Digital Commons Network^™

Differential Progression Of Unhealthy Diet-Induced Hepatocellular Carcinoma In Obese And Non-Obese Mice, Emma Hymel, Elizabeth M. Vlock, Kurt W. Fisher, Paraskevi A. Farazi

Journal Articles: Epidemiology

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) ranks first among liver diseases in Western countries. NAFLD is typically associated with obesity and diabetes, however it also develops in lean individuals without metabolic syndrome. The prevalence of lean NAFLD is 7 percent in the U.S. and 25-30 percent in some Asian countries. NAFLD starts with excess liver fat accumulation (NAFL), progresses to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). The pathogenesis of lean NASH-HCC and how it differs from obese NASH-HCC is not well understood.

METHODS: In this work, we generated a mouse model of lean and obese NASH-HCC using a …

Willingness To Pay For Mangroves’ Coastal Protection: A Case Study In Santo Angel, Calauag, Quezon, Philippines, Wesley Gagarin, Decibel F. Eslava, Rico Ancog, Cristino L. Tiburan Jr, Noelynna Ramos

Forest and Society

The mangroves in Santo Angel in the municipality of Calauag, Quezon Province in the Philippines, provide a wide array of ecological services that range from provisioning of resources and habitat to various floral and faunal species to regulating services including coastal protection. Coastal protection from mangroves is needed by the local community as Santo Angel is susceptible to typhoons and storm surges. However, the mangrove’s ability to provide coastal defense has considerably declined in the past decades due to overexploitation. Using the double-bounded dichotomous choice contingent valuation method, the willingness to pay (WTP) of the local community for a hypothetical …

Loss Of Smad4 Is Associated With Poor Tumor Immunogenicity And Reduced Pd-L1 Expression In Pancreatic Cancer, Daniel R. Principe, Patrick W. Underwood, Sandeep Kumar, Kaytlin E. Timbers, Regina M. Koch, Jose G. Trevino, Hidayatullah G. Munshi, Ajay Rana

Surgery Publications

Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in select immunotherapy regimens shows early promise. Though the TGFβ target SMAD4 is deleted in approximately 55% of PDAC tumors, the effects of SMAD4 loss on tumor immunity have yet to be fully explored. Using a combination of genomic databases and PDAC specimens, we found that tumors with loss of SMAD4 have a comparatively poor T-cell infiltrate. SMAD4 loss was also associated with a reduction in several chemokines with known roles in T-cell recruitment, which was recapitulated …

Should "Morphed" Child Pornography Fall Under The Protection Of The First Amendment's Free Speech Clause?, Carliette Sierralta

Nova Law Review

No abstract provided.

Iguanodons Throughout The Ages (Illustrations), Patrick Estell

The Synapse: Intercollegiate science magazine

No abstract provided.

[Crn 37945] Philosophy 103, Alina N. Feld

Open Educational Resources

This is a syllabus for PHIL 103 a Zero-Cost Course, using an OER textbook.

Acute Ethanol-Induced Liver Injury Is Prevented By Betaine Administration, Madan Kumar Arumugam, Srinivas Chava, Sathish Kumar Perumal, Matthew C. Paal, Karuna Rasineni, Murali Ganesan, Terrence Donohue, Natalia A. Osna, Kusum K. Kharbanda

Journal Articles: Internal Medicine

Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage. We previously demonstrated that chronic ethanol administration causes a decline in the intrahepatic ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). This decline causes impairments in essential methylation reactions that result in alcohol-induced fatty liver (steatosis) and other features of alcohol-associated liver disease (ALD). Co-treatment with betaine during chronic ethanol feeding, normalizes hepatocellular SAM:SAH ratio and alleviates many features of liver damage including steatosis. Here, we sought to examine whether betaine treatment similarly protects against liver injury in …

Clouded Precedent: Tandon V. Newsom And Its Implications For The Shadow Docket, Alexander Gouzoules

Faculty Publications

The Supreme Court’s “shadow docket”—the decisions issued outside its procedures for deciding cases on the merits—has drawn increasing attention and criticism from scholars, commentators, and elected representatives. Shadow docket decisions have been criticized on the grounds that they are made without the benefit of full briefing and argument, and because their abbreviated, per curiam opinions can be difficult for lower courts to interpret.

A spate of shadow docket decisions in the context of free-exercise challenges to COVID-19 public health orders culminated in Tandon v. Newsom, a potentially groundbreaking decision that may upend longstanding doctrines governing claims brought under the Free …

Food, Freedom, Fairness, And The Family Farm, Robin M. Rotman, Sophie Mendelson

Faculty Publications

The concept of the “family farm” holds powerful sway within the American narrative, embodying both nostalgia for an imagined past and anxiety for a future perceived to be under threat. Since the founding of the United States, this cultural ideal has been invoked in support of a rosy vision of agrarian democracy while obscuring the ways in which the U.S. Department of Agriculture’s codified definition of “family farm” has unfairly aggregated advantages for the benefit of a particular kind of family (nuclear) and farmer (white, male, straight). At the same time, consumers are misled by an under-interrogated conflation of family …

Avian Eggshell Coloration Predicts Shell-Matrix Protoporphyrin Content, Charles F. Thompson, Kara E. Hodges, Nathan T. Mortimer, Alysia D. Vrailas-Mortimer, Scott K. Sakaluk, Mark E. Hauber

Faculty Publications – Biological Sciences

Avian eggshell pigmentation may provide information about a female’s physiological condition, in particular her state of oxidative balance. Previously we found that female House Wrens (Troglodytes aedon Vieillot, 1809) with lighter, less-maculated, and redder ground-colored shells were older and produced heavier offspring than females laying more-maculated and browner eggs. The strong pro-oxidant protoporphyrin is responsible for this species’ eggshell pigmentation, so differences in pigmentary coloration may be related to eggshell protoporphyrin content and reflect female oxidative balance and condition during egg formation. Therefore, we tested the assumption that egg-surface coloration is related to the amount of protoporphyrin in the …

Biomarkers Of Inflammation And Oxidative Stress In The Prediction And Management Of Acute Coronary Syndrome, Udaya Ralapanawa, Sivakanesan R

Health Sciences

The assessment of patients presenting with chest pain or symptoms indicative of cardiac ischemia remains a diagnostic challenge. Many types of research have focused on the search for ideal biological markers for the rapid detection of cardiac cell injuries. Markers of inflammation and oxidative stress are the way forward. At present, the biomarker most widely used for diagnosing acute coronary syndrome is cardiac troponin though it has some limitations. Apart from cardiac troponin, several other biomarkers, especially inflammation and oxidative stress markers in acute coronary syndrome, have been investigated. However, most of them still require validation in further studies. As …

Spring Break In Chernobyl: Urbex, Apocalypse, And Materiality In Writing Classrooms, K Shannon Howard

The Journal of the Assembly for Expanded Perspectives on Learning

The practice of urban exploration, or urbex—an activity in which we confront and document landscapes of ruin and make meaning from them—acts as a focal point through which students may investigate and write about the world surrounding them by gaining new perspectives of physical spaces and objects that often go ignored in daily living. More importantly, urbex inspires writing that responds to existing problems in our world (resource scarcity, lack of sustainability, and environmental trauma) while also helping students to conceptualize a better one.

South Dakota State University Graduate Catalog 2022-2023, South Dakota State University

South Dakota State University Catalogs and Bulletins: 1935 to present

No abstract provided.

The Chironian 2021-2022, New York Medical College

The Chironian

The Chironian is distributed to a readership of 16,000 faculty, alumni and employees of New York Medical College, government and community leaders, affiliated hospitals and selected media. Each issue is carefully crafted to provide a balance of articles on cutting-edge research, personality profiles, student accomplishments and alumni news from all five schools on the NYMC campus. Inquiries can be sent to [email protected].

Hauntology And Epistemology In Guillermo Del Toro’S Pan’S Labyrinth And Juan Antonio Bayona’S The Orphanage, Timothy P. Reed

The Coastal Review

This article analyzes the narrative function of the fantastic in two commercial Spanish language movies, Guillermo Del Toro’s 2006 Pan’s Labyrinth and Juan Antonio Bayona’s 2007 The Orphanage, to compare how they encompass and reflect aspects of hauntological theory. The movies show how Ofelia and Laura embrace the fantastic to acquire knowledge and agency by deliberately communicating with specters. Through acknowledging the epistemological implications of the fantastic, deliberate disobedience and self-sacrifice, Ofelia and Laura are able to liberate themselves from a repressive present and envisage a more optimistic future for others too. Hauntological discourse in both films ultimately functions …

Special Tribute To Emily Schulz, Phd, Otrl

OJOT Sponsor Profiles

No abstract provided.

Admissions Publications 2022-2023, University Of Minnesota Morris, Admissions

Miscellaneous Campus Publications

Admissions publications for 2022-2023.

-Thrive

-An Investment That Counts

-People Place Purpose Find Yours At Morris

The Honors Beacon, Issue 20, 2021-2022, Honors Program At Minnesota State University, Mankato

Honors Beacon

2021-2022 newsletter of the Honors Program at Minnesota State University, Mankato.

Biological Sciences Associate Degree Annual Program Outcomes Assessments, 2021-22, Lake Campus, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Biological Sciences Associate Degree program for the 2021-2022 academic year.

Maud Gordon Holmes Arboretum List Of Tree Species, Chloe Mokadam

Maud Gordon Holmes Arboretum database

Maud Gordon Holmes Arboretum database of Tree Species.

Raleigh Hills Medical Center, Raleigh Hills, Oregon, Andrew Tucker, Anthony Bertenelli, Dan Noyes, Karisa Caracol, Matthew Koenigs

Real Estate Development Workshop Projects

Dogwood Development Group proposes a 2 Story Medical Office Building located at 7023 SW Beaverton Hillsdale Hwy, Portland, OR 97225 - on the corner of the impressive 6-way intersection of Scholls Ferry Rd, Oleson Rd, and the Hwy.

The site consists of 3 contiguous parcels, totaling 2.65 acres of rare undeveloped land within the heart of the Raleigh Hills town center area. Currently occupying the easternmost parcel is a longstanding veterinarian office ran by Dr. Daryl B Leu, the owner of the site.

The site presents a few notable challenges due to its proximity to the intersection, access to the …

From Logic To Realism To Brighter Future For Humanity, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This collection of published papers at International Journal of Neutrosophic Science actually began with just a simple request by Dr. Broumi Said, the editor of IJNS, to us, to submit an article for his new journal. Then we submitted a series of new articles discussing various applications of Neutrosophic Logic, a new kind of logic as developed by one of us (FS). We explore a wide range of subject, from Godel’s incompleteness theorem, to possible technocalypse and neutro-futurology, and also additional sections. Hopefully you will find these articles interesting for better understanding of nature.

Pathos, Winter 2022, Portland State University. Student Publications Board

Pathos

Editor: Bret Steggel

Artificial Intelligence And Trade Secret Law, 21 Uic Rev. Intell. Prop. L. 252 (2022), Gregory Gerard Greer

UIC Review of Intellectual Property Law

No abstract provided.

Myths And Clichés: The Doctrinal Myopia Of Publicity Right, 22 Uic Rev. Intell. Prop. L. 50 (2022), Mira Moldawer

UIC Review of Intellectual Property Law

No abstract provided.

Stakeholder Perceptions Of Microplastics Management In Oregon, Maya Hurst-Mayr

Environmental Science and Management Professional Master's Project Reports

There is currently no federal policy in the United States that specifically addresses microplastics (MPs) pollution. However, states are beginning to act on this issue; California's SB 1422 initiates measurement of MPs in drinking water resources and Senate Bill 1263 requires the state to adopt a strategy to reduce the ecological impact of MPs in marine ecosystems. Other West Coast states like Oregon and Washington are expected to follow California's example. It is important to know what the actors who are a part of shaping MPs policy in Oregon would see as barriers and opportunities to doing so. We conducted …

Status Anxiety And Overall Life Satisfaction Of Young Adults In The Bay Area, Samuel Casco

Global Public Health | Senior Theses

The published literature suggests social comparisons have significant negative effects on an individual’s psychological well-being. However, there is little to no research to suggest that an individual’s attainment of societal success has a relationship with one’s perceived life satisfaction.

A mixed-methods study involved young adults ages 18-29 in the Bay Area and were selected via a student researcher in the Global Public Health department of Dominican University of California. 115 participants completed surveys regarding self-perceived life satisfaction and status anxiety through the Qualtrics Survey Collection Tool. A Pearson’s Chi-Squared Test was conducted to find an association between life satisfaction and …

The Stubborn Survival Of The Central Hudson Test For Commercial Speech, Nat Stern

Seattle University Law Review

This Article examines the persistence of the Central Hudson standard in the face of multiple challenges as well as larger implications of its survival. Part I provides a brief overview of the Court’s commercial speech doctrine and the spectrum of criticism of Central Hudson for its allegedly excessive or inadequate protection of expression. Part II surveys a series of developments, especially in the last decade, that threaten to supersede Central Hudson’s “intermediate” standard of scrutiny for commercial speech restrictions. In response, Part III explains how none of these phenomena have resulted in the abandonment of the Central Hudson regime. …

Good Love Is Black: Stories On Black Queer Living In The American South, Danielle Buckingham

Electronic Theses and Dissertations

Black Queer and Trans folks conjure love in their lives, by any means necessary, even in the face of terror. This is what has been at the root of their survival against the anti-Blackness and heterosexism that permeates the nation. Good Love Is Black, highlights their journeys navigating multiple marginalized identities, particularly in the American South. For this project, I spoke with folks who are natives of or currently residing in Mississippi, Alabama, South Carolina, Texas, and Kentucky. This written thesis accompanies a narrative podcast that explores the ways in which their Black, Queer, and Southern Identity informs how they …

"How It Was Made", Bethany Fitts

Electronic Theses and Dissertations

This is a meta-autoethnography describing the researcher’s unfocused, rhizomatic research process throughout the COVID19 pandemic. Themes explored are the COVID19 pandemic, family, death, climate change, queer love, represenation, academia, genre, and religion. The study shows how multiple scales of grief arise during the research process. I locate this method within postcolonial theory of autoethnography that seeks to diversify structures within the academic genre.