Digital Commons Network^™

Quantification Of Bioactive Compounds In Coffea Arabica And Their Impact With Omega-3 Supplementation On Non-High-Density Lipoprotein Levels In Hyperlipidemia-Induced Rats, Sojoud M. Al-Zoubi, Shady H. Awwad, Reem A. Issa, Ahmad Q. Daraosheh, Talal Al-Qaisi, Husni Farah, Khaled W. Omari, Beisan A. Mohammad, Mumen Amer, Rula F. Khuzaie, Mahmoud S. Abu-Samak

Baghdad Science Journal

This study aims to evaluate the levels of coffee lipids, diterpenes, chlorogenic acid (CGA), and caffeine in coffee samples with different roasting levels. Additionally, it aims to assess the impact of coffee extracts with/without omega-3 supplementation on lipid profile parameters. Liquid-liquid and soxhlet extraction, and quantitation were performed using HPLC-DAD. Two groups of Wistar rats were used: non-hyperlipidemic and hyperlipidemic. Blood samples were collected before and after hyperlipidemia induction after six weeks. The lipid profile: total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), non-high-density lipoprotein (non-HDL), and total cholesterol-to-high-density lipoprotein ratio (TC/HDL) were determined. A positive correlation …

Estimation Of Paraoxonase-1 And Dipeptidyl Peptidase In Iraqi Prostatic Cancer With Hormones And Chemotherapy Drugs: A Cross-Sectional Study, Ammar H.Al-Qazzaz, Anwar F. Al-Taie

Baghdad Science Journal

Prostate cancer is a frequent masculine disease, especially when becoming older. Paraoxonase-1 (PON-1) is an enzyme present in the human body that plays an important function in preventing oxidative stress and inflammation. It is mostly linked to high-density lipoprotein (HDL). Dipeptidyl peptidase-4 (DPP-4) is an enzyme regulating blood sugar levels. It is found on many cells surfaces: immune cells, epithelial cells, and pancreatic cells. The aim of this cross-sectional study was to determine the biochemical role of PON-1 effect and DPP-4 enzymes with the anti-cancer ability of vitamin D. Research samples were collected from Iraqi prostate cancer patients (male aged …

Evaluating The Selectivity Of Novel Zic-Hilic Columns And An Application For Determining Antihistaminic Drugs In Pharmaceutical Preparations, Ashraf Saad Rasheed, Mustafa J. Mohammed

Baghdad Science Journal

The hydrophilic interaction liquid chromatography (HILIC) conjugated with UV spectrometry was employed to the determination of two antihistaminic drugs (Acrivastine and fexofenadine) in pharmaceutical formulations using two lab-made zwitterionic HILIC stationary phases (ZIC-2 and ZIC-5). The study aimed to investigate the impact of separation parameters including acetonitrile (ACN) content, pH of the eluent, and acetate buffer concentration on the retention behavior of Acrivastine and fexofenadine. A mixture of 3.0 mM acetate buffer (pH 4.75) and ACN (30:70) was used as eluent, with a flow rate of 0.6 mL/min. The detection wavelength was controlled at 267nm. The linearity of Acrivastine and …

Synthesis, Biological Activity And Molecular Docking Study Of Some New Chalcones, 5,6-Dihydropyrimidin-2-Ol And 5,6-Dihydropyrimidin-2-Thiol Derivatives Bearing 1,2,3- Triazoline, Hayder Raheem Ali, Ahmed Wahed Naser

Baghdad Science Journal

Many new chemicals, including chalcones, derivatives of 5,6-dihydropyrimidin-2-ol and 5,6-dihydropyrimidin-2-thiol, are synthesized in this work. The starting materials are substituted acetophenone derivatives involving 1,2,3-triazoline (1). Chalcone derivatives (2a-h) were obtained by condensing compound (1) with some substituted aromatic aldehydes in the presence of 40% potassium hydroxide KOH. The process of producing pyrimidin-2-ol derivatives (3a–e) by cyclizing produced chalcone derivatives (2a–e) urea in the presence of sodium hydroxide. Equivalent pyrimidin-2-thiol derivatives (4a-d) were produced when chalcone derivatives (2a-d) reacted with thiourea in the presence of sodium hydroxide. The …

Normal And Reverse Flow Injection- Spectrophotometric Determination Of Doxycycline Hyclate In Bulk And Pharmaceutical Samples, Tabarak Mohammed, Hind Hadi

Baghdad Science Journal

The present paper reports the development and validation of an analytical method for doxycycline hyclate (DOX) quantification in pure and dosage forms by normal and reverse flow injection analysis (FIA) techniques. Two types of FIA approaches were employed to automate a diazotization coupling reaction of DOX with diazotized benzidine dihydrochloride. Red azo dye was formed rapidly and measured at maximum wavelength of 488 nm. Calibration curves were prepared over different DOX concentrations with linearity ranges of 10-250 and 1-180 µg/mL for normal and reverse FIA systems respectively with the limits of detection of 2.95 and 0.46 µg/mL and limits of …

Synthesis, Characterization, And Anticancer Evaluation Of Novel Nickel(Ii) And Copper(Ii) Complexes Derived From Isatin Thiosemicarbazones, Shahnaz Abdulhamid Hamad

Baghdad Science Journal

The complex of (2,2'-(7,7'-dimethyl-2,2'-dioxo-1,1',2,2'-tetrahydro-3H,3'H-5,5'-biindole-3,3'-diylidene) dihydrazinecarbo thioamide), denoted as L, was prepared by the reaction of o-tolidine with chloral hydrate and hydroxylamine hydrochloride in the presence of sodium sulfate and a co-solvent, absolute ethanol. The novel complexes of Ni(II) and Cu(II) with the ligand, L, have been synthesized from a reaction of one mole of L with two moles of NiCl₂ and CuCl₂ to produce complexes with the general formula [M₂LCl₂] [where M= Ni(II) or Cu(II)]. All three complexes are novel and have a square planar geometry. The metal ions in the two metal complexes …

Synthesis, Characterization, Biological Activity And Antioxidant Studies Of New Metal Ion Complexes Based On (E)-4-((Benzo[D]Thiazol-2-Ylimino)Methyl)-1,5-Dimethyl-2-Phenylpyrazolidin-3-One, Rafah Saad Talib, Naser Shaalan

Baghdad Science Journal

The study involved synthesis of four new complexes involving bidentate ligand [(E)-4-((benzo[d]thiazol-2-ylimino) methyl)-1,5-dimethyl-2-phenylpyrazolidin-3-one] with the general formula [M(L)₂Cl₂].xH₂O or [MLCl₂]. xH₂O, where M represents Mn²⁺, Co²⁺, Ni²⁺ and Cu²⁺. The ligand was synthesized by treating the 4-Antipyrinecarboxaldehyde and 2-aminobenzothiazoles in an alcoholic solution. The structural characteristics of ligand and complexes were characterized quantitatively and qualitatively by using various techniques including elemental analyses, magnetic susceptibility measurement, molar conductivity, infrared, ultraviolet absorption, Gc-Mass, and ¹H-NMR spectroscopy studies. The physical measurements indicated that the prepared …

Corrosion Protection Of Copper In Salt Medium By Poly 4-Hyroxyaniline Deposited Via Electrodeposition Technique, Ahlam M. Farhan, Rasha A. Jassim, Nafeesa J. Kadhim

Baghdad Science Journal

The polymer was used to inhibit the corrosion of copper metal in salt media in different concentrations at room temperature using potentiometric polarization measurement. The polymer was prepared by mixing (0.1M) 4-Hydroxy aniline (C₆H₇NO) with (0.25M) of ammonium persulfate as the initiator using the electro-deposition technique. The polymer's results showed that copper in (3.5%) NaCl had good corrosion resistance. The findings demonstrate that the %IE for polymer-induced copper corrosion is 89.32% at 10 ppm concentration as a result of the 4-hydroxy aniline polymer's adsorption from salt solution on the surface of copper metal. The numbers from …

Exploring The Processing Of Objects, Settings, And Global Properties In Natural Auditory Scenes, Margaret A. Mcmullin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Our auditory system has a remarkable ability to make sense of complex environments, allowing us to identify what we are hearing and where sounds come from. This process of auditory scene analysis is essential for situational awareness, decision-making, and effective communication in daily life. While much is known about how listeners segregate and identify individual sound sources (e.g., voices), less is understood about how global properties of a scene (e.g., openness, naturalness) contribute to perception. This dissertation examined how object- and setting-level information in natural auditory scenes are processed, and whether they rely on distinct or overlapping mechanisms. In Experiment …

Sox2 Regulates Foregut Squamous Epithelial Homeostasis And Is Lost During Barrett’S Esophagus Development, Ramon U Jin, Yuanwei Xu, T Mamie Lih, Yang-Zhe Huang, Toni M Nittolo, Blake E Sells, Olivia M Dres, Jean S Wang, Qing K Li, Hui Zhang, Jason C Mills

Faculty, Staff and Students Publications

Esophageal adenocarcinoma is increasingly prevalent and is thought to arise from Barrett's esophagus (BE), a metaplastic condition in which chronic acid and bile reflux transforms the esophageal squamous epithelium into a gastric-intestinal glandular mucosa. The molecular determinants driving this metaplasia are poorly understood. We developed a human BE organoid biobank that recapitulates BE's molecular heterogeneity. Bulk and single-cell transcriptomics, supported by patient tissue analysis, revealed that BE differentiation reflects a balance between SOX2 (foregut/esophageal) and CDX2 (hindgut/intestinal) transcription factors. Using squamous-specific inducible Sox2-KO (Krt5CreER/+ Sox2Δ/Δ ROSA26tdTomato/+) mice, we observed increased basal proliferation, reduced squamous differentiation, and expanded metaplastic glands at …

What Is Lost When Time Is Saved: Drawing In Collaboration With The Urban Periphery, Carmen Ribaudo

MFA in Visual Art

I pay attention to the overlooked spaces where land and industry meet, prompting me to wonder what can be gleaned in the oily and cracked urban periphery. With a focus on my hometown St. Louis, this industrial city is my subject matter. And so, I draw in a neighborhood bisected by a highway. I animate with sand near the river confluence on land preserved after a historic flood. I make my own bricks in this Brick City, setting up in locations of former terra cotta clay mines. I sit in the tension of what author Michael Martone calls the “midwestern …

A Bibliometric Analysis Of The Top 100 Cited Papers In Trabeculectomy, Sinan Akosman, Michael Frenkel, Sonia C. Mcnamara, Thomas I. Hong, Reena A. Garg

Journal of Academic Ophthalmology

Purpose: To identify the most frequently cited articles on trabeculectomy through a bibliometric analysis. Methods: The Web of Science was queried using the term “trabeculectomy” to identify the 100 most cited (T100) publications. Articles were listed by title, authors’ affiliated institutions, journal title, year of publication, country of origin, funding sources, and citation count. Results: The T100 articles were published between the years 1975 and 2022. The number of total citations received by each article ranged from 83 to 550. The number one most cited T100 article was titled “Treatment Outcomes in The Tube Versus Trabeculectomy (TVT) Study After Five …

Sleep Disorder Diagnosis Using Eeg Signals And Lstm Deep Learning Method, Mohammad Reza Yousefi, Reza Rahimi

NJF Intelligent Engineering Journal

Diagnosing brain disorders, particularly sleep disorders, has emerged as a critical area of research in both basic sciences and engineering. Sleep disorders encompass a range of conditions, including excessive or insufficient sleep, frequent awakenings, difficulty falling asleep, and challenges in reaching deep sleep stages. A key application of sleep disorder diagnosis lies in supporting the medical community through the development of advanced algorithms and models capable of accurately identifying these disorders based on individual brain signals, such as those captured by electroencephalography (EEG). These sophisticated approaches facilitate the creation of personalized treatment programs, paving the way for more targeted and …

Post-Translational Modifications Of Extracellular Matrix Domains As Prognosticators Of Hepatocellular Carcinoma Via Integrative Serum And Spatial Proteomics, Jade K. Macdonald

MUSC Theses and Dissertations

Hepatocellular carcinoma (HCC) remains a major global health challenge, with rising incidence, high mortality, and a five-year survival rate below 20%. Approximately 90% of HCC cases arise in cirrhosis, a stromal disease characterized by excessive deposition and remodeling of collagenous extracellular matrix (ECM). As HCC progresses, alterations in ECM composition and spatial distribution influence disease progression, emphasizing the potential of the ECM as a biomarker for HCC prognosis and treatment response. However, ECM proteomic analysis is challenging due to complex post-translational modifications, crosslinking, and insolubility. This dissertation molecularly and spatially characterizes the stromal landscape in and around HCC tumors in …

An Evidence-Based Intervention To Increase Trypanosoma Cruzi, A Neglected Parasitic Infection, Diagnosis In Rural And Moderate-Size-City Us Clinics, M K. Lynn, Hunter M. Boehme, Jeffrey Hall, Patrick Kent, Alain H. Litwin, Quang H. Pham, Melissa Nolan Ph.D., Mph, Prisma Chagas Team

Faculty Publications

Background

Chagas disease is a chronic, insidious parasitic infection (Trypanosoma cruzi) that slowly develops to irreversible organomegaly over several decades. The disease is traditionally acquired in endemic Latin American countries during childhood; < 1% of foreign-born adult residents in the United States have been diagnosed or treated with this potentially fatal disease. Low physician knowledge is a primary factor leading to misdiagnosis.

Methods

Starting in April 2022, a 4-part T cruzi clinical education intervention began, which included (i) 2 grand rounds presentations to >100 internal medicine providers; (ii) implementation of a “clinical Chagas champions program” incorporating 14 key clinical staff at varying departments and administrative levels educated on their specific role related to T cruzi screening, diagnosis confirmation, clinical management, and medical billing; ( …

Front Matter, Maya America Editors

Maya America: Journal of Essays, Commentary, and Analysis

Includes Cover Art, Definitions, and Table of Contents

Introductory Note: Maya America Volume 7 Issue 1 2025, Robin Chancer, Alan Lebaron

Maya America: Journal of Essays, Commentary, and Analysis

Maya America Volume 7 Issue 1 presents essays, commentaries, and literature that directly or indirectly address our theme for this journal issue: “Maya Cosmic Health.” The authors examine various topics of health, and the collective work addresses the meaning of health as understood through Maya cosmovision. The editors of this special issue aim to encourage bridge-building between Maya health cosmovision and biomedical or psychological practitioners. In addition, we recognize the opportunity to address rapidly changing technological realities, the responses of Maya peoples, and the emerging potentialities for partnerships.

Paris Trip Blog: The Codex Pérez And The Unesco Conference On Language Technologies, Gaspar Tomas

Maya America: Journal of Essays, Commentary, and Analysis

Gaspar Tomas discusses his trip to Paris, where he attended the UNESCO conference on language technologies. Gaspar has long studied and lived within Maya cosmology; thus he also visited the Codex Pérez. Gaspar explains that technology can and must be employed in the preservation of Indigenous languages. In his own words: “Just as our ancestors once protected our languages, we must remember that ancestral knowledge is not lost; it simply waits to be reclaimed. The responsibility now lies with us to preserve, promote, and archive our voices to shape our future better.”

Full Issue - Maya America V7, I1, Maya America Editors

Maya America: Journal of Essays, Commentary, and Analysis

Full issue of Maya America, volume 7, issue 1.

Highly Oligomeric Drp1 Strategic Positioning At Mitochondria-Sarcoplasmic Reticulum Contacts In Adult Murine Heart Through Actin Anchoring, Celia Fernandez-Sanz, Sergio De La Fuente, Zuzana Nichtova, Marilen Federico, Stephane Duvezin-Caubet, Sebastian Lanvermann, Hui-Ying Tsai, Yanguo Xin, György Csordás, Wang Wang, Arnaud Mourier, Shey-Shing Sheu

Department of Medicine Faculty Papers

Mitochondrial fission and fusion appear to be relatively infrequent in cardiac cells compared to other cell types; however, the proteins involved in these events are highly expressed in adult cardiomyocytes (ACM). Therefore, these proteins likely have additional non-canonical roles. We have previously shown that DRP1 not only participates in mitochondrial fission processes but also regulates mitochondrial bioenergetics in cardiac tissue. However, it is still unknown where the DRP1 that does not participate in mitochondrial fission is located and what its role is at those non-fission spots. Therefore, this manuscript will clarify whether oligomeric DRP1 is located at the SR–mitochondria interface, …

Phosphorylation Deficient Inducible Camp Early Repressor (Icer) Modulates Tumorigenesis And Survival In A Transgenic Zebrafish (Danio Rerio) Model Of Melanoma, Justin Wheelan, Melissa Rose Spigelman, Angelo Cirinelli, James Reilly, Carlos A. Molina

Department of Biology Faculty Scholarship and Creative Works

Melanoma, the most lethal form of skin cancer, is commonly associated with mutations in the BRAF gene, particularly BRAF^V600E, which drives tumor proliferation via the ERK1/2 signaling cascade. While BRAF inhibitors initially demonstrate efficacy, therapeutic resistance remains a significant challenge. Emerging evidence implicates the cAMP signaling pathway, particularly the cAMP response element-binding protein (CREB) and its repressor, inducible cAMP early repressor (ICER), in melanoma progression and drug resistance. ICER, a transcriptional repressor regulated via Ras/MAPK-mediated phosphorylation and ubiquitination, is degraded in melanoma, undermining its tumor-suppressive role. In a braf^V600E; p53 (loss of function) transgenic zebrafish ( …

Genetic Deletion Of The Sodium Phosphate Cotransporter Napi2a Ameliorates Heart Failure In Mice, Hiroko Yamauchi-Sawada, Benjamin D Humphreys, Et Al.

2020-Current year OA Pubs

Apical membrane sodium transporters in renal proximal tubules, such as sodium-glucose co-transporter 2, are attractive therapeutic targets for the treatment of heart failure (HF). Sodium-phosphate co-transporter 2a (NaPi2a) is predominantly expressed in the apical membrane of proximal tubular epithelia and functions to reabsorb filtered phosphate and sodium. It currently remains unclear whether the inhibition of NaPi2a attenuates HF. We found that NaPi2a deficiency improved the cardiac phenotypes of the HF models of transverse aortic constriction (TAC) and doxorubicin (Dox) cardiotoxicity. Natriuretic and phosphaturetic effects were observed in NaPi2a-KO mice under normal conditions, resulting in low serum phosphate and fibroblast growth …

Multimodal Spatial Transcriptomic Characterization Of Mouse Kidney Injury And Repair, Qiao Xuanyuan, Haojia Wu, Hemalatha Sundaramoorthi, Pierre Isnard, Changfeng Chen, Waleed Rahmani, Benjamin D Humphreys

2020-Current year OA Pubs

The transition from acute kidney injury to chronic kidney disease is characterized by significant changes in the cellular composition and molecular interactions within the kidney. Utilizing high-resolution Xenium and whole transcriptome Visium spatial transcriptomics platforms, we analyze over a million cells on 12 male mouse kidneys across six stages of renal injury and repair. We define and validate 20 major kidney cell populations and delineate distinct cellular neighborhoods through this multimodal spatial analysis. We further reveal a specific fibro-inflammatory niche enriched in failed-repair proximal tubule cells, fibroblasts, and immune cells, with conserved neighborhood gene signatures across mouse and human. Within …

Don’T Hold Your Horses: Solutions To The Bureau Of Land Management’S Failure To Manage Wild Horse Populations, Sutaria, Kiran Mahendra

Santa Clara Law Review

Since the Wild Free-Roaming Horses and Burros Act (WFHA) was enacted in 1971 – mandating protection and management of the wild horse and burro population – the BLM has triggered a public outcry over its mismanagement of wild horses. From inhumane roundup processes to a well-intentioned but poorly executed adoption program that inadvertently subjects horses to cruel conditions and slaughter, the BLM’s efforts have continuously undermined wild horse preservation. When an overwhelming majority of Americans push for wild horse protections, and wild horse preservation is a topic that largely receives bipartisan support, it is hard to understand the current status …

The Efficacy Of Rosemary Oil And Microencapsulated Essential Oils On Zeuxapta Seriolae Mitigation In Yellowtail Kingfish, Seriola Lalandi, Md Reaz Chaklader, Lindsey Woolley, Ross Woodward-Williams, Richard Smullen, Gavin J. Partridge

Fisheries Research Articles

Two additives, rosemary oil and a commercial herbal product (HP; AROTEC-G) containing garlic essential oil, carvacrol and thymol were investigated for their potential to reduce the parasitic burden in yellowtail kingfish (YTK; Seriola lalandi) infected with Zeuxapta seriolae. Naturally infected fish were fed diets supplemented with either 2.5 mL.kg−1 rosemary oil or two concentrations of HP (5 and 10 g.kg−1) for 20 days. At 10 and 20 days, the effect of the diets on parasite abundance was evaluated. Feed intake and growth were similar across treatments (p > 0.05). By day 10, both rosemary oil and HP significantly …

Law-Abiding Citizenship And Non-Violent Protest, David Bromwich

Law and Contemporary Problems

No abstract provided.

Caste Formalism: The Law And Politics Of Equality In India, Madhav Khosla, Pratap Bhanu Mehta

Law and Contemporary Problems

No abstract provided.

A Meta-Analysis Of Historic Drinking Water Emergency Events Reported In News Articles, Victor Yu, Haiying Wang, Weiwei Mo

Faculty Publications

This study seeks to investigate historical drinking water contamination events that reported by news media to find the key determinants of their outcomes, including the duration and economic cost, and to quantitatively describe the characteristics of past contamination events. ProQuest Global Newsstream and Regional Business News were used to identify an initial list of events and supplemented by additional search on specific information including the response actions, economic cost, and more. These events were analyzed using descriptive statistics, correlation analysis, and regression modeling. Smaller community water systems were found to be more frequently impacted by contamination events. Use restrictions, except …

Male Mating Preference For Larger Females Does Not Vary Among Age Classes In The Long-Lived Beetle Bolitotherus Cornutus, G. M. Jiron, C. A. Greene, E. D. Brodie Iii, Vincent A. Formica

Biology Faculty Works

Theory and past experimental work suggest that as males age, the strength of their mate preference should decrease. However, the empirical work investigating this question has primarily been conducted in insects that have very short life spans and often live for just a single mating season. This leaves a gap in our understanding of the relationship between male mate preference and age across taxa, as age can conflate with other ecological changes in a single mating season. In this study, we ask how the strength of preference for large female body size changes as males age in a long-lived insect, …

Understanding The Interplay Between The Digital And The Physical In Shared Augmented Reality Gaming: Probing Through Urban Legends, Jiangnan Xu, Sanzida Mojib Luna, Garreth W. Tigwell, Nicolas Lalone, Michael Saker, Samuli Laato, John Dunham, Yihong Wang, Alan Chamberlain, Konstantinos Papangelis

Articles

Shared Augmented Reality (Shared AR) is an emerging technology that enables multiple users to interact synchronously within a collocated AR environment. Yet, there is limited research on the group interactions and dynamics in Shared AR, particularly in the context of gaming. To address this gap, we investigate Shared AR group interactions using a phone-based Shared AR mobile game called Urban Legends. Through in-situ observations, focus groups, and one-on-one interviews with 22 participants, we examine how users collaborate and communicate within the game. Our findings reveal that while verbal communication predominates, non-verbal cues are often overlooked by collocated participants, and …