Digital Commons Network^™

New Virtual Environment Based On Python Programming, Omar Abdulwahabe Mohamad

Iraqi Journal for Computer Science and Mathematics

Python is an amazing language for large and complicated programming ventures. This language usescodes that are simple to use or modify for any software programmer. In this paper, one annoying issue during theproject expansion was described. Once a package is updated to the new version, this package is no longer compatiblewith previous projects, causing trouble when working on the program. To solve this problem, Python supports theprogrammer with a function called virtual environment. This function can construct an independent environment forany venture to avoid conflict. Various steps have been explained to create a virtual environment in Python. Differentexamples have then …

Constitutively Active Sarm1 Variants That Induce Neuropathy Are Enriched In Als Patients, A Joseph Bloom, Xianrong Mao, Amy Strickland, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio

2020-Current year OA Pubs

BACKGROUND: In response to injury, neurons activate a program of organized axon self-destruction initiated by the NAD

METHODS: To investigate whether naturally occurring human variants might disrupt SARM1 autoinhibition and potentially contribute to risk for neurodegenerative disease, we assayed the enzymatic activity of all 42 rare SARM1 alleles identified among 8507 amyotrophic lateral sclerosis (ALS) patients and 9671 controls. We then intrathecally injected mice with virus expressing SARM1 constructs to test the capacity of an ALS-associated constitutively active SARM1 variant to promote neurodegeneration in vivo.

RESULTS: Twelve out of 42 SARM1 missense variants or small in-frame deletions assayed exhibit constitutive …

Impact Assessment Modelling For The Ocean Economy: A Review Of Developments, Cathal O'Donoghue, Cathal Geoghegan, Stephen Hynes, Niall Farrell, Jenny O'Leary, Andreas Tsakiridis

Journal of Ocean and Coastal Economics

With increasing attention being paid to the role of marine related activity in promoting sustainable economic growth as well as development in coastal areas, it is important to be able to model the impact of policy decisions in this area in an ex-ante fashion. This paper provides an overview of an Economic, Social, Spatial and Environmental (ESSE) framework developed for impact assessment of ocean related industries. The modelling approach is applied to the ocean economy of Ireland and combines proven methodologies, namely input-output modelling and microsimulation, in order to assess multi-dimensional impacts. The capabilities of the ESSE modelling framework are …

Blue Growth: A Transitions Approach To Developing Sustainable Pathways, Christina Kelly, Ben Mcateer, Frances Fahy, Liam Carr, Daniel Norton, Desiree Farrell, Rebecca Corless, Stephen Hynes, Zacharoula Kyriazi, Agnès Marhadour, Regis Kalaydjian, Wesley Flannery

Journal of Ocean and Coastal Economics

The sustainable management of Blue Growth is an urgent issue for coastal states. Marine industries have rapidly expanded over the last two decades and this is projected to continue with the European Green Deal and post-COVID economic recovery policies. The intensification of Blue Growth could have adverse socio-ecological implications and must, therefore, be managed in terms of sustainability, natural resource boundaries, and coastal community well-being. Managing Blue Growth in a sustainable manner however, is challenging due to the longstanding inefficiencies and inertia of existing marine governance regimes. Adopting a transitions approach has been advanced as a way of steering regime …

Key Considerations For The Development Of Internationally Comparable Statistics On Ocean Economic Activity, James Jolliffe, Claire Jolly, Barrie Stevens

Journal of Ocean and Coastal Economics

Alongside several member countries, the OECD is embarking upon the development of a satellite account for ocean economic activity that presents international statistics in a harmonised manner. This work complements other initiatives at national and international levels and will support future comprehensive ocean accounts that include marine environment-economy linkages and ecosystem services. The production of internationally comparable statistics is a complex and time consuming endeavour that requires international cooperation. For ocean economic activities, such difficulties are compounded by the need to break down existing statistical information using secondary source material. A key preparation for internationally comparable statistics on ocean economic …

Kentucky Alfalfa Conference: A Team Approach To Alfalfa Education And Technology Transfer, Garry D. Lacefield, Monroe Rasnake, Christi L. Forsythe, Jimmy C. Henning, Bill Talley

IGC Proceedings (1977-2023)

Alfalfa has played an important role in providing farmers of Kentucky with a high yielding, high quality, persistent forage legume for many years. In 1980, a group of individuals under the leadership of University of Kentucky Forage Extension Specialists organized and implemented the first statewide educational event on alfalfa. This initial meeting gave rise to the Kentucky Alfalfa Conference that celebrated it’s twentieth anniversary in February 2000. This annual event has been co-sponsored by the University of Kentucky, Kentucky Forage and Grassland Council, along with other state and national groups including Certified Alfalfa Seed Council, Kentucky Department of Agriculture, Kentucky …

Humboldt In The Time Of Covid : Youth's Mental Health With Paula Nedelcoff Lmft, Noe Sanchez-Nino, Paula Nedlecoff

Humboldt in the Time of COVID - Digital Archive

Our interview conducted on December 6, 2021 at 10:00 AM, took place over zoom. Although both participants Audio was recorded on a separate device. We discuss mental health in general, how local students have adapted to the change, and the challenge students and service providers have encountered in offering therapy.

Copyright, Altruism, Trust Factors In The Use Of Institutional Repositories By Teachers Of Northeast Central Universities Of Assam, Susmita Das, Mukut Sarmah

Library Philosophy and Practice (e-journal)

This study tries to determine the current Institutional Repository (IR) scenario in the central university libraries of Assam. A systematic questionnaire for the respondents was developed to capture the primary data. The surveys were handed out or sent to the target groups, and they were returned by hand or e-mail. Many conditions must be satisfied to properly establish IRs. According to the current study, the main hurdles to IRs in central university libraries of Assam are lack of technical assistance and high-speed internet connection. Why are certain academics allowed to see their work while others are not? What would make …

Documentation And Preservation Of Endangered Manuscripts Through Digital Archiving In North-Eastern States Of India, Dibanjyoti Buragohain, Manashjyoti Deka, Amit Kumar

Library Philosophy and Practice (e-journal)

The preservation and conservation of traditional manuscripts is an age old practice. But for the past two decades or so, preserving the endangered manuscripts through digitization has become the prime concern of governments so that such manuscripts can be kept safely for future generations as manuscripts are considered to be an important asset to know our culture and tradition better. The present study primarily highlights the conservation and archival policies adopted by the British Library to digitize the ancient manuscripts of the North-Eastern states of India. The analysis highlights that the state such as Mizoram, Sikkim, Assam and Arunachal Pradesh …

Gw Covid-19 Intelligence Unit-Brief Report Omicron Variant Of Sars-Cov2, George Washington University

Intelligence Unit Research Briefs

No abstract provided.

Comparison Of Percutaneous Vs Oral Infection Of Hamsters With The Hookworm Ancylostoma Ceylanicum: Parasite Development, Pathology And Primary Immune Response, Richard D. Bungiro, Lisa M. Harrison, Blaise Dondji, Michael Cappello

Biology Faculty Scholarship

Background

Hundreds of millions of people in poor countries continue to suffer from disease caused by bloodfeeding hookworms. While mice and rats are not reliably permissive hosts for any human hookworm species, adult Golden Syrian hamsters are fully permissive for the human and animal pathogen Ancylostoma ceylanicum. Similar to humans, hamsters may be infected with A. ceylanicum third-stage larvae orally or percutaneously. Oral infection typically leads to consistent worm yields in hamsters but may not accurately reflect the clinical and immunological manifestations of human infection resulting from skin penetration.

Methodology/Principal findings

In this study we compared host responses …

The Current - Volume 32 Issue 16, Nova Southeastern University

Student Newspapers

No abstract provided.

Microstratigraphic Preservation Of Ancient Faunal And Hominin Dna In Pleistocene Cave Sediments, Diyendo Massilani, Mike W. Morley, Susan M. Mentzer, Vera Aldeias, Benjamin Vernot, Christopher Miller, Mareike Stahlschmidt, Maxim B. Kozlikin, Michael V. Shunkov, Anatoly P. Derevianko, Nicholas J. Conard, Sarah Wurz, Christopher S. Henshilwood, Javi Vasquez, Elena Essel, Sarah Nagel, Julia Richter, Birgit Nickel, Richard G. Roberts, Svante Pääbo, Viviane Slon, Paul Goldberg, Matthias Meyer

KIP Articles

DNA preserved in sediments has emerged as an important source of information about past ecosystems, independent of the discovery of skeletal remains. However, little is known about the sources of sediment DNA, the factors affecting its long-term preservation, and the extent to which it may be translocated after deposition. Here, we show that impregnated blocks of intact sediment are excellent archives of DNA. DNA distribution is highly heterogeneous at the microscale in the cave sediment we studied, suggesting that postdepositional movement of DNA is unlikely to be a common phenomenon in cases where the stratigraphy is undisturbed. Combining micromorphological analysis …

Play Among The Shadows, Xiong Wei

Theses and Dissertations

This article elaborates Xiong Wei's inspiration and experience from different cultural, political, social systems and art environment as a Chinese artist living in the United States, and the logic and methodology of how he went from a social realist sculptor to a contemporary artist.

I Just Work Here, Carrie Rudd

Theses and Dissertations

Via an in-depth analysis of the artist’s works and the material, social, and historical possibilities of Painting, the following paper investigates the myriad approaches for Painting to communicate complex ideas both physically and psychologically.

A Liquid Line, Sofía Del Mar Collins

Theses and Dissertations

My practice searches for fertility amidst cultural and material detritus. This paper outlines flows embedded in becomingness. My thesis exhibition included Liquidscapes, a series of suspended and wall hung paintings on plastic, Nursery of the Brave, a group of hanging vessels shaped from waste textiles, and Glass City, a video.

A Slippery Slope Of Resemblances, Lauren Clark

Theses and Dissertations

My studio has become an ecosystem. Plastics, linens and found objects are transformed with both “natural” and “artificial” dyes, pigments, and aggregates, until there is a co-corruption akin to an ecology. I am searching for an alternate relationship between phenomena, wonder and knowing.

Trees And Trees And Trees In Me, Areum Yang

Theses and Dissertations

Painting is a recording of my current psychology, and a window through which I can visualize my inner self. My painting won't make my anxiety go away, but it will allow me to work with my emotion and put it in a specific place, so it doesn't control my life.

Christ And American Culture- Some Biblical Reflections, Paul Raabe

Concordia Pages

Going beyond H. Richard Neibuhr’s famous paradox model on “Christ and Culture,” Dr. Paul Raabe contends for a biblical, dynamic tension that exists between the culture and the faith. Using the image of a house, Raabe explores four “rooms” : (1) Christianity affirms culture in some respects; (2) Christianity opposes culture in some respects; (3) Christianity leavens culture in some ways; and (4) Christianity uses cultural forms to communicate its message. Each of the four rooms needs to be lived in for maintaining the tension presented in the Scriptures as a faithful witness to the lordship of Christ.

Ph-Responsive Liposomes Of Dioleoyl Phosphatidylethanolamine And Cholesteryl Hemisuccinate For The Enhanced Anticancer Efficacy Of Cisplatin, Hassan Shah, Asadullah Madni, Muhammad Muzamil Khan, Fiaz-Ud-Din Ahmad, Nasrullah Jan, Safiullah Khan, Muhammad Abdur Rahim, Shahzeb Khan, Meser M. Ali, Mohsin Kazi

Neurosurgery Articles

The current study aimed to develop pH-responsive cisplatin-loaded liposomes (CDDP@PLs) via the thin film hydration method. Formulations with varied ratios of dioleoyl phosphatidylethanolamine (DOPE) to cholesteryl hemisuccinate (CHEMS) were investigated to obtain the optimal particle size, zeta potential, entrapment efficiency, in vitro release profile, and stability. The particle size of the CDDP@PLs was in the range of 153.2 ± 3.08-206.4 ± 2.26 nm, zeta potential was -17.8 ± 1.26 to -24.6 ± 1.72, and PDI displayed an acceptable size distribution. Transmission electron microscopy revealed a spherical shape with ~200 nm size. Fourier transform infrared spectroscopic analysis showed the physicochemical stability …

Chronic Background Radiation Correlates With Sperm Swimming Endurance In Bank Voles From Chernobyl, Kati Kivisaari, Sara Calhim, Zbyszek Boratyríski, Timothy Mousseau, Anders P. Møller, Tapio Mappes

Faculty Publications

Sperm quantity and quality are key features explaining intra- and interspecific variation in male reproductive success. Spermatogenesis is sensitive to ionizing radiation and laboratory studies investigating acute effects of ionizing radiation have indeed found negative effects of radiation on sperm quantity and quality. In nature, levels of natural background radiation vary dramatically, and chronic effects of low-level background radiation exposure on spermatogenesis are poorly understood. The Chernobyl region offers a unique research opportunity for investigating effects of chronic low-level ionizing radiation on reproductive properties of wild organisms. We captured male bank voles (Myodes glareolus) from 24 locations in the Chernobyl …

Plasma Induced Reactive Oxygen Species-Dependent Cytotoxicity In Glioblastoma 3d Tumourspheres, Janith Wanigasekara, Carlos Barcia, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin

Articles

The aim of this study was to determine the effects of a pin‐to‐plate cold atmospheric plasma (CAP) on U‐251 MG three‐dimensional (3D) glioblastoma spheroids under different conditions. 3D tumorspheres showed higher resistance to the CAP treatment compared to 2D monolayer cells. A single CAP treatment was able to induce cytotoxicity, while multiple CAP treatments augmented this effect. CAP was also able to induce cytotoxicity throughout the tumoursphere, and we identified that reactive oxygen species(ROS) plays a major role, while H2O2plays a partial role in CAP‐induced cytotoxicity in tumour-spheres. We conclude that ROS‐dependent cytotoxicity is induced uniformly throughout glioblastoma and epidermoid …

Upregulation Of Cd36, A Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis By Increasing Mmp28 And Decreasing E-Cadherin Expression, James Drury, Piotr G. Rychahou, Courtney O. Kelson, Mariah E. Geisen, Yuanyuan Wu, Daheng He, Chi Wang, Eun Y. Lee, B. Mark Evers, Yekaterina Y. Zaytseva

Surgery Faculty Publications

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis has not been studied. Here, we demonstrate that high expression of CD36 promotes invasion of CRC cells. Consistently, CD36 promoted lung metastasis in the tail vein model and GI metastasis in the cecum injection model. RNA-Seq analysis of CRC cells with altered expression of CD36 revealed an association between high expression of CD36 and upregulation …

Thrombospondin-1 Expression And Modulation Of Wnt And Hippo Signaling Pathways During The Early Phase Of Trypanosoma Cruzi Infection Of Heart Endothelial Cells, Ashutosh Arun, Kayla J. Rayford, Ayorinde Cooley, Tanu Rana, Girish Rachakonda, Fernando Villalta, Siddharth Pratap, Maria F. Lima, Nader Sheibani, Pius N. Nde

Publications and Research

The protozoan parasite, Trypanosoma cruzi, causes severe morbidity and mortality in afflicted individuals. Approximately 30% of T. cruzi infected individuals present with cardiac pathology. The invasive forms of the parasite are carried in the vascular system to infect other cells of the body. During transportation, the molecular mechanisms by which the parasite signals and interact with host endothelial cells (EC) especially heart endothelium is currently unknown. The parasite increases host thrombospondin-1 (TSP1) expression and activates the Wnt/β-catenin and hippo signaling pathways during the early phase of infection. The links between TSP1 and activation of the signaling pathways and …

Ranging Patterns And Site Fidelity Of Snubfin Dolphins In Yawuru Nagulagun/Roebuck Bay, Western Australia, Alexandra D’Cruz, Chandra Salgado Kent, Kelly Waples, Alexander M. Brown, Sarah A. Marley, Deborah Thiele, Holly C. Raudino, Yawuru Native Title Prescribed Body Corporate, Broome, Wa, Australia

Research outputs 2022 to 2026

For long-lived species such as marine mammals, having sufficient data on ranging patterns and space use in a timescale suitable for population management and conservation can be difficult. Yawuru Nagulagun/Roebuck Bay in the northwest of Western Australia supports one of the largest known populations of Australian snubfin dolphins (Orcaella heinsohni)—a species with a limited distribution, vulnerable conservation status, and high cultural value. Understanding the species’ use of this area will inform management for the long-term conservation of this species. We combined 11 years of data collected from a variety of sources between 2007 and 2020 to assess the ranging patterns …

Evaluating A Targeted Cancer Therapy Approach Mediated By Rna, Katharina Woess, Yuchen Sun, Hanae Morio, Anna Stierschneider, Anna Kaufmann, Stefan Hainzl, Lisa Trattner, Thomas Kocher, Birgit Tockner, Victoria Leb-Reichl, Markus Steiner, Gabriele Brachtl, Andrew P. South, Johann W Bauer, Julia Reichelt, Tomomi Furihata, Verena Wally, Ulrich Koller, Josefina Piñón Hofbauer, Christina Guttmann-Gruber

Department of Dermatology and Cutaneous Biology Faculty Papers

Conventional anti-cancer therapies based on chemo- and/or radiotherapy represent highly effective means to kill cancer cells but lack tumor specificity and, therefore, result in a wide range of iatrogenic effects. A promising approach to overcome this obstacle is spliceosome-mediated RNA trans-splicing (SMaRT), which can be leveraged to target tumor cells while leaving normal cells unharmed. Notably, a previously established RNA trans-splicing molecule (RTM44) showed efficacy and specificity in exchanging the coding sequence of a cancer target gene (Ct-SLCO1B3) with the suicide gene HSV1-thymidine kinase in a colorectal cancer model, thereby rendering tumor cells sensitive to the prodrug ganciclovir (GCV). In …

You Will Be Loved: A Mixtape, Ariana M. Rosales

Dissertations and Theses

The following mix-genre portfolio represents my work in literary translation, nonfiction, and fiction writing. These poems, essays, and stories explore the role of gender and sexuality in familial and interpersonal relationships in the social, historical, and political context of contemporary Bolivian and American cultures. The characters inhabiting this collection experience alienation while seeking belonging and meaningful connections in the face of an uncertain political future. These pieces explore themes such as marginalization of queer people, the subjugation and closeting of the indigenous in the face of mestizaje, and the colonial legacy shared by Bolivia and the United States.

Aav5 Delivery Of Crispr-Cas9 Supports Effective Genome Editing In Mouse Lung Airway, Shun-Qing Liang, Christopher J Walkey, Alexa E Martinez, Qin Su, Mary E Dickinson, Dan Wang, William R Lagor, Jason D Heaney, Guangping Gao, Wen Xue

Faculty, Staff and Students Publications

Genome editing in the lung has the potential to provide long-term expression of therapeutic protein to treat lung genetic diseases. Yet efficient delivery of CRISPR to the lung remains a challenge. The NIH Somatic Cell Genome Editing (SCGE) Consortium is developing safe and effective methods for genome editing in disease tissues. Methods developed by consortium members are independently validated by the SCGE small animal testing center to establish rigor and reproducibility. We have developed and validated a dual adeno-associated virus (AAV) CRISPR platform that supports effective editing of a lox-stop-lox-Tomato reporter in mouse lung airway. After intratracheal injection of the …

Map Based Www Tool For Recommending Forage Species, M. H. Hall, D. A. Miller, J. H. Cherney

IGC Proceedings (1977-2023)

Selecting the “best” forage species or species mixture requires a knowledge and understanding of the consuming animal, soil characteristics, and forage species. The multivariate nature of the problem presents challenges to those interested in solving the practical problem of maximizing available resources. Earlier work at Cornell University resulted in a WWW-based interface that allowed the user to provide a soil type or zip code and additional management factors to initiate the species selection. This approach relies on either user knowledge of soil series or an implied relationship between zip code and soil series that may often be wrong. To improve …

Remote Sensing Application To Grassland Monitoring, Z. B. Nan

IGC Proceedings (1977-2023)

Application of remote sensing to the management of grassland resources, the role this plays in developing sustainable grassland farming systems and opportunities for further development are outlined. Use of remote sensing technologies in grassland monitoring has a history of more than 30 years. Both fine- and coarse-grained remote sensing techniques are used to monitor and study grasslands. Fine-grained techniques are used to study landscape scale processes through the use of sensors providing spatial resolution of a few meters, whereas coarse-grained techniques are used to study catchment scale areas, and even entire biomes, using satellite-based sensors with a spatial resolution of …