Digital Commons Network^™

Magi1 Inhibits Interferon Signaling To Promote Influenza A Infection, Yin Wang, Jun-Ichi Abe, Khanh M Chau, Yongxing Wang, Hang Thi Vu, Loka Reddy Velatooru, Fahad Gulraiz, Masaki Imanishi, Venkata S K Samanthapudi, Minh T H Nguyen, Kyung Ae Ko, Ling-Ling Lee, Tamlyn N Thomas, Elizabeth A Olmsted-Davis, Sivareddy Kotla, Keigi Fujiwara, John P Cooke, Di Zhao, Scott E Evans, Nhat-Tu Le

Faculty, Staff and Student Publications

We have shown that membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1), a scaffold protein with six PSD95/DiscLarge/ZO-1 (PDZ) domains, is involved in the regulation of endothelial cell (EC) activation and atherogenesis in mice. In addition to causing acute respiratory disease, influenza A virus (IAV) infection plays an important role in atherogenesis and triggers acute coronary syndromes and fatal myocardial infarction. Therefore, the aim of this study is to investigate the function and regulation of MAGI1 in IAV-induced EC activation. Whereas, EC infection by IAV increases MAGI1 expression, MAGI1 depletion suppresses IAV infection, suggesting that the induction of MAGI1 may …

Morphological Description Of Laevicaulisstuhlmanni (Simroth, 1895) (Pulmonata, Veronicellidae) From Egypt, Reham Fathey Ali, David G Robinson, Fabio Liberto

Faculty, Staff and Student Publications

BACKGROUND: Terrestrial slugs and snails are increasingly becoming serious pests of agricultural, horticultural and ornamental plants in Egypt, resulting in major economic losses.

NEW INFORMATION: This paper provides a detailed morphological and anatomical description of the veronicellid slug Laevicaulisstuhlmanni (Simroth, 1895) that has been recently recorded from Egypt. This population from Egypt is compared with Laevicaulis populations recently reported and described from Libya as L.striatus (Simroth, 1896) and with available data in literature. Some notes and a distribution map of the veronicellids introduced in north-eastern Africa are provided.

Cancer Treatment-Induced Nad+ Depletion In Premature Senescence And Late Cardiovascular Complications, Priyanka Banerjee, Elizabeth A Olmsted-Davis, Anita Deswal, Minh Th Nguyen, Efstratios Koutroumpakis, Nicholas L Palaskas, Steven H Lin, Sivareddy Kotla, Cielito Reyes-Gibby, Sai-Ching J Yeung, Syed Wamique Yusuf, Momoko Yoshimoto, Michihiro Kobayashi, Bing Yu, Keri Schadler, Joerg Herrmann, John P Cooke, Abhishek Jain, Eduardo Chini, Nhat-Tu Le, Jun-Ichi Abe

Faculty, Staff and Student Publications

Numerous studies have revealed the critical role of premature senescence induced by various cancer treatment modalities in the pathogenesis of aging-related diseases. Senescence-associated secretory phenotype (SASP) can be induced by telomere dysfunction. Telomeric DNA damage response induced by some cancer treatments can persist for months, possibly accounting for long-term sequelae of cancer treatments. Telomeric DNA damage-induced mitochondrial dysfunction and increased reactive oxygen species production are hallmarks of premature senescence. Recently, we reported that the nucleus-mitochondria positive feedback loop formed by p90 ribosomal S6 kinase (p90RSK) and phosphorylation of S496 on ERK5 (a unique member of the mitogen-activated protein kinase family …

Crmm 4500: Web Publish L: Html/Css (Syllabus), Jin Yang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Crmm 6500: Web Publish L: Html/Css (Syllabus), Jin Yang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Crmm 4600: Creative Social Video (Syllabus), Michael Robinson

Journalism and Strategic Media Syllabi Archive

Course Description: The course offers instruction, training, practice and analysis on YouTube channel development, including research, organization, branding, and content presentation skills. The course will focus on effective production and editing concepts as they relate to video, audio and graphic design. The framework of the course is centered on YouTube, but the skills translate to all popular social media platforms.

Crmm 4500: Web Publish L: Html/Css (Syllabus), Garrett Pilgrim

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Jrsm 3900: Visual Media (Syllabus), Ruoxu Wang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction to and application of principles of visual communication, including typography, color and organization for print and digital media using Adobe Creative Cloud.

Crmm 6500: Web Publish L: Html/Css (Syllabus), Garrett Pilgrim

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

The Oswald Review Of Undergraduate Research And Criticism In The Discipline Of English: Volume 24, 2022, Douglas Higbee

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Beasts And Bestiality, Deities And Deification: Boethius’ The Consolation Of Philosophy In Milton's Comus, Bret Van Den Brink

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Tennessee's Economy 2020-2021 Reference Guide, Tennessee. Department Of Labor & Workforce Development.

Tennessee's Economy

No abstract provided.

Botanical Aphrodisiacs For Women's Health, Hayley N. Prescott

Electronic Theses and Dissertations

Female Sexual Dysfunction (FSD) affects nearly 40% of women in the United States. While males have five FDA approved drugs for ED, there is only one FDA-approved as-needed treatment for premenopausal women with acquired, generalized Hypoactive Sexual Desire Disorder (HSDD), the most prevalent FSD. The lack of approved drugs is largely due to the biopsychosocial complexity of HSDD; however, there are neurobiological underpinnings evident. Due to the lack of safe efficacious treatment options, we hypothesize that botanical species traditionally used as aphrodisiacs may be promising leads, and exert their effects via activation of melanocortin’s, an excitatory circuit implicated in sexual …

This Is Home: Stories Of H-2a Placemaking In The U.S. And Mexico, Lillian Slaughter

Electronic Theses and Dissertations

This thesis contextualizes the lived experiences of two agricultural guest workers who I work with in Kentucky. Beginning in 1917, the history of agricultural guest worker programs in the United States is detailed up until today with the H-2A visa program. The first chapter pro-vides this history and pays close attention to the impact of the liberalization of Mexico’s econo-my and integration into the larger agricultural market between the US and Canada. In chapter two, census data of Kentucky and the county that the farm is located, provides a background on the Latino population. This chapter focuses on the growth …

The Contributions Of Immediate Retrieval And Spaced Retrieval To Word Learning In Preschoolers With Developmental Language Disorder, Laurence B. Leonard, Patricia Deevy, Eilseen Haebig, Jeffrey D. Karpicke, Christine Weber

Purdue Center for Early Learning Faculty and Staff Publications

Background and Aims Children with developmental language disorder (DLD) benefit from word learning procedures that include a mix of immediate retrieval and spaced retrieval trials. In this study, we examine the relative contribution of these two types of retrieval. Methods We examine data from Haebig et al. (2019) in their study that compared an immediate retrieval condition and a condition of spaced retrieval that also included immediate retrieval trials. Participants were 4- and 5-year old children with DLD and same-age peers with typical language development. Each child learned novel (made-up) words referring to unusual plants and animals in both conditions. …

Lowering The Stakes Of The Employment Contract, Aditi Bagchi

Faculty Scholarship

Every country has to make hard choices about the distribution of entitlements. But employers control the entitlements that individual Americans enjoy to a far greater extent than those in other rich democracies. In this Essay, I argue that, in the absence of the political consensus necessary to deliver state solutions to political questions, employers here are assigned an exaggerated role in employees’ lives. Government incentives for and directives to employers have become a strategy of political deflection. The effect has been to raise the stakes of employment well beyond the scope of those terms and conditions that relate to attracting …

Firearms And Protest: Lessons From The Black Tradition Of Arms, Nicholas J. Johnson

Faculty Scholarship

Kenosha was no aberration. Our history is filled with episodes of righteous protest boiling over into violence. Where violence is imminent, our traditions and laws allow innocents to use corresponding violence in self-defense. This arrangement is imperfect and demands hard thinking about how to refine and possibly improve it. One source of lessons toward this end is the experience of Black freedom fighters who navigated turmoil that dwarfs our current troubles. The principles that guided their struggle help frame a sphere of legitimate gun use during periods of civil unrest. These principles emerge from a considered philosophy and practice of …

Legitimizing Lies, Courtney M. Cox

Faculty Scholarship

Lies are everywhere today. This scourge of misinformation raises difficult questions about how the law can and should respond to falsehoods. Legal discourse has traditionally focused on the law’s choice between penalizing and tolerating lying. But this traditional framing vastly oversimplifies the law’s actual and potential responses. Using trade secrets as a case study, this Article shows that the law sometimes accepts lies as a legitimate option for fulfilling legal requirements and may even require lies in increasingly common circumstances.

Commonly supposed legal and moral commitments against lying do not undermine this reality. To the contrary, the Article reveals that …

Microglia Distribution In The Lateral Ventricles Following Treatment Of Lysolecithin Model Of Multiple Sclerosis, Spencer James Wilson

Browse all Theses and Dissertations

Multiple sclerosis (MS) affects an estimated one million people in the US alone (Wallin et al., 2019). We modeled MS in rats using lysolecithin injection into the corpus callosum to diminish motor function unilaterally through demyelination, meanwhile treating the injury with Fluoxetine, Ibuprofen, and ascorbic acid (FIAA) to increase neurogenesis and oligodendrogenesis. Motor function was assessed using the Montoya Staircase test pre- and post-surgery. Motor capabilities recovered in the contralateral limb, but not in the ipsilateral, and recovery was not significantly affected by treatment. We identified microglia by CX3CR1 and examined its distribution in the adult neurogenic niche, the SVZ …

Escherichia Coli In Lake Erie: Impact On Lake Health, Mary Grmek

Williams Honors College, Honors Research Projects

Lake Erie is a vital resource for its surrounding area, and one of its most important purposes is as a recreational body of water. In determining whether Lake Erie’s water quality meets U.S. EPA standards, daily surveys and water samples were taken on behalf of the Lake County General Health District, as well as E. coli samples every other day. This paper quantified the E. coli count for both Mentor Headlands Beach and Fairport Harbor Beach in Lake County over the swimming seasons for 2020 and 2021, as well as evaluated which variables collected in daily surveys impact E. coli …

Goodwill Going Green: How Green Branding Can Generate $1m In Revenue, Elia Meltzer, Esha S. Vartak, William M. Crone, Ryan T. Richards

Williams Honors College, Honors Research Projects

Goodwill Industries is a nonprofit organization. Not only do they specialize in charity work, but they also have a chain of stores that focus on thrift shopping. Additionally, Goodwill provides other services, such as recycling clothing, electronics, and other goods. Recently, Goodwill of Akron, Ohio received a grant of five million dollars, where the money for the grant would have to be utilized in five years. The main objective of this project was to find a way for Goodwill to use grant money efficiently, to generate revenue for a new transportation initiative.

Our team has recommended utilizing the most popular …

Few-Shot Malware Detection Using A Novel Adversarial Reprogramming Model, Ekula Praveen Kumar

Browse all Theses and Dissertations

The increasing sophistication of malware has made detecting and defending against new strains a major challenge for cybersecurity. One promising approach to this problem is using machine learning techniques that extract representative features and train classification models to detect malware in an early stage. However, training such machine learning-based malware detection models represents a significant challenge that requires a large number of high-quality labeled data samples while it is very costly to obtain them in real-world scenarios. In other words, training machine learning models for malware detection requires the capability to learn from only a few labeled examples. To address …

The Cuyahoga Valley Resource And Development Center, Lindsay Shook, Suzanne Kroll, Donald Alexander, Emily Booth

Williams Honors College, Honors Research Projects

Sustainable design is a growing movement in the industry. As interior designers, it is our obligation to be knowledgeable of how our designs, and therefore the construction, impact the environment around us. Cuyahoga Valley National Park is underdeveloped for a reason, and this section of nature should be preserved. The proposed Cuyahoga Valley Resource and Development Center will be located just outside of the national park boundaries and utilize sustainable design practices and principles. It will serve as a museum and educational resource for the surrounding community to learn more about The Valley.

Will Covid-19 Be Eradicated?, Matthew Kieke

Williams Honors College, Honors Research Projects

In this paper I want to define the meaning of “eradication”, explain the history of various diseases that have been eradicated, and compare and contrast them to covid-19, to answer the question of “Will covid-19 be eradicated”?

Pet Food Protector, Braeden Balch, Trey Dillan, Brandon George, David Owens

Williams Honors College, Honors Research Projects

food consumption while keeping each pet separate from the others. The device will detect a certain pet, using a transmitter and receiver that would be on the collar of the pet and in the device itself, and enable them to access their specific food by way of an opening and closing lid. If the pet leaves the area, the food is no longer accessible. The device will also track the amount of food consumed and regulate how much food should be consumed in a given amount of time. This will allow owners to feed their pets without worrying about overeating …

Photogrammetry Booth, Chidubem Igweagu

Williams Honors College, Honors Research Projects

This is a research type project that involves design, build and simulation sponsored by a faculty member in the Mechanical Engineering department. The title of the proposed project is Photogrammetry_Booth. A photo booth to have pets immobilized by taking an attention needs to be designed and manufactured. 4-6 cameras need to be installed to take photos simultaneously to represent the front, sides, back and arbitrary sides of a pet. An Arduino board and tablet will be installed to control cameras and user interface. The booth is mainly built by T-slotted frames and many functional and decorative parts will be precisely …

Amygdala Modeling With Context And Motivation Using Spiking Neural Networks For Robotics Applications, Matthew Aaron Zeglen

Browse all Theses and Dissertations

Cognitive capabilities for robotic applications are furthered by developing an artificial amygdala that mimics biology. The amygdala portion of the brain is commonly understood to control mood and behavior based upon sensory inputs, motivation, and context. This research builds upon prior work in creating artificial intelligence for robotics which focused on mood-generated actions. However, recent amygdala research suggests a void in greater functionality. This work developed a computational model of an amygdala, integrated this model into a robot model, and developed a comprehensive integration of the robot for simulation, and live embodiment. The developed amygdala, instantiated in the Nengo Brain …

Amine-Functionalized Interpenetrating Polymer Networks For Co2 Capture, James Wills

Williams Honors College, Honors Research Projects

The research performed looked to advance the studies of vacuum swing absorption of Carbon Dioxide to help combat global climate change issues. The focus of the project was to create an anime-polymer sorbent that will weakly absorb and desorb CO2. The sorbent must be durable and be able to withstand multiple uses. The creation of a porous polymer matrix aided in the amines' ability to absorb CO2. Created samples underwent several qualitative and quantitative tests to determine their usefulness as an industrial sorbent. Infrared spectroscopy was used to study the effectiveness of the amine sorbents. Studying the changes in the …

Immunohistochemistry Of The Zebrafish Retina, Alison Ruf

Williams Honors College, Honors Research Projects

The retina is made up of many different essential parts that work together to allow for vision of many different species. Some of these crucial cells and proteins include ganglion cells, bipolar cells, photoreceptors, synaptic markers, such as VGLUT, and receptors that bind glutamate. The basis of this project is to use immunohistochemistry to identify these important aspects of the retina in zebrafish via monoclonal and polyclonal antibodies. The goal being to compare specific cells in a control group retina to an experimental group of zebrafish.

Emanata Presents: Dream (2022)

Emanata, 2014-

Started by illustrator and comics artist Chris Kindred in 2014 with Weird, Vol. 1, Emanata is VCU’s first-ever comics anthology.