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Mhc Class I Tyrosine Phosphorylation Site Y320 Augments Cd8+ T Cell Priming, Effector Function, And Memory Response, Yimo Sun, Gregory A Lizee, Yitao Tang, Priscilla Ortiz, R Eric Davis

Dissertations and Theses (Open Access)

The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K^b had reduced capacity to generate K^b-restricted cytotoxic T lymphocyte (CTL) responses following viral infection, due (at least in part) to defects in endolysosomal trafficking of H-2K^b and antigen cross-presentation by dendritic cells (DCs). In this study, we investigated whether there are additional, post-presentation dependencies on Y320 for T-cell priming. We engineered both human- and mouse-derived antigen-presenting cells (APCs) to express either wild-type MHC-I or variants of …

Neural Activity Within And Between Visual And Executive Areas Is Modulated Post-Locomotion In Rhesus Macaques, Sergey Egranov

Dissertations and Theses (Open Access)

Physical activity has been shown to benefit cognitive and mental health by improving cerebrovascular perfusion and regulating hormone-mediated processes on a systemic level. However, the acute effects of physical activity, such as locomotion, on the neuronal circuits underlying cognitive processes have yet to be fully characterized. This body of work seeks to rectify this gap in knowledge through analysis of how both behavioral performance and neuronal activity signatures in visual and executive brain regions are modulated post-locomotion in rhesus macaques.

To this end, we performed high-yield electrophysiological recordings simultaneously from area V4, a mid-tier visual cortical region, and the dorsolateral …

Investigating Metabolic And Mitochondrial Adaptations Triggered By Blood Flow During The Endothelial-To-Hematopoietic Transition, Paulina Horton

Dissertations and Theses (Open Access)

Hematopoietic stem cell (HSC) transplant is the standard of care for many hematologic diseases. However, many patients cannot benefit from this potentially curative treatment because they cannot find a suitable donor, contributing to a high level of unmet need. Recently, bona fide HSCs capable of robust engraftment and differentiation have been generated from iPSCs utilizing wall shear stress (WSS) to help promote HSC generation. However, the mechanisms through which WSS regulates hematopoiesis remain poorly understood. Scientists, therefore, continue to look for the mechanotransduction pathways that promote hematopoiesis, and key answers may lie in examining the role of extrinsic factors that …

Differential Progression Of Pancreatic Premalignancy In Geographically Distant Murine Transgenic Cohorts Uncovers Key Role Of Microbial Metabolites, Rian M. Howell

Dissertations and Theses (Open Access)

Cancer is a leading cause of death worldwide. Despite recent advances in diagnostic and therapeutic modalities, pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that remains highly lethal. Efforts have been made to increase the understanding of the underlying mechanisms driving early stages of tumor development, when the cancer is most susceptible to intervention. To this end, genetically engineered mouse models (GEMMs) have been developed with the mutations most commonly seen in the patient population. Expression of these mutations in select cellular compartments has resulted in the ability to recapitulate characteristics of human pancreatic cancer such as the development of …

The Dynamics Of Power Transfer In Organizations: Examining Downward Deference And Its Workplace Consequences, Hoang Bao My Nguyen

Dissertations and Theses Collection (Open Access)

This dissertation examines managerial power transfer as a core mechanism through which less-hierarchical management unfolds in organizations. While traditional management research has emphasized formal authority and top-down control, emerging organizational forms increasingly call on managers to share power with subordinates. Despite growing interest in constructs like empowerment, delegation, and participative leadership, the phenomenon of power transfer remains conceptually fragmented and undertheorized.

To address this, the dissertation defines power transfer as the intentional redistribution of authority, control, or resources by powerholders to lower-power individuals. Chapter 1 develops a typology of power transfer behaviors, organized along two key dimensions: extent of control …

The Sheriff's Constitution, Farhang Heydari

Vanderbilt Law School Faculty Publications

The county sheriff is unique among our nation's law enforcers, with an ancient pedigree, elected status, and special protections as a state constitu- tional officer. But these factors combine to cause a recurrent problem elected sheriffs often assert for themselves the power to refuse to enforce criminal laws of their choosing. Today's constitutional sheriffs-a group of sheriffs who view themselves as the highest authority in their county, answerable only to their electorate-are the latest manifestation of this ethos, declaring opposition to gun control measures, pandemic restric- tions, environmental protections, and more. Lest one think these nonen- forcement decisions are entirely …

Dumy And The Nation: How Folklore And Folk Songs Help Compose A Distinct Ukrainian Narrative, Amy Herd

FCRH Honors Program Theses

Historiography and ethnography have played a critical role in the development of modern Slavic nationalisms, particularly in Ukraine. As these studies became increasingly popular in the nineteenth century, scholars and members of the bourgeoisie identified folk culture as the key component for the making of the modern nation. Viewed as an authentic window into national history and tradition due to their limited interaction with the modernizing world, rural folk offered the perfect opportunity to illustrate how Ukraine had always been distinct from Russia and its other historical oppressors. As folk culture fervor gripped the intellectual elite of Eastern Europe, however, …

The Evolving Changes In The Regionalization Of Export Bans On U.S. Poultry Trade From The 2015 And 2022 Highly Pathogenic Avian Influenza Events, Kylie A. Roesler

Graduate Theses and Dissertations

As food security becomes a growing concern worldwide in a trading system dominated by globalization, the safeguarding of a bio-secure food system is at risk. One of the greatest risks to this stability of the system is, highly pathogenic avian influenza or HPAI which is growing in frequency and impact. Therefore, the global response to disease events is evolving into a newfound understanding of disease prevalence across the animal protein industries. This study will analyze the 2022 HPAI event in the United States regarding the regionalization of restrictions imposed by trading partners accounting for trade agreements executed. The examination of …

Evaluating Bone Fracture Healing In A Rabbit Model Using Doppler Imaging Modes, Shear Wave Elastography, X-Ray, And Dual-Energy X-Ray Absorptiometry, Priscilla Machado, Rachel Blackman, Ji-Bin Liu, Collleen Dempsey, Flemming Forsberg, Traci Fox

Department of Radiology Faculty Papers

OBJECTIVE: This study investigated methods of evaluating the bone fracture healing process using superb microvascular imaging (SMI; two modes color SMI [cSMI] and monochromeSMI [mSMI]), and shear wave elastography (SWE), relative to X-ray, dual-energy X-ray absorptiometry (DXA), and platelet endothelial cell adhesion molecule 1 (PECAM-1) also know as cluster of differentiation 31 (CD-31) staining in a rabbit model.

METHODS: This IACUC-approved study involved eight rabbits that underwent a bilateral fibula osteotomy and were followed for 7 or 21 days (Groups 1 and 2 with 4 rabbits in each). Ultrasound examinations using cSMI, mSMI, and SWE were performed on Days 0, …

The Backdrop Of Leadership: How Environmental Awe Influences Charisma Attributions, Jack Mcguire, Nicolas Bastardoz, Leonie J. Hentrup, David De Cremer, Jochen I. Menges

Research Collection Lee Kong Chian School Of Business

Charisma is often attributed to leaders based on how they look, talk, and behave. Yet very little is known about the role of the physical environment in influencing attributions of leader charisma. The role of the physical environment is crucial because leaders inevitably occupy physical spaces that vary across contexts. In this research, we find that the grandeur of the physical environment, specifically in its ability to induce awe, enhances attributions of charisma for leaders who are not already known to be charismatic. First, in a field experiment, we show that a real business leader is attributed with more charisma …

Factors Associated With Men’S Skincare Sales At Shopee Indonesia E-Commerce, Muhamad H. Effendi, Lalu E.H Mulyono

Pharmacology and Clinical Pharmacy Research

Men's skincare use is increasing, along with the awareness of its importance. Shopee, as one of the largest e-commerce platforms in Indonesia, has become the main place for purchasing men's skincare products. However, study on the factors influencing men's skincare sales at e-commerce is still limited. This research aims to identify the factors associated with men's skincare sales at Shopee Indonesia e-commerce. A cross-sectional study, utilizing data from the 100 best-selling men's skincare products on Shopee until September 2024, was conducted. The dependent variable is the number of men's skincare sales, and the independent variables are the number of reviews, …

Effect Of Yellow Root Ethanol Extract (Fibraurea Tinctoria Lour.) On Liver Histopathology Of Paracetamol-Induced Male Swiss Webster Mice, Astina Safari, Juwita Ramadhani, Muhammad Fauzi, Rizki R. Pratama

Pharmacology and Clinical Pharmacy Research

The public most commonly uses paracetamol, an analgesic antipyretic drug available over-the-counter without a doctor's prescription. The use of toxic doses can cause centrilobular necrosis, where paracetamol will form excessive N-acetyl-p-benzoquinone-imine (NAPQI), causing there to be insufficient glutathione to convert NAPQI into non-toxic compounds. The antioxidant activity of yellow root (Fibraurea tinctoria Lour.) can shield the liver from paracetamol-induced liver damage. This study aims to determine the hepatoprotective effect of an ethanol extract of yellow root (Fibraurea tinctoria Lour.) on the liver histopathology picture of mice (Mus muscular) induced by paracetamol. The study used 30 mice divided into six groups, …

Brand Media And Health Perceptions: A Thematic Analysis Of Generational Differences, Julie Irene Diaz

Electronic Theses and Dissertations

This thesis explores the influence of brand identity and media on shaping evolving perceptions of health across generations. The three generations considered are Generation X, Millennials, and Generation Z. The initial hypothesis predicted the popular media and brands that each generation interacts with are most likely to influence their perception. Additionally, the health brands most popular with each generation would influence their overall health perception, based on the identity and values of the brand. A qualitative study was conducted using focus groups to gather data about health perceptions, brand identity, media influence, and holistic health. The findings suggest that individuals …

Immersive Influence: Examining The Impact Of Virtual Reality On Brand Perception Among The Innovation Generation, Holden Gaylor

Electronic Theses and Dissertations

Now more than ever, brands must create innovative and engaging experiences to enhance perception and build consumer trust. Virtual reality (VR) offers an opportunity for brands to achieve these goals by providing immersive, interactive experiences that, when done right, can strengthen key brand metrics. Despite the growing use of VR in experiential marketing, research on VR’s effectiveness in shaping brand perception and influencing authenticity remains limited. Grounded in media richness theory, this study examined how VR impacts brand perception and whether media richness influences authenticity.

Using a mixed-methods approach, 20 participants engaged with the “Wendyverse,” a branded VR environment. Pre-, …

Investigating The Role Of The Hypocretin/Orexin System In A Novel Model Of Polysubstance Dependence, Tyler Zarin

Electronic Theses and Dissertations

Substance use disorders (SUD) in the United States are steadily increasing. Potent and dangerous substances such as methamphetamine (MA) and fentanyl (FEN) are often co-used as a polysubstance (POLY), either intentionally or unknowingly as FEN is a common adulterant. SUD is characterized by physiological and psychological dependence involving the negative reinforcement of anhedonia and withdrawal which drive hypermotivated drug-taking behaviors. Current theory suggests that recruitment of hypocretin/orexin (HCRT) neuropeptide in reward and stress associated brain regions contributes to drug dependence. Despite strong evidence for HCRT’s role in mono-drug dependence, a relevant model for POLY dependence has yet to be developed, …

Intraspecific Genetic Variation In Green Salamanders (Aneides Aeneus) At Bays Mountain Park, Brianna Drake

Electronic Theses and Dissertations

Accurate taxonomy is crucial for conserving vulnerable cryptic species like the green salamander (Aneides aeneus) in the Southern Appalachian Mountains. Prior studies identified three distinct lineages within the A. aeneus complex: Northern Appalachians, Southern Appalachians, and Blue-Ridge Escarpment. One previously collected sample indicated green salamanders in northeast Tennessee fit within the Northern lineage. The present study uses molecular data of A. aeneus at Bays Mountain Park (BMP) in Kingsport, Tennessee, to determine where the BMP population fits within these lineages. It was hypothesized that individuals from BMP belong in the northern lineage. Tail tips were collected from thirty-four …

Shared Roles Of Immune And Stromal Cells In The Pathogenesis Of Human Bronchiolitis Obliterans Syndrome, Patrick W. Mellors, Ana N. Lange, Bruno Casino Remondo, Maksim Shestov, Joseph D. Planer, Andrew R. Peterson, Yun Ying, Su Zhou, Jason D. Christie, Joshua M. Diamond, Edward Cantu, Maria C. Basil, Saar Gill

Surgery Faculty Publications

Bronchiolitis obliterans syndrome (BOS) is a progressive, fatal obstructive lung disease that occurs following lung transplant, where it is termed chronic lung allograft dysfunction BOS (CLAD-BOS), or as the primary manifestation of pulmonary chronic graft versus host disease (cGVHD-BOS) following allogeneic hematopoietic stem cell transplant. Disease pathogenesis is poorly understood; however, chronic alloreactivity is common to both conditions, suggesting a shared pathophysiology. We performed single-cell RNA-Seq (scRNA-Seq) on explanted human lungs from 4 patients with CLAD-BOS, 3 patients with cGVHD-BOS, and 3 deceased controls to identify cell types, genes, and pathways enriched in BOS to better understand disease mechanisms. In …

Bridging The Gap Between Occupational Therapy & Animal-Assisted Therapy (Aat), Aspen Campbell Smith

Occupational Therapy Doctoral Capstones

The Doctoral Capstone Project involves developing advocacy resources to support occupational therapy practitioners in the ethical, safe, and effective integration of animal-assisted therapy (AAT) into clinical practice. The tools aim to increase practitioner awareness, support ethical decision-making, and promote client-centered, evidence-based animal-assisted therapy services.

Rooted In Play: Empowering Development Through Nature-Based Occupational Therapy, Nicole Roper

Occupational Therapy Doctoral Capstones

The doctoral capstone project included advocating for the use of outdoor play by identifying and emphasizing the benefits of occupational therapy (OT) involvement within nature-based therapy for pediatric patients and creating nature-based therapy recourses for caregivers and occupational therapists.

Utilizing Animal-Assisted Therapy To Address Pyschosocial Implications Of The Geriatric Population In A Residential Facility, Blaire Kennon Bassham

Occupational Therapy Doctoral Capstones

Older adults in residential care frequently experience psychosocial challenges such as isolation, depression, and reduced engagement in meaningful activity. Animal-Assisted Therapy (AAT), when integrated into occupational therapy, offers a powerful, evidence-based means to address these concerns by promoting emotional well-being, social connection, and purposeful interaction. This capstone project leveraged AAT as a therapeutic intervention specifically designed to meet psychosocial needs.

Impacts Of Reef Fish Length On Foraging Radius: Exploring Behavioral Patterns Within A Patch Reef Ecosystem, Kilia Brawand

Undergraduate Honors Capstone Projects

Reef fish exhibit various behaviors upon the Great Barrier Reef. One of these behaviors includes that of limiting their grazing distances from a patch reef refuge to a certain maximum distance in order to avoid predators. This is defined as a ‘foraging radius’ or ‘margin of safety’. This ‘foraging radius’ varies among fish due to many factors- including species, morphology, ontogenesis, habitat complexity, and importantly: speed. Quicker fish can outswim predators to safety more efficiently than slower fish, and can therefore afford to travel farther distances to forage. Speed varies among fish for a number of reasons, including fish size …

Insights Into The Role Of The Glymphatic System In The Pathogenesis Of Post-Hemorrhagic Hydrocephalus, Ahmed T Massoud, Dillon A Noltensmeyer, Jenifer Juranek, Charles S Cox, Fred Christian Velasquez, Banghe Zhu, Eva M Sevick-Muraca, Manish N Shah

The Brown Foundation: Institute of Molecular Medicine

Recently, it has been well-established that the glymphatic or glial-lymphatic system plays a vital role in the pathophysiology of various neurological compromise, especially hydrocephalus (HCP). Till now, the complete pathway is not yet fully understood, and little evidence is available from the literature that links hydrocephalus to disorders of the glymphatic system. Most published molecular studies and animal research have shown that, in models with hydrocephalus, the drainage of cerebrospinal fluid (CSF) via the glymphatic system is disrupted. This is strongly observed in normal pressure and post-hemorrhagic hydrocephalus cases. A thorough search of the literature to date yields scarce evidence …

Art And Effort, Saul Gabriel Dominguez Ii

Theses and Dissertations

Since childhood I questioned living and my life itself. I wondered the extent of our own free will since people live to cry, to hate, to think they’ve been born simply to die. I use philosophers and some contemporary fiction to portray a lens of living where we must romanticize the present, rather than an uncertain future, and remove the idea that there is a reason for our living. This method of present thinking is a characteristic of a life-well lived. The manuscript will largely be told from my point of view, a young aspiring author with limited experience, through …

The Onondaga Nation's Land Claim: Rights Without A Remedy?, Larissa Speak

American Indian Law Journal

No abstract provided.

Adolescent Externalizing Symptoms And Parent Emotion Socialization: An Examination Of Longitudinal Effects And Differences By Adolescent Sex, Cheston West

Electronic Theses and Dissertations

Adolescence is an important developmental context with several changes in social and emotional functioning. Though adolescents are gaining independence from their caregivers, they still engage in dynamic interactions with their caregivers who remain key figures in their lives. When adolescents express emotions, caregivers engage in various behaviors in response to these expressions, a process known as emotion socialization. This process has mostly been examined as a parent-driven construct in which parent emotion socialization impacts child-level outcomes, namely internalizing symptoms, with limited research on externalizing symptoms. However, available literature demonstrates that child-level characteristics (e.g., externalizing symptoms) are linked to differences in …

Cranial Ontogeny Of The Extinct Dwarf Tapir Tapirus Polkensis; With Comparison To That Of The Extant Tapirus Bairdii (Tapiridae, Perissodactyla), Johannah Orendorff

Electronic Theses and Dissertations

Tapirus polkensis is the smallest known species of tapir to ever live, and the largest deposit of their fossils is currently located at the GFS in Gray, TN. Phylogenetics suggest that the extant T. bairdii may be the sister taxon to T. polkensis, although they differ greatly in their morphology. Variation exists among adult T. polkensis specimens, with patterns not present in T. bairdii. For this study, as series of 2D GMAs, with TPSs, were rendered on 10 skulls of T. polkensis and 48 skulls of T. bairdii, across both species’ ontogenetic series. Analyses confirmed that growth …

Structural Stability Of Fgf1-Fgf2 Dimer Established Via Salt Bridges With Mutation K296q, Ashleigh Letterman

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast Growth Factors (FGFs) are a family of cell-signaling proteins. FGF, specifically the FGF-1 subfamily, which contains FGF-1 and FGF-2, is important in several biological functions such as wound healing, cell proliferation, and angiogenesis. FGF-1 has cell proliferation properties and FGF-2 has angiogenic properties. These FGFs have great potential for wound-healing therapy medications...

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The Benefits Of Different Graphic Design Elements And What Satisfies Consumers, Kathryn R. Marston

Honors Theses

This thesis investigates the principles, elements, methodologies, and emerging trends of website design. It has a focus on user experience and design elements such as color, shape, and fonts. As websites have evolved from being a place to share information to a place where goods are bought and sold, design directly impacts the satisfaction of the consumer using the website. This study explores the connection between graphic design and user experience elements and satisfaction of consumers.

The research uses qualitative research to discover the impact of graphic design elements of a website including color scheme, button shapes, and font styles …

A Sex Comparison On The Effects Of Caveolin Scaffolding Domain On Fibrosis Formation After Chronic Sympathetic Stimulation, Crimsyn Price

Undergraduate Honors Theses

Cardiovascular disease (CVD) is the leading cause of mortality worldwide. There are various trends that influence the rates of cardiovascular disease in each country. Factors that create these trends involve diet, exercise, genetics, socioeconomic status, and geographical location. Additionally, CVD is typically higher in middle-income and lower-income classes. Hospital routes, rates of poverty, insurance policies, and lifestyle culture are all factors that can impact the time of treatment which in turn affect the rate of CVD. However, we explored in this study the shift in CVD women experience after menopause. Women were excluded from clinical trials until 1986, and the …

Designing Hmi And Scada Laboratory Work For Engineering Students, Julianne Barteck

Undergraduate Honors Theses

Human-machine interfaces are, essentially, the user interfaces used to monitor industrial facility machines and systems, which makes them a common industry tool in engineering. At East Tennessee State University, while human-machine interfaces are briefly covered in lecture and graduate students have set up some basic hands-on work, there exist no formal lab work for students on the topic. This thesis explores the literature surrounding the design of labs for a STEM or engineering-specific university class, and applies the recommendations and methods within that literature to design two laboratory guides on human-machine interfaces. These labs are intended to be implemented in …