Digital Commons Network^™

Assessing The Long-Term Impact Of Goat Grazing On The Abundance Of Rhamnus Cathartica, Isaac W. Stark

Science Symposium

In years past, high levels of biodiversity and herds of roaming grazing animals maintained a delicate balance between species of plants. More recently due to globalization and deforestation foreign species like Rhamnus cathartica have been able to grow unchecked. Our study uses long term data from periodically goat-grazed areas near Bethel University, MN to evaluate the effectiveness of goat grazing to manage invasive plant species. Random one square meter quadrats were established in 2018 (n=70) to compare the differences in R. cathartica stem density between three height categories (0-30 cm, 30-150 cm, >150 cm), as well as other plant species …

Volume 2 Complete Issue, James W. Gallagher

The Geographical Bulletin

Volume 2 Complete Issue

Australia An Dits Outback, Lewis Deitch

The Geographical Bulletin

So states Australian poet A. D. Hope as he vividly describes the land "Down Under.'" It is a continent of widespread aridity whose burnt red and brown colors predominate over much of the landscape. The Continent contains 2,941,526 square miles (with Tasmania, the island state, the Commonwealth comprises an area of 2,967,909 square miles): By comparison, Australia is slightly smaller than the 48 contiguous United States, and roughly the same latitudinal and longitudinal dimensions. In contrast however, the Australian continent is largely uninhabited or at best sparsely settled. The population (at the 1966 Census) of 11,550,4623 is primarily centered in …

Ultrasound-Guided Sciatic And Femoral Nerve Block For Perioperative Pain Management In A Thai Crossbreed Dog Undergoing Tibial Plateau Leveling Osteotomy (Tplo): A Case Report, Wutti Bunjerdsuwan, Sirirat Niyom

The Thai Journal of Veterinary Medicine

This case report presents the use of ultrasound-guided sciatic and femoral nerve blocks as an alternative analgesic technique for perioperative pain control in a Thai crossbreed dog undergoing left tibial plateau leveling osteotomy (TPLO). The orthopedic examination revealed a 4/5 left hindlimb lameness score, with positive results on both the tibial compression test (TCT) and cranial drawer test (CDT). Radiographic evaluation showed the absence of a fat pad sign and osteophyte formation around the left stifle joint. A definitive diagnosis of left cranial cruciate ligament rupture (CCLR) was made. The dog underwent CCLR correction via TPLO, with perioperative pain managed …

Utilization Of Industrial Hemp Biomass Waste (I): Stability Of Cannabidiol In Pre And Post- Encapsulation States, Jerel Crew, Ying Wu, Richard Mu, Ankit Patras

Food and Animal Sciences Faculty Research

After cannabidiol was extracted from the hemp biomass using supercritical CO2 extraction, the residual could be utilized as a source of other valuable ingredients. The stability of the extracted CBD in pre- and post- encapsulation states were evaluated. Dynamic macerations with ethanol and hexane were compared for CBD extraction. The ethanol extract yielded 0.11% ± 0.10 CBD and 1.83% ± 0.00 cannabidiolic acid (CBDA), while the hexane extraction yielded 0.08% ± 0.04 CBD, 1.06% ± 0.04 CBDA, and 0.30% ± 0.04 delta-9-tetrahydrocannabinol (Δ9-THC). Ethanol extraction was selected due to the low THC detection in the extract. The CBD extract was …

Covid-19 And Related Adverse Neurological Complications, Hannah A. Wasson

Honors Thesis

Abstract

The COVID-19 pandemic changed the world drastically, and its impact was monumental. COVID-19 or SARS-CoV-2, or severe acute respiratory syndrome, was the virus responsible for causing such mayhem. This contagious virus can enter the body via different routes, live on surfaces for hours, and be transmitted through the air, increasing infection risk. Once it enters the body, it can trick the body into replicating the virus. From this reaction within the body, signs and symptoms follow. While the name indicates a respiratory illness, the virus can inflict injury on other parts of the body. Due to the organ systems …

Pterygopalatine Ganglion Blocks In Medicine: Bridging Neuromodulation And Pain Relief, Tori B. Ostrand

Honors Thesis

Chronic pain affects millions of individuals worldwide, presenting as a multifactorial condition that impacts physical, emotional, and socioeconomic well-being. Despite the availability of both pharmacological and non-pharmacological therapies, significant side effects, limited efficacy, and addiction risks drive the need for new, innovative treatments. The pterygopalatine ganglion block (PPGB) is emerging as a promising interventional approach that targets autonomic and neurogenic pathways that may be implicated in chronic pain mechanisms. This thesis reviews the neuroanatomy of the pterygopalatine ganglion, its potential role in autonomic regulation and pain mediation, and its clinical applications in treating headache syndromes such as cluster headaches and …

Integration Of Hydrological Simulations Into The Design Process To Assess The Performance Of Green Infrastructure Designs, Clara Jimenez

Design Research

With the growing threat of flooding in coastal and inland communities, it is necessary to migrate nature-based solutions such as green infrastructure. However, one of the challenges that designers face with this strategy lies in the design phase where it is difficult to quantify the performance with traditional design tools. Thus, there is an incentive to incorporate hydrological models within GIS to aid designers in quantifying performance. The goal of this research is to demonstrate that hydrological simulations can be used as a design tool for designers–such as landscape architects & architects– to analyze the feasibility of green infrastructure designs …

Exploring The Landscape Of Animal Advocacy In Egypt: Insights Into Stray, Wildlife, And Farmed Animal Rights, Yara Moussa, Wasseem Emam

General - Animal Protection

This article examines the landscape of animal advocacy in Egypt, a nascent and growing field in one of Africa’s largest economies and most densely populated countries. It focuses on three types of animal advocacy: 1) stray animal welfare, 2) wildlife conservation, and 3) farmed animal welfare. The paper critically analyses current practices and trends in each of these areas, highlighting the main challenges and opportunities facing the growth of the movement. Our research draws on insights from interviews with active animal welfare organizations, situating their practical experiences, daily operational struggles, as well as instances of success, within Egypt’s wider socio-economic …

Wandering From The River: On- And Off-River Abundance Of Interior Least Terns Along The 59-Mile Reach Of The Missouri National Recreational River, Zoe D. Donelan

Honors Thesis

The Interior Least Tern, a summer nesting species native to the sandbars of the Missouri River, faces significant loss of foraging habitat and forage fish populations as a result of modern river regulation. Alternative foraging sites may be located several kilometers from tern nesting colonies at either on-river or off-river wetland sites. To understand how Least Terns use available foraging habitat, we conducted population surveys along the 59-mile reach of the Missouri National Recreational River (MNRR) in Southeastern South Dakota. We conducted land-based surveys at nine on-river public-access sites along the Missouri River and 12 off-river wetland sites within 30 …

Relationship Between Maternal Plasma Retinol And Provitamin A Carotenoids With Fetal And Infant Kidney Development, Anum Akbar

Theses & Dissertations

Vitamin A plays a critical role in fetal organ development. Studies suggest that maternal vitamin A deficiency affects fetal nephron numbers, potentially leading to smaller kidney sizes and an increased risk of chronic kidney disease later in life. However, human studies exploring maternal vitamin A's impact on fetal kidney development lack longitudinal data and within-cohort comparisons. Furthermore, the influence of provitamin A carotenoids (α-carotene, β-carotene, β-cryptoxanthin) on kidney size remains unexplored. This dissertation addresses these gaps by analyzing relationships between maternal and cord plasma retinol and provitamin A carotenoid concentrations with fetal and infant kidney sizes. Our prospective cohort …

The Art Of Dreaming: A Surrealist Approach To Dream Analysis, Shelby Wright

Honors Thesis

Over the past two years, I created a series of paintings to explore the meaning of my nightmares. This study analyzes the themes and symbols in these dreams through the psychological frameworks of Sigmund Freud and Carl Jung. Freud’s causal approach focuses on repressed desires, while Jung’s method relies on mythological symbols and archetypes in the collective unconscious. Drawing on the ideas of André Breton and the Surrealist movement, I examine how art can bridge dreams and waking life. By painting my dreams, I aim to better understand my unconscious and invite viewers to question their perception of reality. This …

Microknight: A Covert Learning Approach For Educational Videogames, Rain A. Wynes

Departmental Honors & Graduate Capstone Projects

Educational video games are a vastly underutilized and poorly developed method of teaching individuals. Research has shown that implementing fun into the learning environment has many benefits, including increased comprehension and knowledge retention while decreasing the cognitive load experienced by the learners. Given this information, educational video games seem like a natural route. However, previous iterations have failed to capitalize on these benefits.

This research focuses on player engagement for the new development model, emphasizing imparting educational material. The goal is to create an educational video game that properly educates the player on a given subject while promoting an entertaining …

Temporal Assessment Of Fish Communities In A South Central Plains Ecoregion Watershed, Tara L. Schnelting

ATU Theses and Dissertations 2021 - Present

Among South Central Plains ecoregion fish communities, there is limited knowledge of the importance of headwaters yet this information is needed to understand their role in fish communities. I addressed this gap by assessing seasonal changes in fish communities in headwater streams of the Moro Creek watershed, Arkansas. I conducted two studies pertaining to temporal fish community assessments: (i) utilize multi-season, community occupancy models to estimate μ (species probability), Ω (community occupancy mean), and p (detection probability) and (ii) utilize beta diversity (β) analyses to address the diversity across different scales in the headwaters of the Moro Creek …

From Fables To Facts: Discovering The World Through Stories And Science, Lucille Helen Vanek

Graduate Student Portfolios, Professional Papers, and Capstone Projects

From Fables to Facts: Discovering the World Through Stories and Science examines the integration of narrative storytelling and hands-on scientific exploration as a means of cultivating environmental literacy, ethical reflection, and sustained engagement with the natural world. Grounded in environmental philosophy, aesthetics, and ethics, the project draws on theoretical insights from Holmes Rolston III, Marcia Muelder Eaton, Allen Carlson, Arnold Berleant, and C. Thi Nguyen to develop a multidimensional model of education that unites imagination, cognition, and participatory experience. Implemented in diverse Montana community settings—including libraries, early learning centers, science museums, and faith-based organizations—the program paired fables, parables, and literary …

Red Cows, Yellow Dogs: Political Identity, Political Polarization, And Media Skepticism In A Single-Party Socialist Republic, Huu Dat Tran

LSU Doctoral Dissertations

This dissertation examines the interplay among political identity, trust in government and media, and patterns of media consumption in Vietnam, a single‐party socialist republic in Southeast Asia. Moving beyond the liberal democratic focus of existing scholarship, the dissertation challenges the assumption of political homogeneity in authoritarian settings and empirically explores the extent and character of polarization.

The dissertation takes a quantitative approach and employs multiple statistical techniques, including latent profile analysis (LPA) and structural equation modeling (SEM). It uncovers multiple latent political profiles within Vietnamese society, defined by varying degrees of trust in the government and ideological orientation. Further analysis …

Navigating Lipid Nanoparticle Design: From Microfluidic Optimization For Rna Delivery In Pancreatic Cancer To Extended-Release Formulations For Hiv-1 Therapy., Farhana Islam

Theses & Dissertations

Lipid nanoparticles (LNPs) have emerged as a powerful platform for the delivery of RNA and small-molecule therapeutics, enabling improved drug stability, biodistribution, and cellular uptake. This study explores the formulation and optimization of LNPs for two distinct therapeutic applications: (1) mRNA-based therapy for pancreatic cancer (PC) and (2) extended-action fostemsavir (FTR) delivery for HIV-1 treatment. For PC therapy, a library of 48 mRNA-LNP formulations was developed for intraperitoneal (IP) administration in an orthotopic pancreatic tumor mouse model. Using microfluidic assembly, LNPs were engineered with varying lipid compositions and characterized based on size, zeta potential, and cytotoxicity. Biodistribution and mRNA expression …

Schistosoma Haematobium Infection In Ethiopian Children: Evaluating Praziquantel Efficacy, Nutritional Effects, And Diagnosis Using Flukecatcher, Louis Fok

Theses & Dissertations

Urogenital schistosomiasis continues to impact the wellbeing of hundreds of millions of people worldwide and remains a significant public health challenge across Ethiopia. Despite existing knowledge on the disease, there remain significant unanswered questions with regard to its treatment and diagnosis. This dissertation evaluated the efficacy of praziquantel at treating urogenital schistosomiasis, improving nutritional parameters among children and the performance of FlukeCatcher at detecting and determining the intensity of infection. In effecting this, a total of 977 children aged 5 through 15 from the Afar and Gambella regions of Ethiopia were screened for S. haematobium infection using urine filtration microscopy …

Cholestasis And Fluid Flow Are Biomechanic Regulators Of Cholangiocarcinoma Progression, Andrew Oleksijew

Theses & Dissertations

Cholestasis, altered or absent bile flow, is associated with poor survival in patients with cholangiocarcinoma, an aggressive cancer of the biliary epithelium. Changes in bile flow often result in stricture or obstruction. Experimental cholestasis promoted tumor growth and progression. However, studies are needed that directly assess the mechanical interaction between bile flow, or bile shear stress, and cholangiocarcinoma signaling. We hypothesized that cholestasis and absent bile shear stress activated cancer signaling and increased aggressive cellular behaviors such as proliferation and migration. Fluid shear stress approximating bile flow was applied by orbital culture plate method and compared to identical static culture …

Multi-Modal Mri For The Pre-Clinical Evaluation Of Hiv-Linked Changes In The Central Nervous System, Gabriel Gauthier

Theses & Dissertations

Though the inception of anti-retroviral therapy (ART) has fundamentally changed the life expectancy of human immunodeficiency virus (HIV) patients, accessibility and outcomes vary enormously along demographic lines. Even for people living with HIV (PLWH) with perfect access and adherence to anti-retroviral drugs (ARVs), modern treatment plans are fundamentally unable to secure complete viral remission for patients. The cause of this perpetual infection is the persistence of viral reservoirs in the central nervous system (CNS), hidden beyond the reach of modern ARVs, leaving patients to deal with lifelong medication side-effects and risks of developing HIV-associated neurodegenerative disorders (HAND). Despite improving outcomes …

Apolipoprotein E4, Tauopathy, And Brain Injury: Molecular Insights Into Alzheimer's Disease Pathology, Nashanthea J. Roland

Theses & Dissertations

Alzheimer’s disease (AD) is the world’s leading cause of dementia, characterized by progressive atrophy of the hippocampal and cortical brain regions, synapse damage and loss, and a buildup of senile plaques and neurofibrillary tangles composed of β-amyloid peptides and hyperphosphorylated tau, respectively. While age is the most significant risk factor for developing AD, apolipoprotein E4 (APOE4) is the strongest genetic risk factor for AD. Although it is known that APOE4 influences tau pathology, the molecular mechanisms by which APOE4 drives AD pathogenesis and progression remain unclear. In addition to intrinsic contributions to AD, there are many extrinsic factors that can …

A Comparison Of Resurgence Following Dra And Dro, Alysa Georgopoulos

Theses & Dissertations

Resurgence, a form of behavioral relapse, occurs when a previously reduced target behavior reemerges after an alternative source of reinforcement is discontinued. Differential reinforcement of alternative behavior (DRA) and differential reinforcement of other behavior (DRO) are commonly used strategies to reduce undesired behaviors. Although both are effective, unanticipated periods of extinction (e.g., service lapses or staff turnover) may lead to resurgence of the original target behavior. Romano and St. Peter (2017) found that behavior reduced via DRO was more prone to resurgence than behavior reduced via DRA. However, their study used a different number of response options between conditions (one …

Drivers And Mechanisms Of Golgi Fragmentation As A Modulator Of Disease, Amanda Macke

Theses & Dissertations

The Golgi apparatus plays a pivotal role in post-translational modification, trafficking, and secretion of proteins, ensuring proper cellular function. As a result, its fragmentation has been implicated in multiple pathological conditions, including alcohol-induced liver injury and prostate cancer (PCa). Despite its known impact on cellular homeostasis, the molecular mechanisms governing Golgi fragmentation remain to be clarified. Additionally, we have only just begun to understand the vast consequences of Golgi disorganization on disease progression.

This dissertation investigates the drivers and mechanisms of Golgi fragmentation, with a focus on its role as a modulator of disease. Using both in vitro and in …

Evaluating The Therapeutic Potential Of Geranylgeranyl Diphosphate Synthase Inhibitor, Ram2061, In Myeloma Bone Disease, Molly Muehlebach

Theses & Dissertations

Multiple myeloma (MM) is a hematological malignancy of the plasma cells which often results in lytic bone disease. Myeloma bone disease (MBD), characterized by diffuse osteopenia, bone lesions, or pathological fracture, results from MM mediated promotion of osteoclast resorption and dual inhibition of bone formation, drastically reducing bone strength and integrity. Development of MBD is known to significantly impact patient quality of life and increase risk of mortality. Considering that up to 80-95% of MM patients are expected to develop bone disease post-initial MM diagnosis, there is a significant need within this population for therapeutics which address both MM disease …

Intrinsic And Extrinsic Drivers Of Bioaerosol Decay: Investigating Pathogen Stability Of Bacteriophage Ms2, Sin Nombre Virus, And Sars-Cov-2 In Simulated Environments, Elizabeth A. Klug

Theses & Dissertations

The threat posed by a virus as a bioaerosol depends largely on its stability under various environmental conditions (relative humidity (RH), sunlight, ozone, etc.). This stability is typically studied through aerosol decay—how the virus' viability changes over time when exposed environmental conditions. The Goldberg rotating drum, a widely used tool for studying bioaerosols, has been the basis of such research (Goldberg et al., 1958). However, it has significant limitations, including an inability to measure initial pathogen infectivity loss and the use of small sample volumes. Additionally, it does not answer the question of what intrinsic factors (lipids, proteins, nucleic acids) …

Investigating The Effects Of Transcription Factor Binding And Genetic Variants In The Striatum Of Post-Mortem Cohorts With Opioid Use Disorder, Rajashree Chakraborty

Theses & Dissertations

The opioid crisis has emerged as one of the most pressing public health challenges of our time, with Opioid Use Disorder (OUD) affecting millions of lives across the globe. Studying OUD is not merely an academic pursuit but a critical necessity in addressing this multifaceted epidemic. The urgency of this research is underscored by the staggering prevalence of OUD, with an estimated 3.7% of U.S. adults requiring treatment in 2022 alone. Despite the availability of effective medications for OUD, a significant treatment gap persists, with only a quarter of those in need receiving these life-saving interventions. The far-reaching consequences of …

Optimizing Peptide Nucleic Acid-Based Pretargeting For Enhanced Targeted Radionuclide Therapy, Mohamed Altai, Ábel Nagy, Pauline Granit, Wahed Zedan, Myriam Cerezo-Magaña, Julie Park, Katharina Lückerath, Susanne Geres, Marie Sydoff, Daniel L J Thorek, Kristina Westerlund, David Ulmert, Amelie Eriksson Karlström

2020-Current year OA Pubs

Radiolabeled targeting agents have emerged as valuable tools for the treatment of disseminated cancer. Monoclonal antibodies (mAbs) are widely employed as carriers for diagnostic and therapeutic radionuclides due to their exceptional specificity and affinity. However, their prolonged circulatory half-life can diminish diagnostic efficacy and increase radiation exposure to non-target tissues in therapeutic applications, resulting in dose-limiting toxicities. To overcome this limitation, pretargeting technologies emerge as promising strategies to enhance tumor-to-background ratio and reduce radiation exposure of healthy tissues. Our previous work introduced a pretargeting concept leveraging the specific interaction between two peptide nucleic acid (PNA) probes, HP1 and HP2, as …

Feasibility Analysis For The Implementation Of An Anaerobic Digestion System In The City Of Pittsburgh, Pa, Gianna L. Kolencik

Electronic Theses and Dissertations

The current study is investigating the feasibility of an anaerobic digestion system

in Pittsburgh, Pennsylvania, at the old State Correctional Institute (SCI-Pittsburgh)

located at 1922 Westhall St. This location is immediately upstream of the Allegheny

County Sanitary Authority (ALCOSAN) along the Ohio River. Municipal solid waste

from ALCOSAN may be used as the main form of feedstock. ALCOSAN produced

roughly 36,500 tons of dry sludge in the reporting year 2023-2024. Based on the volume

of dry sludge from ALCOSAN it is estimated that an anaerobic digestion system could

yield approximately 29,930,000 kWh of energy, which is enough to power over …

Creative Expression Through Worldbuilding: A Study On The Connections Between Literature And Music Through Analysis Of Brandon Sanderson's The Stormlight Archive, Lauralei S. Palmer

Honors Theses

This thesis examines the worldbuilding connections visible throughout fantasy literature and musical works. Though their tools seem different, authors, composers, and performers use equivalent techniques to draw in their audiences and produce an immersive, emotional experience. This research focuses on American author Brandon Sanderson’s highly detailed worldbuilding in his epic fantasy series, The Stormlight Archive. The Stormlight Archive exhibits the three pillars of worldbuilding: completeness, invention, and consistency. This research also examines Franz Liszt’s Les Préludes, a symphonic poem based on Alfonse Lamartine’s poem, Ode. Finally, this thesis culminates in the fusion of literary and musical worldbuilding in description …

Mechanical Engineering Senior Design Capstone Modine Engineering: Collapsible Hvac Coil Expansion Table, Austin M. Hipskind

Honors Theses

For the Mechanical Engineering Senior Design class, teams of seniors were asked to find a sponsor company willing to provide a problem they were experiencing at a local plant. Using the skills gained throughout college, they were asked to go through a standardized problem-solving method to develop a solution for the sponsor company. I was teamed with Fernando Arellano and Henry Lindsey to work with Modine Engineering on creating a modular and collapsible table for use with large, custom-designed coils. This table would have to hold large, heavy coils during the expansion process. Modine requested a 3D design, the cost …