Digital Commons Network^™

Psychiatric And Neuropsychological Sequelae Of Herpes Simplex Encephalitis, Carla F. Cabrera, Charles J. Golden

Archives of Assessment Psychology

Herpes simplex encephalitis (HSE) is caused by the herpes simplex virus (HSV), often from the Type 1 (HSV-1) viral infection. This neurotropic double-stranded DNA virus impairs the integrity and permeability of the blood-brain barrier, allowing the virus to enter the brain. In several studies, HSV-1 impacts the temporal lobe, frontal lobe, and limbic system, leading to brain damage. While significant progress has occurred in understanding this infection, clinicians should be vigilant for acute and chronic complications associated with HSE, such as autoimmune encephalitis, differential diagnoses, and psychological disorders. A growing body of literature focuses on the evidence of an association …

Assessing Aggressivity With The Comprehensive System-Revised, Part I: The Rorschach Gacono & Meloy Extended Aggression Scores: An Updated Review, Carl B. Gacono, Jason M. Smith

Archives of Assessment Psychology

Determining a patient's aggressivity is a function of assessing multiple factors, including personality vulnerabilities, past behaviors, and potential future circumstances. Evaluating the nature and predominance of aggressive drive, impulse control, affect lability, inhibitory mechanisms, cognitive deficits, and conscious and unconscious attitudes (e.g., use of devaluation; the presence of internal identifications and imagery) is essential. All of these issues have correlates in the Comprehensive System (CS; Exner, 2003; also CS-R; Fontan & Andronikof, 2022) and supplemental Rorschach data (primitive defenses: Cooper et al., 1988; Lerner & Lerner, 1980; object relations phenomena: Kwawer, 1980; extended aggression scores: Gacono & Meloy, 1994). Pre-Oedipal …

Cathepsin S Is A Novel Target For Age-Related Dry Eye, Zhiyuan Yu, Jinmiao Li, Gowthaman Govindarajan, Sarah F Hamm-Alvarez, Jehan Alam, De-Quan Li, Cintia S De Paiva

Faculty, Staff and Students Publications

Cathepsin S (CTSS) is a protease that is proinflammatory on epithelial cells. The purpose of this study was to investigate the role of CTSS in age-related dry eye disease. Ctss−/− mice [in a C57BL/6 (B6) background] of different ages were compared to B6 mice. CTSS activity in tears and lacrimal gland (LG) lysates was measured. The corneal barrier function was investigated in naïve mice or after topical administration of CTSS eye drops 5X/day for two days. Eyes were collected, and conjunctival goblet cell density was measured in PAS-stained sections. Immunoreactivity of the tight junction proteins, ZO-1 and occludin, was …

Graphene Based Electrochemical Biosensors For The Detection Of Blood Biomarkers Of Alzheimer’S Disease, Jagriti Sethi

School of Engineering, Computing and Mathematics Theses

Alzheimer’s disease (AD) is a neurodegenerative disorder that affects millions of people around the world with no available treatments to cure, reverse or even slow down the disease progression. Detection of AD in the early stages, before the massive neuronal loss, is key to developing disease-modifying treatments and preventive strategies. The current AD diagnosis is largely based on evaluation tests such as Mini-Mental State Examination (MMSE), imaging techniques such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and postmortem autopsies. It is expensive and only available at the later/severe stages when the brain of the patient is already damaged …

Nikolai Ivanovich Vavilov, James P. Smith Jr

Botanical Studies

No abstract provided.

Mechanically Injurious Plants, James P. Smith Jr

Botanical Studies

No abstract provided.

Poisonous Plants: A Glossary Of Commonly Used Terms, James P. Smith Jr

Botanical Studies

No abstract provided.

Purposeful Use Of Poisonous Plants, James P. Smith Jr

Botanical Studies

No abstract provided.

Poisonous Plants Of Home And Garden, James P. Smith Jr

Botanical Studies

No abstract provided.

Using Heidisongs Music As An Instructional Tool In The Elementary School Classroom: A Case Study, Leia Denise Jobe

Doctoral Dissertations and Projects

The purpose of this qualitative multiple case study is to understand how teachers use HeidiSongs music as an instructional tool in the elementary school classroom. HeidiSongs uses multisensory structured language education to teach by engaging multiple senses simultaneously to increase retention. The theories guiding this study include Gardner’s theory of multiple intelligences, which involves kinesthetic intelligences among other types of intelligences, and Krashen’s theory of second language acquisition. HeidiSongs uses both musical and kinesthetic activities to enhance literacy. The central research question focused on how teachers use HeidiSongs music as an instructional tool in the elementary school classroom. The sub-questions …

Christian Devotional Meditation And Holistic Well Being, Raymond D. Paxton

Doctoral Dissertations and Projects

Holistic well-being is a concept that implies humans are multidimensional and require a broad approach to help them achieve life contentment and satisfaction. Spirituality, relationships, emotional functioning, and biology all play a part in achieving this life balance and satisfaction. Interpersonal neurobiology suggests that early life experiences can contribute to underdeveloped brain structures resulting in the diminished ability to form meaningful attachment relationships that help foster contentment as an adult. This ability to engage in positive and supportive relationships has impact on life and holistic well-being. Further, the inability to form close relationships, engage, and emotionally connect with others has …

A Phenomenological Study Exploring The Client And Stylist Interaction As A Culturally Specific Form Of Coping With Stress For Black Women In The United States, Nicole Michelle Holden

Doctoral Dissertations and Projects

The purpose of this study is to describe the experience of Black women who visit the salon regularly in the United States. This study is constructed around the culturally intimate relationship of the stylist-client interaction in the Black community as a historical coping mechanism in which Black women utilize for stress and life challenges rather than seek professional mental health services. Although COVID-19 continues to mount a significant mortality rate and financial hardships, its disproportionate effects on communities of color will have lasting implications on their mental health. The need for mental health services has increased due to the mental …

Embryonic Hypotaurine Levels Contribute To Strain-Dependent Susceptibility In Mouse Models Of Valproate-Induced Neural Tube Defects, John W Steele, Ying Linda Lin, Nellie Chen, Bogdan J Wlodarczyk, Qiuying Chen, Nabeel Attarwala, Madhu Venkatesalu, Robert M Cabrera, Steven S Gross, Richard H Finnell

Faculty, Staff and Students Publications

Valproic acid (VPA, valproate, Depakote) is a commonly used anti-seizure medication (ASM) in the treatment of epilepsy and a variety of other neurological disorders. While VPA and other ASMs are efficacious for management of seizures, they also increase the risk for adverse pregnancy outcomes, including neural tube defects (NTDs). Thus, the utility of these drugs during pregnancy and in women of childbearing potential presents a continuing public health challenge. Elucidating the underlying genetic or metabolic risk factors for VPA-affected pregnancies may lead to development of non-teratogenic ASMs, novel prevention strategies, or more targeted methods for managing epileptic pregnancies. To address …

Decidualization Of Human Endometrial Stromal Cells Requires Steroid Receptor Coactivator-3, Vineet K Maurya, Maria M Szwarc, David M Lonard, William E Gibbons, San-Pin Wu, Bert W O'Malley, Francesco J Demayo, John P Lydon

Faculty, Staff and Students Publications

Steroid receptor coactivator-3 (SRC-3; also known as NCOA3 or AIB1) is a member of the multifunctional p160/SRC family of coactivators, which also includes SRC-1 and SRC-2. Clinical and cell-based studies as well as investigations on mice have demonstrated pivotal roles for each SRC in numerous physiological and pathophysiological contexts, underscoring their functional pleiotropy. We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. We show here that, like SRC-2, SRC-3 is expressed in the epithelial and stromal …

High Energy And Power Density Peptidoglycan Musclesthrough Super-Viscous Nanoconfined Water, Haozhen Wang, Zhi-Lun Liu, Jianpei Lao, Sheng Zhang, Rinat Abzalimov, Tong Wang, Xi Chen

Advanced Science Research Center

Water-responsive (WR) materials that reversibly deform in response to humidity changes show great potential for developing muscle-like actuators for miniature and biomimetic robotics. Here, it is presented that Bacillus (B.) subtilis’ peptidoglycan (PG) exhibits WR actuation energy and power densities reaching 72.6 MJ m−3 and 9.1 MW m−3, respectively, orders of magnitude higher than those of frequently used actuators, such as piezoelectric actuators and dielectric elastomers. PG can deform as much as 27.2% within 110 ms, and its actuation pressure reaches ≈354.6 MPa. Surprisingly, PG exhibits an energy conversion efficiency of ≈66.8%, which can be attributed to its super-viscous nanoconfined …

Stat6 Suppression Prevents Bleomycin-Induced Dermal Fibrosis, Hua Sun, Ashish Damania, Megan L Mair, Eniola Otukoya, Yi-Dong Li, Katherine Polsky, Yuying Zeng, Jeremiah A Alt, Martin J Citardi, David B Corry, Amber U Luong, John Morgan Knight

Faculty, Staff and Student Publications

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish a murine model of chronic unified eosinophilic airway inflammation, mice were challenged with Aspergillus niger, and sinonasal mucosa and lung tissue were evaluated by immunohistochemistry, flow cytometry, and gene expression. Inhalation of A niger conidia resulted in a Th2-biased lung and sinus inflammation that typifies allergic asthma and CRS. Gene network and pathway analysis correlated with human disease with upregulation of not only the JAK-STAT and helper T-cell pathways, but also less expected pathways governing …

Experiences Of Counselors Who Provide Services To African American Men With Repeated Domestic Violence Abuse Reports, Miselene Kruer

Walden Dissertations and Doctoral Studies

Domestic violence has been a major concern in the United States. To effectively work with domestic violence offenders, counselors must have the skills and knowledge needed. The purpose of this qualitative phenomenological study was to understand lived experiences of counselors who provide in-home counseling services to African American men who are repeat domestic violence offenders and received a subsequent abuse report within 6 months after in-home services were discontinued. The goal was to try to develop an understanding of experiences of counselors who provide services to these men. Interviews were used to collect data. I used Otter to transcribe all …

The Growth Of Online Retailing In India, Srinivas Samprathi

Walden Dissertations and Doctoral Studies

Industrial experts have agreed that India’s small-scale industries are intensely competitive due to globalization, domestic economic liberalization, and digitization. The purpose of this quantitative correlational study was to evaluate the relationship between transaction costs, customer satisfaction, and customer trust in online shopping with the growth of online retailing in India. The theoretical foundation for this research study was the theory of planned behavior, and the unified theory of acceptance and the use of technology. The research questions examined India’s online retailing growth due to transaction costs, customer satisfaction, and customer trust. The study used a quantitative correlational research design. The …

The Impact Of Poverty And Gender-Based Disaster Education On Household Preparedness Planning In Male Latino Migrant Workers, Malikah Taylor

Walden Dissertations and Doctoral Studies

Natural disasters cause catastrophic damage to a community through death, injury, and property loss. Urban areas are predisposed to these events due to their built environment and the dense population of vulnerable groups. Urban male Latino migrant workers are an at-risk population with multiple social determinants of health that should be considered when implementing risk reduction plans. Programs that do not target this entire community only enhance the vulnerability of this group. This study examined the relationship between poverty and household preparedness in this community, controlling for gender. The socioecological model provided the foundation for this retrospective secondary analysis. Statistical …

Unique Challenges To Diagnosing Human Herpesvirus-6 (Hhv-6) Encephalitis Following Post-Hematopoietic Stem Cell Transplant: A Case And Brief Review, Harrison Zhu, Amir Ali, Karrune V Woan, Eric Tam, George Yaghmour, Alan Flores, Preet Chaudhary

Faculty, Staff and Students Publications

A patient with an ultimate diagnosis of human herpesvirus-6 (HHV-6) encephalitis developed central nervous system (CNS) symptoms 13 days after undergoing myeloablative haploidentical allogeneic hematopoietic stem cell transplant (HSCT). Due to the patient's body habitus, magnetic resonance (MR) imaging was not obtained until the onset of retrograde amnesia on day +24. MR imaging and other clinical findings eliminated all skepticism of HHV-6 encephalitis and HHV-6 antivirals were initiated on day +28, leading to gradual recovery. This case demonstrates some of the factors that may complicate the diagnosis of post-alloHSCT HHV-6 encephalitis. Because HHV-6 encephalitis and viremia can occur without warning, …

The Double Burden Of Intra-Household Malnutrition Among Mother–Child Dyads In South Africa, Puveshni Crozier

Walden Dissertations and Doctoral Studies

Household-level double burden of malnutrition (HL-DBM) challenges traditional South African vertical malnutrition programs. Research has associated a household with an overweight/obese mother of reproductive age and her under 5-year-old child with signs of undernutrition (wasting, stunting, or thinness) with socioeconomic levels, maternal characteristics, features of the household, and child’s demographics. Grounded in the social determinants of health conceptual framework, this study aimed to investigate the determinants of HL-DBM in South Africa across the reproductive-child health continuum. Using the representative 2017 Wave 5 South African National Income Dynamics Study survey secondary data, a total sample of 314 homes met this non-experimental …

D-Lib Magazine Pioneered Web-Based Scholarly Communication, Michael L. Nelson, Herbert Van De Sompel

Computer Science Faculty Publications

The web began with a vision of, as stated by Tim Berners-Lee in 1991, “that much academic information should be freely available to anyone”. For many years, the development of the web and the development of digital libraries and other scholarly communications infrastructure proceeded in tandem. A milestone occurred in July, 1995, when the first issue of D-Lib Magazine was published as an online, HTML-only, open access magazine, serving as the focal point for the then emerging digital library research community. In 2017 it ceased publication, in part due to the maturity of the community it served as well as …

A Steroid Receptor Coactivator Small Molecule "Stimulator" Attenuates Post-Stroke Ischemic Brain Injury, Lisa K Mcclendon, Roberto L Garcia, Tyler Lazaro, Ariadna Robledo, Viren Vasandani, Zean Aaron Evan Luna, Abhijit S Rao, Aditya Srivatsan, David M Lonard, Clifford C Dacso, Peter Kan, Bert W O'Malley

Faculty, Staff and Students Publications

Introduction: Pathologic remodeling of the brain following ischemic stroke results in neuronal loss, increased inflammation, oxidative stress, astrogliosis, and a progressive decrease in brain function. We recently demonstrated that stimulation of steroid receptor coactivator 3 with the small-molecule stimulator MCB-613 improves cardiac function in a mouse model of myocardial ischemia. Since steroid receptor coactivators are ubiquitously expressed in the brain, we reasoned that an MCB-613 derivative (MCB-10-1), could protect the brain following ischemic injury. To test this, we administered MCB-10-1 to rats following middle cerebral artery occlusion and reperfusion.

Methods: Neurologic impairment and tissue damage responses were evaluated on day …

An Overview Of Carbon Footprint Mitigation Strategies. Machine Learning For Societal Improvement, Modernization, And Progress, Vishnu S. Pendyala, Saritha Podali

Faculty Research, Scholarly, and Creative Activity

Among the most pressing issues in the world today is the impact of globalization and energy consumption on the environment. Despite the growing regulatory framework to prevent ecological degradation, sustainability continues to be a problem. Machine learning can help with the transition toward a net-zero carbon society. Substantial work has been done in this direction. Changing electrical systems, transportation, buildings, industry, and land use are all necessary to reduce greenhouse gas emissions. Considering the carbon footprint aspect of sustainability, this chapter provides a detailed overview of how machine learning can be applied to forge a path to ecological sustainability in …

Functional Studies Of Genetic Variants Associated With Human Diseases In Notch Signaling-Related Genes Using Drosophila, Sheng-An Yang, Jose L Salazar, David Li-Kroeger, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

Rare variants in the many genes related to Notch signaling cause diverse Mendelian diseases that affect myriad organ systems. In addition, genome- and exome-wide association studies have linked common and rare variants in Notch-related genes to common diseases and phenotypic traits. Moreover, somatic mutations in these genes have been observed in many types of cancer, some of which are classified as oncogenic and others as tumor suppressive. While functional characterization of some of these variants has been performed through experimental studies, the number of ‘variants of unknown significance’ identified in patients with diverse conditions keeps increasing as high-throughput sequencing technologies …

Advancements In The Quest To Map, Monitor, And Manipulate Neural Circuitry, Jessica L Swanson, Pey-Shyuan Chin, Juan M Romero, Snigdha Srivastava, Joshua Ortiz-Guzman, Patrick J Hunt, Benjamin R Arenkiel

Duncan NRI Faculty and Staff Publications

Neural circuits and the cells that comprise them represent the functional units of the brain. Circuits relay and process sensory information, maintain homeostasis, drive behaviors, and facilitate cognitive functions such as learning and memory. Creating a functionally-precise map of the mammalian brain requires anatomically tracing neural circuits, monitoring their activity patterns, and manipulating their activity to infer function. Advancements in cell-type-specific genetic tools allow interrogation of neural circuits with increased precision. This review provides a broad overview of recombination-based and activity-driven genetic targeting approaches, contemporary viral tracing strategies, electrophysiological recording methods, newly developed calcium, and voltage indicators, and neurotransmitter/neuropeptide biosensors …

Food Plants With Toxic Properties, James P. Smith Jr

Botanical Studies

No abstract provided.

Underwater Video As A Tool To Quantify Fish Density In Complex Coastal Habitats, Ronald Baker, Dakota Bilbrey, Aaron Bland, Frank D’Alonzo Iii, Hannah Ehrmann, Sharon Havard, Zoe Porter, Sarah Ramsden, Alexandra Rodriquez

University Faculty and Staff Publications

Habitat loss is a serious issue threatening biodiversity across the planet, including coastal habitats that support important fish populations. Many coastal areas have been extensively modified by the construction of infrastructure such as ports, seawalls, docks, and armored shorelines. In addition, habitat restoration and enhancement projects often include constructed breakwaters or reefs. Such infrastructure may have incidental or intended habitat values for fish, yet their physical complexity makes quantitatively sampling these habitats with traditional gears challenging. We used a fleet of unbaited underwater video cameras to quantify fish communities across a variety of constructed and natural habitats in Perdido and …

Fish And Invertebrate Use Of Restored Vs. Natural Oyster Reefs In A Shallow Temperate Latitude Estuary, Jonathan H. Grabowski, Christopher J. Baillie, Adam Baukus, Rachael Carlyle, F. Joel Fodrie, Rachel K. Gittman, A. Randall Hughes, David L. Kimbro, Juhyung Lee, Hunter S. Lenihan, Sean P. Powers, Kevin Sullivan

University Faculty and Staff Publications

Coastal marine habitats continue to be degraded, thereby compelling largescale restoration in many parts of the world. Whether restored habitats function similarly to natural habitats and fully recover lost ecosystem services is unclear. In estuaries, oyster reefs have been degraded by multiple anthropogenic activities including destructive fishing practices and reduced water quality, motivating restoration to maintain oyster fisheries and other ecosystem services, often at relatively high cost. We compared fish and invertebrate communities on recently restored (0–1 year post-restoration), older restored (3–4 years post-restoration), and natural oyster reefs to determine if and when restored reefs support functionally similar faunal communities. …

Evolution Of Genetic Networks For Human Creativity, I Zwir, C Del-Val, M Hintsanen, K M Cloninger, R Romero-Zaliz, A Mesa, J Arnedo, R Salas, G F Poblete, E Raitoharju, O Raitakari, L Keltikangas-Järvinen, G A De Erausquin, I Tattersall, T Lehtimäki, C R Cloninger

Staff and Researcher Publications

The genetic basis for the emergence of creativity in modern humans remains a mystery despite sequencing the genomes of chimpanzees and Neanderthals, our closest hominid relatives. Data-driven methods allowed us to uncover networks of genes distinguishing the three major systems of modern human personality and adaptability: emotional reactivity, self-control, and self-awareness. Now we have identified which of these genes are present in chimpanzees and Neanderthals. We replicated our findings in separate analyses of three high-coverage genomes of Neanderthals. We found that Neanderthals had nearly the same genes for emotional reactivity as chimpanzees, and they were intermediate between modern humans and …