Digital Commons Network^™

Pioneer Tales (Vol. 6, No. 2), San Bernardino Historical & Pioneer Society

Pioneer Tales

No abstract provided.

Pioneer Tales (Vol. 4, No. 4), San Bernardino Historical & Pioneer Society

Pioneer Tales

No abstract provided.

The Clean Water Act And The Ocean: An Unfulfilled Promise, Robin Kundis Craig

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Introduction To Data Science, Spencer P. Greenhalgh

Information Science Textbook Gallery

This book was developed for ICT/LIS 661: Introduction to Data Science, as offered in the University of Kentucky's School of Information Science. It adapts and expands on openly licensed materials to introduce readers to basic statistical concepts, the R programming language, and philosophical critique of data science.

This open access textbook was supported by the University of Kentucky Libraries Alternative Textbook program

Guanabenz In The Horse – A Preliminary Report On Clinical Effects And Comparison To Clonidine And Other Alpha-2 Adrenergic Agonists, Andreas F. Lehner, L. Dirikolu, Thomas Tobin

Veterinary Science Faculty Publications

In veterinary medicine, a number of alpha-2 receptor agonists are marketed as sedatives/hypnotics and analgesics, with their principal use being the chemical restraint of large and small animals. Guanabenz (Wytensin®) is an alpha-2 adrenergic receptor agonist marketed for use in humans as an anti-hypertensive agent. Recent reports indicate that guanabenz has been administered to horses in small doses (0.04 mg/kg) for its anti-hypertensive effects. While this offers both benefits of sedation of the horse as well as amelioration of pulmonary hypertension during running exercise and consequent Exercise-Induced Pulmonary Hemorrhage (EIPH), guanabenz is currently proscribed in most racing jurisdictions and its …

Opioid Accountability, Daniel G. Aaron

Utah Law Faculty Scholarship

The opioid crisis has steadily killed Americans for twenty years. In total, we have lost 450,000 American lives since the 1990s, and countless more suffer from chronic addiction.

After years of piecemeal efforts to address this massive loss of life and health, the opioid litigation, largely centralized in Ohio federal district court, has brought significant hope for change. But there is a notable divide between the popular sense of the litigation and its reality. A full 57% of Americans believe that opioid companies should be held accountable for precipitating a public health crisis. However, the litigation has been dedicated to …

Spokane Climate Project: Chapter 5, Fire And Smoke Impact Study For Spokane, Washington, Mike Peterson, Levi Keesecker, Wei Li, Terry Lawhead, Katherine Rowden, Joel Breems, Jerusha Hampson, Katherine Hegewisch, Gonzaga University Climate Institute

Climate, Water, and the Environment Research

Examines the rise in wildfire activity projected for Spokane and the Pacific Northwest throughout this century. Focusses on the health impacts that smoke from historical wildfires has had on Spokane’s residents and the health impacts that smoke from future wildfires is projected to have on Spokane residents.

The full version of this report as well as a full list of the citations and methodologies employed for this analysis can be found at the Spokane Climate Project website: https://www.spokaneclimateproject.org/.

Block The Barf: Using A Validated Scale To Measure Nausea., Jane Choe, Lauren Maloy

2021

No abstract provided.

Loneliness In Covid-19, Life, And Law, Olivia Ash, Peter H. Huang

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Coerced Testimony Of A Witness, As Opposed To The Fabrication Of Evidence, Should Not Be Used As A Basis To Satisfy A § 1983 Claim For Alleged Due Process Violations In An Underlying Criminal Matter, 55 Uic L. Rev. 40 (2022), Jonathan Federman, Kyle Fleck

UIC Law Review

No abstract provided.

Anhedonia And Impulsivity In College Alcohol Use: A Path Analysis, Sydney N. Stamatovich

Dissertations and Theses

This study tested a path model to explore whether different types of anhedonia are associated with alcohol use and problems via different types of impulsivity in 640 college students (ages 18-25). This study parsed anhedonia into four specific facets: consummatory and anticipatory anhedonia, and “recreational” and social anhedonia. Consummatory anhedonia (i.e., the “liking” of a reward) was hypothesized to be associated with alcohol use and problems via sensation seeking, a component of impulsivity where individuals tend to seek out rewarding, yet sometimes risky stimuli. Further, anticipatory anhedonia (i.e., the process of “looking forward to” or “wanting” a reward) was hypothesized …

The Bad Place And The Not Place, Andrew Maudal

Dissertations and Theses

Do we, as an audience, gravitate toward apocalyptic settings to connect with outlying characters that defy the odds to survive the impossible? Or is it instead to fantasize about what we would do without societal norms, without rules, and without anything to hold us back. In my writing, I endeavor to walk the line of absolute bleakness and hopeful change while focusing on the compassion forged through friendship. Literary critics have long argued that society oppresses the lower class through laws, social upbringing, and cultural institutes. In youth a struggle forms within us between how we want our true selves …

It Was Never About A Cake: Masterpiece Cakeshop And The Crusade To Weaponize Religious Freedom, Andrew L. Seidel

Loyola University Chicago Law Journal

No abstract provided.

The Expression Of Satanist Identity: Does Visible Identification Of Satanism Predict Discrimination And Depression?, Allyson Dudley

All Graduate Theses, Dissertations, and Other Capstone Projects

The current research examines the relationship between visible expression of religion, identification within Satanism, experiences of discrimination, and depression in a sample of modern Satanists (n = 1,272). Historically, Satanism has been scrutinized as immoral and a threat to public safety. The current research attempts to challenge that viewpoint by employing culturally competent methods and understanding of modern Satanism. Findings indicate a negative relationship between expression of Satanism and discrimination, expression of Satanism and depressive symptoms, in-group ties and discrimination, and identification (in-group ties and in-group affect) and depressive symptoms. Results show a positive relationship between identification with Satanism and …

The Effects Of Effluent Discharge Into The Santa Fé River, João Vito Bezerra Dragone

Undergraduate Journal of Mathematical Modeling: One + Two

The discharge of effluents into rivers is something that has occurred a lot throughout our history, rivers like the Mississippi River and the Tiete River (São Paulo, Brazil) have been targets for many years. Therefore, in this paper I choose to show, through hard data and some assumptions, the impact of sewage dumping in water bodies, in this case the Santa Fé River, Florida and the reason why we should avoid dumping these effluents into the rivers.

Hymnal Of Teeth: Southern Stories Of Folk And Fey, James E. Phillips Iii

Honors Undergraduate Theses

We are the stories we tell. Folk and fairy tales are reflections of the cultures that pass them down. Contemporary literary traditions, such as the Southern Gothic and tales of magical realism, also provide unique ways of responding to concerns within our society. This thesis attempts to merge these literary traditions to create a collection of Southern folk and fairy tales. These stories vary in style from very traditional fairy tales to more modern styles of magical realism and lyrical poetry. This collection was crafted after studying an extensive reading list of novels and short story collections written by masters …

The Importance Of Emotional And Physical Safety In The Success And Development Of Public Spaces, Isabella Wilhelm

Honors Undergraduate Theses

Our day-to-day lives consist of formal and informal settlements in the built environment. As humans, we gravitate towards successful informal settlements (public spaces) to conduct activities such as socializing and recharging. Previous research has highlighted the importance of distinct factors in determining the success of public spaces. Still, research has failed to develop the foundation that makes all public places prosper. Through examining successful and unsuccessful public places through case studies, this research analyses the success and importance of our emotional and physical safety in public spaces through the presence or absence of sound, light, nature, boundaries, and order.

On Your Painted Wings, Sandra M. Ford

Honors Undergraduate Theses

The intent of this thesis is to explore historical issues of Cuban restrictions on emigration through a magical realism lens. Drawing inspiration from Cuban-American writer Ana Menéndez and Columbian writer Gabriel García Márquez, this thesis focuses on family relationships, especially how grief shapes those relationships and the people in them. The thesis approaches these issues of family, grief, and Cuban emigration by weaving a more grounded central narrative with an original fairytale.

Good Patients, Susan Mesler-Evans

Honors Undergraduate Theses

This thesis is the first 21 chapters (approximately 150 pages) of a novel, Good Patients, accompanied by a complete synopsis. Good Patients is a social satire which seeks to touch on the flaws of the American healthcare system and social media culture, and how these two intersect for many people. To prepare for writing, I spent my first semester completing a guided reading list and preparing the synopsis, both of which were approved by my thesis chair. While writing, I consulted several medical articles to make my work as accurate as possible. The novel explores the way social media …

Revealing The Black Form: Black Bodies In Nineteenth-Century French Orientalist Visual Art, Nathanael Amir Justin Lapierre

Honors Undergraduate Theses

In the nineteenth century, Orientalism functioned as a Western tool for dominating and restructuring the perception of the Orient. In France, where Orientalism found favor amongst artists, Orientalist works were produced in the literary and visual arts to inform and control the narrative about the East. Influenced by the Napoleonic imperial conquests and an increased French presence in the East, Orientalism became an integral movement in the French visual arts. The relationship between France and the Orient was one of power and domination, which was mirrored in that between the French and the Blacks.

As a part of the Western …

Everything But The Smell: The Ethics Of The “Connective Turn” In Argentinian Memory Activism, Megan L. Corbin

Languages & Cultures Faculty Publications

This chapter interrogates what is lost and what is gained in [the] turn toward cyberspace as a new venue for interacting with a traumatic past. It will first examine the discussions and debates that took place in Argentina as former detention centres were converted into sites of memory, using the debate about the recovery of Escuela Mecánica de la Armada [ESMA] (the Navy School of Mechanics) as an illustrative example. Then, it will compare the features of some of actual memory sites in Buenos Aires with the interactive documentary features on the website, specifically focusing on the narrative logic and …

Learning From The Collective Space In Making Culture And Making Space : A Case Study From Yogyakarta City, Indonesia, Zita Wahyu Larasati, Pinurba Parama Pratiyudha, Galih Prabaningrum, Devy Dhian Cahyati, Krisdyatmiko Krisdyatmiko

Journal of Urban Culture Research

The contestation of urban space is a dialectical process in defining space by stakeholders in urban areas. We will explain the efforts of city citizens to form a collective space by promoting a making culture. With the spirit of Do It Yourself and Do It With Others, the collective space produces shared knowledge and democratizes data to increase the capacity of urban citizens. This study is grounded on empirical research in Yogyakarta through in-depth interviews, focus group discussions, and participant observation. We discuss the formation of collective space in urban informality to encourage urban communities. This study finds that the …

2021 Kentucky River Watershed Watch: Annual Report, Malissa Mcalister, Steven Evans

Kentucky River Watershed Watch

No abstract provided.

Investigating The Impact Of Unlimited Sucrose During Adolescence On Flex Maze Performance In Rats, Emma Klopatek, Emily Tobolski, Bailey Harvey, Danielle Frances, Taylor Garrels, Gillian Lado

Science University Research Symposium (SURS)

As depression continues to impact many people, there are important considerations to be taken in how depression impacts people's learning and motivations. The objective of this study is to examine the effects of unlimited sucrose consumption during adolescence, which can mimic symptoms of depression, on spatial memory and motivation in rats. The flex maze is used in the present study to assess these behaviors. Before initial training on the flex maze, 6 male rats were separated into two groups: an experimental group with unlimited access to 5% sucrose (and water) for approximately 3 weeks and a control group with free …

Bowling Online: Introduction To Social Worlds In Second Life, Hope Mac Donald

Graduate Research Theses & Dissertations

During the ongoing covid pandemic, people with underlying conditions that could become comorbidities were forced to retreat into their homes and were banned from social spaces if they wanted to survive. Those with capital could participate in online social spaces. With the push towards considering Covid an endemic disease, which by definition means repeated outbreaks, immunocompromised people will be forced to continually withdraw from social spaces. Virtual worlds and other digital communities may be helpful in dealing with the social isolation and anxiety caused by having to distance oneself in order to protect themselves. Virtual worlds are not a perfect …

Editorial: Emerging And Re-Emerging Viral Zoonoses, Naveen Kumar, Vladimir N. Uversky, Shailly Tomar, Kenneth S. M. Li, Keith Chappell, Susanna K. P. Lau

Molecular Medicine Faculty Publications

No abstract provided.

An Ayurgenomics Approach: Prakriti-Based Drug Discovery And Development For Personalized Care, Zoufang Huang, Vivek P. Chavda, Rajashri Bezbaruah, Vladimir N. Uversky, Sucharitha Palagati, Aayushi B. Patel, Zhe-Sheng Chen

Molecular Medicine Faculty Publications

Originating in ancient India, Ayurveda is an alternative medicinal approach that provides substantial evidence for a theoretical-level analysis of all aspects of life. Unlike modern medicine, Ayurveda is based upon tridoshas (Vata, pitta, and Kapha) and Prakriti. On the other hand, the research of all the genes involved at the proteomics, metabolomics, and transcriptome levels are referred to as genomics. Geoclimatic regions (deshanupatini), familial characteristics (kulanupatini), and ethnicity (jatiprasakta) have all been shown to affect phenotypic variability. The combination of genomics with Ayurveda known as ayurgenomics provided new insights into tridosha that may pave the way for precision medicine (personalized …

Msh3 Homology And Potential Recombination Link To Sars-Cov-2 Furin Cleavage Site, Balamurali K. Ambati, Akhil Varshney, Kenneth Lundstrom, Giorgio Palù, Bruce D. Uhal, Vladimir N. Uversky, Adam M. Brufsky

Molecular Medicine Faculty Publications

Among numerous point mutation differences between the SARS-CoV-2 and the bat RaTG13 coronavirus, only the 12-nucleotide furin cleavage site (FCS) exceeds 3 nucleotides. A BLAST search revealed that a 19 nucleotide portion of the SARS-CoV-2 genome encompassing the furin cleavage site is a 100% complementary match to a codon-optimized proprietary sequence that is the reverse complement of the human mutS homolog (MSH3). The reverse complement sequence present in SARS-CoV-2 may occur randomly but other possibilities must be considered. Recombination in an intermediate host is an unlikely explanation. Single stranded RNA viruses such as SARS-CoV-2 utilize negative strand RNA templates in …

Bmi1 Silencing Induces Mitochondrial Dysfunction In Lung Epithelial Cells Exposed To Hyperoxia, Helena Hernández-Cuervo, Ramani Soundararajan, Sahebgowda Sidramagowda Patil, Mason T. Breitzig, Matthew Alleyn, Lakshmi Galam, Richard Lockey, Vladimir N. Uversky, Narasaiah Kolliputi

Molecular Medicine Faculty Publications

Acute Lung Injury (ALI), characterized by bilateral pulmonary infiltrates that restrict gas exchange, leads to respiratory failure. It is caused by an innate immune response with white blood cell infiltration of the lungs, release of cytokines, an increase in reactive oxygen species (ROS), oxidative stress, and changes in mitochondrial function. Mitochondrial alterations, changes in respiration, ATP production and the unbalancing fusion and fission processes are key events in ALI pathogenesis and increase mitophagy. Research indicates that BMI1 (B cell-specific Moloney murine leukemia virus integration site 1), a protein of the Polycomb repressive complex 1, is a cell cycle and survival …

What Is Parvalbumin For?, Eugene A. Permyakov, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Parvalbumin (PA) is a small, acidic, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily. Structural and physical properties of PA are well studied but recently two highly conserved structural motifs consisting of three amino acids each (clusters I and II), which contribute to the hydrophobic core of the EF-hand domains, have been revealed. Despite several decades of studies, physiological functions of PA are still poorly known. Since no target proteins have been revealed for PA so far, it is believed that PA acts as a slow calcium buffer. Numerous experiments on various muscle systems have shown that PA accelerates the …