Digital Commons Network^™

The Commons: Tools For Reading, Writing, And Rhetoric, Jill M. Parrott, Dominic J. Ashby, Jonathon Collins

EKUOPEN: Open Textbooks

The Commons: Tools for Reading, Writing, and Rhetoric gives instructors and students of college writing courses a single source for information on metacognitive critical reading, rhetorical awareness, and MLA formatting basics as well as interesting and relevant reading and viewing content. Its approach is interdisciplinary, bringing in material from ecology, sociology, psychology, technology, popular culture, political science, cultural studies, and literature. Each essay, website, video, infographic, and poem has been carefully chosen to speak to the Eastern Kentucky University community, but everyone can find something that speaks to our common human experience and our need to communicate and connect with …

Longwood Magazine 2022 Winter, Longwood University

Alumni Newsletters & Bulletins

No abstract provided.

Response 2022, Seattle Pacific University

Seattle Pacific Alumni Magazines

No abstract provided.

Lawrence, Fall/Winter 2022, Lawrence University

Alumni Magazines

No abstract provided.

What’S A Guanaco?: Tracing The Llama Diaspora Through And Beyond South America, Emily Wakild

History Faculty Publications and Presentations

Let us begin with Spook the llama. Spook lived in the animal enclosures at New York’s Central Park Zoo in 1912. Caretakers described Spook as a “morose, cantankerous” soul inhabiting the back of the deer range. Initially forlorn by this location, he looked out the back door at the road that circled past the pen. The busy street proved entertaining as it was full of noisy automobiles and anxious drivers honking. Spook watched the cars and, before long, learned to honk. Or so reported the head keeper at the zoo, Bill Snyder, who claimed “Spook thrust his head forward, drew …

Fracture Callus Evaluation In The Setting Of Breast Cancer Metastasis And Rescue Of Healing Via Inhibition Of Erk1/2, Christopher Dussik

Yale Medicine Thesis Digital Library

Background: Pathological fractures of the femoral shaft are devastating complications of metastatic breast cancer that afflict a myriad of women worldwide. Those affected suffer from debilitating pain, loss of function, and diminished quality of life. Intramedullary nailing with locking screw fixation provides the foundation of femoral fracture repair. However, cancer-induced changes within the local osseous environment drastically impair normal bone healing, leading to nonunion, reduced quality of life, and delays in medical oncologic care. At this time, comparatively little is known about the underlying mechanisms involved in impaired pathological fracture healing. A more thorough understanding of the influence breast cancer …

Andje Franjic & Andja Jakovljevic, Maracic Maracic, Josipa Karaca

SICANJE

No abstract provided.

The Mozart Conversation Or The Aria Of Nannerl Mozart: Drama In Three Acts And Two Tableaux, Emmanuel M. Dubois

Emmanuel Dubois Compositions

1 play (v + 66 pages) ; includes Synopsis, Cast of characters, Setting, Costumes, Props

The full-length historic drama examines the impact of emerging feminism in the Mozart family during the Enlightenment era.

As social changes cause the rejection of sexism, Nannerl, Mozart's sister disrupts male ordained traditions as she affirms her genius as a musician. The new social trends disrupt the affectionate relationship with her brother Wolfgang, who is psychologically exhausted by the stress to perform. The parents, Leopold and Anna Maria, invoke the respect of old traditions to exploit financially the genius of their son and to minimize …

Benjamin Percy And Queer Ecomasculinities: Ideas Of The Short Story From Hemingway To The Present, Thomas Edward Hahn

Theses and Dissertations

The 21st Century has ushered in a need to problemetize and challenge traditional boundaries between social and philosophical realms. It is therefore more important now than ever to revisit the classification of literary genres, specially the short story. Through the intersection of queer, literary, and ecocritical theory, this book reexamines the current identity of the contemporary American short story in order to posit that it is a queer formation, a hybrid of both the novel and the poem, among the generic literary landscape. Through this queer literary form, the short story subsequently has the ironic potential to reveal insight into …

Senate Journal, Colorado General Assembly

Colorado House and Senate Journals

No abstract provided.

Munson Hall, Central Washington University

What is in a Name?

No abstract provided.

Cardiovascular Applications Of Artificial Intelligence In Research, Diagnosis, And Disease Management, Viswanathan Rajagopalan, Houwei Cao

Center for No Boundary Thinking

Despite significant advancements in diagnosis and disease management, cardiovascular (CV) disorders remain the No. 1 killer both in the United States and across the world, and innovative and transformative technologies such as artificial intelligence (AI) are increasingly employed in CV medicine. In this chapter, the authors introduce different AI and machine learning (ML) tools including support vector machine (SVM), gradient boosting machine (GBM), and deep learning models (DL), and their applicability to advance CV diagnosis and disease classification, and risk prediction and patient management. The applications include, but are not limited to, electrocardiogram, imaging, genomics, and drug research in different …

Snow Globe, Siobhan Cooney

Brushing

No abstract provided.

Zip8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense Against Bacterial Pneumonia, Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell

Journal Articles: Environmental, Agricultural & Occupational Health

Pneumococcal pneumonia is a leading cause of morbidity and mortality worldwide. An increased susceptibility is due, in part, to compromised immune function. Zinc is required for proper immune function, and an insufficient dietary intake increases the risk of pneumonia. Our group was the first to reveal that the Zn transporter, ZIP8, is required for host defense. Furthermore, the gut microbiota that is essential for lung immunity is adversely impacted by a commonly occurring defective ZIP8 allele in humans. Taken together, we hypothesized that loss of the ZIP8 function would lead to intestinal dysbiosis and impaired host defense against pneumonia. To …

Sars-Cov-2 Dysregulates Neutrophil Degranulation And Reduces Lymphocyte Counts, Abenaya Muralidharan, Todd A. Wyatt, St. Patrick Reid

Journal Articles: Environmental, Agricultural & Occupational Health

SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 patients. However, the mechanisms underlying this clinical outcome and the reasons for its correlation to poor prognosis are unclear. Furthermore, the mechanisms involved in healthy neutrophils acquiring a SARS-CoV-2-mediated detrimental role are yet to be fully understood. In this study, we isolated circulating neutrophils from healthy donors for treatment with supernates from infected epithelial cells and direct infection with SARS-CoV-2 in vitro. Infected epithelial cells …

Aldehyde Trapping By Adx-102 Is Protective Against Cigarette Smoke And Alcohol Mediated Lung Cell Injury, Carmen A. Ochoa, Claire Nissen, Deanna Mosley, Christopher Bauer, Destiny Jordan, Kristina L. Bailey, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Most individuals diagnosed with alcohol use disorders smoke cigarettes. Large concentrations of malondialdehyde and acetaldehyde are found in lungs co-exposed to cigarette smoke and alcohol. Aldehydes directly injure lungs and form aldehyde protein adducts, impacting epithelial functions. Recently, 2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol (ADX-102) was developed as an aldehyde-trapping drug. We hypothesized that aldehyde-trapping compounds are protective against lung injury derived from cigarette smoke and alcohol co-exposure. To test this hypothesis, we pretreated mouse ciliated tracheal epithelial cells with 0–100 µM of ADX-102 followed by co-exposure to 5% cigarette smoke extract and 50 mM of ethanol. Pretreatment with ADX-102 dose-dependently protected against smoke and …

Surface Modification Of Biodegradable Microparticles With The Novel Host-Derived Immunostimulant Cpdi-02 Significantly Increases Short-Term And Long-Term Mucosal And Systemic Antibodies Against Encapsulated Protein Antigen In Young Naïve Mice After Respiratory Immunization, Jacob E. Parriott, Jason P. Stewart, D. David Smith, Stephen M. Curran, Christopher D. Bauer, Todd A. Wyatt, Joy A. Phillips, Elizabeth Lyden, Geoffrey M. Thiele, Joseph A. Vetro Phd

Journal Articles: Environmental, Agricultural & Occupational Health

Generating long-lived mucosal and systemic antibodies through respiratory immunization with protective antigens encapsulated in nanoscale biodegradable particles could potentially decrease or eliminate the incidence of many infectious diseases, but requires the incorporation of a suitable mucosal immunostimulant. We previously found that respiratory immunization with a model protein antigen (LPS-free OVA) encapsulated in PLGA 50:50 nanoparticles (~380 nm diameter) surface-modified with complement peptide-derived immunostimulant 02 (CPDI-02; formerly EP67) through 2 kDa PEG linkers increases mucosal and systemic OVA-specific memory T-cells with long-lived surface phenotypes in young, naïve female C57BL/6 mice. Here, we determined if respiratory immunization with LPS-free OVA encapsulated in …

Post-Endotoxin Exposure-Induced Lung Inflammation And Resolution Consequences Beneficially Impacted By Lung-Delivered Il-10 Therapy, Jill A. Poole, Rohit Gaurav, Aaron Schwab, Amy J. Nelson, Angela Gleason, Debra J. Romberger, Todd A. Wyatt

Journal Articles: Environmental, Agricultural & Occupational Health

Although lung diseases typically result from long-term exposures, even a robust, one-time exposure can result in long-lasting consequences. Endotoxin is a ubiquitous environmental/occupational inflammatory agent often used to model airway inflammation. Using a murine model, the return to lung homeostasis following high dose inhalant lipopolysaccharide (LPS, 10-100 μg) exposure were delineated over 2 weeks. LPS-induced rapid weight loss, release of proinflammatory mediators, and inflammatory cell influx with prolonged persistence of activated macrophages CD11c⁺CD11b⁺ and recruited/transitioning CD11c^intCD11b⁺ monocyte-macrophages out to 2 weeks. Next, lung-delivered recombinant (r) interleukin (IL)-10 was intratracheally administered for 3 doses initiated …

Who’S Afraid Of Bob Jones?: 'Fundamental National Public Policy' And Critical Race Theory In A Delicate Democracy, Lynn D. Lu

Publications and Research

In Summer of 2021, Republican legislators across the United States introduced a host of bills to prohibit government funding for schools or agencies that teach critical race theory (“CRT”), described by the American Association of Law Schools not as a single doctrine but a set of “frameworks” to “explain and illustrate how structural racism produces racial inequity within our social, economic, political, legal, and educational systems[,] even absent individual racist intent.” Characterizing such an explicitly race-conscious analysis of legal and social institutions as “divisive,” opponents of CRT, such as former Vice President Mike Pence, labeled it “nothing short of state-sponsored …

Cas Accents, Vol. 24, No. 2 (2022 Uplb Graduation Issue), College Of Arts And Sciences, University Of The Philippines Los Baños

CAS Accents

No abstract provided.

Cas Accents, Vol. 24, No. 3 (50th Cas Foundation Anniversary Issue - Part 1), College Of Arts And Sciences, University Of The Philippines Los Baños

CAS Accents

No abstract provided.

The Effects Of Atir Blocker On The Severity Of Covid-19 In Hypertensive Inpatients And Virulence Of Sars-Cov-2 In Hypertensive Hace2 Transgenic Mice., Xiaoliang Jiang, Huadong Li, Yong Liu, Linlin Bao, Lingjun Zhan, Hong Gao, Wei Deng, Jing Xue, Jiangning Liu, Xing Liu, Junli Li, Jie Wang, Shuang Wu, Mingzhe Yan, Wei Luo, Pedro A. Jose, Chuan Qin, Xiuhong Yang, Dingyu Zhang, Zhiwei Yang

Medicine Faculty Publications

No abstract provided.

The Scientific Divulgation In Neurosurgery., Rodrigo Ramos-Zuñiga, Sergio Manuel Ibarra-Navarro

Archives of Neurosurgery

The communication of scientific findings in a young discipline in the evolution of knowledge about the human nervous system, has had a consistent and significant advance. This interdisciplinary and multidisciplinary vision has been a fundamental educational axis in the development of neurosurgery in terms of innovation, scientific progress, technological development and quality of patient care. It is therefore essential that scientific writing and communication channels continue to preserve these quality standards, to validate without bias and with certainty, the value and strength of the advances of neurosurgery as a science.

Resurrecting Usia: A Second Act At The National Archives, Criss Austin, Audrey Amidon, Ivy Donnell, Heidi Holmstrom

The Journal of e-Media Studies

When the films of the United States Information Agency (USIA) first began arriving at the National Archives and Records Administration (NARA) in the 1970s, the Smith-Mundt Act stood as a barrier to access. Congress blocked distribution of the films within the United States to avoid the appearance of propagandizing its own citizens with content created for foreign audiences. In 1990, the legal prohibition was lifted and researchers could begin to probe the contents of the massive collection, but broad access was not possible until NARA archivists and preservationists put in a great deal of work behind the scenes. With the …

Address Of The Warrioress: Old Testament Warfare And Women's Role In Wartime Role In W, Madeline Ruby Nielsen

Seattle Pacific Seminary Theses

This thesis examines the manners and methods employed in the battles of Old Testament passages and what they reveal about the spiritual formation of God’s people in times of combat. Paralleled with this examination, this thesis analyzes certain female figures who have played a significant role in Old Testament narratives of combat and violence. Through this study, the analysis of female figures reveal how their character and/ or actions impacted the precipitation of warfare, participation in military victory, and finally establishing their own testimonies that challenge the implications and integrity of the Biblical master narratives.

The Healing Body: Recovering The Church's Mission Of Shalom, Heather Long Mcdaniel

Seattle Pacific Seminary Projects

Christianity is an embodied faith. God shaped human beings from the dust of the earth in God’s own image, in relationship with God, each other, and creation, and called us “good”. Our bodies, souls, and relationships are inextricably intertwined, and full health can be defined as a state of shalom, the flourishing of our whole selves in the context of our relationships and environment. Alienation, sickness, injustice, and suffering are experienced as brokenness in our bodies, souls, relationships, institutions, and environment. Restoration of health involves identifying and healing what is broken. God affirmed the goodness and worth of our bodies …

Notch3 Expression In Zebrafish With Inherited Degeneration Vs. Inflicted Damage, Meghan Graeca

Senior Honors Projects

Some mammalian species demonstrate the ability to regenerate functional photoreceptors after retinal injury, including those with mutations that result in non-syndromic diseases such as retinitis pigmentosa. Previous research has shown that regenerative capability exists in non-mutated animals following injury inflicted by light damage. Studies have suggested that, in mutated animals with inherited degeneration, regeneration does not occur spontaneously. However, mutated animals have exhibited regeneration following inflicted damage. Regenerative capabilities have been shown to be linked to the highly conserved Notch signaling pathway. To determine if differences in Notch signaling play a role in the lack of regeneration in zebrafish with …

Encouraging Little People’S Big Questions: An Elementary School Teacher’S Guide To Encouraging Philosophical Inquiry In Decision Making, Morgan Flanagan

Mahurin Honors College Capstone Experience/Thesis Projects

Children serve as natural philosophers. Their innate sense of questioning, in a classroom setting, with the right instruction, can be beneficial to understanding many abstract concepts. This project is a user-friendly elementary school teachers’ guide to encouraging philosophical questions and thoughts in young students. Teachers should be able to utilize the guide as a skeleton in forming their own lesson plans. The guide is not a completed lesson plan, rather an array of activities and literature that can be incorporated into pre-existing units or be used as a tool in creating new ones. Outlines include literature synopsis, overall philosophical themes, …

Eng 100: Things That Belong In The Garden, Ellen Sego

English 100-200-300 Conference

No abstract provided.

Eng 300: The Efficacy Of Bacteriophage & Lysin Antimicrobials In Industrial & Commercial Settings, Bella Norman

English 100-200-300 Conference

No abstract provided.