34 people. Rural enterprise criminology and the metabolic rift concept are brought into dialogue to elaborate a foundation from which to articulate the multifactorial process that eventuated in the flood. The article fills an absence in the social sciences on the significant loss of life that moves beyond descriptive narratives of the tragedy and dated positivist epistemology. The article displaces determinist explanations of natural science and popular invocations of ‘acts of God’ and …

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The Cardiovascular Care Of The Pediatric Athlete, Peter N Dean, Julie A Brothers, Kristin Burns, Jonathan B Edelson, Susan Etheridge, Dermot M Phelan, Keri Shafer, Chris Snyder, Silvana Molossi, Alfred Danielian, Eli M Friedman, Jeff Hsu, Mustafa Husaini, Eugene H Chung, Matthew W Martinez, Aaron L Baggish, Benjamin D Levine, Jonathan H Kim, American College Of Cardiology Sports & Exercise Cardiology Council Apr 2025

The Cardiovascular Care Of The Pediatric Athlete, Peter N Dean, Julie A Brothers, Kristin Burns, Jonathan B Edelson, Susan Etheridge, Dermot M Phelan, Keri Shafer, Chris Snyder, Silvana Molossi, Alfred Danielian, Eli M Friedman, Jeff Hsu, Mustafa Husaini, Eugene H Chung, Matthew W Martinez, Aaron L Baggish, Benjamin D Levine, Jonathan H Kim, American College Of Cardiology Sports & Exercise Cardiology Council

Faculty, Staff and Students Publications

Sports cardiology broadly encompasses the cardiovascular care of individuals who place a high premium on habitual exercise, sports performance, and/or sports competition. Some of the essential aspects within sports cardiology include the preparticipation cardiac evaluation and the management of cardiac diseases in athletes. Although most sports cardiology practitioners are trained in adult cardiology, a significant number of individuals who participate in sports are pediatric-aged, < 18 years old. Up to two-thirds of children in middle and high school participate in organized sports or are involved in nonorganized recreational sports. The cardiovascular care of pediatric-aged athletes can be challenging because many of the classic tenets and principles in adult sports cardiology do not fully generalize to pediatrics, and there is a lack of the evidence base that may be present for adult athletes. The epidemiology, presentation, and progression of cardiovascular diseases can be significantly different between pediatric and adult athletes. The evaluation of potential diseases and management considerations may also differ between pediatric and adult athletes. Similar to adults, there are "gray zones" where it is difficult to differentiate between normal exercise-induced cardiac remodeling and true cardiac pathology, but the additional lack of normative standards further complicates assessments in pediatric athletes. Management decisions for pediatric athletes are generally based on limited data but carry substantial short- and long-term implications. Thus, shared decision-making as part of the determination of clinical management strategies and for sports participation is critical and requires the participation of the parents or guardian(s). In this state-of-the-art review, key differences between pediatric and adult-aged athletes are highlighted. Specifically, how to define the "pediatric athlete," consider cardiovascular adaptations observed among pediatric athletes, determine preparticipation screening options and optimal symptom-driven evaluations in children, and consider best practices for pediatric athletes with several key cardiac conditions are detailed. The purpose of this document is to represent the first primary reference available to providers who care for pediatric athletes with cardiovascular concerns.

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Nbeal2 Knockout Mice Are Not Protected Against Hypoxia-Induced Pulmonary Vascular Remodeling And Pulmonary Hypertension, Janelle N Posey, Mariah Jordan, Caitlin V Lewis, Christina Sul, Evgenia Dobrinskikh, Delaney Swindle, Frederik Denorme, David Irwin, Jorge Di Paola, Kurt Stenmark, Eva S Nozik, Cassidy Delaney Apr 2025

Nbeal2 Knockout Mice Are Not Protected Against Hypoxia-Induced Pulmonary Vascular Remodeling And Pulmonary Hypertension, Janelle N Posey, Mariah Jordan, Caitlin V Lewis, Christina Sul, Evgenia Dobrinskikh, Delaney Swindle, Frederik Denorme, David Irwin, Jorge Di Paola, Kurt Stenmark, Eva S Nozik, Cassidy Delaney

2020-Current year OA Pubs

Inflammation drives the initiation and progression of pulmonary hypertension (PH). Platelets, increasingly recognized as immune cells, are activated and increased in the lungs of patients with PH. Platelet activation leads to the release of α-granule chemokines, many of which are implicated in PH. We hypothesized that hypoxia-induced secretion of platelet α-granule-stored proteins and PH would be prevented in Neurobeachin-like 2 knockout (Nbeal2-/-) α-granule-deficient mice. Wild-type (WT) and Nbeal2-/- mice were maintained in normoxia or exposed to 10% hypobaric hypoxia for 3, 14, 21, or 35 days. We observed macrothrombocytopenia, increased circulating neutrophils and monocytes, and increased lung interstitial macrophages (IMs) …

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