Digital Commons Network^™

Protein-Nucleic Acid Language Model-Assisted Design Of Precise And Compact Adenine Base Editor, Jingxuan Ren, Jiawei Yao, Qiuyu Cao, Yinuo Li, Yang Li, Ziyi Zhang, Xiyu Ge, Shengfang Wang, Yang Zhang, Xiaogang Wang, Xiaohui Zhang

Faculty, Staff and Students Publications

Adenine base editors (ABEs) are powerful tools for gene therapy. However, efficient version of ABEs (e.g. ABE8e) always induce excessive bystander and off-target editing events and are large in size, hindering their potential in clinical disease treatment. Here, we develop a pre-trained Protein-Nucleic Acid Constrained Language Model to design ABE8e with high activity, reduced editing window and decreased size. By further engineering, the smallest ABE8e- PNLM-pcABE- with a 27% size reduction, exhibits high activity, precise 3-nt editing window, and reduced off-target events near background level in HEK293T cells. Compared to ABE8e, PNLM-pcABE has up to 133.5-fold precision improvement in pathogenic …

Paper Straws At Usd, Rodrigo J. Mor Gimeno

Sustainable Supply Chain Management

This learning journal reflects my experience throughout the semester learning about sustainability, climate change, and supply chains. Through class discussions, documentaries, and assignments, I explored topics such as carbon footprint, circular economy, ethics, and life cycle analysis. The paper on plastic straws and the group life cycle project helped me understand how everyday products have environmental, social, and economic impacts, and how consumer choices and global systems are strongly connected.

Needs Analysis: Ar As An Innovative Learning Media Solution For Elementary School Students, Rosfaniarti Rosfaniarti, Makmum Raharjo, Meilinda Meilinda

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to identify the need for the development of Augmented Reality (AR)-based learning media as an innovative solution in elementary school learning. The needs analysis method was conducted using a mixed methods approach through questionnaires and interviews with 103 students and 5 teachers. The data were analyzed descriptively and quantitatively to obtain a comprehensive picture of instructional needs. The results showed that student needs were in the high category, with a percentage of 80.64%-85.30%. The socio-cultural aspect was the highest need (85.30%), followed by the pedagogical and technical aspects, while the cognitive aspect had the lowest value (80.64%). …

Founder Worship, Effective Altruism, And Corporate Governance, Jennifer S. Fan, Xuan-Thao Nguyen

Kentucky Law Journal

No abstract provided.

Affordability And Usability Of Digital Learning Resources In Higher Education: A Case Of Online Mathematics Tutorials For Engineering Students At The University Of Dar Es Salaam, Fatuma S. Ikuja, Idrissa S. Amour, Abdi T. Abdalla

Tanzania Journal of Engineering and Technology (TJET)

Effective learning requires engagements with both learning contents and instructor’s personalized support. Large class sizes often limit opportunities for personalized instruction and timely feedback. Digital resources offer a viable solution to enhanced engagement and independent learning. This study investigated the affordability and usability of online digital learning resources for mathematics tutorials, specifically targeting engineering students at the University of Dar es Salaam. A quasi-experimental research design was adopted, focusing on digitization of undergraduate course: Matrices and Basic Calculus for Non-Majors (MT161). The course was delivered through the Moodle Learning Management System integrating STACK to support Mathematics questions. Data was collected …

In-Depth Review Of Animal Anatomy In Veterinary Medicine, Fatima Ayad Hasan, Sarah Kamal Naser

Al-Bahir

This review explores the significance of animal anatomy across different fields, emphasizing both microscopic and macroscopic structures. The text covers teaching methods in veterinary medicine, with a focus on diagnostics and surgery. It also delves into various anatomical and moral issues, alongside contemporary teaching approaches. The importance of anatomy in both biological and clinical contexts continues to be central in advancing veterinary education, even with the presence of various digital tools and cutting-edge imaging technologies.

Health Implications Of Heavy Metal Contamination In Commercially Available Deodorant And Antiperspirant Products Sold In Benghazi, Libya, Maysson Yaghi, Khaled Elsherif

Al-Bahir

The extensive usage of deodorants and antiperspirants raises concerns about the potential health risks posed by heavy metal content. This study quantified the levels of five heavy metals: Aluminum, Zirconium, Lead, Cadmium, and Chromium in 22 commercial products widely used in Benghazi, Libya, and assessed the associated health risks. Samples, categorized into gel, stick, and roll-on formulations, were analyzed using iCAP TQ ICP-MS. Al and Zr showed the widest concentration ranges, reflecting their intentional use as active ingredients. Al levels ranged from trace amounts (0.032 mg/kg) up to a maximum of 99.10 mg/kg, while Zr was found exclusively in gel …

Editor's Note, John B. Craig

Journal of Access, Retention, and Inclusion in Higher Education

No abstract provided.

Metamaterial-Based Microstrip Antenna For Safe Detection Of Tiny Breast Tumors, Shrouk E. El-Sawy, Mohamed G. Abdelfattah, Nihal F.F. Areed, Ahmed Shaban Samra

Mansoura Engineering Journal

This study describes the construction of a compact microstrip patch antenna (MPA) with a triangular-shaped metamaterial layer for the safe detection of tiny breast tumors at 2.4 GHz. The metamaterial considerably improves the antenna's gain and directivity when compared to typical designs that do not include it, resulting in improved detection performance. The radiating patch of proposed antenna measures 29.3 × 38 × 1.6 mm and has been tested through simulations and experimental tests, exhibiting successful tumor identification in a realistic breast phantom. The results of both calculations and testing demonstrate a sensitivity of 6.643 dB/mm, allowing for precise detection …

Potential Cost Savings At A Single Tertiary Care Center Through Implementation Of A 340b-Compliant Multiuse Drop Protocol For Cataract Surgery, Carla Baaklini, Sabrina Duong, Jieon Jenny Kim, Samer Hajji, Aaron D. Webel

Journal of Academic Ophthalmology

The University of Missouri Healthcare system is seeking to implement a multiuse drop protocol for cataract surgeries, allowing preoperative eye drop bottles to be utilized for multiple patients rather than being discarded after single use. This presents an opportunity for reducing medical waste and achieving considerable cost savings. A key challenge, however, lies in maintaining compliance with the 340B Drug Pricing Program, which currently limits our ability to fully adopt this practice. We additionally encountered barriers including infection control concerns and staff adaptation to new workflows. We detail the barriers we have encountered thus far and present a potential 340B-compliant …

In Recent Research: Exosomal And Molecular Regulators Of Browning And Thermogenesis In Adipose Tissues, Merve İnel, Bahadir Öztürk

Turkish Journal of Medical Sciences

This review synthesizes current knowledge on the molecular mechanisms regulating brown, white, and beige adipose tissues, with particular emphasis on the browning process of white adipose tissue. Rather than considering adipose tissue as a passive energy reservoir, this review underscores its active role as a dynamic endocrine and metabolic organ. Brown and beige adipose tissues, recognized for their thermogenic capacity and contribution to energy expenditure, have emerged as promising therapeutic targets for the treatment of obesity, type 2 diabetes, and related metabolic disorders. The review draws upon recent findings on adrenergic signaling, transcription factors, exosomal microRNAs, and other novel regulatory …

The Impact Of Hypophosphatemia On Biochemical Profile And Renal Outcomes In Primary Hyperparathyroidism: A Nationwide Retrospective Study, Nai̇m Ata, Beki̇r Uçan, Hali̇l Durantaş, Oğulcan Boz, Mustafa Şahi̇n, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Muhammed Kizilgül

Turkish Journal of Medical Sciences

Background/aim: Although low phosphorus (P) concentrations are a recognized feature of primary hyperparathyroidism (PHPT), they are not among the diagnostic or surgical criteria. The present study evaluates the association between serum phosphorus levels and clinical outcomes in PHPT patients.

Materials and methods: A search of the Turkish Ministry of Health’s National Electronic Database was conducted using ICD-10 diagnostic codes and laboratory data to identify PHPT cases within the Turkish population from 2017 to 2022.

Results: The records of a total of 113,330 PHPT patients (77.5% female; mean age 58.9 ± 15.6 years) were analyzed, revealing a mean serum phosphorus level …

Relcovaptan: A Promising Therapeutic Agent In Traumatic Spinal Cord Injury That Acts By Modulating Newly Identified Transcriptional Regulators Of Aquaporins Compared To Tolvaptan, Şeyma İş, Duygu Ceman, Meri̇h İş, Neşe Keser, Şaban Teki̇n

Turkish Journal of Medical Sciences

Background/aim: Every year, hundreds of thousands of people worldwide suffer from traumatic spinal cord injury (tSCI), which causes irreversible damage, edema, and inflammation. Despite its devastating impact, no safe and effective medication is available. Edema formation is one of the earliest pathological events in tSCI, beginning within minutes after injury. Cytotoxic edema progresses to vasogenic edema, exacerbating irreversible damage. Our study aimed to investigate a therapeutic approach targeting cytotoxic edema in the acute phase of tSCI to improve treatment outcomes. Aquaporins (AQPs) are crucial in edema formation and tSCI pathogenesis. Vasopressin, also known as the antidiuretic hormone, modulates Aqp expression …

The Impact Of Tizanidine, Thiocolchicoside, And Cyclobenzaprine On Vascular Function In Ovariectomized Rats, Sümeyye Nur Gürsoy, Tolga Esmerli̇gi̇l, Uğur Berkay İnce, Turhan Dost, Buket Demi̇rci̇

Turkish Journal of Medical Sciences

Background/aim: Menopause is associated with increased vascular risk. This study investigated the effects of 3 centrally acting muscle relaxants—tizanidine (TZ), thiocolchicoside (TCC), and cyclobenzaprine (CBZ)—on vascular reactivity in ovariectomized (OVX) rats as a model of menopause.

Materials and methods: Body weight, blood glucose, blood pressure, and heart rate were recorded, and the rats underwent oophorectomy surgery. Eight weeks after the operation, the rats were divided into 5 groups: sham operated rats, OVX rats, OVX rats treated with TZ (OVX + TZ), OVX rats treated with TCC (OVX + TCC), and OVX rats treated with CBZ (OVX + CBZ). All drug …

Natural Progression Of Meningeal Lymphatic Dysfunction In App/Ps1 Mice Creates A Critical Window For Alzheimer’S Disease Intervention, Zilong Shen, Xibin Zhou, Chunxiang Zhou

Turkish Journal of Medical Sciences

Background/aim: Meningeal lymphatic vessels (mLVs) facilitate the clearance of toxic metabolites like amyloid-beta (Aβ) from the central nervous system. Dysfunction in MLVs is implicated in Alzheimer’s disease (AD). However, current knowledge relies on exogenous intervention models that fail to capture spontaneous mLV decline during AD progression. In this study, we investigated the age-dependent correlation between mLV/deep cervical lymph node (dCLN) dysfunction and Aβ pathology in APP/PS1 mice under noninterventional conditions.

Materials and methods: APP/PS1 and wild-type (WT) mice at 3, 6, and 9 months of age were evaluated. Cognitive function was tested using the Morris water maze. mLV/dCLN drainage was …

Moltkia Coerulea Extracts Alleviate Caspase-3 Activity Via Reducing Oxidative Stress In Lps-Induced Neurotoxicity In Bv-2 Cells, Asli Can Ağca, Derya Altay, Hüdaverdi̇ Kul, Asli F. Ceylan, Betül Sever Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Moltkia coerulea, a medicinal plant traditionally used for its neuroprotective properties, contains diverse phenolic compounds. However, its mechanisms of action in neuroinflammation remain unclear. We hypothesized that extracts of M. coerulea may protect microglial cells from lipopolysaccharide (LPS)-induced oxidative stress and apoptosis by modulating reactive oxygen species (ROS) and caspase-3 activity.

Materials and methods: Aqueous and methanol extracts (5–50 μg/mL) were tested in BV-2 microglial cells. Cell viability was assessed by MTT assay, while ROS generation and caspase-3 activity were measured using fluorescence-based kits. The effective concentration (10 μg/mL) was selected for mechanistic assays based on viability data and …

A Rodent Model Of Enhanced Anticipation Of Positive Events: Sex-Specific Modifications In Cognitive Bias And Emotional Resilience, Sarah C. Hartvigsen, Megan Hooper, Olivia Harding, Evelyn Barringer, Aditya Narayanan, Brendan Crockett, Yulia Shatalov, Paean Luby, Braden Wixted, Molly Kent, Kelly Lambert

Psychology Faculty Publications

While it is known that chronic unpredictable stress and negative events adversely affect neurobiological outcomes, much less is known regarding the neurobiological impact of positive emotions such as chronic anticipation of appetitive events. From a translational perspective, an enhanced understanding of the impact of extended exposure to positive emotions may provide novel insights into effective non-pharmacological, behavior-based approaches to enhance mental resilience. Here, we investigate a novel rodent model of chronic Unpredictable Positive Event Response (UPER) training in male and female Long Evans rats to examine behavioral, neural, and endocrine effects of enhanced anticipation of positive events. Rats were exposed …

Geologic And Geochemical Investigation Of The Ruby Graphite Deposit, Mikayla Taylor

Graduate Theses & Non-Theses

The Ruby Graphite project (RGP, also known as the Crystal Graphite deposit) is located in the southern Ruby Mountains, Beaverhead County. The deposit contains coarse-grained and highly crystalline graphite, which is a sought-after critical commodity in today’s global economy. The graphite is hosted by high-grade meta-sedimentary and meta-igneous rocks that reached peak metamorphism during the ~ 1.7 Ma Big Sky Orogeny. In this study, samples were collected from outcrops, mine dumps, and new (2023) drill core from the Ground Hog and Bird’s Nest locations. Rock types include calcitic marble, biotite-garnet schist, pegmatite, diopside-rich skarn, altered ultramafic intrusions, and a possible …

Development And Evaluation Of Wireless Monitoring Systems For Touchless Respiratory Monitor Validation, Dustin Marquardt

Graduate Theses & Non-Theses

The Touchless Respiratory Monitor (TRM) is a non-invasive system that uses contactless methods to measure respiratory rate and tidal volume. The main technologies employed are LiDAR for tidal volume measurement and a thermal camera for respiratory rate monitoring. These novel methods require validation against established techniques such as capnometry and respiratory inductance plethysmography. Commercial respiratory monitoring equipment is often expensive and dependent on proprietary software, creating barriers to widespread use. To address this, a custom, modular, and low-cost evaluation system was developed to streamline the validation of the TRM. The prototype system integrates a pulse oximeter, capnometer, spirometer, and respiratory …

The Witch, The Fairy, And The Woman: Femininity, Morality, And The Supernatural In Hungarian Fairy Tales, Emese Izso

Undergraduate Honors Theses

This thesis examines the ways female supernatural beings are portrayed in Hungarian fairy tales, with a special focus on how their femininity, morality, and power manifest in their depiction. A close reading of fifty-two Hungarian fairy tales with prevalent female supernatural characters reveals that the spaces they occupy, the forms they take, and the gender roles they fulfill both influence each other and the portrayal of women in these stories. Depending on the space they reside in (whether that is the human domestic sphere, a magical kingdom ruled by a specific species, or a liminal zone of magical wilderness), women …

Library Newsletter: December ‘25, Iwasaki Library

Iwasaki Newsletters

This Library Newsletter reached faculty, staff, and students of Emerson College on December 12th, 2025. This is the only published issue of December. This is the seventh issue of the 3rd volume. It includes top stories such as a thank you for joining us at Relaxapalooza, a reminder about when the library is open over the winter break, a congratulations piece to the winners of the Liberal Arts survey, and a poll on which streaming film matches your creative energy.

Fcf India, Arturo Torres Torres Landa, Rachel Lin-Peistrup

Miller Center Fellowship

Afforestation has critically emerged and been widely adopted for ecological restoration and climate change resilience in rural India.

There is a rise in carbon credit schemes and their integration of small farmers into global environmental markets; the relevance of such schemes, however, must not be measured solely by carbon returns. This research explores the larger social, economic, and cultural context of afforestation by conducting a mixed-methods analysis of tree-planting actions undertaken by FCF India, with special regard to the experiences of farmers in Assam. We seek to gauge whether such non-carbon aspects offer transparent and measurable channels of value, and …

Variation In Nectar Rewards Under Water Limitation Across Flowering Species, Madeline Isabelle Gregor

Undergraduate Honors Theses

Drought is becoming an increasingly dominant force shaping plant–pollinator interactions, yet we still know little about how nectar rewards respond to water limitation across species commonly used to support pollinators. We examined nectar volume and sucrose content in six flowering species relevant to California’s Mediterranean climate and quantified how drought alters these traits for four of those species. Under well-watered conditions, species differed in their nectar production, spanning more than two orders of magnitude. Perennial species such as Epilobium canum and Scrophularia californica produced the highest nectar volumes and sucrose amounts, suggesting that they contribute substantial carbohydrate resources when moisture …

Subculture And Identity As An Escape From The Societal Norms Of Power Imbalance And Authoritative Abuse, Sarah Goldberg

Master's Theses

By definition, a “bolthole” is an animal’s escape or burrow; or, a person’s escape or place of refuge. It also connotes construction, building, even sculpture - relating proletarian materials to themes of working-class labor and the need for escape. Through sculpture, installation, drawing, and oil painting, Bolthole as a body of work examines power imbalance as a societal norm, and identity and subculture as a rejection of the influence of capitalist institutions. Animal symbolism is used in combination with figurative work and portraiture, directly comparing power imbalances between humans to those in nature; such as predator and prey, parent and …

Effects Of Beach Renourishment On Sea Turtle Nesting Success, Caydence Pennington

Honors Theses

Beach geomorphology has a profound influence on nesting animals, particularly sea turtles, whose reproductive success depends on suitable sand conditions and stable shorelines. In many densely populated coastal regions, beach renourishment projects are implemented to combat erosion and protect infrastructure, yet these alterations can also affect sea turtle nesting ecology. This study evaluated the effects of beach renourishment on loggerhead sea turtle (Caretta caretta) nesting activity on Longboat Key, Florida, from 2021-2024. Nesting activity, hatch success, and depredation patterns were compared between nourished and reference beach zones to determine whether nourishment had an impact on these events. Nesting …

Determinants Of Farmers’ Choices Of Adaptation Strategies In Rural Semi-Arid Agricultural Communities Of Tanzania: A Case Study Of Mwanga And Same Districts In Kilimanjaro Region, Bahati Ally Magesa

Journal of Humanities and Social Sciences

Climate change is a global phenomenon that poses a significant threat to agricultural farming and the livelihoods of farmers, particularly in semi-arid regions of Sub-Saharan Africa. Since agriculture is the primary source of employment in the region, enhancing the sector’s adaptive capacity has become increasingly important. This paper examines the key determinants influencing farmers’ choices of adaptation strategies to climate change impacts in the Mwanga and Same Districts of Tanzania. A total of 200 farmers participated in a household survey conducted using a simple random sampling technique. A binary logistic regression model was employed to analyse the association between selected …

The Syntax And Semantics Of Reciprocal Constructions In Chibarwe: A Lexical Mapping Account, Tendai Chirimaunga

Journal of Humanities and Social Sciences

Bantu languages have a robust structure, which is usually stated to be agglutinative, accommodates affixations of a wide range of morphemes both as prefixes (to the left of the root), as well suffixes (to the right of the root) before placing the terminal vowel. In their verbal morphology, the reciprocal is one of the many derivational affixes that have, however, not gained similar prominence as the study of the applicative and the causative construction. The thrust of this study is to investigate the syntax and semantics of reciprocal constructions in ChiBarwe, a marginalised cross-border language spoken in Zimbabwe and Mozambique. …

Understanding Outer Membrane Vesicle Biogenesis In Bacteroides Thetaiotaomicron, Evan J. Pardue

Arts & Sciences Graduate Student Theses and Dissertations

Outer membrane vesicles (OMVs) are small proteoliposomes generated by active protrusion of the outer membrane (OM) in Gram-negative bacteria during growth. Over 60 years of experimentation has ascribed numerous functions to OMVs produced by different bacteria. However, the mechanism(s) by which OMVs are produced is poorly understood. Due to this, the field remains controversial because many regard OMVs as byproducts of cell lysis and question their physiological relevance. Previous studies in Pseudomonas aeruginosa and related species confirmed that these microbes undergo programmed cell death that results in the stochastic release of vesicles and cellular contents. On the contrary, Bacteroides spp. …

Libraries Accessibility Plan 2025-2027

Accessibility Committee

Two-year plan providing a roadmap for committee projects and goals. Authored in 2025 by the University Libraries Accessibility Committee as an internal document.

Relationship Between Working Memory And Reading Comprehension: A Secondary Meta-Analysis, Gennadi Mikhailik

Doctoral Dissertations

Although working memory (WM) capacity has been highlighted in many theories of first-language (L1) and second-language (L2) reading comprehension, some scholars argue that its importance may be overstated and that existing findings are still inconclusive. Even with extensive research since 1995, the literature has lacked a thorough quantitative review of these results. This study shows that WM capacity is positively related to reading comprehension. The current secondary meta-analysis examined the relationship between WM capacity and reading comprehension in both L1 and L2, using two authoritative meta-analytic datasets: Daneman and Merikle’s (1996) for L1 and Jeon and Yamashita’s (2022) for L2. …