Digital Commons Network^™

The Enduring Role Of Conflict In The Perpetuation Of Famine: Advancing 'The Right To Adequate Food' For Sustainable Peace, Robert M. Bane

Dissertations and Theses

The present thesis evaluates developments and trends in global conflict dynamics, global systems of governance, and global hunger. Together, the thesis investigates and upholds the notion that famine is a ‘man-made’ phenomenon and explains how famine persists in a world abundant with food. Through analysis and research the following is found: the occurrence of global conflict is accelerating alongside an increase in the severity of organized violence dynamics; global authoritarianism is expanding presenting a threat to global freedoms and liberal democracy; as these trends are occurring, world hunger is steadily on the rise reflecting a significant backsliding of progress achieved …

Shear Thickening In Dense Bidisperse Suspensions By Dynamic Simulation, Nelya Malbranche

Dissertations and Theses

Shear thickening, which corresponds to an increase of viscosity with shear rate, is ubiquitously observed in many concentrated suspensions and, as such, has implications for many industrial materials and geological phenomena. Controlling shear thickening is of significant importance, and many studies have been devoted to it. Recent works link shear thickening to the shear-induced transition from a lubricated particle interaction at low shear stress to a predominantly frictional interaction at high stress. In this dissertation, we investigate bidispersity and focus on mechanisms contributing to the viscosity evolution in rate-dependent suspensions, something that has not been addressed before. We perform detailed …

Exosome- And Microrna-Based Therapeutic Approach For Tendinopathy, Angela Wang Ilaltdinov

Dissertations and Theses

Tendinopathy, characterized by degeneration and chronic inflammation, is a significant clinical burden. Current treatments focus on symptom management but do not sufficiently address its underlying pathology; however, stem cell-based approaches aimed at repairing diseased tissues may overcome this limitation. Therapeutic effects of stem cells may be due in part to paracrine actions, including some mediated by exosomes – extracellular vesicles secreted by cells that play a role in cell communication. MicroRNA (miRNA), small non-coding RNA carried by exosomes, are likely responsible for many exosome effects. Exosomes and miRNA therapies show promise in treating diseases such as cancer and arthritis, but …

Depletion And Enrichment Of Phytosterols In Soybean Oil Lipid Emulsions Directly Associate With Serum Markers Of Cholestasis In Preterm Parenteral Nutrition-Fed Pigs, Greg Guthrie, Barbara Stoll, Shaji Chacko, Mahmoud Mohammad, Candace Style, Mariatu Verla, Oluyinka Olutoye, Deborah Schady, Charlotte Lauridsen, Nick Tataryn, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

Background: Clinical reports show a positive correlation between phytosterol concentrations and severity of cholestatic liver disease markers in infants during long-term administration of parenteral lipid emulsions. Establishing a causal link between phytosterols and cholestasis has been complicated by confounding factors of lipid emulsion load, fatty acid composition, and vitamin E in many of these studies. The goal of this study is to determine whether altering the phytosterol concentration within a common soybean oil-based emulsion will alter the onset and severity of cholestasis in parenterally fed preterm piglets.

Methods: Preterm piglets were administered, for 21 days, either enteral nutrition (ENT) or …

The Criticism Of Eurocentrism And International Law: Countering And Pluralizing The Research, Teaching, And Practice Of Eurocentric International Law, Makane Moïse Mbengue, Olabisi D. Akinkugbe

Articles, Book Chapters, & Popular Press

This Chapter draws on Third World Approaches to International Law (TWAIL) in examining the question: how does the research and teaching of international law in the Global South challenge Eurocentrism in international law. The Chapter focuses on the emergent activities within Global South that pluralize Eurocentric international law’s dominance in the research production, teaching, and practice arenas. The Chapter pushes against the unfair over-representation of European countries in the scholarly production and institutions of international law. To illustrate the often-underexplored regional diversity of international law outside Europe, the Chapter reflects on the contemporary roles of critical Global South scholars and …

The (Pfas)T And The Furious: Applying Hazardous Waste Management Frameworks To The Global Presence Of Pfas, Maggie Clark

Journal of Air Law and Commerce

International treaties governing transboundary hazardous waste are a result of the theory of sustainable development. These conventions have developed over several decades but still lack authority over one of the biggest waste exporters: the United States. As forever chemicals like GenX become a spotlight for future waste regulation, can these conventions project a framework to apply to the currently unregulated chemical that predominantly travels across the Atlantic Ocean between the Netherlands and the United States? This Article seeks to apply various transboundary waste international laws to the market for GenX, identify problems, and propose solutions.

Bibliometric And Visual Analysis Of Research On The Links Between The Gut Microbiota And Pain From 2002 To 2021, Menghan Mao, Yanyu Zhou, Yingfu Jiao, Suqing Yin, Chiwai Cheung, Weifeng Yu, Po Gao, Liqun Yang

Children’s Nutrition Research Center Staff Publications

Background and aims: The gut microbiota is involved in the regulation of pain, which is proved by plenty of evidence. Although a substantial quantity of research on the link between the gut microbiota and pain has emerged, no study has focused on the bibliometric analysis of this topic. We aim to present a bibliometric review of publications over the past 20 years and predict research hot spots.

Methods: Relevant publications between 2002 and 2021 were extracted from the Science Citation Index-Expanded (SCI-EXPANDED) of the Web of Science Core Collection (WoSCC) database on April 22, 2022. CiteSpace (version 5.8 R3c), VOSviewer, …

Gabra5 Plays A Sexually Dimorphic Role In Pomc Neuron Activity And Glucose Balance, Zhou Pei, Yang He, Jonathan C Bean, Yongjie Yang, Hailan Liu, Meng Yu, Kaifan Yu, Ilirjana Hyseni, Xing Cai, Hesong Liu, Na Qu, Longlong Tu, Kristine M Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Camille Hs Potts, Nikolas A Scarcelli, Zili Yan, Pingwen Xu, Qi Wu, Yanlin He, Yong Xu, Chunmei Wang

Children’s Nutrition Research Center Staff Publications

Pro-opiomelanocortin (POMC) neurons are important for the regulation of body weight and glucose balance. The inhibitory tone to POMC neurons is mediated primarily by the GABA receptors. However, the detailed mechanisms and functions of GABA receptors are not well understood. The α5 subunit of GABAA receptor, Gabra5, is reported to regulate feeding, and we found that Gabra5 is highly expressed in POMC neurons. To explore the function of Gabra5 in POMC neurons, we knocked down Gabra5 specifically from mature hypothalamic POMC neurons using the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 strategy. This POMC-specific knock-down of Gabra5 did not affect …

Associations Of Prenatal Phthalate Exposure With Neurobehavioral Outcomes In 45- And 75-Month-Old Infants, Jenna L N Sprowles, Kelsey L C Dzwilewski, Francheska M Merced-Nieves, Salma M A Musaad, Susan L Schantz, Sarah D Geiger

Children’s Nutrition Research Center Staff Publications

Phthalates are ubiquitous endocrine-disrupting chemicals, and research indicates that prenatal exposure to some phthalates may affect neurodevelopment. In a prospective birth cohort study, five first-morning urine samples collected across pregnancy were pooled and the following phthalate biomarkers assessed: sum of di-(2-ethylhexyl) phthalate metabolites (ΣDEHP), sum of diisononyl phthalate metabolites (ΣDINP), sum of dibutyl phthalate metabolites (ΣDBP), sum of anti-androgenic metabolites (ΣAA), monoethyl phthalate (MEP), and sum of all phthalate metabolites (ΣAll). The Ages & Stages Questionnaires® (ASQ), a standardized parent-reported, age-adapted screening tool, measured communication, personal-social, problem solving, and motor domains in infants at 4.5 and 7.5 months (n = …

Tissue-Specific Mechanisms Of Bile Acid Homeostasis And Activation Of Fxr-Fgf19 Signaling In Preterm And Term Neonatal Pigs, Caitlin Vonderohe, Greg Guthrie, Barbara Stoll, Shaji Chacko, Harry Dawson, Douglas G Burrin

Children’s Nutrition Research Center Staff Publications

The tissue-specific molecular mechanisms involved in perinatal liver and intestinal farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling are poorly defined. Our aim was to establish how gestational age and feeding status affect bile acid synthesis pathway, bile acid pool size, ileal response to bile acid stimulation, genes involved in bile acid-FXR-FGF19 signaling and plasma FGF19 in neonatal pigs. Term (n = 23) and preterm (n = 33) pigs were born via cesarean section at 100% and 90% gestation, respectively. Plasma FGF19, hepatic bile acid and oxysterol profiles, and FXR target gene expression were assessed in pigs …

Articulator Q2 2022

Metro Denver Dental Society Articulator Magazine

The MDDS Articulator magazine has been serving as the voice for Denver's dental community for over 100 years.

Distributed to approximately 2,000 dental professionals quarterly, the Articulator features local news, industry trends, practice management guidance, data-driven research and more. The award-winning publication is available to member dentists in both print and digital forms.

Issues include cover and feature articles alongside regular columns with regional news impacting the Metro Denver membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Enhancing Stakeholder Engagement To Achieve The Sustainable Management Of Free-Roaming Equids, Celeste Carlisle, Dan Adams

Human–Wildlife Interactions

Wild horse (Equus caballus) and burro (E. asinus; WHB) stakeholders in the American West are divergent in their views of free-roaming equids on public lands. Management authority for free-roaming equids on designated public lands was given to the Bureau of Land Management (BLM) and the U.S. Forest Service (USFS) in 1971 by U.S. Congress with the passing of the Wild and Free-Roaming Horses and Burros Act (WFRHBA). In 1976, the Federal Land Policy and Management Act (FLPMA) mandated the BLM to manage public lands for multiple-uses, which included livestock grazing, energy development, recreation, and timber harvest. …

Wyoming’S Wild Horse Ranch: History And Description Of A Socio-Ecological Experiment, Alex Sas-Jaworsky, John Derek Scasta

Human–Wildlife Interactions

The growing population of free-roaming horses (Equus ferus caballus) on western public rangelands has necessitated that federal agencies, such as the Bureau of Land Management (BLM) and U.S. Forest Service, develop novel approaches to curb growth including reproduction management. However, bureaucracy has hindered effective research and application of horse management on public lands and examples on private lands may present new solutions. Here we present the history and current population management strategy for the Wild Horse Ranch (WHR) located in southeastern Wyoming, USA, as an example of an ongoing private entity managing horses. Prior to 1985, this ~6,000-ha …

New Research And Wild Horse And Burro Management, David Jenkins

Human–Wildlife Interactions

In the United States, the Wild Free-Roaming Horses and Burros Act (WFRHBA) gave the Bureau of Land Management (BLM) and the U.S. Forest Service the statutory obligation to manage and protect free-roaming equids (i.e., wild horses [Equus ferus] and burros [E. asinus]) on designated management areas on public land. The WFRHBA was intended to ensure that wild horses and burros on the public lands exist in self-sustaining herds in perpetuity, alongside other congressionally mandated, multiple uses of public lands. The BLM recently published a strategic research plan for their wild horse and burro program. The research …

Feral Horses, Feral Asses, And Professional Politicians: Broodings From A Beleaguered Biologist, Vernon C. Bleich

Human–Wildlife Interactions

As a member of National Wild Horse and Burro Advisory Board, I gained insight into several aspects of feral equid management that previously had been somewhat cryptic. Foremost in my experience, though, was the dedication and professionalism of the board members with whom I served. During my tenure, the professional approach to management and the frustration faced by employees within the Horse and Burro Program became increasingly apparent. Further came the realization that the effectiveness of the board and program can be improved substantially, if (1) the board is provided the opportunity to rebut or counter incorrect or misleading information …

Healthy Western Lands: A Proposal For Healthy Rangelands, Wildlife, And Free-Roaming Horses And Burros, James S. Sedinger, Rebekah Stetson

Human–Wildlife Interactions

The Coalition for Healthy Nevada Lands, Wildlife and Free-roaming Horses (CHNL) is dedicated to proper management of free-roaming horses (Equus caballus) and burros (E. asinus) so rangelands are healthy, which benefits wildlife and the horses and burros themselves. The CHNL proposes the rapid reduction of horses and burros on designated public lands to achieve appropriate management levels (AML). After these reductions, the use of fertility control, supplemented with some gathers and adoption of gathered horses, should allow the Bureau of Land Management to economically maintain horse and burro populations at AML. The CHNL believes this approach …

Cover, Editorial Staff, Journal Information

Human–Wildlife Interactions

This includes the cover, editorial staff, and journal information.

Texas Hunters’ Perceptions Regarding The Acceptability Of Toxicants To Control Wild Pig Populations, Keith M. Carlisle, Sophie Mckee, Hailey E. Ellis, Lauren M. Jaebker, John M. Tomeček, Alan D. Bright, Rachael L. Connally, Maureen G. Frank, Stephanie A. Shwiff

Human–Wildlife Interactions

Wild pigs (Sus scrofa) are an invasive species in the United States. They damage agriculture, degrade water quality and ecological communities, and host a number of viruses, parasites, and bacteria transmissible to humans and animals. In states such as Texas, USA, where wild pigs cause extensive damage to agriculture and property, officials have considered allowing for the use of toxicants to control wild pig populations. To provide decision-makers with information regarding stakeholders’ perceptions of the use of toxicants to control wild pigs, we surveyed Texas hunters in 2019 to assess the level of acceptance of a hypothetical wild …

Mitigating Bighorn Sheep–Vehicle Collisions And Habitat Fragmentation With Overpasses And Adaptive Mitigation, Jeffrey W. Gagnon, Chad D. Loberger, Kari S. Ogren, Scott C. Sprague, Susan R. Boe, Raymond E. Schweinsburg

Human–Wildlife Interactions

As transportation infrastructure expands to accommodate increasing human population growth, wildlife–vehicle conflicts (WVCs) are a growing concern for motorist safety and wildlife populations. In the case of large ungulates, minimal information exists on successful mitigation of WVCs involving bighorn sheep (Ovis canadensis) and habitat fragmentation. Too address this void, we evaluated the effectiveness of 3 new wildlife overpasses, 3 culverts, 2 bridges, and ungulate exclusionary fencing as potential desert bighorn sheep (O. c. nelsoni; sheep) crossing opportunities along US Highway 93 in Arizona, USA. We evaluated sheep movements using global positioning system (GPS) radio-transmitter collars and …

Bear-Caused Human Fatalities In Yellowstone National Park: Characteristics And Trends, Kerry A. Gunther

Human–Wildlife Interactions

Three fatal bear (Ursus spp.) attacks in Yellowstone National Park (YNP), USA, from 2011 to 2015 were a catalyst for YNP managers to evaluate the circumstances of bear-caused fatalities as well as the bear safety messages it distributes to park visitors. I reviewed records of all fatal bear attacks that occurred in YNP from 1872 to 2018. Seven of the 8 fatalities were caused by grizzly bears (U. arctos horribilis). The per capita risk of being killed by a grizzly bear was 1 fatality for every 26.2 million park visits. Most fatal bear attacks in YNP involved …

Impact Of Covid-19 On Aviation-Wildlife Strikes Across Europe, Isabel C. Metz, Marta Giordano, Dionysios Ntampakis, Marianna Moira, Anneke Hamann, Rosanne Blijleven, Jürgen J. Ebert, Alessandro Montemaggiori

Human–Wildlife Interactions

Collisions between aircraft and wildlife (i.e., wildlife strikes) pose a serious threat toward the safety of aircraft, its crew, and passengers. The effects of COVID-19 related travel restrictions on wildlife strikes are unknown. With this study, we aim to address this information gap by assessing the changes of wildlife hazard management performance across European airports during the lockdown period (e.g., period of reduced operations and borders closure in spring 2020). We also sought to raise awareness of the importance of wildlife strike prevention in times of reduced operations. The objective of our study was to compare wildlife strike data before …

Symbiotic Relationship Between Local People And Asiatic Black Bears, Jangchuk Gyeltshen

Human–Wildlife Interactions

There are 8 species of bears (Ursidae) in the world; of these, 6 species are known to occur in Asia. However, in Bhutan, there are only 2 species: the Asiatic black bear (Ursus thibetanus) and the sloth bear (Melursus ursinus). The Asiatic black bear is legally protected by the Forest and Nature Conservation Act of Bhutan 1995. The bear is categorized as vulnerable by the International Union for Conservation of Nature and also included under Appendix I of the Convention on International Trade in Endangered Species. Human–bear conflicts are prevalent in Bhutan, especially at the village …

A Call For Ethical And Responsible Treatment Of Invasive Species By Recreational Anglers, Kevin A. Adeli

Human–Wildlife Interactions

Invasive species pose a prominent threat to global biodiversity, with aquatic ecosystems being particularly susceptible. In an effort to limit the spread of aquatic invasive species, numerous public awareness programs have been launched, and several regions have enacted “must-kill” angling regulations, which prohibit the live release of invasive fish species when captured. Many education programs, however, demonize invasive species and lack any instruction for humane euthanasia. This unbalanced approach has translated into widespread mistreatment of invasive species among recreational anglers. This piece addresses these concerns by discussing their significance and providing recommendations for how education programs can adopt a more …

Evaluation Of Virtual Screening Strategies For The Identification Of Γ-Secretase Inhibitors And Modulators, Alicia Ioppolo, Melissa Eccles, David Groth, Giuseppe Verdile, Mark Agostino

Research outputs 2022 to 2026

γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors. However, aberrant proteolysis of substrates has implications in the progression of disease pathologies, including Alzheimer’s disease (AD), cancers, and skin disorders. While several γ-secretase inhibitors have been identified, there has been toxicity observed in clinical trials associated with non-selective enzyme inhibition. To address this, γ-secretase modulators have been identified and pursued as more selective agents. Recent structural evidence has provided an insight into how γ-secretase inhibitors and modulators are recognized …

Digitalization In Food Supply Chains: A Bibliometric Review And Key-Route Main Path Analysis, Abderahman Rejeb, Karim Rejeb, Alireza Abdollahi, Suhaiza Zailani, Mohammad Iranmanesh, Morteza Ghobakhloo

Research outputs 2022 to 2026

Technological advances such as blockchain, artificial intelligence, big data, social media, and geographic information systems represent a building block of the digital transformation that supports the resilience of the food supply chain (FSC) and increases its efficiency. This paper reviews the literature surrounding digitalization in FSCs. A bibliometric and key-route main path analysis was carried out to objectively and analytically uncover the knowledge development in digitalization within the context of sustainable FSCs. The research began with the selection of 2140 articles published over nearly five decades. Then, the articles were examined according to several bibliometric metrics such as year of …

Identifying Effective Interventions To Promote Consumption Of Protein-Rich Foods From Lower Ecological Footprint Sources: A Systematic Literature Review, Rimante Ronto, Golsa Saberi, Gianna Maxi Leila Robbers, Stephanie Godrich, Mark Lawrence, Shawn Somerset, Jessica Fanzo, Josephine Chau

Research outputs 2022 to 2026

Addressing overconsumption of protein-rich foods from high ecological footprint sources can have positive impacts on health such as reduction of non-communicable disease risk and protecting the natural environment. With the increased attention towards development of ecologically sustainable diets, this systematic review aimed to critically review literature on effectiveness of those interventions aiming to promote protein-rich foods from lower ecological footprint sources. Five electronic databases (Medline, Web of Science, Scopus, Embase and Global Health) were searched for articles published up to January 2021. Quantitative studies were eligible for inclusion if they reported on actual or intended consumption of protein-rich animal-derived and/or …

Strength Training In Swimming, Klaus Wirth, Michael Keiner, Stefan Fuhrmann, Alfred Nimmerichter, Gregory G. Haff

Research outputs 2022 to 2026

This narrative review deals with the topic of strength training in swimming, which has been a controversial issue for decades. It is not only about the importance for the performance at start, turn and swim speed, but also about the question of how to design a strength training program. Different approaches are discussed in the literature, with two aspects in the foreground. On the one hand is the discussion about the optimal intensity in strength training and, on the other hand, is the question of how specific strength training should be designed. In addition to a summary of the current …

A Myc-Znf148-Id1/3 Regulatory Axis Modulating Cancer Stem Cell Traits In Aggressive Breast Cancer, Mijeong Kim, Manjot Singh, Bum-Kyu Lee, Moira Hibbs, Kirsty Richardson, Lesley Ellies, Larissa Wintle, Lisa M. Stuart, Jenny Y. Wang, Dominic C. Voon, Pilar Blancafort, Jianlong Wang, Jonghwan Kim, Peter J. Leedman, Andrew J. Woo

Research outputs 2022 to 2026

The MYC proto-oncogene (MYC) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. In this study, we identified zinc finger transcription factor 148 (ZNF148, also called Zfp148 and ZBP-89) as a direct target of MYC. ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer …

Exploring Food Supply Chain Trends In The Covid-19 Era: A Bibliometric Review, Abderahman Rejeb, Karim Rejeb, Andrea Appolloni, Mohammad Iranmanesh, Horst Treiblmaier, Sandeep Jagtap

Research outputs 2022 to 2026

Recently, the food supply chain (FSC) has been severely disrupted due to the COVID-19 pandemic, putting the vital flow of food products from farmers and producers to the ultimate consumers at risk. Furthermore, due to the pandemic, several food organizations have been prompted to rethink their strategies for the future. Although the literature on FSC research in the COVID-19 era is increasing, no attempt has been made to summarize this stream of research using bibliometric techniques. This paper fills this knowledge gap and looks at the current scholarly discourse around the FSC and COVID-19. Applying bibliometric techniques, 287 journal articles …

Maya-Kwobabiny: Re-Embedding Language At Kepa Kurl, Western Australia, Clint Bracknell, Amy Budrikis, Roma Yibiyung Winmar

Research outputs 2022 to 2026

This paper describes a Nyungar language revitalisation project in the southern region of Western Australia conducted in partnership between a university research team and the Esperance Tjaltjraak Native Title Aboriginal Corporation. It discusses how linguistic analysis of historical Nyungar documentation was essential to addressing community aims of re-embedding the language into the community, developing and using pedagogical resources, and exploring new domains for language use. In particular, this paper focuses on the community’s desire for the reclamation of a dialectal flavour of Nyungar that is distinctive to the Esperance region, and the factors contributing to a successful partnership between the …