Digital Commons Network^™

Inhibition Of Mcl-1 And Mek Overcomes Mek Inhibitor Resistance In Triple-Negative And Inflammatory Breast Cancers, Mohd Mughees, Moises Tacam, Alex W Tan, Mary Kathryn Pitner, Lakesla R Iles, Xiaoding Hu, Emilly S Villodre, Bisrat G Debeb, Takahiro Kogawa, Bora Lim, Rachel M Layman, Wendy A Woodward, Naoto T Ueno, Debu Tripathy, Savitri Krishnamurthy, Yuan Qi, Lajos Pusztai, Jian Wang, Varsha Gandhi, Geoffrey Bartholomeusz, Chandra Bartholomeusz

Faculty, Staff and Student Publications

The MAPK pathway can drive resistance in highly aggressive breast cancers. Our previous work showed that the MEK inhibitor (MEKi) AZD6244 (selumetinib) prevented lung metastasis in a breast cancer xenograft model. In clinical studies, MEKis as single agents have had only modest activity against solid tumors due to the onset of resistance. Using synthetic lethality siRNA screening, we identified myeloid cell leukemia-1 (MCL-1) as a potential contributor to AZD6244 resistance. We hypothesized that MCL-1 promotes MEKi resistance in highly aggressive breast cancers and that MCL-1 inhibition overcomes AZD6244 resistance. We established two AZD6244-resistant cell lines: MDA-MB-231-R (triple-negative breast cancer) and …

Efficacy Of Atr Kinase Inhibitor Elimusertib Monotherapy Or Combination In Tumors With Dna Damage Response Pathway And Other Genomic Alterations, Kaushik Varadarajan, Christian X Cruz Pico, Kurt W Evans, Maria Gabriela Raso, Yasmeen Qamar Rizvi, Xiaofeng Zheng, Dhruv Chachad, Timothy P Diperi, Bailiang Wang, Stephen M Scott, Ming Zhao, Argun Akcakanat, Antje M Wengner, Timothy A Yap, Funda Meric-Bernstam

Faculty, Staff and Student Publications

The ataxia telangiectasia and RAD3-related (ATR) kinase functions with ataxia telangiectasia-mutated (ATM) kinase as a modulator of DNA damage response (DDR). We assessed the antitumor effects of the ATR inhibitor elimusertib (BAY-1895344) in patient-derived xenograft (PDX) models with DDR alterations. Antitumor activity was assessed by change in tumor volume (TV) from baseline. Responses were categorized as follows: partial response (PR), ≥30% decrease in TV; ≥20% increase in TV, progressive disease; and non-PR/progressive disease, stable disease (SD). Event-free survival was defined as time for tumor doubling (EFS-2). Of 21 PDX models tested, 11 had significant prolongation of EFS-2 with elimusertib monotherapy. …

Age-Dependent Brain Responses To Mechanical Stress Determine Resilience In A Chronic Lymphatic Drainage Impairment Model, Zachary Gursky, Zohaib Nisar Khan, Sunil Koundal, Ankita Bhardwaj, Joaquin Caceres Melgarejo, Kaiming Xu, Xinan Chen, Hung-Mo Lin, Xianfeng Gu, Hedok Lee, Jonathan Kipnis, Yoav Dori, Allen Tannenbaum, Laura Santambrogio, Helene Benveniste

2020-Current year OA Pubs

The outflow of 'dirty' brain fluids from the glymphatic system drains via the meningeal lymphatic vessels to the lymph nodes in the neck, primarily the deep cervical lymph nodes (dcLN). However, it is unclear whether dcLN drainage is essential for normal cerebral homeostasis. Using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and computational fluid dynamics, we studied the impact of long-term mechanical stress from compromised dcLN drainage on brain solute and fluid outflow in anesthetized rats. We found that in young, but not middle-aged, rats, impairment of dcLN drainage was linked to moderately increased intracranial pressure and the emergence of extracranial …

O5-02 How And Why Preconception Health Among People Living With Obesity Could Be Improved By Including Obesity As A Health Condition In: Abstracts From The 10th Meeting Of The Association For The Study Of Obesity: Uk Congress On Obesity 2025, Heather Hopper, Kerryn Husk, Kate Maslin, Jill Shawe

School of Nursing and Midwifery

University Of Plymouth, Plymouth, UKPeople living with obesity have a greater chance of developingcomplications during pregnancy and are over-represented inmaternal mortality data relating to both direct and indirect causesduring pregnancy and up to a year after the birth of their child. Inaddition, epigenetic influences result in metabolic changes inoffspring of people living with obesity leading to a greater chanceof them experiencing long-term health consequences. In view ofthese health concerns, people living with obesity are advised to loseweight in the preconception period, before becoming pregnant.Sustained weight loss, however, can be difficult to achieve, andpeople do not always seek preconception advice. The …

Psma-1-Dota Potentially For Effective Targeted Radioligand Therapy Of Prostate Cancer, Xinning Wang, Olga Sergeeva, Maxim Sergeev, Lifang Zhang, Zoey Lockwood, Zhenghong Lee, James P. Basilion

Faculty Scholarship

Purpose: While PSMA-targeted radioligand therapy (RLT) has shown remarkable efficacy for treating end-stage prostate cancer, the α-emitting RLT often results in severe salivary gland toxicity, limiting its use. Various strategies to mitigate this side effect have been attempted with limited success. Accordingly, this study introduced a new PSMA-targeting ligand with more favorable binding characteristics than the existing ligands. Procedures: The binding affinity of PSMA-1-DOTA to PSMA was compared with that of PSMA-11 and PSMA I&T. Comparison of uptake in the salivary glands, kidneys and PC3pip tumor cells in the xenograft mouse models between [⁶⁸Ga]Ga-PSMA-1-DOTA, [⁶⁸Ga]Ga-PSMA-11 and [⁶⁸Ga]Ga-PSMA I&T was conducted …

Commensal Colonization Of Candida Albicans In The Mouse Gastrointestinal Tract Is Mediated Via Expression Of Candidalysin And Adhesins, Kelsey E Mauk, Pedro Miramón, Michael C Lorenz, Léa Lortal, Julian R Naglik, Bernhard Hube, Lynn Bimler, Farrah Kheradmand, David B Corry

Faculty, Staff and Students Publications

The ubiquitous fungal pathogen Candida albicans has the potential to either asymptomatically colonize the gastrointestinal (GI) tract or become an invasive pathogen through mechanisms that remain incompletely understood. Here we explored the fungal, host, and environmental factors that influence the ability of C. albicans to colonize the mouse GI tract using a representative clinical strain, CLCA10. After a single gavage challenge (5 × 106 CFU C. albicans), specific pathogen-free (SPF) mice remained colonized with C. albicans strain CLCA10, but not other Candida species, for at least 58 days with the fungus confined largely to the gut luminal …

Encapsulation Of Disease-Causing And Commensal Mitis Group Non-Pneumococcal Streptococci, Daniel M Musher, Mathias Müsken, M John Hicks, Lesley Mcgee, Bernard Beall

Faculty, Staff and Students Publications

Background: Mitis group non-pneumococcal streptococci (MGNPS), specifically Streptococcus mitis, Streptococcus infantis and Streptococcus oralis, have recently been shown to cause pneumonia and/or bacteremia. These organisms often have capsular (cps) operons resembling those in pneumococci, and some express cps-generated polysaccharides that antigenically cross-react with pneumococcal capsular serotypes. But, to date, a series of MGNPS isolates has not been studied by electron microscopy (EM) for the presence of a capsule.

Methods: We studied 21 MGNPS; 11 were isolated from sputum and determined to have caused pneumonia, 3 were isolated from blood, and 7 were commensal isolates cultured …

Healing The Sacred: The Fight To Restore Onondaga Lake And Honor Indigenous Land, Adam Dj Brett, Betty Lyons Hill

International Journal on Responsibility

The Onondaga Nation is petitioning the Organization of American States (OAS) for land rights to Onondaga Lake, a notoriously polluted body of water in Central New York State. The Onondaga Nation is one of six nations of the Haudenosaunee Confederacy (Iroquois), and Onondaga Lake is the sacred site where Gayanashagowa, the Great Law of Peace, was established. As Keepers of the Central Fire, the Onondaga Nation bears the responsibility of maintaining unity and peace within the Haudenosaunee Confederacy. This article examines the history of the lake, its significance to the Haudenosaunee Confederacy, and the consequences of its desecration through …

Fun! Friends! Famous People! Why Fans Attend Anime Conventions, Billy Tringali, Maria Alberto, Jeremiah Martinez

Proceedings from the Document Academy

In 2021 during the global Covid-19 lockdowns, Billy and Maria ran an IRB-exempted online survey, looking to hear from fans who attend anime conventions. Conventions had been shut down as non-essential services that drew large crowds, and we hoped to capture a screenshot of this moment, to better learn from it in the future. And the resulting data collection went quite well – we were able to partner with a major anime organization to share the survey, and our 1000+ respondents had a lot to say about the conventions they were missing during lockdowns.

Ultimately, we found a significant emphasis …

Make It Pink: Superman, Pink Kryptonite, And Fandom, Tom Ue, Kristofer Starzomski-Wilson

Proceedings from the Document Academy

This paper explores several representations of pink kryptonite. In Doug Murphy’s animated short film True Colors (2017), Superman (Jason J. Lewis) transforms into a woman when he’s exposed to this substance. This short, as we have shown elsewhere (2025), offers a useful lens for examining the perpetuation and the critique of gender stereotypes in superhero media: Superman may be equally capable regardless of his sex, but the film pokes fun at, rather than celebrates, his transformation. Pink kryptonite rarely appears in the canon. A single panel in Supergirl (2003) has received perhaps the most sustained attention. Tom Ue’s archival work …

How Subversive Is Shipping Really? An Analysis Of Heteronormative Elements In Same-Sex Relationships Focused On German-Language Anime And Manga Fan Fiction, Saskia Dreßler

Proceedings from the Document Academy

This study investigates whether German-language fan fictions featuring lesbian and gay characters within the anime and manga domain can be regarded as genuinely queer. It situates these fan works within the specific traditions and practices of German fandom. Employing qualitative content analysis, the research examines two prominent fandoms, Naruto and Sailor Moon, focusing on the presence of heteronormative narrative patterns in fan fiction with queer protagonists. The study analyzes which aspects of the original media are adapted and how these adaptations shape the portrayal of queer identities. Furthermore, fan comments are examined to assess the extent to which readers …

Five Years Of Fanlis: Papers From The Fanlis 2025 Symposium, Lyn Robinson, Ludi Price

Proceedings from the Document Academy

We began the FanLIS project in 2020, as a basis from which to study, understand and progress information communication as it relates to fan works. Most of us are fans of something, and thus we all have the potential to appreciate and enjoy the fiction, artwork, music, poetry, plays, games and interactive experiences crafted by creative fans within our area of interest, in both analogue and digital formats. Fandom is perhaps the ultimate inclusive discipline.

Library and information science (LIS) theory and practice consider authorship, publication, distribution, indexing, access, storage, preservation, document and management related policies, use, reception and understanding …

Thermal Spreader Materials On Flexible Polymer Substrates

Defensive Publications Series

The present disclosure is generally directed to techniques and materials for thermal spreader materials, such as for use in products and applications with flexible polymer-based substrates

Learning In Virtual Environments With Varying Levels Of Sensory Information, Maryam Derayati Far

Psychology Theses and Dissertations

The sensory environment plays a critical role in shaping learners’ attention, engagement, and retention. This thesis investigates how varying levels of sensory input in virtual reality (VR) classrooms influence learning for two age groups—children and young adults—and explores how individual differences in sensory processing moderate these effects. Using immersive VR technology to simulate classroom settings, two experimental studies were conducted. Study One involved 60 children aged 6–15 years, recruited primarily through a university-run summer camp. Study Two included 57 undergraduate students aged 18–36 years, recruited through a research participation pool. In both studies, participants were randomly assigned to either a …

Post-Finasteride Syndrome: Medically Unexplained, Stewart Justman

Global Humanities and Religions Faculty Publications

Post-Finasteride Syndrome (PFS) is a controversial illness associated with a host of distressing symptoms—most notably sexual dysfunctions—reported to persist long beyond the intake of finasteride itself. It appears the PFS population consists exclusively of younger patients with alopecia, even though millions take a higher (if pharmacologically similar) dosage of finasteride for benign prostatic hyperplasia. This dichotomy is not what one would expect to observe if finasteride caused PFS. No medical explanation of this one-sided syndrome exists. The surge of cases of PFS following a publicity spike in 2011 and 2012 suggests that PFS owes much nonbiological factors. The present analysis …

September 2025, Office Of Research

Research Update

No abstract provided.

One Hundred Ninety-Nine Dead Birds: Review Of The Scientific Basis Of Ecological Incident Reporting Requirements For Pesticide Registrants Under Fifra § 6(A)(2), Nimish B. Vyas, Cynthia Palmer

Buffalo Environmental Law Journal

The U.S. Environmental Protection Agency (EPA) regulates pesticide use in the United States. The EPA is charged by the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) with ensuring that a pesticide will not cause unreasonable adverse effects on the environment. Incident reports (documentation of exposure and injury from pesticide applications) can serve as a reality check on the pesticide registration decisions made by the EPA scientists and risk managers. The EPA collects incident reports on human, domestic animal, and ecological injury. The FIFRA section 6(a)(2) rule requires the pesticide registrant (generally, the company or other entity that wishes to market …

Manatees In Hot Water: How The Florida Manatee Became Dependent On Power Plant Warm Water Outfalls, Michaela Morris

Buffalo Environmental Law Journal

Each winter in Florida, thousands of manatees gather in the warm water outflows of power plants. These refuges play a crucial role for the Florida manatee: when ocean temperatures drop, manatees shelter at these artificial sources to survive. But in recent years, thousands of manatees wintering at the Florida Power & Light Company’s Cape Canaveral Clean Energy Center have died. The reason? Seagrass beds––a primary food source for manatees––are vanishing, killed off by pollution from agricultural, industrial, and residential sources.

This Article documents the historical, political, and regulatory conditions that led to manatees’ reliance on power plants. First, the political …

Item 4: Activity 3: Surfacing Values Through Moral Foundation Conversations, Kara Dillard

Kara Dillard, Civic Leadership: Theories and Practice

This activity explores the concept of motivated reasoning and the moral foundations people hold that make them believe wicked issues are “wicked.” Students will explore their own values and think about how their values change depending on the issue. Students will also practice talking with people who have different values than them on any given issue.

Actividad En Clase 2: Vistas Públicas Como Mecanismo De Participación Cívica, Leila Rodriguez

Leila Rodriguez, Participación Cívica en/para Puerto Rico

En Puerto Rico, las vistas públicas son espacios importantes de diálogo y discusión entre la sociedad civil y los representantes del gobierno. Estos eventos están abiertos al público y representan una oportunidad para presentar diferentes perspectivas antes de que se tomen decisiones oficiales sobre temas importantes. Participar en vistas públicas es una parte fundamental del ejercicio democrático. Los organismos gubernamentales que celebran vistas públicas incluyen el Senado, la Cámara de Representantes y varios Departamentos. La Junta de Supervisión y Administración Financiera de Puerto Rico, creada bajo la Ley PROMESA en 2016, también realiza vistas públicas. La Junta está compuesta por …

A Complicated History Of Mitogenome Introgression Among Luxilus Species (Teleostei, Family Leuciscidae) In The Ozark Highlands, David D. Duvernell, Carson Arnold, Shila Koju, Abby J. Wicks, Thomas E. Dowling

Biological Sciences Faculty Research & Creative Works

Hybridization is common among minnows and shiners in the family Leuciscidae, and mitonuclear discordance can reveal evidence of historical hybridization and introgression events that have shaped extant species and populations. We have identified a notable case of serial mitogenome replacement in populations of two shiner species, Luxilus zonatus and L. chrysocephalus, which are syntopic in drainages throughout the northern and eastern Ozark Interior Highlands of North America. These mitogenome replacement events involved L. zonatus acquiring the mitogenome of L. chrysocephalus, and populations of L. chrysocephalus acquiring the mitogenome of an allopatric congeneric species, L. cornutus. The latter species has a …

The Fate Of Intra- And Extracellular Antibiotic Resistance Genes Through Advanced Wastewater Treatment Process, Celestene Adrianne Sebag

Graduate Theses and Dissertations

More areas across the globe are becoming affected by water stress or water scarcity. The decrease in available freshwater due to overconsumption reveals the direct need to consider other sources for necessities such as drinking water or food production. Agricultural irrigation uses 70% of the world’s freshwater, making the focus on safe and reliable reclaimed water for agricultural reuse imperative. However, contaminants of emerging concern (CECs), such as antibiotics and their resulting antibiotic resistance genes (ARGs), can spread and affect human health if reclaimed water is not treated to the proper level. Antibiotics are widely used in human medicine and …

Item 1. Course Syllabus: History Of Civic Engagement And Voting Rights Since Reconstruction, American History Ii, Tanja Bacani

Tanja Bacani, History of Civic Engagement and Voting Rights Since Reconstruction

This syllabus is for a survey course that combines common themes in American history since 1865 with a specific focus on civic engagement and voting rights. It is centered around the stories of everyday Americans who participated in the Progressive Movement, the Civil Rights Movement, labor rights, and other turning points in American history related to civic engagement. The syllabus and course assignments highlight the role of oral history in preserving stories and introduce students to the methods and impact of historical advocates for justice. The goal is to help students reflect on their own roles in advocacy, allyship, and …

Dairy And Food Science News, Sept 2025, Department Of Dairy And Food Science

Dairy & Food Science News

Message from the Department Head
Dairy Drive Football Game
Dairy Foods Research @SDSU: Opportunities Galore Webinar
Faculty Updates
Faculty Surveys and Studies
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2025 Burger Bash
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Student Updates
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Events & Calendar

Wofford Today Fall 2025, Wofford College. Office Of Marketing And Communications

Wofford Today

No abstract provided.

Biol 484-H01: Evolution Of Animal Behavior Lab - Honors, Caroline Devan

Biology Syllabi

No abstract provided.

Biol 475-H01: Ecological Field Methods - Honors, Kathleen Farley

Biology Syllabi

No abstract provided.

Ds 650-001: Data Visualization And Interpretation, Aritra Dasgupta

Data Science Syllabi

No abstract provided.

Me 311: Thermodynamics I, Section 103, Abul Ali

Mechanical and Industrial Engineering Syllabi

No abstract provided.

Me 312: Thermodynamics Ii, Section 001, Abul Ali

Mechanical and Industrial Engineering Syllabi

No abstract provided.