Digital Commons Network^™

Oral Absorption And Drug Interaction Kinetics Of Moxifloxacin In An Animal Model Of Weightlessness, Dong Liang, Jing Ma, Bo Wei

Faculty Publications

To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly …

Correlation Of Economic Status And Trace Metals Concentrations In Surface Soils In The Houston Metropolitan Area., Sanata Dama

Dissertations (2016-Present)

Urban surface soils are contaminated by trace metals from various anthropogenic sources such as traffic and industrial facilities. Socio-economically disadvantaged communities are generally located closer to these sources and likely exposed more to toxic metals. This study aims to investigate the surface soil contamination by trace metals. Surface soils were collected from parks (n=75) and playgrounds of elementary schools (n=6) located in 33 postal codes split into four groups with different economic status (average annual household income) and industrial emissions (releases reported to the Toxic Release Inventory). Postal codes were ordered into high/middle income (> $40,000/year) without emissions, high/middle income …

Look, Don't Touch, Shreya Mahesh '22, Temi Ijisesan '22

History of the Environment

This book follows two children, Georgia and Dakota, on an adventure where they learn about the importance of understanding and respecting wilderness.

Wofford Today Winter 2021, Wofford College. Office Of Marketing And Communications

Wofford Today

No abstract provided.

The Role Of Trading Services In The Development Of The Country's Economy, F.B. Abdurkarimov

Economics and Innovative Technologies

Abstract. This article discusses the negative impact of COVID-19 on the sharp decline in production and consumption worldwide, the disruption of global production chains and trade links, falling commodity prices on world markets and deteriorating conditions. emphasis is placed on the implementation of an active foreign trade policy to enter the world market, to pursue a foreign trade policy aimed at further strengthening their position in the interests of national producers.

Managing Well-Being Values Of Employees - Keys To Successful Human Resource Management, Y. Yakubova

Economics and Innovative Technologies

The latest literature on human resource management indicated the employees well-being is positively correlated with their productivity and creativity at work. Understanding what shapes the well-being and ability to manage it is now prerequisite to successful employee and talent management. The question arises, what determines well-being and what values drive employees well-being? The discussion below revises through the latest findings in the field and provides a useful insight for the professionals in the related disciplines. Some of the key factors determining subjective well-being have been identified below. It is intended that the findings can also benefit the employee management methods …

The Independent Ed. 9 Vol. 1, Rollins College Students

The Independent

Managing Staff

Em O'Malley, Editor-in-Chief

Taylor Ingrassia, Rising Editor-in-Chief

Francisco Wang Yu, Chief Creative Officer

Scott Novak & Mary Catherine Pflug, Co-Founders

Designers/Artists

Ghina Fawaz, Dassika Gilkey, Katie Monaghan, Konstantin Freiherr Von Stein

Editors

Senior Editors: Alekhya Reddy, Julie Bennie

Copy Editors: Aqsa Hasan, Carlie Henning, Jiya Manchanda

Contributors

Adrianna Arosemana, Mona Belakbir, Delaney Benton, George Carpenter, Paula Espinosa, Taylor Ingrassia, Arielle Junca, Madison Linn, Roo Morton, Em O'Malley, Alekhya Reddy, Sydney Schenone

How Long Has The College Presented Its Annual Festival Of Christmas?, Mackenzie Ciske '17

Ask the Abbot

Abbot Pennings answers a question about Festival of Christmas, archived from the SNC website.

Southern Adventist University Commencement Program December 16 And December 17, Southern Adventist University

Commencement Programs

Program for Southern Adventist University December graduation. The commencement service took place at the Iles Physical Education Center on December 16 and December 17, 2021.

Picture Perfect: Ephemera, Icons, And Disaster, Riley Patrick

Architecture Thesis Prep

The abstract, authorless fabrication of an AI image juxtaposed with the legible photography of the constructed recognition perspective connects the awe-inspiring concept of the “natural” disaster with the tangible reality of its actual and potential destruction, found at culturally known physicalities. It is part of architecture’s responsibility to utilize its agency in demystifying the climate crisis, utilizing potent imagery to manifest the danger and effects of these disasters in a contributing effort to protect America’s cultural icons. Representation therefore holds power in communicating immediacy and emotional investment to the climate crisis. The cultural l legibility of national parks is well …

Vitamin C For Sepsis Intervention: From Redox Biochemistry To Clinical Medicine, Y R. Li, Hong Zhu

Osteopathic Medicine, Jerry M. Wallace School of

Vitamin C, also known as ascorbic acid or ascorbate, is a water-soluble vitamin synthesized in plants as well as in animals except humans and several other animal species. Humans obtain vitamin C from dietary sources and via vitamin supplementation. Vitamin C possesses important biological functions, including serving as a cofactor for many enzymes, acting as an antioxidant and anti-inflammatory compound, and participating in regulating stem cell biology and epigenetics. The multifunctional nature of vitamin C contributes to its essentialness in maintaining and safeguarding physiological homeostasis, especially regulation of immunity and inflammatory responses. In this context, vitamin C has been investigated …

Adaptive Navigation Of Three-Dimensional Scalar Fields With Multiple Uavs, Robert Ka-Hing Lee

Engineering Ph.D. Theses

Adaptive Navigation (AN) control strategies allow an agent to autonomously alter its trajectory based on realtime measurements of its environment. Compared to conventional navigation methods, AN techniques can potentially reduce the time and energy needed to explore scalar characteristics of unknown and dynamic regions of interest (e.g., temperature, concentration level). Multiple Uncrewed Aerial Vehicle (UAV) approaches to AN can improve performance by exploiting synchronized spatially-dispersed measurements to generate realtime information regarding the structure of the local scalar field for use in navigation decisions. This dissertation presents initial results of a comprehensive program to develop, verify, and experimentally implement mission-level AN …

The Forbidden Female: Epistemophilia In The Domestic Gothic Tradition, Katelyn Govoni

Master’s Theses and Projects

Women in eighteenth-century Gothic novels are often portrayed by scholars as mildly rebellious in their characters and behaviors, but ultimately submissive to male characters until eventually returning to domestic circumstances similar to their origins. I join these scholarly conversations about Gothic heroines through my analysis of female curiosity and epistemophilia as they are applied to the domestic sphere. I concur with the critics who see female knowledge and sexuality as inextricably connected and feared in the domain of patriarchal influence. I argue, however, that rather than being trapped in the domestic sphere, novelist Ann Radcliffe’s heroines apply epistemophilia—a drive to …

Delegation, Administration, And Improvisation, Kevin Arlyck

Notre Dame Law Review

Nondelegation originalism is having its moment. Recent Supreme Court opinions suggest that a majority of Justices may be prepared to impose strict constitutional limits on Congress’s power to delegate policymaking authority to the executive branch. In response, scholars have scoured the historical record for evidence affirming or refuting a more stringent version of nondelegation than current Supreme Court doctrine demands. Though the debate ranges widely, sharp disputes have arisen over whether a series of apparently broad Founding-era delegations defeat originalist arguments in favor of a more demanding modern doctrine. Proponents—whom I call “nondelegationists”—argue that these historical delegations can all be …

Light Pollution Levels On Beaches: How Window Tinting Effects Disorientation Of Sea Turtles On Hilton Head Island, Kathryn (Kate) Hettiger

Biology: Student Scholarship & Creative Works

Loggerhead sea turtles, an endangered species, are decreasing at alarming rates worldwide. Artificial light from beachfront hotels on Hilton Head Island are causing disorientation in Loggerhead sea turtle hatchlings affecting their ability to successfully find the ocean. To mitigate this, exterior windows facing the ocean will be tinted using either tinting spray, which will be implemented at the Marriott Grande Ocean, or using tinting film, which will be implemented at the Marriott Westin. During the typical nesting and hatching season (May-October), sea turtle hatchling tracks will be recorded using drones to compare the effects of various levels of light pollution …

Dopamine Precursor’S Effect On Habitation In Hermit Crabs, Chandler Carlson, Will Mcclenny, Robert Grossman

Psychology Student Research Showcase

A Research Methods Project supervised by Dr. David Stahlman (Fall 2021)

Characterization And In Vitro And In Vivo Evaluation Of Tacrolimus-Loaded Poly(Ε-Caprolactone) Nanocapsules For The Management Of Atopic Dermatitis, Guilherme Dos Anjos Camargo, Leandro Ferreira, Diego José Schebelski, Amanda Martinez Lyra

Faculty and Student Publications

Background: Tacrolimus (TAC) is a drug of natural origin used in conventional topical dosage forms to control atopic dermatitis. However, direct application of the drug often causes adverse side effects in some patients. Hence, drug nanoencapsulation could be used as an improved novel therapy to mitigate the adverse effects and enhance bioavailability of the drug. Methods: Physicochemical properties, in vitro drug release experiments, and in vivo anti-inflammatory activity studies were performed. Results: TAC-loaded nanocapsules were successfully prepared by the interfacial deposition of preformed polymer using poly(ε-caprolactone) (PCL). The nanoparticu-late systems presented a spherical shape with a smooth and regular surface, …

Issue 383: November 11-December 2, 2021, The Local Voice

The Local Voice

No abstract provided.

Unmasking The Mouse: Cultural Appropriation In Disney Films, Rebecca Domas

Honors Student Research

The artworld has largely revolved around traditional institutions like museums for centuries, however with the age of technology quickly evolving new artforms have risen to challenge these traditional spaces. Large corporations like The Walt Disney Company, have revolutionized the world of art and have become a prominent voice in representing cultures to a large population of the public. The two forces may be comparably different on the surface; however both are going through a progressive change as they enter the discussion of inclusive representation and accusations of cultural appropriation. The act of cultural appropriation concerns the negatively generated adaptations of …

The Temporal And Frequent Pattern Mining Analysis And Machine Learning Forecasting On Mobile Sourced Urban Air Pollutants, Jianbang Du

Dissertations (2016-Present)

Ground-level ozone and atmospheric fine particles (PM2.5) have been recognized as critical air pollutants that act as important contributors to the toxicity of anthropogenic air pollution in urban areas. To limit the adverse impacts on public health and ecosystems of ground-level ozone and PM2.5, it is necessary and imperative to identify a practical and effective way to predict the upcoming pollution concentration levels accurately. Under this need, various research was conducted aiming to perform the forecasting of ground-level ozone and PM2.5 that mainly utilized the time-series and neural network analysis. In the meantime, machine learning is also adopted in analysis …

An Investigation Into The Use Of An Herbal Labor Induction Tincture Containing Black Cohosh, Cramp Bark, Partridgeberry, And Motherwort On Contractile Responses Produced From Isolated Strips Of Mouse Uterine Tissues, Clayton Neuenschwander, Katrina Wu, Teresa F. Degolier

Biological Sciences Faculty Publications

Introduction: Alternative solutions in the form of herbal remedies meant to ease or expedite the process of labor have often been pursued and administered but have seldom been quantitatively tested for efficacy. Published research has shown some validation for some commonly used herbs such as blue cohosh (Caulophyllum thalictroides), red raspberry (Rubus idaeus), castor bean (Ricinus communis) and evening primrose (Oenothera biennis) on isolated mouse uterine strips. Methods: This study tested an array of herbs used by midwives in a labor induction tincture, which included black cohosh (Actaea racemosa), cramp bark (Viburnum opulus), partridgeberry (Mitchella repens), and motherwort (Leonurus cardiaca). …

Nanoceria Potently Reduce Superoxide Fluxes From Mitochondrial Electron Transport Chain And Plasma Membrane Nadph Oxidase In Human Macrophages, Y R. Li, Hong Zhu

Osteopathic Medicine, Jerry M. Wallace School of

Cerium oxide nanoparticles, also known as nanoceria, possess antioxidative and anti-inflammatory activities in animal models of inflammatory disorders, such as sepsis. However, it remains unclear how nanoceria affect cellular superoxide fluxes in macrophages, a critical type of cells involved in inflammatory disorders. Using human ML-1 cell-derived macrophages, we showed that nanoceria at 1-100 μg/ml potently reduced superoxide flux from the mitochondrial electron transport chain (METC) in a concentration-dependent manner. The inhibitory effects of nanoceria were also shown in succinate-driven mitochondria isolated from the macrophages. Furthermore, nanoceria markedly mitigated the total intracellular superoxide flux in the macrophages. These data suggest that …

We Are ... Marshall, December 1, 2021, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Climate Change Planning: Soil Carbon Regulating Ecosystem Services And Land Cover Change Analysis To Inform Disclosures For The State Of Rhode Island, Usa, Elena A. Mikhailova, Lili Lin, Zhenbang Hao, Hamdi A. Zurqani, Christopher J. Post, Mark A. Schlautman, Gregory C. Post, Peyton I. Mitchell

Open Access Publishing Fund

The state of Rhode Island (RI) has established its greenhouse gas (GHG) emissions reduction goals, which require rapidly acquired and updatable science-based data to make these goals enforceable and effective. The combination of remote sensing and soil information data can estimate the past and model future GHG emissions because of conversion of “low disturbance” land covers (e.g., evergreen forest, hay/pasture) to “high disturbance” land covers (e.g., low-, medium-, and high-intensity developed land). These modeled future emissions can be used as a predevelopment potential GHG emissions information disclosure. This study demonstrates the rapid assessment of the value of regulating ecosystems services …

Cover Crops To Improve Soil Health In The North American Great Plains, Augustine K. Obour, Logan M. Simon, Jonathon D. Holman, Patrick M. Carr, Meagan Schipanski, Steven Fonte, Rajan Ghimire, Thandiwe Nleya, Humberto Blanco-Canqui

Agronomy, Horticulture and Plant Science Faculty Publications

Rotating cereal crops (e.g., wheat [Triticum aestivum L.] with a 10- to 21-mo summer fallow period [fallow]) is a common farming practice in dryland (rainfed) agricultural regions. Fallow is associated with several challenges including low precipitation storage efficiency, depletion of soil organic carbon (SOC), loss of soil fertility, little crop residue retention and soil erosion, and few control options for herbicide-resistant (HR) weeds. The inability to effectively control HR weeds poses a major challenge to maintaining soil and water conservation practices such as no-tillage, as some producers are considering tillage to control weeds. Cover crop (CC) integration into wheat-based …

Kshv Susceptibility And Transmission Within Tonsillar Specimens, Farizeh Aalam

Pharmaceutical Sciences (PhD) Dissertations

Despite nearly three decades of research, not much is known regarding the early stages of development for KSHV lymphoproliferative disorders, hindering our ability to develop prophylactic measures or effective treatments. This dissertation will focus on the host and viral factors influencing the magnitude and dynamics of KSHV infection in the human tonsil to pave the way for future interventions directed at limiting person-to-person transmission of KSHV.

To understand the contribution of host factors to KSHV susceptibility in B lymphocytes, we generated a library of 40 tonsillar specimens. Our results indicate that the immunological composition of tonsillar lymphocytes varies across our …

Hsva: Hierarchical Semantic-Visual Adaptation For Zero-Shot Learning, Shiming Chen, Guo Sen Xie, Yang Liu, Qinmu Peng, Baigui Sun, Hao Li, Xinge You, Ling Shao

Machine Learning Faculty Publications

Zero-shot learning (ZSL) tackles the unseen class recognition problem, transferring semantic knowledge from seen classes to unseen ones. Typically, to guarantee desirable knowledge transfer, a common (latent) space is adopted for associating the visual and semantic domains in ZSL. However, existing common space learning methods align the semantic and visual domains by merely mitigating distribution disagreement through one-step adaptation. This strategy is usually ineffective due to the heterogeneous nature of the feature representations in the two domains, which intrinsically contain both distribution and structure variations. To address this and advance ZSL, we propose a novel hierarchical semantic-visual adaptation (HSVA) framework. …

Understory Vegetation Composition And Small Mammal Abundance In An Exotic Eucalyptus Forest Vs Adjacent Native Habitat, Kelly Mcfadden

Master of Science in Environmental Sciences and Management Projects

None provided

Transcriptome Profiles Of The Skeletal Muscle Of Mature Cows During Feed Restriction And Realimentation, Hannah C. Cunningham-Hollinger, Larry A. Kuehn, Kristi M. Cammack, Kristin E. Hales, William T. Oliver, Matthew S. Crouse, Celine Chen, Harvey C. Freetly, Amanda K. Lindholm-Perry

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Objective: Realimentation can compensate for weight loss from poor-quality feedstuffs or drought. Mature cows fluctuate in body weight throughout the year due to nutrient availability. The objective of this study was to determine whether cows that differ in weight gain during realimentation also differ in the abundance of transcripts for enzymes associated with energy utilization in skeletal muscle. Mature cows were subjected to feed restriction followed by ad libitum feed. Skeletal muscle transcriptome expression differences during the two feeding periods were determined from cows with greater (n = 6) and less (n = 6) weight gain during the ad libitum …

"Blazing The Trail" For The Future: Bipoc Students' Experiences With Colleges Of Agriculture, Logan Moss

Agricultural Education, Communications and Technology Undergraduate Honors Theses

Since its founding, the United States has faced a constant turmoil surrounding the equitable treatment of people from non-Caucasian backgrounds, especially regarding education. This study sought to examine BIPOC (Black, Indigenous and People of Color) students experiences prior to entry and during their studies in colleges of agriculture within the State of Arkansas. Research has shown that across the country there are discrepancies between the percentage of BIPOC students in the State, university, and colleges of agriculture. This study used a qualitative interview method to determine the factors influencing minority students to enter and stay within a program of study …