Digital Commons Network^™

The Bare Truth Behind A Sore Throat, Jennifer W. Glusman Do, Jamel Mansur Md, Martin E. Anderson, Mallory Logsdon Do

Advocate GME

Introduction/Background: A fully vaccinated 16-year-old female from Mexico with PMH of sinusitis requiring surgery, presented with a three-month history of chronic pharyngitis despite multiple courses of antibiotics, difficulty swallowing, voice changes, fevers, chills, and a 30-pound weight loss. ROS revealed acute-onset worsening throat pain, right-sided headache, ear pain, cough, and biliteral lacrimation. On exam, she was non-toxic, visibly uncomfortable. She had a severely muffled voice, lacrimation, bilateral tonsillar hypertrophy, pseudomembranes on right tonsil/pharynx, and difficulty swallowing thick secretions. Her neck was supple with normal ROM and no tenderness. She saturated well on room air but was tachycardic, had mild hepatosplenomegaly, …

Cradle: Empowering Foundation Agents Towards General Computer Control, Weihao Tan, Et. Al.

Research Collection School Of Computing and Information Systems

Despite their success in specific scenarios, existing foundation agents still struggle to generalize across various virtual scenarios, mainly due to the dramatically different encapsulations of environments with manually designed observation and action spaces. To handle this issue, we propose the General Computer Control (GCC) setting to restrict foundation agents to interact with software through the most unified and standardized interface, i.e., using screenshots as input and keyboard and mouse actions as output. We introduce Cradle, a modular and flexible LMM-powered framework, as a preliminary attempt towards GCC. Enhanced by six key modules, Information Gathering, Self-Reflection, Task Inference, Skill Curation, Action …

Models Of Care For Indigenous Children In Rural And Remote Settings: A Global Scoping Review, Joseph Freeman, Thomas Stubbs, Verity Chadwick, Anita Pickard, Tuguy Esgin, Elizabeth J. Elliott, Alexandra Martiniuk

Research outputs 2022 to 2026

Indigenous communities internationally have demonstrated remarkable strength despite significant challenges. Health disparities among Indigenous peoples persist due to historical injustices and ongoing racial discrimination, not inherent vulnerabilities. Disparities are rooted in a legacy of colonisation, systemic exclusion, and socio-economic inequities impacting access to healthcare, education, and employment. Preliminary searches show limited literature on models of care for remote living Indigenous children. This review aimed to identify internationally, effective models of care for Indigenous children in rural and remote areas. A scoping review was conducted, analysing literature on models of care for remote Indigenous children. This study followed the JBI’s Scoping …

The Therapeutic Potential Of Butyrate And Lauric Acid In Modulating Glial And Neuronal Activity In Alzheimer’S Disease, Rathnayaka Mudiyanselage Uththara Sachinthanie Senarath, Lotta E. Oikari, Prashant Bharadwaj, Vijay Jayasena, Ralph N. Martins, Wanakulasuriya Mary Ann Dipika Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by amyloid-β plaque accumulation, tau tangles, and extensive neuroinflammation. Neuroinflammation, driven by glial cells like microglia and astrocytes, plays a critical role in AD progression. Initially, these cells provide protective functions, such as debris clearance and neurotrophic support. However, as AD progresses, chronic activation of these cells exacerbates inflammation, contributing to synaptic dysfunction, neuronal loss, and cognitive decline. Microglia release pro-inflammatory cytokines and reactive oxygen species (ROS), while astrocytes undergo reactive astrogliosis, further impairing neuronal health. This maladaptive response from glial cells significantly accelerates disease pathology. Current AD treatments primarily aim …

Winds Of Change: Charting A Pathway To Ecosystem Monitoring Using Airborne Environmental Dna, Rachel L. Tulloch, Clare I.M. Adams, Matthew A. Barnes, Elizabeth L. Clare, Henrik C. Van De Ven, Andrew Cridge, Francisco Encinas-Viso, Kristen Fernandes, Dianne M. Gleeson, Erin Hill, Anna J.M. Hopkins, Anna M. Kearns, Gracie C. Kroos, Anna J. Macdonald, Francesco Martoni, Angela Mcgaughran, Todd G.B. Mclay, Linda E. Neaves, Paul Nevill, Andrew Pugh, Kye J. Robinson, Fabian Roger, Tracey V. Steinrucken, Mieke Van Der Heyde, Cecilia Villacorta-Rath, Jenny Vivian

Research outputs 2022 to 2026

Airborne environmental DNA (airborne eDNA) analysis leverages the globally ubiquitous medium of air to deliver broad species distribution data and support ecosystem monitoring across diverse environments. As this emerging technology matures, addressing critical challenges and seizing key opportunities will be essential to fully realize its potentially transformative impact. In June 2024, the Southern eDNA Society convened over 100 researchers, industry leaders, and biodiversity management stakeholders in a landmark workshop to evaluate the current state of airborne eDNA research and chart a course for future development. Participants explored opportunities for integrating airborne eDNA into existing monitoring systems, but they unanimously agreed …

Climate Fiction Of The Anthropocene, Joseph Paul Ferguson, Cassandra Tytler, Peta J. White, Susan Oliver

Research outputs 2022 to 2026

No abstract provided.

Post-Anthropocene Provocations: Human-Sized Scholars’ Rocks, Cronenbergian Flesh Caves And Zen Garden Design Cues For A Future Proof Re(Image)Ining, Brenton Rossow, Darren Tynan

Research outputs 2022 to 2026

This research explores concertinaing past, present and future interventional creative and pedagogical practices to address the challenges of the Post-Anthropocene era. We argue that the Post-Anthropocene is marked by biotechnological entanglements, environmental violence and digital overstimulation. The discussions herein critique a hyperattentive achievement society characterised by a scattering of attention, a near-constant screen-mediated stream of digital material and tasks and the commodification of leisure time. Enlisting Byung-Chul Han’s concept of hyperattention and themes and motifs from David Cronenberg’s films, the authors propose “FUTURE PROOF re(image)ining” as a collaborative Cli-Fi narrative concept. The project reimagines objects from an initial art installation …

L-Quebrachitol Modulates The Anti-Convulsant Effects Of Carbamazepine Possibly Through Voltage-Gated Sodium Channel Blocking Mechanism In Chicks: In Vivo And In Silico Studies, Asifa Asrafi, Mohammad Aslam, Ali G. Alkhathami, Md. Sakib Hossain, Imam Hossen Rakib, Md. Sakib Al Hasan, Feroz Khan Nun, Md. Faisal Amin, Muhammad Torequl Islam

School of Integrative Biological & Chemical Sciences Faculty Publications

Introduction: L-Quebrachitol (LQB), a naturally occurring bioactive compound, exhibits anti-inflammatory, anti-oxidant, anti-cancer, and anti-diabetic properties. However, its therapeutic potential in convulsant management remains largely unexplored. The objective of this study was to investigate the anticonvulsant effects of LQB in an In Vivo model and to examine its molecular interactions via In Silico docking simulations.

Methods: In the In Vivo study, pentylenetetrazol (PTZ) was administered intraperitoneally (i.p.) at 80 mg/kg to induce convulsions, and the test animals were treated orally with three doses of LQB (1, 5, and 10 mg/kg), with carbamazepine (CBZ) at 80 mg/kg as a standard drug.

Results: …

Bibliometric Analysis Of Congenital Toxoplasmosis: A Ten-Year (2013-2023) Review Of Research Publications, Festus Mulakoli, Horatius Musembi, Ann Kimani

School of Nursing & Midwifery, East Africa

Background:Toxoplasma gondii, an obligate intracellular protozoan, infects more than one-third of the global population and causes toxoplasmosis, which can lead to severe fetal complications in pregnant women. The global prevalence of latent toxoplasmosis in pregnant women is 33.8%, with regional variations and risk factors, including the consumption of undercooked meat, exposure to cat feces, and consumption of contaminated water. Pregnant women lack sufficient awareness of these risk factors, necessitating enhanced education, regular screening, and counseling during antenatal care for early detection and management.

Aim: This study performed a comprehensive bibliometric analysis of research on congenital toxoplasmosis published between 2013 …

The Methane Clumped Isotope Signatures Of The Acetoclastic And Methylotrophic Methanogenesis Pathways, Mia L. Thompson

Dartmouth College Master’s Theses

Methane is a potent greenhouse gas and critical energy source for the global economy. Atmospheric methane concentrations play a critical role in global warming, while mitigating methane emissions may provide route to short-term reduction of warming effects. In order to track rates and sources of emissions, it is first necessary to understand the sources and sinks of methane; yet, there are challenges in distinguishing abiotic (water/rock), thermogenic, and biogenic methane. Traditional approaches of using the bulk isotopes of carbon (δ¹³C) and hydrogen (δD) of methane have limitations due to overlapping signatures and sensitivity to substrate isotope composition. In …

Rattler Python, Samer Jabor

Systems Manuals - 2026

The Rattler Python project is an interactive game-based learning system that intends to teach the basic concepts of Python programming through guided instruction, gameplay challenges, and review-based assessments. The document contains a proposal for this system consisting of problem definition, background research, existing solutions, and the proposed product, together with the system scope, assumptions, and the organization of the remainder of this document.

First-In-Human Phase 1 Study Of Khk2455 Monotherapy And In Combination With Mogamulizumab In Patients With Advanced Solid Tumors, Timothy A Yap, Olivier Rixe, Capucine Baldini, Ursa Brown-Glaberman, Sergey Efuni, David S Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H Shiue, Yi Liu, Matthew W Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam

Faculty, Staff and Student Publications

Background: Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long-acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme. Mogamulizumab is a humanized immunoglobulin G1 monoclonal antibody targeting CCR4. KHK2455 + mogamulizumab demonstrated enhanced antitumor activity in preclinical studies, which led to a first-in-human, two-part, multicenter, open-label, phase 1, dose-escalation, cohort-expansion trial (ClinicalTrials.gov identifier NCT02867007) evaluating the safety/tolerability, pharmacokinetics, and IDO1 activity of KHK2455 alone and in combination with mogamulizumab in patients with treatment-refractory advanced solid tumors. …

Course Descriptions, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

A Novel Enrichment-Free, Low-Volume Filtration And Rapid Lysis (Elr) Method In Combination With Real-Time Pcr For Detection Of Shiga Toxin-Producing Escherichia Coli (Stec) In Water, Zina Alfahl, Louise O’Connor, Dearbháile Morris, Terry J. Smith, Jean O'Dwyer, Paul D. Hynds, Martin Cormican, Liam P. Burke

Research Outputs: 2025-Present

Consequences of Shiga toxin-producing Escherichia coli (STEC) infection can range in severity from asymptomatic infection to haemolytic uraemic syndrome, renal failure and death. Groundwater-derived drinking water is an important route for STEC transmission. Detection of STEC in water is crucial for timely response and public health interventions; however, currently used culture-based methods are time-consuming and laborious. Therefore, there is a need for rapid methods that maintain high sensitivity and specificity [1]. We describe a novel, sensitive, enrichment-free water filtration method using a convenient sample volume (100 ml) to detect DNA markers of STEC serogroups and virulence factors within 6 h. …

The Loss Of Opa1 Accelerates Intervertebral Disc Degeneration And Osteoarthritis In Aged Mice, Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige Boneski, Hiromi Sesaki, Ruteja Barve, John Collins, Makarand Risbud

Department of Orthopaedic Surgery Faculty Papers

Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a mitochondrial fusion protein, in their homeostasis. OPA1 knockdown in NP cells altered mitochondrial size and cristae shape and increased the oxygen consumption rate. OPA1 governed the morphology of multiple organelles, including peroxisomes, early endosomes and cis-Golgi and loss resulted in the dysregulation of autophagy. Metabolic profiling and

Focus On Wildlife Swifts & Swallows Of Nh, Haley Andreozzi, Pam Hunt

UNH Cooperative Extension

No abstract provided.

Teratogenic Effects Of Serotonin Receptor 2b Disruption On The Migration And Cardiac Derivatives Of The Cardiac Neural Crest, Brian K. Wells, Gwyneth K. Garramone, Amira Mahomed, Max Ezin

Biology Faculty Works

Background: Cardiac neural crest cells (cNCCs) are critical for heart development, and their disruption can result in congenital heart defects. Serotonin (5-HT) signaling, specifically via 5-HT2B and 5-HT2C receptors, regulates diverse physiological processes, including neural crest migration. This study investigates how modulation of 5-HT2B and 5-HT2C receptor activity impacts cNCC migration and the development of their derivatives, with relevance to serotonergic drug safety during pregnancy.

Methods

Chicken embryos at HH8 were treated with 50 μL of 20 μM 1-Methylpsilocin (1-MP), an inverse agonist of 5-HT2B and agonist of 5-HT2C, and collected at HH14 to assess cNCC migration. Embryos were pre-treated …

The Role Of Private Law In Promoting Building Safety: The Case Of Singapore, Edward S. W. Ti

Research Collection Yong Pung How School Of Law

Singapore is a tiny granite rock situated just north of the equator. Lacking land, and indeed any kind of natural resource, means that the trend for urban development in the city-state will always be densifi cation; 96 per cent of residents in Singapore already live in multi-owned housing, ie high-rise apartments. 1 Singapore is also a rapidly greying nation. 2 It has been observed that persons over 70 years old are four times more vulnerable in the event of a fi re, 3 and fi re safety is a critical aspect of building safety. Safety features and measures in the …

Mammals Of Malheur National Wildlife Refuge And Surrounding Harney County, Oregon, John E. Cornely, Leslie N. Carraway

Monographs of the Western North American Naturalist

Malheur National Wildlife Refuge (NWR), located in southeastern Oregon, is part of the National Wildlife Refuge System (NWRS) of the United States. Currently, NWRS includes more than 568 NWRs, 38 Wetland Management Districts, and 5 Marine National Monuments. Malheur NWR, like a majority of the refuges in the NWRS, was established for the conservation of migratory birds. Many of these NWRs also provide significant habitat for mammals. Malheur NWR, one of the oldest (established 1908) and largest refuges in the system, is one of those with significant habitat for mammals. In addition to the refuge, we have included Harney County, …

Renal G Protein-Coupled Estrogen Receptor 1 Regulates The Epithelial Sodium Channel Promoting Natriuresis To A Greater Extent In Females, Victoria L Nasci, Jean C Bopassa, Elena Mironova, Megan Rhoads, Ravneet Singh, Dennis P Buehler, David M Pollock, Oleh M Pochynyuk, James D Stockand, Eman Y Gohar

Faculty, Staff and Student Publications

Hypertension prevalence is lower in women than men. Enhanced renal sodium (Na+) handling in females has been implicated in sex-differences in hypertension. Epithelial Na+ channel (ENaC) is a key contributor to Na+ homeostasis and is regulated by estrogen. Recent evidence suggests G protein-coupled estrogen receptor 1 (GPER1) evokes a female-specific natriuresis that involves endothelin-1 (ET-1). ET-1 has been shown to downregulate ENaC activity, but whether GPER1 regulates ENaC to modulate natriuresis is unknown. We tested the hypothesis that renal GPER1 functionally interacts with ENaC to promote natriuresis in a sex-specific manner. RNAscope confirmed co-expression of GPER1 and ENaC in rat …

Behind The Painting, Aries Calderon

Digressions: Literary & Art Journal

Artist Statement

"'Behind The Painting,' is a representative piece on how messy how felt when it came to my junior year of my college year. I always had this idea that once college ended, it was only a straight-forward path from here, or so I grew up to believe if I continued to follow down this path my parents have paved for me. You would think being in this position of stability, it would be easy for anyone to just listen and do everything blindly as you are guided towards success, but it turned out to be the most hurtful …

Berel Dov Lerner, Human-Divine Interactions In The Hebrew Scriptures: Covenants And Cross-Purposes, Shira Weiss

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Principal Component Analysis Of Emotion Related Concepts, Ana Kellermann Jimenez

Clinical Psychology Dissertations

Past research has established the overlap between several emotion-related factors, such as alexithymia, empathy, emotional intelligence, mindfulness, and mentalization. The aim of the present study was to analyze where these variables overlapped and how they related to different psychological and psychopathological variables. This was accomplished through the use of a Principal Component Analysis (PCA) and four canonical correlation models. The results indicated that there was an eight-component structure that included Alexithymia, Valuing Emotions, Mistrusting Emotions, Positive Reframe, Perspective-Taking, Empathetic Concern, Emotional Pessimism, and Avoiding Emotions. The internal reliability of the components ranged from adequate to excellent. The validity of the …

High-Impact Chronic Pain And Cognitive Decline Among Mexicans Aged 60 And Older From 2012 To 2018, Sadaf Arefi Milani, Sirena Gutierrez, Brandon O'Grady, Rebeca Wong, Rafael Samper-Ternent, Brian Downer

Faculty, Staff and Student Publications

Pain is associated with cognitive decline, but prior research has not considered differences between high- and low-impact chronic pain or low-and middle-income countries, such as Mexico. Our objective was to evaluate the association between high-impact chronic pain and cognitive decline among older adults in Mexico. We used data from the 2012-2018 Mexican Health and Aging Study (MHAS), a nationally representative study of older Mexican adults (60+). Pain, measured at each wave, was categorized as high-impact chronic pain (pain that limits daily activities), low-impact chronic pain (pain that did not limit daily activities), and no chronic pain. Cognition was measured at …

Diet, Gut Microbiota, And Histidine Metabolism Toward Imidazole Propionate Production In Relation To Type 2 Diabetes, Hongbo Yang, Kai Luo, Brandilyn A Peters, Yi Wang, Yanbo Zhang, Martha Daviglus, Amber Pirzada, Christina Cordero, Bing Yu, Robert D Burk, Robert Kaplan, Qibin Qi

Faculty, Staff and Student Publications

Objective: To examine associations of serum imidazole propionate (ImP), histidine, and their ratio with incident type 2 diabetes (T2D) and related dietary and gut microbial factors in U.S. Hispanic/Latino people.

Research design and methods: In the Hispanic Community Health Study/Study of Latinos, we evaluated serum ImP, histidine, and ImP-to-histidine ratio at baseline (2008-2011) and their cross-sectional associations with dietary intake and prospective associations with incident T2D over ∼12 years (n = 4,632). In a subsample with gut microbiota data during a follow-up visit (2016-2018), we examined gut microbial species associated with serum ImP and their potential interactions with dietary intake. …

Annual Review Of Seqra Cases And Developments, Michael B. Gerrard

Faculty Scholarship

The New York State Environmental Quality Review Act (SEQRA) turns 50 this year. The statute has changed only a little in the last half century, but it continues to be a font of litigation. The courts decided 43 cases under SEQRA in 2024.

Implementation of SEQRA is also raising policy issues. The legislature is considering whether to amend SEQRA to speed up affordable housing projects, and the State Department of Environmental Conservation (DEC) is drafting regulations concerning the role SEQRA should play in advancing environmental justice.

A constant theme is the tension between thoroughly studying important project impacts and involving …

Wild Hogs In The Water: Contested Infrastructural Ecologies Of Reservoir Storage In Texas, Sayd Randle

Research Collection College of Integrative Studies

Reservoirs are developed to store water in reserve for future use. But once built, reservoir sites inevitably hold more than just water, often serving as a key habitat for a range of species. This paper examines how one such animal has transformed water storage facilities and nearby landscapes into contested ground in urbanising areas of Texas, USA. Living around the reservoirs, feral hogs complicate the process of urbanisation by degrading the stockpiled water and infrastructure at the storage sites themselves and by damaging private property throughout the surrounding landscape. Tracking local efforts to manage the hogs, the case study illustrates …

The Immunological Benefits Of Breast Feeding (Review Article), Ahmed Al-Harbi, Asmaa Shetawi

Iraqi Postgraduate Medical Journal

Breast feeding (BF) provides infants with the most suitable nutrients from birth tell weaning. The major part of mother breast milk (MBM) is water in which the other components dissolve. These components include nutrients and immune factors. The concentration of these components varies by time after delivery. Breast milk even provides infants with various types of bacterial species that contribute for development of infant microbiota.Components that are regarded important for shaping of infant immune response include different factors. MBM contains oligosaccharides which are associated with guts defenses, cytokines that participate in inflammation and immune cells activation, immunoglobulins that arm infant’s …

Dark Patterns As Disloyal Design, Johanna Gunawan, Woodrow Hartzog, Neil Richards, David Choffnes, Christo Wilson

Faculty Scholarship

Lawmakers have started to regulate “dark patterns,” understood to be design practices meant to influence technology users’ decisions through manipulative or deceptive means. Most agree that dark patterns are undesirable, but open questions remain as to which design choices should be subjected to scrutiny, much less the best way to regulate them.

In this Article, we propose adapting the concept of dark patterns to better fit legal frameworks. Critics allege that the legal conceptualizations of dark patterns are overbroad, impractical, and counterproductive. We argue that law and policy conceptualizations of dark patterns suffer from three deficiencies: First, dark patterns lack …

Advanced Biodegradable Antimicrobial Coatings By Combining Biopolymers And Natural Antimicrobials For The Active Packaging And Extending The Shelf-Life Of Fish And Other Seafood Products: A Review, Hariharan S. Melarcode, Onur Ertugrul, Paola C. Alzate Calderon, Joseph P. Kerry, Michael A. Morris

Research Outputs: 2025-Present

Fish and other seafood products are an integral and valuable part of human diets. In advanced nations, the transportation of fish and other seafood products to customers requires packaging and display. Due to their intrinsic physicochemical properties, seafood products are particularly susceptible to microbial growth, resulting in shorter shelf lives and higher spoilage rates compared to other animal-derived proteins, such as meat. To prevent microbial spoilage and preserve the freshness and quality of fish and other seafood products, petroleum-based plastic materials are commonly used in combination with packaging technologies, such as vacuum packaging and modified atmosphere packaging. However, as these …