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Multifaceted Roles Of Epac Signaling In Renal Functions, Oleh Pochynyuk, Kyrylo Pyrshev, Xiaodong Cheng May 2025

Multifaceted Roles Of Epac Signaling In Renal Functions, Oleh Pochynyuk, Kyrylo Pyrshev, Xiaodong Cheng

The Brown Foundation: Institute of Molecular Medicine

3',5'-cyclic adenosine monophosphate (cAMP) is a fundamental secondary messenger capable of rapidly amplifying and propagating cellular signals in response to various extracellular stimuli. cAMP plays a significant role in hormone-mediated regulation of renal fluid and electrolyte balance. Impaired signaling of cAMP has been linked to a variety of pathological ramifications in the kidneys. This review explores the physiological functions of exchange proteins directly activated by cAMP (Epac) in renal water balance and the regulation of solute transport in the renal tubule. Additionally, the involvement of Epac signaling in renal pathologies such as acute kidney injury, chronic kidney disease, and polycystic …

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Staff Education For Nursing Teach-Back Facilitation To Reduce Frequent Readmission, Chikamunario Joy Ekeke May 2025

Staff Education For Nursing Teach-Back Facilitation To Reduce Frequent Readmission, Chikamunario Joy Ekeke

Walden Dissertations and Doctoral Studies

Background: Teach-Back method of education is a simple technique that can be used to check, and correct inaccurate recall of patients’ instructions. It has a great impact on patients’ recall and understanding of discharged information in a healthcare setting and to help minimize hazards such as non-medication adherence, frequent re-hospitalization, and poor self-care/home care (Talevski et al., 2020). Gap in Practice/Problem: “Frequent readmission (30 days Return) of patients in a Rural Psychiatric Center.” The Practice Focus Question: “Does staff education on “teach-back” facilitate the knowledge and confidence level of staff in providing discharged patient education and subsequently minimize frequent rehospitalization?” …

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Sustainability Planning For Waste Management In Midwestern Small Suburban Cities, Karen Frances Goodwin May 2025

Sustainability Planning For Waste Management In Midwestern Small Suburban Cities, Karen Frances Goodwin

Walden Dissertations and Doctoral Studies

Sustainability planning in small suburban cities, particularly as it relates to waste management programs, remains an underexplored area in scholarly research. Without long-term planning, these cities often react to issues in a fragmented manner rather than implementing proactive policies, negatively affecting public health and well-being. The purpose of this study was to examine sustainable waste management policy processes that enable sustainability planning in Midwestern small suburban cities. Using Jones et al.’s local adaptive capacity framework and Q-methodology, viewpoint patterns were analyzed to understand what motivates decision-makers to foster an environment conducive to sustainability planning. Thirty-one participants representing three local government …

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Structural And Molecular Basis Of Pcna-Activated Fan1 Nuclease Function In Dna Repair, F. Li, A. S. Phadte, M. Bhatia, S. Barndt, A.R. Monte Carlo, Iii, C.F.D. Hou, R. Yang, S. Strock, A. Pluciennik May 2025

Structural And Molecular Basis Of Pcna-Activated Fan1 Nuclease Function In Dna Repair, F. Li, A. S. Phadte, M. Bhatia, S. Barndt, A.R. Monte Carlo, Iii, C.F.D. Hou, R. Yang, S. Strock, A. Pluciennik

Department of Biochemistry and Molecular Biology Faculty Papers

FAN1 is a DNA dependent nuclease whose proper function is essential for maintaining human health. For example, a genetic variant in FAN1, Arg507 to His hastens onset of Huntington's disease, a repeat expansion disorder for which there is no cure. How the Arg507His mutation affects FAN1 structure and enzymatic function is unknown. Using cryo-EM and biochemistry, we have discovered that FAN1 arginine 507 is critical for its interaction with PCNA, and mutation of Arg507 to His attenuates assembly of the FAN1-PCNA complex on a disease-relevant extrahelical DNA extrusions formed within DNA repeats. This mutation concomitantly abolishes PCNA-FAN1-dependent cleavage of such …

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Immunotherapy With Nebulized Pattern Recognition Receptor Agonists Restores Severe Immune Paralysis And Improves Outcomes In Mice With Influenza-Associated Pulmonary Aspergillosis, Jezreel Pantaleón García, Sebastian Wurster, Nathaniel D Albert, Uddalak Bharadwaj, Keerthi Bhoda, Vikram K Kulkarni, Mbaya Ntita, Paris Rodríguez Carstens, Madeleine Burch-Eapen, Daniela Covarrubias López, Jania Foncerrada Lizaola, Katherine E Larsen, Lauren M Matula, Seyed J Moghaddam, Yongxing Wang, Dimitrios P Kontoyiannis, Scott E Evans May 2025

Immunotherapy With Nebulized Pattern Recognition Receptor Agonists Restores Severe Immune Paralysis And Improves Outcomes In Mice With Influenza-Associated Pulmonary Aspergillosis, Jezreel Pantaleón García, Sebastian Wurster, Nathaniel D Albert, Uddalak Bharadwaj, Keerthi Bhoda, Vikram K Kulkarni, Mbaya Ntita, Paris Rodríguez Carstens, Madeleine Burch-Eapen, Daniela Covarrubias López, Jania Foncerrada Lizaola, Katherine E Larsen, Lauren M Matula, Seyed J Moghaddam, Yongxing Wang, Dimitrios P Kontoyiannis, Scott E Evans

Faculty, Staff and Student Publications

Influenza-associated pulmonary aspergillosis (IAPA) is a potentially deadly superinfection in patients with influenza pneumonia, especially those with severe disease, underlying immunosuppression, corticosteroid therapy, or requiring intensive care support. Given the high mortality of IAPA, adjunct immunomodulatory strategies remain a critical unmet need. Previously, the desensitization of pattern recognition pathways has been described as a hallmark of IAPA pathogenesis and a predictor of mortality in IAPA patients. Therefore, we studied the impact of nebulized Toll-like receptor 2/6/9 agonists Pam2 CSK4 (Pam2) and CpG oligodeoxynucleotides (ODNs) on infection outcomes and pulmonary immunopathology in a corticosteroid-immunosuppressed murine IAPA model. Mice with IAPA receiving …

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Forward Genetic Screen In Zebrafish Identifies New Fungal Regulators That Limit Host-Protective Candida-Innate Immune Interaction, Bailey A Blair, Emma Bragdon, Gursimran Dhillon, Nnamdi Baker, Lena Stasiak, Mya Muthig, Pedro Miramon, Michael C Lorenz, Robert T Wheeler May 2025

Forward Genetic Screen In Zebrafish Identifies New Fungal Regulators That Limit Host-Protective Candida-Innate Immune Interaction, Bailey A Blair, Emma Bragdon, Gursimran Dhillon, Nnamdi Baker, Lena Stasiak, Mya Muthig, Pedro Miramon, Michael C Lorenz, Robert T Wheeler

Faculty, Staff and Student Publications

Candida is one of the most frequent causes of bloodstream infections, and our first line of defense against these invasive infections is the innate immune system. The early immune response is critical in controlling Candida albicans infection, but C. albicans has several strategies to evade host immune attack. Phagocytosis of C. albicans blocks hyphal growth, limiting host damage and virulence, but how C. albicans limits early recruitment and phagocytosis in vertebrate infection is poorly understood. To study innate immune evasion by intravital imaging, we utilized the transparent larval zebrafish infection model to screen 131 C. albicans mutants for altered …

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Joy In Lifelong Learning: An Introduction To Planning For Learning Disabilities In Museum Education, Elaine L. Davis May 2025

Joy In Lifelong Learning: An Introduction To Planning For Learning Disabilities In Museum Education, Elaine L. Davis

Seton Hall University Dissertations and Theses (ETDs)

For over a century, the role of museums as learning institutions has been considered alongside that of schools. However, special education practices are rarely adapted for museum education, requiring educators in museum contexts to undertake extra work to accommodate those with learning disabilities. This thesis used Qualitative Comparative Analysis and Textual Analysis to review pedagogical white papers and academic research on museum programs aimed at neurodivergent audiences. The findings were used to create a professional development guide for museum educators at a range of different types of museums.

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Determination Of Chlorpheniramine Maleate In Its Pharmaceutical Preparations Using Homemade Turbidity Flow Injection Analyzer, Muntadhar M. Jabbar, Elham N. Mezaal May 2025

Determination Of Chlorpheniramine Maleate In Its Pharmaceutical Preparations Using Homemade Turbidity Flow Injection Analyzer, Muntadhar M. Jabbar, Elham N. Mezaal

Baghdad Science Journal

By using continuous flow injection analysis technology, a new analytical method was presented for the determination of chlorpheniramine maleate (CPM) in its pure form and in some of its pharmaceutical preparations. The study was based on the reaction of CPM with ammonium ceric(IV) sulphate (ACS) in an acidic medium, where the reaction resulted in a slightly yellowish white precipitate. It was studied using Ayah 6S × 1-ST-2D solar cell CFI analyzer (homemade) by measuring the light reflected from the surfaces of precipitate particles at (0–180°). Several experiments were conducted to study and improve the chemical and physical parameters. The correlation …

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An Assessment Of Inorganic Contaminants Levels In The Wastewater Of Lifting And Treatment Sewage Stations In Karbala, Iraq, Mohammed Nasser Hussain, Ahmed Fadhil Khudhair, Hussain Jawad Ahmed May 2025

An Assessment Of Inorganic Contaminants Levels In The Wastewater Of Lifting And Treatment Sewage Stations In Karbala, Iraq, Mohammed Nasser Hussain, Ahmed Fadhil Khudhair, Hussain Jawad Ahmed

Baghdad Science Journal

The investigation in this study includes examining the impact of wastewater at ten different stations. Eight lifting stations and two treatment stations in the center and district of Al-Hurr in the Karbala city. The study’s goal is to determine the operational effectiveness of the main treatment unit project in Karbala and the Al-Hurr treatment unit and its impact on wastewater quality, disclosing the qualitative features of wastewater in the study area, controlling waste water from treatment plants, and utilizing its service in other fields. More than 70 trace elements were examined in this study by using inductively coupled plasma mass …

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Preparation Of Novel Adsorbents Via Functionalized Mcm-41 Prepared From Plant Residues, Raghad Saad Hatem, Hayder Hamied Mihsen, Alaa Frak Hussain May 2025

Preparation Of Novel Adsorbents Via Functionalized Mcm-41 Prepared From Plant Residues, Raghad Saad Hatem, Hayder Hamied Mihsen, Alaa Frak Hussain

Baghdad Science Journal

In this study, mesoporous silica MCM-41 was functionalized with 3-aminopropyltriethoxysilane (APTES) to obtain MCM-41@APTES, which contains primary amine groups. In the next step, 5-bromosalicylaldehyde was refluxed with MCM-41@APTES in toluene to obtain the Schiff base-functionalized mesoporous silica material, MCM-41@APTES-BSAL. MCM-41@APTES and MCM-41@APTES-BSAL were characterized via FT-IR, FESEM-EDX, TEM, N2-adsorption-desorption, XRD, and TGA/DTA. The XRD and TEM investigations showed that MCM-41@APTES and MCM-41@APTES-BSAL were generated with extremely ordered hexagonal arrangements. The findings from the N2-adsorption–desorption analysis revealed that the average pore diameters, total pore volumes, and specific surface areas were 7.530 nm, 0.292 cm3g-1, and 155.19 m …

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Synthesis And Characterization Of New Petroleum Demulsifies From Poly Acryl Amide With Poly Vinyl Alcohol And Studying Photolysis, Zaynab Hussein Fadel, Sura K. Ibrahim, Sana Hitur Awad, Faris Hamood Mohammed May 2025

Synthesis And Characterization Of New Petroleum Demulsifies From Poly Acryl Amide With Poly Vinyl Alcohol And Studying Photolysis, Zaynab Hussein Fadel, Sura K. Ibrahim, Sana Hitur Awad, Faris Hamood Mohammed

Baghdad Science Journal

One of the most important problems associated with oil production is the formation of stable (water-in-oil) emulsions, and these emulsions greatly affect the process of treating the oil and ridding it of water.The creation of these emulsions throughout the oil production process is an expensive state, and the low water level of crude oil emulsions enhances performance while lowering the risk of equipment and pipeline deterioration. One technique to lower the water content is to break down crude oil emulsions chemically by demulsification. The water droplets quickly collide because the emulsifier renders the thin film separating the water droplets and …

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Chronic Inflammatory Pain And Chronic Thc Vapor Inhalation Alter Midbrain Neuronal Activity, Leslie K. Kelley, Nicholas W. Gilpin, Jason W. Middleton May 2025

Chronic Inflammatory Pain And Chronic Thc Vapor Inhalation Alter Midbrain Neuronal Activity, Leslie K. Kelley, Nicholas W. Gilpin, Jason W. Middleton

School of Medicine Faculty Publications

In an effort to reduce reliance on opioids for the treatment of pain in the clinic, ongoing work is testing the utility of cannabinoid drugs as a potential alternative for treatment of chronic pain. We tested chronic delta-9 tetrahydrocannabinol (THC) vapor inhalation effects on intrinsic and synaptic properties of ventrolateral periaqueductal gray (vlPAG) neurons in male and female rats treated with complete Freund's adjuvant (CFA). We report that chronic THC vapor inhalation modulates intrinsic and synaptic properties of vlPAG neurons, including reductions in action potential firing rate and spontaneous inhibitory synaptic transmission in males, and that these effects occur specifically …

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Theta Oscillons In Behaving Rats, M S Zobaer, Nastaran Lotfi, Carli M Domenico, Clarissa Hoffman, Luca Perotti, Daoyun Ji, Yuri Dabaghian May 2025

Theta Oscillons In Behaving Rats, M S Zobaer, Nastaran Lotfi, Carli M Domenico, Clarissa Hoffman, Luca Perotti, Daoyun Ji, Yuri Dabaghian

Faculty, Staff and Students Publications

Recently discovered constituents of the brain waves—the oscillons—provide a high-resolution representation of the extracellular field dynamics. Here, we study the most robust, highest-amplitude oscillons recorded in actively behaving male rats, which underlie the traditional θ-waves. The resemblances between θ-oscillons and the conventional θ-waves are manifested primarily at the ballpark level—mean frequencies, mean amplitudes, and bandwidths. In addition, both hippocampal and cortical oscillons exhibit a number of intricate, behavior-attuned, transient properties that suggest a new vantage point for understanding the θ-rhythms’ structure, origins and functions. In particular, we demonstrate that oscillons are frequency-modulated waves, with speed-controlled …

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Genome-Wide Allele-Specific Expression In Multi-Tissue Samples From Healthy Male Baboons Reveals The Transcriptional Complexity Of Mammals, Ramesh Ramasamy, Muthuswamy Raveendran, R Alan Harris, Hiep D Le, Ludovic S Mure, Giorgia Benegiamo, Ouria Dkhissi-Benyahya, Howard Cooper, Jeffrey Rogers, Satchidananda Panda May 2025

Genome-Wide Allele-Specific Expression In Multi-Tissue Samples From Healthy Male Baboons Reveals The Transcriptional Complexity Of Mammals, Ramesh Ramasamy, Muthuswamy Raveendran, R Alan Harris, Hiep D Le, Ludovic S Mure, Giorgia Benegiamo, Ouria Dkhissi-Benyahya, Howard Cooper, Jeffrey Rogers, Satchidananda Panda

Faculty, Staff and Students Publications

Allele-specific expression (ASE) is pivotal in understanding the genetic underpinnings of phenotypic variation within species, differences in disease susceptibility, and responses to environmental factors. We processed 11 different tissue types collected from 12 age-matched healthy olive baboons (Papio anubis) for genome-wide ASE analysis. By sequencing their genomes at a minimum depth of 30×, we identified over 16 million single-nucleotide variants (SNVs). We also generated long-read sequencing data, enabling the phasing of all variants present within the coding regions of 96.5% of assayable protein-coding genes as a single haplotype block. Given the extensive heterozygosity of baboons relative to humans, we could …

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Automatic Determination Of Interactive Actions For Different Portions Of Digital Media, Manasa Babu May 2025

Automatic Determination Of Interactive Actions For Different Portions Of Digital Media, Manasa Babu

Defensive Publications Series

Media files lack interactive functionality, requiring users to manually perform actions related to the information displayed. This disclosure describes techniques to provide enhanced media interactivity by enabling context-aware selection and actions with reference to different portions of media content. Per the techniques, media content is analyzed to determine interactive actions that can be taken with reference to different portions of the media. The analysis includes determining the boundaries of the selection. The context of selection such as type of media and the overall content can also be taken into account. The selection mechanism can also adapt to user input. A …

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Experiential Learning Through Service Learning -- Integrating The Social Inequality Classroom, Mehmet Soyer, Mike Spence, Zach Johnson May 2025

Experiential Learning Through Service Learning -- Integrating The Social Inequality Classroom, Mehmet Soyer, Mike Spence, Zach Johnson

Utah Conference on Community Engagement

This session explores the role of service-learning in social inequality education, highlighting an experiential learning assignment that engages students with local non-profits. Participants will learn how structured reflections and community engagement deepen students' understanding of inequality and civic responsibility. The session will provide practical insights into implementing service-learning to foster critical thinking and social change.

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Reaching Communities And Serving People: Assessing Utah's Legal Needs, Pamela Beatse J.D, Scotti Hill J.D, Keenan Carroll J.D., Hannah Kiely M.A May 2025

Reaching Communities And Serving People: Assessing Utah's Legal Needs, Pamela Beatse J.D, Scotti Hill J.D, Keenan Carroll J.D., Hannah Kiely M.A

Utah Conference on Community Engagement

"Utah Legal Services (ULS) conducted a comprehensive legal needs assessment in 2024 to gather the necessary data and information to better meet its mission of providing high-quality civil legal aid without cost to people who are unable to afford legal representation or are facing disadvantages. Using the combination of an online survey, a series of focus groups throughout the Wasatch front, individual or group interviews, and several community soundboards, ULS conducted a broad, statewide survey. We connected with representatives, organizations, advocates, case managers, and leaders in the community as well as with client-eligible Utahns and ULS staff. This process allowed …

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How Are You? Increasing Pre-Service Educators' Out-Of-Class Communication With Social And Emotional Learning, Brittany Severino May 2025

How Are You? Increasing Pre-Service Educators' Out-Of-Class Communication With Social And Emotional Learning, Brittany Severino

International Journal for the Scholarship of Teaching & Learning

Social and Emotional Learning (SEL) can be embedded within professors’ teaching pedagogy to help support students’ mental well-being and create an inclusive learning environment. However, studies that explore implementing specific SEL strategies within higher education are extremely limited. To explore the potential benefits, the researcher and professor of this study engaged in the Scholarship of Teaching and Learning (SoTL), by evaluating the potential impact of a consistent SEL check-in at the start of each class session on the student-initiated out-of-class communication (OCC), attendance, and academic performance of undergraduate education majors pursuing a special education certification or minor. Quantitative and qualitative …

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Avatars Vs. Actors: Comparison Shows Little Difference In Role-Play Simulations For Psychology Students, Melinda Russell-Stamp, Jean R. Norman, Kennedy Parker May 2025

Avatars Vs. Actors: Comparison Shows Little Difference In Role-Play Simulations For Psychology Students, Melinda Russell-Stamp, Jean R. Norman, Kennedy Parker

International Journal for the Scholarship of Teaching & Learning

Role-playing using avatars has been demonstrated as effective, but it has not been compared to role-playing with a live actor. In this study, undergraduate psychology students (N=93) conducted a clinical interview in a role-play with an avatar or live actor. Mixed methods included a survey and written reflection. The study found no differences in student interest-enjoyment, skills-knowledge, comfort level, or utility value in survey scales found to be reliable. High levels of active learning were found in qualitative data in both conditions, though it was significantly higher in the avatar group. High levels of benefits from group work also were …

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Zoo Animal, Kristen Gainey May 2025

Zoo Animal, Kristen Gainey

The Echo

No abstract provided.

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An Eyeful Of Stars, Ainsley Buss May 2025

An Eyeful Of Stars, Ainsley Buss

The Echo

No abstract provided.

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The Legend Of The Sea Squids, Stephen Turner May 2025

The Legend Of The Sea Squids, Stephen Turner

The Echo

No abstract provided.

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Preface & Table Of Contents, Furman University May 2025

Preface & Table Of Contents, Furman University

The Echo

No abstract provided.

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Echo 2025 - Complete Issue May 2025

Echo 2025 - Complete Issue

The Echo

No abstract provided.

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Proceedings Of The 12th Research Symposium At Mammoth Cave National Park, Pat Kambesis Editor, Lee Anne Bledsoe Editor, Ana K. Celis Editor May 2025

Proceedings Of The 12th Research Symposium At Mammoth Cave National Park, Pat Kambesis Editor, Lee Anne Bledsoe Editor, Ana K. Celis Editor

Mammoth Cave Research Symposia

Proceedings of the 12th Research Symposium at Mammoth Cave National Park: Celebrating 100 Years of Scientific Research & Resource Management in the Mammoh Cave Region.

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Genetic Correlations Between Enteric Methane And Traits Of Economic Importance In A Beef Finishing System, Clodagh V. Ryan, Thierry Pabiou, Deirdre C. Purfield May 2025

Genetic Correlations Between Enteric Methane And Traits Of Economic Importance In A Beef Finishing System, Clodagh V. Ryan, Thierry Pabiou, Deirdre C. Purfield

Department of Biological Sciences Publications

With the pressing global challenge of climate change, the potential to breed cattle that produce less lifetime methane offers a transformative solution that is both sustainable and impactful. The objective of this study was to determine the genetic correlations between enteric methane emissions and economically important traits included in the current Terminal Index used to breed animals for meat in Ireland. This Terminal Index is typical of terminal-type indexes used globally, constituting traits associated with calving performance, carcass merit, and efficiency traits such as feed intake and age at finish, as well as some ancillary traits such as docility. Methane …

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Exploring The Therapeutic Potential Of Plant Extract-Loaded Polymeric Nanoparticles For Advanced Wound Healing: A Comprehensive Review, Samar A. Salim, Tasneem Abed, Esraa Abdelazim, Noura Eissa, Mahmoud Elsabahy, Elbadawy Kamoun May 2025

Exploring The Therapeutic Potential Of Plant Extract-Loaded Polymeric Nanoparticles For Advanced Wound Healing: A Comprehensive Review, Samar A. Salim, Tasneem Abed, Esraa Abdelazim, Noura Eissa, Mahmoud Elsabahy, Elbadawy Kamoun

Nanotechnology Research Centre

No abstract provided.

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Pilot/ Validation Of Protocol For An Alternative To Clinical, Morgan Sylvester May 2025

Pilot/ Validation Of Protocol For An Alternative To Clinical, Morgan Sylvester

Honors Theses

All across the country, Clinical Microbiology laboratories are being consolidated into one location for an entire hospital network10. Though this helps reduce cost and staffing needs, it creates issues for the next generation of Medical Laboratory Scientists (MLS) trying to find clinical sites to complete clinical practicum rotations to complete the necessary certification processes. To combat this issue, it was proposed that MLS programs create alternative curriculums to offer in place of clinical rotations to reduce the amount of time students need in these rotations from three weeks to one week. This study investigated one alternative with the intent that …

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What Falls Away, Nancy Mccadden May 2025

What Falls Away, Nancy Mccadden

Master’s Theses and Projects

No abstract provided.

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Truest Potential Of Canvas: Self-Actualization And Art In The Criminal Justice Classroom, Rachel Johnnie Dimonda May 2025

Truest Potential Of Canvas: Self-Actualization And Art In The Criminal Justice Classroom, Rachel Johnnie Dimonda

Master’s Theses and Projects

No abstract provided.

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