Digital Commons Network^™

The Impact Of Consuming An Electrolyte Drink Pre Vs Post-Workout On Recovery As Measured Through Urinary Indicators In Collegiate Cross-Country Runners, Laura Taylor, Aidan Becher, Madelynn Struck, Momodou Colley

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

BACKGROUND: Hydration is crucial in sports, as dehydration can decrease strength, endurance, and power. Drinking electrolytes before and after intense exercise can promote hydration. Few studies have compared the difference in consuming electrolytes pre/post-workout. The impact of consuming electrolyte drinks can be assessed by comparing pre/post-workout urinary biomarkers (UB). PURPOSE: To determine if drinking electrolytes before/after a workout improves post-workout recovery as measured by heart rate (HR) and UB in collegiate Cross Country (CC) runners. METHODS: 21 CC runners (43% men, 20±3 years) were divided into four groups. For four weeks (Sep-Oct 2024), participants consumed Liquid IV (LIV) or a …

Foraging Efficiency Of Rural And Urban House Sparrows, Passer Domesticus, Among Natural And Unnatural Obstacles, Annie Waldron, Katie Kowalyk, Mara Gutierrez

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

Urbanization may lead to food displacement for many animals. Urban birds are exposed to man-made objects that can result in variable food locations, unlike rural birds who inhabit areas where food locations are typically consistent. The introduction of unnatural obstacles may affect a sparrow's ability to find and reach food sources. Scientific studies have yet to find a significant increase in problem-solving skills related to foraging in urban versus rural birds. Our research seeks to determine the foraging efficiency of rural and urban house sparrows when exposed to obstructed food sources. Novel objects near a food source may scare birds …

Hope College Abstracts: 24th Annual Celebration Of Undergraduate Research And Creative Activity, Hope College

24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity (2025)

The 24th Annual A. Paul and Carol C. Schaap Celebration of Undergraduate Research and Creative Activity was held on April 11, 2025 in the Richard and Helen DeVos Fieldhouse at Hope College and featured student-faculty collaborative research projects. This program is a record reflective of those projects between the 2024-2025 academic year.

Bird Observations Across Belmont's Campus, Jeremy T. Little, Josiah C. Mustaleski

SPARK Symposium Presentations

Over the course of 10 weeks our team collected data about bird sightings on Belmont’s campus. Sessions were recorded using eBird and Merlin Bird ID to correctly identify the birds and record accurate numbers. We conducted sessions at 3 different spots on campus, each with differing types and amounts of vegetation and human presence. These sessions were 20 minutes in duration and were conducted twice a week at each location. The data gathered was used to gain a better understanding of the bird trends and demographics on campus. This data was also used for WellCore events in conjunction with the …

Integrating Visual Pedagogies With The Digital Platform To Establish Authenticity As A Gold Standard In Chinese Ideological And Political Education, Ruiqian Su

USF Tampa Graduate Theses and Dissertations

This qualitative study investigates the role of visual pedagogies, including photo-elicitation via Xiaohongshu, in fostering authentic engagement in asynchronous discussions within Chinese Ideological and Political Education (CIPE). It examines both the pedagogical opportunities and challenges associated with integrating visual content—such as images, videos, and multimedia—into CIPE. In response to limitations in traditional CIPE teaching methods, particularly in promoting critical thinking and meaningful student interaction, the research explores how digital tools can enhance engagement and provide a culturally responsive framework for ideological education.

The study addresses two central research questions: (1) How do CIPE instructors perceive the role of visual pedagogies …

The Impact Of Perfusion Techniques On Inflammatory Response During Cardiopulmonary Bypass; A Scoping Review, Rodolfo Alfaro

Student Works

Background: Cardiopulmonary bypass (CPB) is an essential part of cardiac surgery, but it leads to SIRS (systemic inflammatory response syndrome) which in turn increases postoperative complications. There are many proposed approaches to reduce inflammation, but there is no clear best practice on the approach to use. This scoping review aims to explore the literature and classify the studies that investigate the effects of various CPB perfusion techniques on inflammatory responses to determine the possible best practices and the gaps that exist in the literature.

Methods: The present scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews …

The Level 2025-04, Nathan Leigh, Adam Zenger, Christena Leamer, Mardis Buness, David Lendrum, Greg George, Jakob Kryman, Kristin Reynolds

The Level

No abstract provided.

Characterization Of Fibrotic Liver Tissue Microstructure For Predicting Shear Wave Speed Variability: A Machine-Learning-Based Computational Study, Emily J. Miller, Yongmei M. Jin, Jingfeng Jiang

Michigan Tech Publications

Objective: This study aimed to establish a link between the microstructure of simulated fibrotic liver tissues and the measured shear wave speed variability using a machine-learning-based approach. Approach: Fibrotic liver tissues were simulated using biphasic random fields. The underlying microstructure of the simulated fibrotic liver pathology (sFLP) was characterized using spatial pattern distribution analysis.A machine learning (ML) technique was implemented to identify top-rated spatial characteristic (SC) features and provide context for shear wave speed (SWS) variability, ultimately enabling us to use the SWS variability to infer its underlying tissue microstructure. Different combinations of top-three features were tested to understand the …

Analysis Of Psychoactive Compounds In The Web-Building Behavior Of Mangora Maculata, Diane R. Castner

Undergraduate Honors Thesis Projects

The arachnid central nervous system (CNS) functions in an analogous way to the human CNS, despite spiders not having a central brain. Previous studies on spider behavior and web formation have investigated the impacts of stimulants, depressants, sedatives, and hallucinogens, but the impacts of serotonin reuptake inhibitors (SSRIs), such as fluoxetine are unknown. This study examined the impacts of caffeine, nicotine, ethanol, and fluoxetine on the web building behavior of Mangora maculata. Webs were characterized by 9 metrics: web entirety, size of web, radial angles, cell length, number of large holes, frequency of forking of spiral threads, radial angle consistency, …

Investigating The Effects Of Sex And Estrous Cycle On The Incubation Of Cue-Induced Oxycodone Craving, Bhumiben Pradipkumar Patel

Theses and Dissertations

The overprescription and misuse of opioids like oxycodone has played a significant role in the ongoing opioid crisis. While effective painkillers, drugs like oxycodone are also reinforcing and often misused. While sex and ovarian hormones can impact the analgesic effects of these drugs, the impact of these factors on oxycodone reinforcement are not fully understood. This relationship between ovarian hormones and opioid reward is further complicated by the fact that opioid use can disrupt ovarian hormone levels and produce reproductive cycle irregularities. Using a rat model of drug craving and relapse vulnerability, we found that chronic oxycodone exposure produced reproductive …

Volume Cxliv, Number 17, April 11, 2025, Lawrence University

The Lawrentian

No abstract provided.

Association Of Driving With Blood Delta-9-Tetrahydrocannabinol: A Systematic Review, Danial Behzad, Sampson Zhao, Reena Besa, Bruna Brands, Christine M. Wickens, Marilyn A. Huestis, Bernard Le Foll, Patricia Di Ciano

Institute of Emerging Health Professions Faculty Papers

IMPORTANCE: Driving under the influence of cannabis increases the risk of motor vehicle collisions. In some jurisdictions, deterrence rests on the ability to detect delta-9-tetrahydrocannabinol (THC) in blood. Recent evidence suggests that there may be a nuanced relationship of blood THC to driving.

OBJECTIVE: The purpose of this systematic review was to summarize all published papers investigating the presence of a linear relationship between blood THC and driving, primarily measured by simulated driving in the lab.

OUTCOMES: The main outcomes assessed included "weaving"/lateral control (eg, standard deviation of lateral position), speed, car following (following distance; coherence), reaction time, and overall …

Ahr Activation At The Air-Blood Barrier Alters Systemic Microrna Release After Inhalation Of Particulate Matter Containing Environmentally Persistent Free Radicals, Ankit Aryal, Ashlyn C. Harmon, Alexandra Noël, Qingzhao Yu, Kurt J. Varner, Tammy R. Dugas

School of Public Health Faculty Publications

Particulate matter containing environmentally persistent free radicals (EPFRs) is formed when organic pollutants are incompletely burned and adsorb to the surface of particles containing redox-active metals. Our prior studies showed that in mice, EPFR inhalation impaired vascular relaxation in a dose- and endothelium-dependent manner. We also observed that activation of the aryl hydrocarbon receptor (AhR) in the alveolar type-II (AT-II) cells that form the air-blood interface stimulates the release of systemic factors that promote endothelial dysfunction in vessels peripheral to the lung. AhR is a recognized regulator of microRNA (miRNA) biogenesis, and miRNA control diverse signaling pathways. We thus hypothesized …

Whole Genome Sequencing Analysis Of Body Mass Index Identifies Novel African Ancestry-Specific Risk Allele, Xinruo Zhang, Jennifer A Brody, Mariaelisa Graff, Heather M Highland, Nathalie Chami, Hanfei Xu, Zhe Wang, Kendra R Ferrier, Geetha Chittoor, Navya Shilpa Josyula, Mariah Meyer, Shreyash Gupta, Xihao Li, Zilin Li, Matthew A Allison, Diane M Becker, Lawrence F Bielak, Joshua C Bis, Meher Preethi Boorgula, Donald W Bowden, Jai G Broome, Erin J Buth, Christopher S Carlson, Kyong-Mi Chang, Sameer Chavan, Yen-Feng Chiu, Lee-Ming Chuang, Matthew P Conomos, Dawn L Demeo, Mengmeng Du, Ravindranath Duggirala, Celeste Eng, Alison E Fohner, Barry I Freedman, Melanie E Garrett, Xiuqing Guo, Chris Haiman, Benjamin D Heavner, Bertha Hidalgo, James E Hixson, Yuk-Lam Ho, Brian D Hobbs, Donglei Hu, Qin Hui, Chii-Min Hwu, Rebecca D Jackson, Deepti Jain, Rita R Kalyani, Sharon L R Kardia, Tanika N Kelly, Ethan M Lange, Michael Lenoir, Changwei Li, Loic Le Marchand, Merry-Lynn N Mcdonald, Caitlin P Mchugh, Alanna C Morrison, Take Naseri, Jeffrey O'Connell, Christopher J O'Donnell, Nicholette D Palmer, James S Pankow, James A Perry, Ulrike Peters, Michael H Preuss, D C Rao, Elizabeth A Regan, Sefuiva M Reupena, Dan M Roden, Jose Rodriguez-Santana, Colleen M Sitlani, Jennifer A Smith, Hemant K Tiwari, Ramachandran S Vasan, Zeyuan Wang, Daniel E Weeks, Jennifer Wessel, Kerri L Wiggins, Lynne R Wilkens, Peter W F Wilson, Lisa R Yanek, Zachary T Yoneda, Wei Zhao, Sebastian Zöllner, Donna K Arnett, Allison E Ashley-Koch, Kathleen C Barnes, John Blangero, Eric Boerwinkle, Esteban G Burchard, April P Carson, Daniel I Chasman, Yii-Der Ida Chen, Joanne E Curran, Myriam Fornage, Victor R Gordeuk, Jiang He, Susan R Heckbert, Lifang Hou, Marguerite R Irvin, Charles Kooperberg, Ryan L Minster, Braxton D Mitchell, Mehdi Nouraie, Bruce M Psaty, Laura M Raffield, Alexander P Reiner, Stephen S Rich, Jerome I Rotter, M Benjamin Shoemaker, Nicholas L Smith, Kent D Taylor, Marilyn J Telen, Scott T Weiss, Yingze Zhang, Nancy Heard-Costa, Yan V Sun, Xihong Lin, L Adrienne Cupples, Leslie A Lange, Ching-Ti Liu, Ruth J F Loos, Kari E North, Anne E Justice

Faculty, Staff and Student Publications

Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P <  5 × 10

Enhancing Frequency Event Detection In Power Systems Using Two Optimization Methods With Variable Weighted Metrics, Hussain A. Alghamdi, Midrar A. Adham, Umar Farooq, Robert B. Bass

Electrical and Computer Engineering Faculty Publications and Presentations

This research presents a novel technique that refines the performance of a frequency event detection algorithm with four adjustable parameters based on signal processing and statistical methods. The algorithm parameters were optimized using two well-established optimization techniques: Grey Wolf Optimization and Particle Swarm Optimization. Unlike conventional approaches that apply equally weighted metrics within the objective function, this work implements variable weighted metrics that prioritize specificity, thereby strengthening detection accuracy by minimizing false-positive events. Realistic small- and large-scale frequency datasets were processed and analyzed, incorporating various events, quasi-events, and non-events obtained from a phasor measurement unit in the Western Interconnection. An …

The Role Of Cholinergic Ventral Pallidum Cells In Effortful Motivation, Elizabeth A. Bien

Dartmouth College Ph.D Dissertations

Maladaptive reward-seeking behavior can be driven by one of several different components including excessive craving elicited by cues that predict rewards, failing to effortfully pursue rewards when it is beneficial to do so, and compulsively seeking rewards when it is no longer advantageous to do so. This thesis includes experiments focusing on these three different components of reward-seeking behavior to better understand how reward-seeking can become maladaptive. First, we wanted to examine the role that sex plays in the acquisition and compulsiveness of sign-tracking behavior in the Long Evans rat, a strain that is commonly used as the background for …

Global And Regional Disparities In Access To Specialist Sarcoma Services, Tomas Zamora, Eduardo Botello, Thomas Jenkins, Charlotte Jeys, Minna Laitinen, Ajay Puri, Lee Jeys, Boom Consensus Meeting Participants, Santiago Abad Repiso, Hesham Abdelbary, Alejandro Abiad Mejia, Ahmed Abood, Juan C Abril Martin, Adesegun Abudu, Ayman Abu Elhamd, Marthelena Acosta, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Ibrahim Alshaygy, Jose I Albergo, John Alexander, Patricio A Alfaro, Bugra Alpan, Jose Amaya-Valero, Megan Anderson, Dimosthenis Andreou, Lucas Annabell, Christopher Anthony, Ahmed Aoude, William Aston, Libe Asua Mentxaka, Christine Azzopardi, Thomas Baad-Hansen, Ismail T Badr, Francisco Baixauli-Garcia, Gavin Baker, Tessa Balach, Giacomo G Baldi, Janie Barry, Georges Basile, Stefano Bastoni, Mohammad H Basuki, Henrik Bauer, Lee Bayliss, Ricardo G Becker, Angad Bedi, Joseph Benevenia, Francisco Bengoa, Peter Bergh, Marko Bergovec, Nicholas Bernthal, Odion Binitie, David Boddie, Michele Boffano, Patricia Bonilla Huertas, Anna B Borgognoni, Rajesh Botchu, Richard A Boyle, Jos Bramer, Rahat Brar, Harriet Branford-White, Demien Broekhuis, Samuel E Broida, Tymoteusz Budny, Zachary D Burke, Jorge Cabrolier, Jose A Calvo-Haro, Jorge R Calvo-Tapies, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Pedro I Carvallo, Nicolas Casales Fresenga, Jose M Casanova, Oscar Ceballos, Juan L Cebrian Parra, Laura K Certain, Sara Chancon Cartaya, Chung M Chan, Yoon Joo Cho, Peter Choong, Yang-Guk Chung, David Ciechanowicz, David Clever, Sebastian Colina, Luis Consuegra, Cory Couch, Gillian Cribb, Carlos Cuervo, Laurence A Cusick, Solomon Dadia, Tanios Dagher, Dietmar Dammerer, Mark Davies, Nerys Davies, Luis P De La Rosa Martino, Francisco J De Santos De La Fuente, Marieke De Vaal, Claudia Deckers, Javier Delgado Obando, Shaneel Deo, Niklas Deventer, Claudia Di Bella, Gregory Domson, Davide M Donati, Desiree M Dorleijn, Jacques Du Toit, Debra Dunne, Rodolfo Duran Ciarrochi, Walid Ebeid, Elina Ekman, Ahmed M El Ghoneimy, Makoto Endo, Levent Eralp, Mahmoud Etaiwi, Scott Evans, Robin Evrard, Will Eward, Alberto Farese, Peter C Ferguson, Pedro F Ferreira Cardoso, Fabrice Fiorenza, Michael Flint, Hector Flores, Joao Freitas, Bruno Fuchs, Tomohiro Fujiwara, Philipp T Funovics, Marcos Galli Serra, Zakareya Gamie, Carlos Garces-Zarzalejo, Aaron Gazendam, Carsten Gebert, Jasper G Gerbers, Craig Gerrand, Ghaith Abou-Nouar, Michelle Ghert, Kanishka M Ghosh, Max Gibbons, Luis C Gomez-Mier, Jesus Gomez-Vallejo, Anne Gomez-Mascard, Marcos R Gonzalez, Fausto Gonzalez-Lizan, Georg Gosheger, Stuart Goudie, Krista Goulding, Stavros D Goumenos, Anthony Griffin, Ashish Gulia, Sanjay Gupta, Amit Gupta, Maurice Guzman, Mohammed Haitham, Jendrik Hardes, Francisco Hardoy, Yusuf Hasan, Georg Hauer, Helard Havard, Rex Haydon, John Healey, Nerea Hernandez Gonzalez, Adriana Hernandez-Lopez, Asle Hesla, Matthew Hess, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Matthew T Houdek, Eleanor Houghton, Oluwaseyi K Idowu, Joseph Ippolito, Marc Isler, Shintaro Iwata, Jake Jagiello, Neil Jenkins, Tom Jeys, Luke Johnson, Andy Johnston, Min Wook Joo, Paul C Jutte, Kadri Kaldas, Amar Kamat, Sudhir Kannan, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Vineet Kurisunkal, Richard Kyte, Jose M Lamo De Espinosa, Alexander L Lazarides, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Maryse Lejoly, Valerae O Lewis, Peng Lin, Francisco Linares, Santiago A Lozano-Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Fermin J Mandia Mancebo, Sara Martos Torrejon, Christian Marx, Eric Mascard, Jean-Camille Mattei, Louise Mccullough, Sam Mcmahon, Manuel R Medellin Rincon, Benjamin Miller, Shinji Miwa, Gustavo Molina Uribe, Bryan Moon, Thomas Hilton, Diego J Moriel Garcesco, Carol Morris, Guy Morris, Steward Morrison, Sophie Mottard, Marcio Moura, Linde Muster, Robert Nakayama, Prashant Narhari, Ana Navas, Prakash Nayak, Johannes Neugebauer, Erik T Newman, Jyrki Nieminen, Emmy Nyqvist, Lukas Nystrom, Sarah O'Reilly-Harbidge, Gary O'Toole, Vania Oliveira, André Olivier, Mohamed Omar, Eduardo J Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Elisa Pala, Emanuela Palmerini, Grant Pang, Panayiotis Papagelopoulos, Giovanni Paraliticci, Michael C Parry, Sam Patton, David Peake, Ana Peiro Ibanez, Israel Perez Munoz, Ganapathy R Perianayagam, Michael M Petersen, Joris Ploegmakers, Robin Pollock, Gerard Powell, Juan Pretell, Jan Puetzler, Faisal Qamar, Anand Raja, Raja B Rajasekaran, Dipak Ramkumar, R L Randall, Kenneth Rankin, Kevin A Raskin, Kumaran Rassppan, Lauris Repsa, Mickael Ropars, Peter Rose, Pietro Ruggieri, Wael Sadek, German Salcedo, Aasim Saleemi, Andrea Sambri, Hartej Sar, Roberto Scanferla, Thomas Schubert, Jan Schwarze, Guido Scoccianti, Ashley Scrimshire, Tetsuya Sekita, Ahmad Shehadeh, Ahmed Shoaib, Bhim Shreemal, Felix Shumelinsky, Geoffrey Siegel, Claudio Silveri, Robert Silverwood, Friedl Sinnaeve, Jerome Sison, Andrea Slade, Maria A Smolle, Franz Snyman, Scott Sommerville, Sahil Sood, Andre Spiguel, Hugo St-Yves, Eric L Staals, Silvia Stacchiotti, Nikolas Stavropoulos, Peter Steadman, Jonathan D Stevenson, Mikaela Sullivan, Gwen Sys, Bartlomiej Szostakowski, Angela Tamburini, Yuta Taniguchi, Thomas Temple, Christoph Theil, Joachim Thorkildsen, Meagan Tibbo, Roger Tillman, Yu Toda, Kaspar Tootsi, Ferran Torner-Rubies, Frank Traub, Ioannis Trikoupis, Panagiotis Tsagkozis, Kim Tsoi, Hiroyuki Tsuchiya, Veli-Matti Vainio, Antonio Valcarcel, Juan Valencia, Annelies Van Beeck, Michiel Van De Sande, Thomas Van Den Berghe, Ingrid Van Der Geest, Lizz Van Der Heijden, Robert Van Der Wal, Kirsten Van Langevelde, Gualter Vaz, Roberto Velez Villa, Floortje Verspoor, Koenraad Verstraete, Julia Visgauss, Oleg Vyrva, Hazem Wafa, Sebastian Walter, Wan F Wan Ismail, Edward Wang, Patrick Q Wang, David Warnock, Joel Werier, Wolfram Weschenfelder, Kwok-Chuen Wong, Marjan Wouthuyzen-Bakker, Jay Wunder, Indica Wysinghe, Norio Yamamoto, Zhaoming Ye, Seung-Jae Yoon, Suraya Zainul Abidin, Pierluca Zecchetto, Liuzhe Zhang, Juan P Zumarraga, Miguel A Clara-Altamirano

Faculty, Staff and Student Publications

Aims: Cancer care guidelines have been developed in many subspecialities, usually in advanced health systems. However, there are notable global disparities in healthcare access, which can impact sarcoma care. Unfortunately, there is a lack of global data on this subject. Our aim was to describe access to sarcoma care based on a comprehensive global survey among orthopaedic oncologists, and assess for global as well as regional differences.

Methods: A 25-question survey was emailed to the attendees of the 2024 Birmingham Orthopaedic Oncology Meeting and included questions about the respondents' training and practice, access to sarcoma centres, and specific items for …

Natural Killer Cells’ Functional Impairment Drives The Immune Escape Of Pre-Malignant Clones In Early-Stage Myelodysplastic Syndromes, Juan Jose Rodriguez-Sevilla, Irene Ganan-Gomez, Bijender Kumar, Natthakan Thongon, Feiyang Ma, Kelly S Chien, Yi J Kim, Hui Yang, Sanam Loghavi, Roselyn Tan, Vera Adema, Zongrui Li, Tomoyuki Tanaka, Hidetaka Uryu, Rashmi Kanagal-Shamanna, Gheath Al-Atrash, Rafael Bejar, Pinaki Prosad Banerjee, Sophia Lynn Cha, Guillermo Montalban-Bravo, Max Dougherty, Maria Claudina Fernandez Laurita, Noelle Wheeler, Baosen Jia, Eirini P Papapetrou, Franco Izzo, Daniela E Dueñas, Salome Mcallen, Yiqian Gu, Gabriele Todisco, Francesca Ficara, Matteo Giovanni Della Porta, Abhinav Jain, Koichi Takahashi, Karen Clise-Dwyer, Stephanie Halene, Maria Teresa Sabrina Bertilaccio, Guillermo Garcia-Manero, May Daher, Simona Colla

Faculty, Staff and Student Publications

Dissecting the preneoplastic disease states' biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic stem cells (HSCs), most of which are mutated by the time of diagnosis. Here, we sought to elucidate how MDS HSCs evade immune surveillance and expand in patients with clonal cytopenias of undetermined significance (CCUS), the pre-malignant stage of MDS. We used multi-omic single-cell approaches and functional in vitro studies to show that immune escape at disease initiation is …

Histone H3 Cysteine 110 Enhances Iron Metabolism And Modulates Replicative Life Span In Saccharomyces Cerevisiae, Chen Cheng, Brenna S Mccauley, Nedas Matulionis, Maria Vogelauer, Dimitrios Camacho, Heather R Christofk, Weiwei Dang, Nicholas A T Irwin, Siavash K Kurdistani

Center on Aging Staff Publications

The discovery of histone H3 copper reductase activity provides a novel metabolic framework for understanding the functions of core histone residues, which, unlike N-terminal residues, have remained largely unexplored. We previously demonstrated that histone H3 cysteine 110 (H3C110) contributes to cupric (Cu2+) ion binding and its reduction to the cuprous (Cu1+) form. However, this residue is absent in Saccharomyces cerevisiae, raising questions about its evolutionary and functional significance. Here, we report that H3C110 has been lost in many fungal lineages despite near-universal conservation across eukaryotes. Introduction of H3C110 into S. cerevisiae increased intracellular Cu1+ levels and ameliorated the iron …

Impacts Of Riverine Heatwaves On Rates Of Ecosystem Metabolism In The United States, Spencer J. Tassone, Michelle Kelly, Olivia N. Beidler, Michael L. Pace, Amy Marcarelli

Michigan Tech Publications

Rivers produce and decompose large amounts of carbon globally due, in part, to high rates of gross primary production (GPP) and ecosystem respiration (ER), collectively known as ecosystem metabolism. Water temperature is a major driver of ecosystem metabolism, and in-stream temperatures are increasing globally, including extreme temperature events called heatwaves. This study used published estimates of daily GPP and ER from 48 stream and river locations in the United States to examine how ecosystem metabolism responds to riverine heatwaves. During low-severity heatwaves, GPP and ER increase proportionally, resulting in no net difference. However, during severe and extreme heatwaves, GPP declined …

Applications Of Clustered Regularly Interspaced Short Palindromic Repeats In Food Security And Nutraceuticals, Rukayat Abiodun Oyegoke, Jahswill Toluwanimi Osifade, Adenike Temidayo Oladiji

Al-Bahir

The CRISPR/Cas9 system is a revolutionary genome-editing tool that enables precise and inheritable modifications, transforming plant genetic engineering. Previous literature has indicated that, in agriculture, CRISPR has improved crop yield, biofortification, and resistance to environmental stressors, fostering resilient and high-yielding crops essential for sustaining a growing global population. In nutraceuticals, CRISPR has enhanced the biosynthesis of bioactive compounds such as anthocyanins, flavonoids, and omega-3 fatty acids, improving the nutritional and therapeutic value of crops.

Despite its immense potential, CRISPR technology faces technical, ethical, and regulatory challenges, including off-target effects, accessibility concerns, and public acceptance. Addressing these issues is crucial for …

Talking Trash: The Development Of International Legal Governance Over Marine Plastic Pollution, Olivia B. Berryman

Global Tides

Increasing amounts of marine plastic pollution entering into the ocean endangers the lives of sea animals, harms the health of human seafood consumers, degrades the marine ecosystem, and contributes to climate change. Despite these consequences, there remains no international legally binding treaty that is solely devoted towards mitigating marine plastic pollution. While there are current treaties in place that have created some regulations to control the entrance of marine plastics into the ocean, none have achieved significant reduction and prevention of the issue due to flaws such as weak enforcement mechanisms and lenient restrictions on ocean dumping. Thus, this research …

After The Economic Downfall At The Coastal Frontier: A Portrait Of Women Persisting Amidst Sea Abrasion In Northern Bekasi, Muhammad R. A. Ghifari, Gilang Mahadika

Antropologi Indonesia

This article explores the socio-environmental transformations in Muara Gembong, a coastal frontier in northern Bekasi, Indonesia, that once thrived as a hub for shrimp and milkfish farming but is now grappling with environmental degradation and economic decline. By drawing on feminist political ecology (FPE), the study examines how women in the region have adapted to the deteriorating environment, driven by coastal erosion, mangrove loss, and the collapse of fish pond businesses. While men traditionally dominated the local economy as aquaculturists, women have assumed critical roles in sustaining household livelihoods through creative economic activities, such as weaving wlingi laut (Cyperus malaccensis) …

Painted Hognose, Sophia Charles

Research & Creativity Showcase

Due to fear and false information, snakes often get a bad reputation for being… Well, snakes. People who are cruel and untrustworthy are sometimes referred to as “snakes” however this is a misrepresentation of a snake’s nature. My first pet snake was a Western Hognose Snake (Heterodon nasicus) that showed me how wonderful and inquisitive snakes truly are. I’ve been caring for snakes for over a decade and it’s a special experience to have an animal that is normally reclusive and fearful to grow to trust and interact with you.

Painted Hognose is my homage to these beautiful and misunderstood …

Simpleberry, Mark Eresanara

Research & Creativity Showcase

Sweetness has always been something I’ve gravitated toward—not just in flavor, but in feeling. With Simple Berry, I wanted to explore how something as small as a jar of jam can bring comfort, familiarity, and joy into people’s daily lives. This project gave me the chance to blend visual storytelling with brand identity in a way that feels both playful and grounded.

The campaign uses visual metaphor as a central unifier, inspired by nature’s purest instinct: attraction to sweetness. I chose animals like the bee, butterfly, and hummingbird—creatures naturally drawn to nectar—to mirror how consumers are drawn to the jam …

Interwoven Lives: A Historical Journey, Aimee Cordova

Research & Creativity Showcase

In this exhibition, "Interwoven Lives," I explore the profound and ongoing relationship between humans and animals throughout history. This collection of paintings delves into the intricate connections that have shaped our shared existence and reflects on how these bonds have evolved. From the earliest cave paintings to contemporary art, artists have depicted the relationship between animals and humans. These artworks serve as a testament to the significance of animals in our lives as companions, symbols, spiritual beings, partners in warfare, food sources, and sources of inspiration. By studying the history of different cultures’ relationships with animals, we gain insight into …

Sounds Of Battle And Battle Of Sounds: Belliphonic In Tolkien, Ali Mirzabayati

Journal of Tolkien Research

This paper explores the concept of the belliphonic—a term denoting the acoustic dimensions of warfare—within the context of J.R.R. Tolkien’s The Hobbit, focusing on the Battle of the Five Armies. While modern war studies have mainly centered on the mechanized soundscapes of twentieth-century conflict, this study engages with recent scholarly efforts to recover the sonic textures of medieval battle. Drawing on theories of wartime acoustics and examples from medieval literature, the paper examines how Tolkien, informed by his expertise in Old and Middle English texts and his lived experience in World War I, crafts a dynamic and psychologically …

How Taste Shaped The Use Of Botanical Drugs, Marco Leonti

Oxford ICSB

The perception of taste and flavour (a combination of taste, smell and chemesthesis) also referred to as chemosensation, enables animals to find high-value foods and avoid toxins. Humans have learned to use unpalatable and toxic substances as medicines, yet the importance of chemosensation in this process is poorly understood. We generated tasting-panel data for botanical drugs and applied phylogenetic generalised linear mixed models to test whether intensity and complexity of chemosensory qualities as well as particular tastes and flavours can predict ancient Graeco-Roman drug use. We found chemosensation to be strongly predictive of therapeutic use: botanical drugs with high therapeutic …

The Relevance Of Gut Microbiota For The Activity Of Herbal Drugs, Rudolf Bauer

Oxford ICSB

Despite intensive research, the active principles and mechanisms of action of many herbal drugs are still not clear. Moreover, the bioavailability of many polar plant constituents is rather limited, why they are not likely to act systemically. Therefore, alternative approaches to explain their activity have to be considered. Gut microbiota and the human body form a symbiosis which is essential for our health and well-being. Dysbiosis can lead to various diseases, like inflammation, obesity, asthma, diabetes, and even cancer. Therefore, gut microbiota are a relevant target for herbal drugs, and may help to understand their effects. For example, Faecalibacterium prausnitzii …

Heavy Metals In Healthy Water Samples Used By Newborn In Al-Najaf Governorate, Iraq, Ban Hussein Ali, Ali Abid Abojassim

Al-Bahir

Water is essential for life, so monitoring water quality is important. This research focuses on measuring heavy metals (Lead, Pb; Cadmium, Cd; Chromium, Cr (in 14 healthy water samples of two types; bottled water and filtered water used by newborn children in Al-Najaf governorate, Iraq. Atomic absorption spectroscopy (AA-7000, Japan) was used to conduct the experimental analysis. Also, health risks parameters (non-carcinogenic and carcinogenic) due to Pd, Cd, and Cr concentrations were calculated. The results of Pb, Cd, and Cr concentrations in mg/L for bottled water samples were ranged 0.03-0.83, 0.01-0.69, and 0.01-0.76, respectively, while the range values for filter …