Digital Commons Network^™

Fabrication And Characterization Of A Ph-Sensitive Intelligent Film Incorporating Dragon Fruit Skin Extract, Nurnabila Afiqah Azlim, Abdorreza Mohammadi Nafchi, Nazila Oladzadabbasabadi, Fazilah Ariffin, Pantea Ghalambor, Shima Jafarzadeh, A. A. Al-Hassan

Research outputs 2022 to 2026

A novel intelligent pH-sensing indicator based on gelatin film and anthocyanin extracted from dragon fruit skin (Hylocereus polyrhizus) (DFSE) as a natural dye was developed to monitor food freshness by the casting method. Anthocyanin content of DFSE was 15.66 ± 1.59 mg/L. Dragon fruit bovine gelatin films were characterized by Fourier transform infrared spectroscopy (FTIR) and observed by a scanning electron microscope (SEM). Moisture content, mechanical properties, water solubility, water vapor permeability (WVP), light transmittance, color, and pH-sensing evaluations were evaluated for potential application. FTIR spectroscopy revealed that the extracted anthocyanin could interact with the other film components through hydrogen …

Policing The Global Countryside: Toward A Research Agenda, Richard Yarwood

School of Geography, Earth and Environmental Sciences

No abstract provided.

P300 Or Cbp Is Required For Insulin-Stimulated Glucose Uptake In Skeletal Muscle And Adipocytes, Vitor F. Martins, Gretchen A. Meyer, Et Al.

2020-Current year OA Pubs

While current thinking posits that insulin signaling to glucose transporter 4 (GLUT4) exocytic translocation and glucose uptake in skeletal muscle and adipocytes is controlled by phosphorylation-based signaling, many proteins in this pathway are acetylated on lysine residues. However, the importance of acetylation and lysine acetyltransferases to insulin-stimulated glucose uptake is incompletely defined. Here, we demonstrate that combined loss of the acetyltransferases E1A binding protein p300 (p300) and cAMP response element binding protein binding protein (CBP) in mouse skeletal muscle caused a complete loss of insulin-stimulated glucose uptake. Similarly, brief (i.e., 1 hour) pharmacological inhibition of p300/CBP acetyltransferase activity recapitulated this …

Mapk4 Promotes Triple Negative Breast Cancer Growth And Reduces Tumor Sensitivity To Pi3k Blockade, Wei Wang, Dong Han, Qinbo Cai, Tao Shen, Bingning Dong, Michael T Lewis, Runsheng Wang, Yanling Meng, Wolong Zhou, Ping Yi, Chad J Creighton, David D Moore, Feng Yang

Faculty, Staff and Students Publications

About 15-20% of breast cancer (BCa) is triple-negative BCa (TNBC), a devastating disease with limited therapeutic options. Aberrations in the PI3K/PTEN signaling pathway are common in TNBC. However, the therapeutic impact of PI3K inhibitors in TNBC has been limited and the mechanism(s) underlying this lack of efficacy remain elusive. Here, we demonstrate that a large subset of TNBC expresses significant levels of MAPK4, and this expression is critical for driving AKT activation independent of PI3K and promoting TNBC cell and xenograft growth. The ability of MAPK4 to bypass PI3K for AKT activation potentially provides a direct mechanism regulating tumor sensitivity …

The Role Of Endoplasmic Reticulum Modifications In Protein Export In Plasmodium Falciparum, Alexander Polino

Arts & Sciences Graduate Student Theses and Dissertations

Following invasion of a host red blood cell (RBC), the malaria parasite Plasmodium falciparum undertakes a program of dramatic host cell renovation. The parasite exports hundreds of effectors into the RBC, altering its shape and rigidity, increasing its permeability to nutrients, and constituting an intracellular transport network that traffics adhesins to the RBC surface. These adhesins mediate binding of the parasitized RBC to the host vascular endothelium, allowing the parasite to avoid destruction in the spleen, but contributing to the pathogenesis of cerebral malaria. Most of these exported effectors bear a pentameric amino acid sequence that marks them for protein …

Pilgering Researchers Or Researching Pilgrims: Experiences From Four Student Projects On The Camino De Santiago 2016-2019, Andreas Braun

International Journal of Religious Tourism and Pilgrimage

Between 2016 and 2019, I accompanied four student groups on the Camino de Santiago - however the planned 2020 project was cancelled due to the coronavirus epidemic. In this article, I describe the project, its planning, its implementation, and its conclusion, as well as some experiences and impressions of the participating students on the basis of an ethnographical approach. The projects presented have two objectives: on the one hand, to teach the students qualitative and quantitative research methods in a delimited, protected environment, and on the other hand, to introduce the students to the fascination of pilgrimage and the Camino …

Non-Dual Experiences For The Dual Pilgrim: From The Spanish Way Of Saint James To The Japanese Kumano Kodo, Fernando Echarri

International Journal of Religious Tourism and Pilgrimage

The twinning of Sacred Paths is a new experience because of the possible synergy it creates. This article studies the twinning of the Way of Saint James in Spain with the Japanese Kumano Kodo. This twinning unites the pilgrimages, unites spirituality, unites nature, unites creation, unites culture, but in totally different contexts. From Western Christian culture we pass to Eastern Buddhist-Shintoist culture. The pilgrim acquires significant life experiences, Non-Dual experiences on both routes and is transformed, and thus accredited, as a dual pilgrim. Different spheres of the person will be affected: the perceptual sphere, emotional sphere, cognitive sphere, social, relational, …

The Need To Improve Social Competences In Future Teachers, Saodat Abdurashidovna Toshtemirova

Mental Enlightenment Scientific-Methodological Journal

This article focuses on the content, purpose of social competence and the need to improve it in future teachers. The ideas on social competence, the analysis of the literature are presented and the principles of development of social competence in future teachers are defined. The requirements for the professional activity of future teachers are indicated, in particular, the purpose, necessity, importance, development factors and the results of the formation of social competences for the teacher are listed.

Semantic Specificity Of The Proverbs Belonging To The Thematic Group “Language” In The Uzbek Language, Nurbek Djumanazarovich Juraev

Mental Enlightenment Scientific-Methodological Journal

In modern world linguistics, the semantic maturity of our Uzbek proverbs, which have passed down from century to century, recognized as a unique gem of our folklore. They contain dozens of semantic aspects of a word, all the examples of artistic means, poetic movements. Over the years, it has used regularly in live speech and interpersonal communication, as well as in artistic, historical, and scientific works. In the following article, the semantic specificity of the proverbs belonging to the thematic group “language” in the Uzbek language studied by the author and provided relevant examples.

The Matters Of Translating The Figurative Language Devices Used By Alisher Navoi In Description Of Word, Language And Speech Ethics, Sevara Nematovna Fazildinova

Mental Enlightenment Scientific-Methodological Journal

The current article represents the analysis of figurative language usage including literary devices simile, metaphor, and hyperbole in description of the word, language and speech ethics in the works of great poet Alisher Navoi. The principle objective of this research work is to analyze the degree of translation of literary devices and comparing the lingua stylistic peculiarities of the source and target language. Moreover, we have looked at some literary devices that reflect the linguistic and cultural characteristics in the original text and present the greatest difficulty in translation. The solution of translation problems of lingua-cultural nature is provided by …

Physics Learning For Non-Physical Specialists In High School System, Utkir Mirzaqobilovich Farmonov, Nizom Abdurazzakovich Taylanov

Mental Enlightenment Scientific-Methodological Journal

This article is devoted to the learning process of physics for non-physics specialists in high schools. When training specialists studying in the relevant specialties of higher professional education, the university has the right to use the specified structure, content and procedure for implementing a cycle of general mathematical and natural science disciplines, changing the depth of elaboration of individual sections of the programs. This can lead to a redistribution of educational material between lectures, seminars and laboratory workers, a change in their nature and focus

Innovative Methods Of Teaching Music At The Institution Of Additional Education (On The Example Of Children’S Music School), Navbakhor Khamraqulovna Khasanova

Mental Enlightenment Scientific-Methodological Journal

In the article the author considers the methods of teaching music in a children's music school in detail. In the course of the work, the author turned to the characterization of the concept of "method" in didactics. Research provides a variety of activities of teachers and students that leads didactics to different interpretations of this concept, thus on this basis, prompts them to distinguish a different number of teaching methods, to give them the appropriate terminology. The author agrees with the opinion of most authors, according to which a teaching method is a way of organizing educational and cognitive activities. …

Features Of Non-Traditional Forms Of The Lesson, Abduaziz Abdujabborovich Baymаtov, Aliboy Qo’Ziboyevich Berdiyev

Mental Enlightenment Scientific-Methodological Journal

Today, more and more attention is paid to a person as a person - his consciousness, spirituality, culture, morality, as well as a highly developed intellect and intellectual potential.Accordingly, there is no doubt about the extreme importance, the urgent need for such training of the younger generation, in which educated intellectual individuals with knowledge of the basics of science, general culture, the ability to think independently and flexibly, proactively, creatively solve life and professional issues would graduate from high school. During the lessons and classes we should focus on each person and take into consideration their interest too. Being aware …

Issue 385: January 10-27, 2022, The Local Voice

The Local Voice

Local Favorites Awards Results

Hope In Jesus, Anna Bennett

The Main Thing Devotional

"But now, O Jacob, [personalize it by adding in your name _____] listen to the Lord who created you. O Israel [your name____], the one who formed you says, “Do not be afraid, for I have ransomed you. I have called you by name; you are mine. When you go through deep waters, I will be with you. When you go through rivers of difficulty, you will not drown. When you walk through the fire of oppression, you will not be burned up, the flames will not consume you. For …

Introduction To Epigenetics, Yevgeniy Grigoryev

Open Educational Resources

Syllabus for Bio481 Introduction to Epigenetics

Transcranial Direct Current Stimulation On Parkinson’S Disease: Systematic Review And Meta-Analysis, Paloma Cristina Alves De Oliveira, Thiago Anderson Brito De Araújo, Daniel Gomes Da Silva Machado, Abner Cardoso Rodrigues, Marom Bikson, Suellen Marinho Andrade, Alexandre Hideki Okano, Hougelle Simplicio, Rodrigo Pegado, Edgard Morya

Publications and Research

Background: Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson’s disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD.

Objective: Investigate isolated tDCS effect in different brain areas and number of stimulated targets on PD motor symptoms.

Methods: A systematic review was carried out up to February 2021, in databases: Cochrane Library, EMBASE, PubMed/MEDLINE, Scopus, and Web of science. Full text articles evaluating effect of active tDCS (anodic or cathodic) vs. sham or control on motor symptoms of PD were …

Investigating The Effects Of Climate Change On The Phenology Of Achillea Millefolium, Aquilegia Coerulea, And Penstemon Cyanocaulis, Hannah O’Toole, Kailey Hicks, Lisa Long, Jackson Garske, Anna Sher

DU Undergraduate Research Journal Archive

As the effects of climate change are starting to unearth themselves, the impacts can be observed by tracking the patterns of cyclical natural phenomena also known as phenology, and monitoring how they have changed over time. These cycles are at the crux of making ecosystems viable for their local biodiversity, and understanding the ongoing change allows for further understanding of the ecosystem’s change over time. In this study, we look at the ordinal flowering dates of the Achillea millefolium, Aquilegia coerulea, and Penstemon cyanocaulis over the past century. Our data give insight into how warmer temperatures occurring earlier in …

Promoting Democracy And Penance: The United States, Western Europe, And German Memory Of The Holocaust, Mathew Greenlee, Elizabeth Campbell

DU Undergraduate Research Journal Archive

This research, using the writings of German and international intellectuals, journalists, and politicians, explores the late-twentieth-century German memory of the Holocaust and demonstrates the ways it was influenced by the international community. The path of this development was rocky and uncertain, with historical revisionism, denialism, and unchallenged taboo, but also sincere historical engagement. Reflecting a broader trend in the field of history, this work emphasizes the influence of the transnational in cultural shifts; rather than depict the German collective memory as static, or solely domestic, it seeks to demonstrate the influence of international actors, beliefs, and ideas at major inflection …

Land Use Conflicts Between Wind And Solar Renewable Energy And Agriculture Uses, Peggy Kirk Hall, Whitney Morgan, Jesse Richardson

Law Faculty Scholarship

No abstract provided.

Crow's Nest, January 10, 2022, Crow's Nest Staff

Crow's Nest

The January 10, 2022, issue of the Crow's Nest.

The Allergy Mediator Histamine Confers Resistance To Immunotherapy In Cancer Patients Via Activation Of The Macrophage Histamine Receptor H1, Hongzhong Li, Yi Xiao, Qin Li, Jun Yao, Xiangliang Yuan, Yuan Zhang, Xuedong Yin, Yohei Saito, Huihui Fan, Ping Li, Wen-Ling Kuo, Angela Halpin, Don L Gibbons, Hideo Yagita, Zhongming Zhao, Da Pang, Guosheng Ren, Cassian Yee, J Jack Lee, Dihua Yu

Faculty, Staff and Student Publications

Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective analyses revealed that cancer patients who took antihistamines during immunotherapy treatment had significantly improved survival. We uncovered that histamine and histamine receptor H1 (HRH1) are frequently increased in the tumor microenvironment and induce T cell dysfunction. Mechanistically, HRH1-activated macrophages polarize toward an M2-like immunosuppressive phenotype with increased expression of the immune checkpoint VISTA, rendering T cells dysfunctional. HRH1 knockout or antihistamine treatment reverted macrophage immunosuppression, revitalized T cell cytotoxic function, and restored immunotherapy response. Allergy, via the histamine-HRH1 axis, facilitated tumor growth and induced immunotherapy resistance in mice and humans. …

Artificial Intelligence Framework Identifies Candidate Targets For Drug Repurposing In Alzheimer’S Disease, Jiansong Fang, Pengyue Zhang, Quan Wang, Chien Wei Chiang, Yadi Zhou, Yuan Hou, Jielin Xu, Rui Chen, Bin Zhang, Stephen J. Lewis, James B. Leverenz, Andrew A. Pieper, Bingshan Li, Lang Li, Jeffrey Cummings, Feixiong Cheng

Brain Health Faculty Research

Background: Genome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer’s disease (AD). However, utilizing GWAS and multi-omics data to identify high-confidence AD risk genes (ARGs) and druggable targets that can guide development of new therapeutics for patients suffering from AD has heretofore not been successful. Methods: To address this critical problem in the field, we have developed a network-based artificial intelligence framework that is capable of integrating multi-omics data along with human protein–protein interactome networks to accurately infer accurate drug targets impacted by GWAS-identified variants to identify new therapeutics. When applied to AD, this approach integrates GWAS findings, …

Obesity And The Development Of Lung Fibrosis, Xia Guo, Christudas Sunil, Guoqing Qian

Cellular and Molecular Biology Faculty Publications and Presentations

Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory complications including fibrotic changes in the lung. The influence of obesity on the lung is multifactorial, which is related to both mechanical injury and various inflammatory mediators produced by excessive adipose tissues, and infiltrated immune cells. Adiposity causes increased production of inflammatory mediators, for example, cytokines, chemokines, and adipokines, both locally and in the systemic circulation, thereby rendering susceptibility to respiratory diseases, and altered responses. Lung fibrosis is closely related to chronic inflammation in the lung. Current data suggest a link between lung fibrosis and …

Women Of Power: Mapping The Spiritual Journeys Of Caribbean Women Across Regional Fiction As Portrayed In The Book Of Night Women, Texaco, And Erzulie's Skirt, Natalie Sandy D'Auvergne-Lamotte

LSU Doctoral Dissertations

Contemporary Caribbean fiction serves as an active agent for refining and expanding definitions of Caribbeanness. This study aims at demonstrating how Caribbean writers use representations of Caribbean women to contribute to an opaquer regional vision that argues against homogenizing ideas of Caribbeanness. The Book of Night Women, Texaco, and Erzulie’s Skirt, respectively written by Marlon James (Jamaica), Patrick Chamoiseau (Martinique), and Anna-Maurine Lara (Dominican Republic), work by making space for more historically accurate and locally representative images of Caribbeanness through the Caribbean women they portray. Though characters live on different islands (at different times), they still manage to represent …

Fabc Theology Of The Laity And Its Relevance For Forming Leaders In Asia’S Local Churches, Charles Bertille

Loyola Papers

This paper examines the Federation of Asian Bishops’ Conferences (FABC)’s Theology of the Laity and its relevance for forming leaders in the local Churches of Asia. Grounded in the ecclesiology of the People of God articulated by Second Vatican Council, the study highlights the dignity, charisms, and co-responsibility of the baptized in the Church’s mission. It analyzes how the Institute of Formation–Fondacio (IFF) Asia’s basic formation program embodies the FABC vision of a “new way of being Church” through holistic, communitarian, and missionary formation. The paper argues that empowering the laity through contextual formation fosters discipleship, leadership, and active participation …

The Fabc Vision Of Inculturation And The Pedagogical Renewal Of Catechesis In The Philippines, William M. Parde Jr.

Loyola Papers

Advocating the crafting of inculturated catechisms, this paper calls for a pedagogy of faith built not from the desks of catechetical authorities but from the ground. In this pedagogical renewal, necessitated by changing times and circumstances, the paper finds a rallying point and guiding principle in the FABC’s call for inculturation understood as “dialogue.” At the same time, it identifies a number of ongoing challenges that hinder this process, including notions and methodologies of inculturation that can be unilateral and amount to a kind of imposition on the receiving culture, which possesses its own customs and practices. The paper then …

Fabc@50: Renewing The Clergy Of Asia, Mylo Hubert C. Vergara

Loyola Papers

In this paper, the author shares his experiences of working with and for the Federation of Asian Bishops’ Conferences in this important area, thus giving us a picture of how an FABC office operates. The seminars organized and papers produced reveal how the FABC-OC has been true to its mission to renew and empower the clergy in the Asian context to deal with the contemporary challenges in their priestly life and ministry. The paper also identifies a number of vital prospects that the FABC-OC is currently aiming at towards the renewal of the clergy in Asia, as well as to …

The Fabc Vision Of Youth As Evangelizers In Asia, Particularly In The Archdiocese Of Goa, India, Antonetta Pereira

Loyola Papers

This study examines the vision of youth as evangelizers in Asia as articulated by the Federation of Asian Bishops’ Conferences (FABC), with particular reference to the pastoral context of the Church in Goa. Grounded in the theological themes of communio ecclesiology, evangelization, and missional participation, the paper argues that young people should be recognized not merely as recipients of pastoral care but as active agents of the Church’s missionary mission. Considering the social and cultural realities affecting Asian youth, the study highlights the importance of accompaniment, formation in mission, and a relevant spirituality. It proposes practical pastoral directions to empower …

On Education Today: A Thought Experiment, Angelo B. Balsita

Loyola Papers

No abstract provided.