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Exosomes Derived From Bone Substitute-Induced Gingival Mesenchymal Stem Cells Promote Angiogenesis, Chongyu Shen, Zheng Guan, Rui Chu, Zhengyin Li, Jiangting Lu, Liangkun Xie

Journal of Dental Sciences

Background/purpose: In certain clinical bone grafting scenarios, bone substitutes frequently interface with the adjacent soft tissues. This study aimed to investigate whether deproteinized bovine bone mineral (DBBM) and coralline hydroxyapatite (CHA) induce paracrine responses in human gingival mesenchymal stem cells (GMSCs), thereby altering the pro-angiogenic capacity of their derived exosomes, and to profile specific cargo alterations.

Materials and methods: Exosomes were isolated from GMSCs co-cultured with DBBM (DBBM-G-EXO) or CHA (CHA-G-EXO), while native GMSCs-derived exosomes (G-EXO) were collected as controls. The angiogenic effects of these exosomes on human umbilical vein endothelial cells (HUVEC) were evaluated via cell proliferation, scratch wound …

Memoryart: Enhancing Llms Via Multi-Memory Models With Adaptive Resonance Theory For Healthcare Agents, Renke Dai, Hebin Hu, Jiahui Zhang, Yilin Kang, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Though promising in healthcare consultation applications, large language models (LLMs) face critical limitations in retaining and utilizing long-term memory across multiturn interactions. In particular, existing memory enhancing paradigms are constrained by limited context windows and embedding-based retrieval, often failing to maintain task relevance and still suffering from memory prototype collapse in multi-turn healthcare consultation. To address these challenges, we propose a cognitively-inspired memory framework named MemoryART, which is grounded in Adaptive Resonance Theory (ART)—a cognitive and learning theory of how humans and animals adapt to dynamic environments. MemoryART employs three memory modules—working memory, episodic memory, and semantic memory to support …

Artem: Enhancing Large Language Model Agents With Spatial-Temporal Episodic Memory, Cassandra Hui Ming Tan, Budhitama Subagdja, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Current large language models (LLMs) exhibit significant deficiencies in episodic memory tasks including encoding, storing, and retrieving specific information from temporally dependent events over a long period of time. Recent approaches to handle memory tasks in LLMs, such as in-context learning, retrieval-augmented generation (RAG), and fine-tuning, may resolve the long-term retention issues, but are still inadequate to handle tasks requiring chronological awareness of the stored information. We introduce Agentic Retrieval with Temporal-Episodic Memory (ARTEM), a hybrid LLM-based agent architecture integrating LLMs with a self-organizing neural network named Spatial-Temporal Episodic Memory (STEM), designed to handle episodic memory tasks. Our approach employs …

Realign: Text-To-Motion Generation Via Step-Aware Reward-Guided Alignment, Wanjiang Weng, Xiaofeng Tan, Junbo Wang, Guo-Sen Xie, Pan Zhou, Hongsong Wang

Research Collection School Of Computing and Information Systems

Text-to-motion generation, which synthesizes 3D human motions from text inputs, holds immense potential for applications in gaming, film, and robotics. Recently, diffusion-based methods have been shown to generate more diversity and realistic motion. However, there exists a misalignment between text and motion distributions in diffusion models, which leads to semantically inconsistent or low-quality motions. To address this limitation, we propose Reward-guided sampling Alignment (ReAlign), comprising a step-aware reward model to assess alignment quality during the denoising sampling and a reward-guided strategy that directs the diffusion process toward an optimally aligned distribution. This reward model integrates step-aware tokens and combines a …

The Journey Of High School Teachers Evolving Into Career Educators, Diane B. Ried

UNF Graduate Theses and Dissertations

Abstract

Teacher attrition has been a major challenge in the United States for decades, but more so after covid. This case study explored and expanded the understanding of the different levels of environmental impact on high school teacher retention in a Florida high school as they evolved into career educators. The present study used Bronfenbrenner’s (1979) Ecological Systems Theory to examine the teacher’s retention in a county in northcentral Florida. In order to better understand the experience of career development, this study used Savickas’ Career Construction Theory (2019). This case study investigated strategies, supports, and diversity related initiatives impacting a …

Evaluating The Impact Of Cognitive Distraction On Spaceflight-Relevant Task Performance Using Surface Electromyography And Motion Capture, Allyson K. Mitchell

UNF Graduate Theses and Dissertations

Cognitive distraction poses a risk to astronaut performance during complex, multitasking operations in spaceflight environments. This study examined the effects of cognitive load on neuromuscular coordination and task execution using surface electromyography (sEMG) and motion capture. Thirteen participants performed spaceflight-relevant tasks under undistracted and distracted conditions, with distraction induced through verbal questioning. EMG signals from eight upper-extremity muscles were processed using envelope filtering, peak normalization, and time normalization to enable inter-subject comparison, and group-level mean activation with standard deviation was analyzed. While overall muscle activation was similar between conditions, phase-dependent differences were observed, with undistracted trials showing higher activation during …

Regulation And Localization Of Urease In Sporosarcina Pasteurii: Implications For Coastal Protection, Amar Kosovac

UNF Graduate Theses and Dissertations

Coastal erosion is a persistent problem exacerbated by global warming. As the climate changes, the southeastern coast is likely to experience an increased frequency and intensity of storms, which can significantly damage the coastline. The coast is crucial as it serves as a habitat for numerous animals, supports tourism, and underpins infrastructure. Microbially induced calcite precipitation (MICP) is a novel method to enhance erosion resistance in sandy soils using the non-pathogenic bacterium Sporosarcina pasteurii. S. pasteurii produces urease to catalyze urea into bicarbonate, which drives the precipitation of calcium carbonate. Maximal expression of urease is a limiting factor for …

Population Genomics And Evolution Of Pseudomonas Aeruginosa, Samara T. Choudhury

Electronic Theses & Dissertations (2024 - present)

Pseudomonas aeruginosa is a Gram-negative bacterium ubiquitous in diverse environments and an opportunistic pathogen in humans. It is a leading cause of chronic lung infections in cystic fibrosis patients and of hospital-acquired pneumonia and sepsis. With a large flexible genome and abundant mobile genetic elements, P. aeruginosa exhibits high levels of antimicrobial resistance (AMR), making it a significant public health threat. Evolutionary processes such as homologous recombination, and horizontal gene transfer generate extensive genomic diversity in this species and facilitate the spread of resistance genes. In this dissertation, I investigate the genetic and evolutionary factors shaping P. aeruginosa population structure …

Audiovisual Motion Onset Asynchrony As Expectation Violation: Effects On Memory And Liking In Media Contexts, Sijia Song

Electronic Theses & Dissertations (2024 - present)

This research presents the first systematic investigation of motion-onset asynchrony (MOA) as a form of audiovisual temporal incongruency grounded in contemporary spatial audio and extended reality (xR) systems. MOA—the delay between the onset of visual and auditory motion—was manipulated at three levels (0 s, 1.1 s, 3 s) to test its effects on cognitive (memory) and affective (liking) outcomes during short 2D animated video viewing. Guided by inverted-U models of expectation violation, it was hypothesized that moderate MOA would be associated with the highest memory performance and liking ratings and that liking would mediate MOA’s effects on memory. Across two …

Providers' Perceptions Of Barriers And Facilitators To Implementing Non-Pharmacological Treatment For Adults With Chronic Pain: A Meta-Synthesis, Mikhaela Mcfarlin

Electronic Theses & Dissertations (2024 - present)

Background. Chronic pain is a public health concern impacting approximately 20% of adults in the U.S. Nonpharmacological interventions are considered first-line treatments for patients with chronic pain, yet nonpharmacological interventions remain significantly underutilized. While previous research has explored barriers from the patient’s perspective, limited attention has been paid to providers’ experiences implementing these treatments. This qualitative meta-synthesis aimed to examine provider-perceived barriers and facilitators to implementing nonpharmacolgical treatments for adults with chronic pain. Methods. Independent reviewers conducted systematic searches across PubMed, PsycInfo, CINAHL, and ProQuest Dissertations using relevant (e.g., “mental health provider”, “nonpharmacological”) and applied inclusion criteria to …

Models Of Emulation: Representations Of Foreign, Indigenous, And Accented Speech In Early American Literature, Elaina A. Frulla

Electronic Theses & Dissertations (2024 - present)

“Models of Emulation: Representations of Foreign, Indigenous, and Accented Speech in Early American Literature” explores how American writers used depictions of “nonstandard” English and accented English language speech, traditionally described as “literary dialect,” as a way to negotiate identity, power, and political belonging in the formative years of nation building after the American Revolution. Beginning with Noah Webster’s mission to establish a standardized pronunciation of the English language that would simplify and purify spoken American-English and definitively differentiate it from what he saw as the corrupted, cosmopolitan British-English model, each of the three chapters examines literary representations of nonstandard emulated …

New Game Start: Playing With Power, Community And Change In Video Gaming Culture, Jonathan D. Muller

Electronic Theses & Dissertations (2024 - present)

Video gaming culture has long been a site associated with norms and values of whiteness, masculinity, and neoliberalism, with games, players, and developers all reinforcing these. Recently though, gaming culture has been directly involved with social movements and forms of resistance that are contrary to these norms and values. The typical gamer is no longer a white man, and gaming culture is now acknowledged to include race and gender dynamics that are close to that of the broader population. These communal shifts have both challenged and reinforced existing power structures. This research addresses these shifts and struggles by analyzing how …

Genetic Diversity Of Cryptosporidium Species In New York State, Kimberly A. Mergen

Electronic Theses & Dissertations (2024 - present)

The knowledge regarding Cryptosporidium infections in New York State (NYS) is severely lacking in two ways: 1) there are currently no NYS-based data regarding the subtypes of Cryptosporidium parvum and Cryptosporidium hominis, which are the two most prevalent species that infect humans and 2) information regarding uncommon Cryptosporidium species that infect the New York population is also unavailable. Filling these gaps concerning this pathogenic parasite would provide a substantial amount of information when considering public health, outbreak investigations, and prevention measures. Therefore, improving Cryptosporidium subtype and species surveillance in NYS will aid in prevention and control efforts as well …

Viral Diversification And Host-Specific Fitness Of Powassan, Heartland, And Bourbon Viruses In New York State, Rachel E. Lange

Electronic Theses & Dissertations (2024 - present)

This dissertation reports important progress for our understanding of emerging and re-emerging tick-borne viruses circulating in North America including Powassan, Deer Tick, Heartland, and Bourbon viruses. Chapter 2 describes important tools for these viruses including multiplex assays for viral and bacterial pathogens in field-collected ticks and mammals, development of full genome sequencing assays and bioinformatic pipelines for evolutionary analysis, and establishment of tick-specific tools for viral isolation and characterization. Chapter 3 focuses on the disease focality of Deer Tick virus, reporting transovarial transmission in nature in Ixodes scapularis for the first time, further evidence to incriminate shrews as potential Deer …

Emotional Factors Influencing Adaptive Memory: An Examination Of The Role Of Valence In The Survival Processing Effect, Dailyn Q. Clark

Electronic Theses & Dissertations (2024 - present)

Encoding information (e.g., words) in terms of their survival value produces enhanced recall relative to encoding the same information in terms of its value to other schematically similar situations (Nairne et al., 2007). In the survival memory paradigm, a scenario focused on imagining being stranded in the grasslands of a foreign land is followed by the rating of individual words (e.g., orange, mountain) as to their relevance to that scenario (Nairne et al., 2007). Using an incidental test of memory, it is often revealed that memory for those words is higher than for those same words encoded under non-survival, control …

Studies Towards Chemical Synthesis Of Homogeneous Prion Glycoprotein, Baotong Tian

Electronic Theses & Dissertations (2024 - present)

Prion diseases are fatal neurodegenerative disorders initiated by conformational misfolding of the prion protein (PrP), which generates pathogenic conformers that propagate via templated conversion and accumulate as aggregates. Glycosylation can modulate the PrP folding energy landscape, thereby biasing folding trajectories and the distribution of resulting conformational states. Bank vole PrP contains two N-linked glycosylation sites, and disentangling the contributions of site occupancy versus glycan structure requires homogeneous, site-defined glycoforms. In contrast, biosynthetic expression typically produces heterogeneous glycoform ensembles due to multistep Golgi processing, precluding independent control of glycan identity at each site. Here we report a chemical synthesis strategy of …

As If It Were Food: A Prose Translation Of The Old English Genesis B, Kane R. Malone

Electronic Theses & Dissertations (2024 - present)

The anonymous Old English poem known as “Genesis B” comes down to us as one of the most inherently human retellings of the Fall of Adam and Eve. Despite this, the piece is seldom read by the average twenty-first century middle-school learner. The poem, originally penned in Old English, has been translated into modern English numerous times, yet as I read through a variety of these translations, they all seemed to downplay the human element which I found intriguing. Thus, I created my own translation of “Genesis B” with a more general audience in mind, looking to create something that …

Rethinking Theories Of Political Discourse: The Limitations Of The Deliberative-Agonistic Split, Connor Moran

Electronic Theses & Dissertations (2024 - present)

What are “theories of political discourse,” why do they matter to political theory, and where do current ones fall short? This dissertation mines the existing resources availed by contemporary democratic theory in order to respond to the discursive challenge of “pernicious polarization,” particularly in the United States. The most comprehensive and influential theories of political discourse today have been furnished by the almost 40-year debate between deliberative democracy and agonism, both of which offer normative models centered on ameliorating the quality of political discourse.

The key finding of the dissertation is that the foundational works of the deliberative-agonistic split lack …

The Chemistry Of Red Lipstick: The Impact Red Lipstick Has On Society, Lilliana Weldeslassie

Electronic Theses & Dissertations (2024 - present)

Cosmetic chemistry is deeply embedded in everyday life, shaping the products people use from morning to night. Among these, red lipstick stands out as a formulation that blends complex chemistry with a cultural meaning. This thesis examines the scientific foundations of red lipstick through its chemical composition, pigment structure, toxicological history, analytical methods, and evolving sustainability practices. Historically, red lipsticks relied on high-risk ingredients such as lead, mercury, and other toxic metals, reflecting an era before chemical safety and regulatory oversight were incorporated.²¹ Modern formulations have established safer synthetic dyes, natural waxes, plant-based oils, and stabilizers created to optimize …

Reviving Southern Divides: Multilevel Explorations Of Gentrification’S Role In School Resegregation In Tallahassee, Florida From 1999 – 2015, Ola U. Kalu

Electronic Theses & Dissertations (2024 - present)

This dissertation examines whether neighborhood gentrification in Tallahassee reshaped Title I elementary schools by improving academic outcomes, changing who enrolled, or both, from 1999 to 2015. Using Bronfenbrenner's Ecological Systems Model as a conceptual scaffold, the study situates schools within their neighborhood and district contexts across three nested analytical levels. A two-wave panel design using 2010 and 2015 school-year observations is linked to a 2000 Census baseline to connect school data with spatially weighted neighborhood change indicators. Mixed-effects multilevel models and fixed-effects robustness checks estimate the associations between neighborhood change indicators and two continuous dependent variables: standardized ELA achievement and …

Multifunctional And Adaptive: Tracking How Fibroblasts Respond To Tissue Injury And Facilitate Tissue Remodeling, Joey R. Tavarez

Electronic Theses & Dissertations (2024 - present)

Fibrosis is characterized by an accumulation of proteins in the extracellular matrix (ECM) that results in altered tissue architecture and reduced organ function. In the salivary glands, fibrosis leads to loss of saliva, dysbiosis of the oral microbiome, an increase in oral infections, difficulty in digestion of food and an overall reduction in the quality of life. Understanding the progression of fibrosis and how it affects human health is a crucial step for designing effective therapeutics. Understanding fibroblast function is integral to advancing the field due to the many roles they play in maintaining the ECM. To perform preliminary analysis, …

Constructing The Political “Other”: Affective Polarization And Cross-Ideological Portrayals On Instagram, Amanda M. Novellin

Electronic Theses & Dissertations (2024 - present)

Instagram has frequently been characterized by users as a platform that permits the circulation of hostile and adversarial political content due to comparatively limited moderation practices. In January 2025, Meta CEO Mark Zuckerberg announced changes to content moderation policies on Facebook and Instagram, including the removal of third-party fact-checking mechanisms. These platform-level changes further reshaped the political information environment in which online discourse occurs. However, even prior to these policy changes, Instagram had established itself as a prominent space for highly polarized political expression across the ideological spectrum.

This thesis examines how political polarization in the United States is reflected …

German Science, American Manufacturing: Ethnic Capital, Transnational Technology, And Corporate Development At Bausch & Lomb, 1853–1953, George L. Grobe Iv

Electronic Theses & Dissertations (2024 - present)

This dissertation examines the first century of the Bausch & Lomb Optical Company, founded in Rochester, NY in 1853 by German immigrants John Jacob Bausch and Henry Lomb. It argues the firm’s success was driven by leveraging of management’s German ethnic identity as “ethnic capital” to access resources like financial liquidity, immigrant labor, and technical expertise. These resources allowed for the transformation of the firm from a small optical retail shop into a major manufacturer of advanced optical instruments. However, as later generations of the family Americanized, the ability of the firm to leverage ethnic capital eroded until breaking completely …

Barriers And Corridors: Timber Rattlesnake Habitat Connectivity In New York, Lauren Rose

Electronic Theses & Dissertations (2024 - present)

Habitat fragmentation poses a significant threat to species that rely on landscape connectivity for movement in search of food, water, and mates. The timber rattlesnake (Crotalus horridus), listed as a threatened species in New York State, travels an average of 1.5 miles—and up to five miles—from permanent denning sites to reach habitat suitable for gestation, foraging, basking, and overwintering. Ongoing development in the lower Hudson Valley has increasingly fragmented these critical habitats, restricting movement between den populations. This thesis evaluates landscape barriers that contribute to population isolation and identifies opportunities to restore connectivity among timber rattlesnake metapopulations.

Using …

Inflammation In Early Borrelia Burgdorferi Skin Infection, Ariana Nobles

Electronic Theses & Dissertations (2024 - present)

Borrelia burgdorferi (Bb) is the causative agent of approximately 476,000 cases of Lyme disease in the United States and rising. Bb is spread through infected saliva of the black-legged tick, Ixodes scapularis, to the host. Patients infected with Bb experience short-term symptoms, such as erythema migrans (EMs), fatigue, pain, and cognitive impairment. If left untreated, Bb infection will cause long-term health complications, like Lyme neuroborreliosis and Lyme arthritis. It is postulated that symptoms associated with Lyme disease are driven in part by inflammation.

My thesis focuses on the skin as it holds significant immunological importance in the …

Becoming-With The Earth: Contemplative Practice As A Critical Onto-Epistemic Resource For Planetary Belonging, Care, And World-Making, Megan M. Fowler

Electronic Theses & Dissertations (2024 - present)

In an era of accelerating planetary crisis, social work is called to reimagine its theories, methods, and practices beyond anthropocentric frameworks that separate human wellbeing from the health of the Earth and its resplendent living systems. Working in the space of transformative eco-social work, a growing chorus of voices contends that eco-centric responses require broadening the scope of health, welfare, justice, and care to extend beyond the human, to include the more-than-human world upon which all life intimately depends—understandings resonant with Indigenous and other relational knowledge systems long marginalized by colonialist-capitalist-modernity. Drawing from eco-feminist, eco-queer, decolonial, and post-anthropocentric lineages of …

Development And Applications Of Fluorescence Microscopy Protocol To Investigate Borrelia Burgdorferi Immune Interactions In The Skin, Rebecca V. Landry

Electronic Theses & Dissertations (2024 - present)

The skin is an immunological organ that acts as the hosts’ first line of defense against infectious agents. Infectious disease vectors like ticks breach this barrier by feeding on hosts, transmitting pathogens like Borrelia burgdorferi in the process. Uncleared infection with B. burgdorferi causes Lyme disease, the most prevalent vector-borne disease in the United States. Previous research has explained many elements of Lyme disease pathogenesis and immunity including the dissemination of the spirochete, innate immune cells performing phagocytosis, the production of antibodies by the humoral response, and the impact of prophylactic treatment with monoclonal antibodies. A remaining gap in the …

Perceptions Of Psilocybin-Assisted Psychotherapy And Standard Interventions For Nicotine Cessation, Philip Kamilar-Britt

Electronic Theses & Dissertations (2024 - present)

Clinical trials suggest potential therapeutic utility of psilocybin-assisted psychotherapy (PAP) for nicotine cessation. In response to promising outcomes, research into PAP for nicotine dependence is growing. However, attitudes towards PAP among the general public, especially daily nicotine users, remains understudied. To address this knowledge gap, we recruited daily nicotine users (N=534) to complete an anonymous online survey with questions on demographics, nicotine use, prior history with psychedelics, and attitudes towards PAP and standard interventions for nicotine cessation. As hypothesized, daily nicotine users were more familiar with standard interventions and rated them more favorably than PAP. Despite differences in treatment attitudes, …

Cognate Awareness Training For Novice L2 Learners: Orthographic And Phonological Routes To Vocabulary Learning, Jennifer M. Martin

Electronic Theses & Dissertations (2024 - present)

Within the study of cross-linguistic influence, research on cognate facilitation has consistently shown that proficient bilinguals process cognates (e.g., English “sock” and German “Socke”) more efficiently than non-cognates. However, less is known about how novice adult learners may benefit from these similarities during the earliest stages of second language acquisition or how instructional interventions might facilitate this process. This dissertation addressed this gap through experiments with English-speaking adults learning German. A series of experiments examined the effects of cross-linguistic similarity and explicit cognate awareness training on vocabulary acquisition. Experiment 1A found robust similarity effects in written recall and …

Nation, Nature And Childhood In Five Curricula: Towards Earthly Education, Zsuzsa Millei, Katarzyna Gawlicz, Lucy Hopkins, Camilla Eline Andersen, Danielle Ekman Ladru

Research outputs 2022 to 2026

This article explores the relations between nation, nature and childhood in five early childhood education curricula in the Nordic, post-socialist and settler-colonial states with the focus on the role education plays in the face of the climate crisis. The authors identify three interconnecting themes in which nation, nature and childhood are entangled in these curricula: 1) national nature as an object of learning; 2) nature and home/birth land and Country; and 3) stewardship for national nature. Exploring these themes from the perspective of alternative pedagogies developed to address the child–nature relations during the Anthropocene, the authors argue that these notions …