Digital Commons Network^™

Reassessing The Role Of Anthropogenic Climate Change In The Extinction Of Silphium, Paul Pollaro, Paul Robertson

Faculty Publications

The famed ancient herb, known to the Romans as silphium (Greeksilphion), is widely regarded as the first recorded instance of human-induced species extinction. Modern scholars have largely credited direct exploitation (e.g., over-harvesting; over-grazing) as the primary cause of silphium's extinction, due to an overwhelming demand for the plant in ancient times. Recent research has revealed strict cold-stratification requirements for the germination of silphium's closest living relatives, revealing the likelihood that silphium shared these same germination requirements. Documented environmental changes in ancient Cyrenaica (e.g., widespread deforestation; cropland expansion) likely resulted in accelerated rates of desertification throughout the region as well as …

Future Of Winter In Northeastern North America: Climate Indicators Portray Warming And Snow Loss That Will Impact Ecosystems And Communities, Elizabeth Burakowski, Alix Contosta, Danielle Grogan, Sarah Nelson, Sarah Garlick, Nora Casson

Faculty Publications

Winters in northeastern North America have warmed faster than summers, with impacts on ecosystems and society. Global climate models (GCMs) indicate that winters will continue to warm and lose snow in the future, but uncertainty remains regarding the magnitude of warming. Here, we project future trends in winter indicators under lower and higher climate-warming scenarios based on emission levels across northeastern North America at a fine spatial scale (1/16°) relevant to climate-related decision making. Under both climate scenarios, winters continue to warm with coincident increases in days above freezing, decreases in days with snow cover, and fewer nights below freezing. …

Autism To Higher Education: Tools For Parents, Amber L. Jordan, Shannon Emery

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Over the years, a marked increase in the number of students with High Functioning Autism (HFA) attending colleges and universities has occurred. This can be attributed to: (a) the passage of legislation such as the Individuals with Disabilities Act (IDEA) and the Americans with Disabilities Act of 1990 (ADA); (b) revisions to the Diagnostic and Statistical Manual (DSM); and (c) early intervention and treatment (Pillay, 2012). Although the increase in enrollment may be an indicator that a more welcoming climate for individuals with HFA has been created, many institutions are not adequately prepared to accommodate these students and parents have …

An Empirical Study On The Efficacy Of Evolutionary Algorithms For Automated Neural Architecture Search, Andrew D. Cuccinello

Theses and Dissertations

The configuration and architecture design of neural networks is a time consuming process that has been shown to provide significant training speed and prediction improvements. Traditionally, this process is done manually, but this requires a large amount of expert knowledge and significant investment of labor. As a result it is beneficial to have automated ways to optimize model architectures. In this thesis, we study the use of evolutionary algorithm for neural architecture search (NAS). Moreover, we investigate the effect of integrating evolutionary NAS into deep reinforcement learning to learn control policy for ATARI game playing. Empirical classification results on the …

Selective Small Molecule Targeting Of Mcl-1 In Multiple Myeloma, Omar S. Al Odat

Theses and Dissertations

Multiple Myeloma (MM) is a deadly blood malignancy, characterized by the uncontrolled proliferation of aberrantly differentiated plasma cells. MM is challenging to diagnose and treat, accounting for approximately 12% of hematologic malignancies. The overexpression of anti-apoptotic group of Bcl-2 family proteins, particularly Myeloid cell leukemia 1 (Mcl-1), play a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis. Thus, inhibition of the Mcl-1 protein is an attractive therapeutic strategy against myeloma cells. Over the last decade, the development of selective Mcl-1 inhibitors has seen remarkable advancement. In this project, …

Fibrogenesis And Adipogenesis In Farm Animals And Rodents, Chaoyang Li

LSU Doctoral Dissertations

In this dissertation, we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on different animal models to help the discovery of new treatments in cardiovascular disease, beef breeding strategies, and feed nutrition modifications.

Wayu, the Japanese Black cow, are well-known for their high IMF content, while the Brahman cattle have much less marbling. The development of IMF correlated with the increase in the size and number of IMF adipocytes, which have identified to be derived from a group of progenitor cells known as fibro/adipogenic progenitor (FAP) cells because of their bipotent differentiation ability. Interestingly, the …

Decision Making In International Supply Chain Investment, Noah Quint Curtin

Undergraduate Theses, Capstones, and Recitals

In this paper, supply chain decision-makers where and how to internationally invest into supply chains. I focus on outside institutional factors, and intra-firm behavioral factors that affect where and how they invest. I first review the literature on international investment at large. Later for my part of the research, I conduct a series of semi-structured interviews with international supply chain decision-maker primarily in Denver to better understand their processes. I find that they value business models higher than “hunches”, but also that tacit knowledge and relationships play an important role in their processes.

Cultural Sensitivity: A Requirement When Developing Food Safety Interventions, Lillian Nabwiire, Angela M. Shaw, Gail R. Nonnecke, David D. Minner, Ellen Johnsen, Louis E. Petersen Jr

Journal of Extension

Extension materials that are sensitive to changing demographics and culture increase relevance and compliance with food safety practices. Produce safety extension materials were developed for U.S. Virgin Islands (USVI) produce growers to help with compliance with a new food safety rule. We developed employee training materials based on a needs assessment and behavioral change was evaluated six months after dissemination. The original materials were not seen as culturally appropriate but after modifications, improvements in food safety practices and behavior changes were observed. These results suggest that extension educators should seek feedback from target populations about potential interventions before implementation.

Langerhans Cells And Cdc1s Play Redundant Roles In Mrna-Lnp Induced Protective Anti-Influenza And Anti-Sars-Cov-2 Immune Responses, Sonia Ndeupen, Aurélie Bouteau, Christopher Herbst, Zhen Qin, Sonya Jacobsen, Nicholas E Powers, Zachary Hutchins, Drishya Kurup, Leila Zabihi Diba, Megan Watson, Holly Ramage, Botond Z. Igyártó

Department of Microbiology and Immunology Faculty Papers

Nucleoside modified mRNA combined with Acuitas Therapeutics' lipid nanoparticles (LNPs) has been shown to support robust humoral immune responses in many preclinical animal vaccine studies and later in humans with the SARS-CoV-2 vaccination. We recently showed that this platform is highly inflammatory due to the LNPs' ionizable lipid component. The inflammatory property is key to support the development of potent humoral immune responses. However, the mechanism by which this platform drives T follicular helper (Tfh) cells and humoral immune responses remains unknown. Here we show that lack of Langerhans cells or cDC1s neither significantly affected the induction of PR8 HA …

Neutralizing Interleukin-6 In Tumor-Bearing Mice Does Not Abrogate Behavioral Fatigue Induced By Lewis Lung Carcinoma, Kiersten Scott, Thien Trong Phan, A Phillip West, Cullen M Taniguchi, Robert Dantzer

Faculty, Staff and Student Publications

Tumor growth is associated with metabolic reprogramming of various organs including the liver. This metabolic reprogramming is responsible for the development of behavioral fatigue represented by decreased voluntary wheel running in a murine model of lung cancer. To determine whether interleukin (IL-)6 induced by the tumor is responsible for the metabolic reprogramming, mice injected with Lewis lung carcinoma cells in the flank were treated with an anti-mouse IL-6 monoclonal neutralizing antibody using a 2 × 2 factorial design (+/- tumor and +/- anti-IL-6 antibody). Endpoints were represented by behavioral, metabolic and immune phenotypes. Despite its ability to abrogate the increase …

Bicyclic Azetidines Target Acute And Chronic Stages Of Toxoplasma Gondii By Inhibiting Parasite Phenylalanyl T-Rna Synthetase, Joshua B Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L Schreiber, Anil K Gupta, Arnab K Chatterjee, L David Sibley

Open Access Publications

Toxoplasma gondii commonly infects humans and while most infections are controlled by the immune response, currently approved drugs are not capable of clearing chronic infection in humans. Hence, approximately one third of the world's human population is at risk of reactivation, potentially leading to severe sequelae. To identify new candidates for treating chronic infection, we investigated a series of compounds derived from diversity-oriented synthesis. Bicyclic azetidines are potent low nanomolar inhibitors of phenylalanine tRNA synthetase (PheRS) in T. gondii, with excellent selectivity. Biochemical and genetic studies validate PheRS as the primary target of bicyclic azetidines in T. gondii, providing a …

Neuronal Population Activity Dynamics Reveal A Low-Dimensional Signature Of Operant Learning In Aplysia, Renan M Costa, Douglas A Baxter, John H Byrne

Faculty, Staff and Student Publications

Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal shift in module recruitment as the primary signature of operant learning. Our findings can help guide characterization of learning signatures in systems in which only a smaller fraction of the relevant neuronal population …

2022-01-24 Message From The Provost, Morehead State University. Office Of The Provost.

Staff Congress Records

An announcement sent by the Provost of Morehead State University to faculty and staff regarding upcoming events, activities and news from January 24, 2022.

Macromolecular Composition And Substrate Range Of Three Marine Fungi Across Major Cell Types, Seth Thomas, Sabine K. Lengger, Kimberley E. Bird, Ro Allen, Michael Cunliffe

School of Biological and Marine Sciences

Abstract Marine fungi exist as three major cell types: unicellular yeasts, filamentous hyphae and zoosporic early-diverging forms, such as the Chytridiomycota (chytrids). To begin to understand the ecological and biogeochemical influence of these cell types within the wider context of other plankton groups, cell size and macromolecular composition must be assessed across all three cell types. Using a mass–balance approach to culture, we describe quantitative differences in substrate uptake and subsequent macromolecular distribution in three model marine fungi: the yeast Metschnikowia zobellii, the filamentous Epicoccum nigrum and chytrid Rhizophydium littoreum. We compared these model cell types with select oleaginous phytoplankton …

Drug Resistance In The Canine Filarial Parasite, Dirofilaria Immitis: Emergence And Clinical Epidemiology In The Lower Mississippi River Alluvial Valley, Cassan Nicole Pulaski

LSU Doctoral Dissertations

Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 in the Lower Mississippi Delta region. If proven, and not controlled in the early stages, the emergence of ML drug resistance threatens to become a widespread problem in the US that may limit the effectiveness of current preventive drug treatment methods. To validate practice reports, a statewide survey of Louisiana veterinarians was done to define the extent of the problem and identify focal ‘hotspots’ of reported ML LOEs using Geographic Information Systems (GIS) …

Farmers’ Perceptions On Different Forage Types In Southern Highlands Of Tanzania, B. Nzogela, S. W. Mwendia, A. J. Mwilawa, J. Kizima, J. Bwire, A. O. Notenbaert

IGC Proceedings (1977-2023)

Feed and forages take the bulk of inputs required in livestock production. Inadequate forages in quality and quantity in sub-Saharan Africa is responsible for low livestock productivity. Addressing livestock feed requirements presents quick wins in livestock productivity compared to breeding and health. In a Climate Smart Dairy project implemented in Tanzania, we demontrated several forage options to farmers including, two cultivars of Pennisetum purpureum, two Urochloa hybrids, Chrloris gayana and Tripsacum andersonii (control). Where applicable, the grasses were intercropped with either one of the following forage legume, Desmodium intortum, Lablab purpureus or Stylosanthes guiyanensis. Fourteen forage treaments …

Examining The Impact Of Patch Burning On Livestock Grazing Patterns In Edwards Plateau, Texas, W. G. Gao, J. P. A. Angerer, X. B. W. Wu, D. T. Tolleson

IGC Proceedings (1977-2023)

Production of sheep, goat, and cattle are major agricultural enterprises on West Texas rangelands, especially in the Edwards Plateau. In this region, the use of fire as a management tool was suppressed until recently. Although previous studies have been conducted to evaluate cattle use of burned versus unburned patches, there has been a lack of studies where combinations of livestock species grazing together on patch burned areas have been evaluated. The objective of this study is to examine grazing patterns of cattle, sheep and goats, both spatially and temporally, on areas where patch burning has been implemented. The study site …

Evaluation Of Morphogenesis And Yield Of Three Pennisetum Purpureum Varieties In South-West, Nigeria, Victoria O. A. Ojo, T. A. Adeyemi, D. K. Oyaniran, G. A. Akinade, Olufemi S. Onifade

IGC Proceedings (1977-2023)

This experiment, conducted at the Federal University of Agriculture, Abeokuta, Nigeria evaluated the morphogenesis of three varieties of Pennisetum purpureum used in this study, which were the local, purple, and FI variety at different stages of growth. The plants were established through vegetative plant parts (stems) sourced from a previously established plot and planted using 1 m × 1 m spacing on plots measuring 4 m × 5 m. The plants were fertilized with split doses of poultry manure at 4 t/ha (equivalent to 120 kg N/ha). The experiment was laid out as a Randomized Complete Block Design. Data on …

Effects Of Stages Of Growth On Dry Matter Yield And Nutrient Composition Of Red Clover In The Year Of Establishment In Jos, Plateau State, Nigeria, T. T. Akpensuen, J. T. Amodu, O. A. T. Namo, R. J. Tanko

IGC Proceedings (1977-2023)

An experiment was conducted in Jos, Nigeria to evaluate the effects of stages of growth on dry matter yield and nutrient composition of Red clover (Trifolium pratense var. AberClaret) in the year of establishment. The treatments were five (5) stages of growth (5, 9, 13, 17 and 21) weeks after sowing (WAS). The five stages of growth were replicated five times in a Latin Square Design. The land was divided into twenty five plots of 3 m X 3 m each. The spacing between each plot was 1m along the rows and columns. Growth components and DM yield were …

Comparison Of Lateral Flow To Other Pregnancy Determination Methods In Order To Determine Accuracy Of Pregnancy Status In Beef Cattle Pre And Postpartum, Adalaide C. Kline, Julie Walker, Taylor N. Andrews, Saulo Menegatti Zoca, Kaitlin M. Epperson, Lacey K. Quail, Jaclyn N. Ketchum, Jerica J.J. Rich, Jim R. Rhoades, George Perry

SDSU Beef Day 2022 Summary Publication

Study Description:

Blood samples were collected from six different Bos taurus herds between day 27 and 285 of gestation (heifers n = 1,205 and cows n = 1,539). Blood samples to determine PAG clearance interval were collected weekly postpartum for up to 12 weeks (heifers n = 418 and cows n = 657). Serum was tested using the lateral flow test and were read by two technicians who were blind to pregnancy status. Level of agreement between the tests were determined by Pearson’s correlation coefficients and Kappa scores. The MIXED procedure of SAS was used to evaluate the effect of …

Effects Of Maturity And Drying Method On The Nutritive Value Of Tropical Grasses In Nicaragua, Rocky Lemus, R. Van Der Hoek, Y. C. Newman, M. Mena, K. A. Albrecht

IGC Proceedings (1977-2023)

Tropical grasses are key components for both grazing and conserved forages in sustainable livestock systems (beef and dairy) in Central America. The objective of the study was to evaluate grasses used in Nicaragua and their nutritive value contribution as preserved forage during the dry season under different drying methods. Five tropical bunch grasses (Andropogon gayanus, Hyparrheniarufa, Urochloabrizantha, Megathyrsus maximus, and Cenchruspurpureus) were sampled across different farms in Nicaragua in 2014 and 2015 using three replications. Forage samples were collected at 2, 4, 6, and 8-wk maturity as well as season long samples. Samples drying …

State And Transition Models In Space And Time – Using Stms To Understand Broad Patterns Of Ecosystem Change In Iceland, I. C. Barrio, D. S. Hik, T. A. Mulloy, J. Thorsson, K. Svavarsdóttir, B. Marteinsdóttir, I. S. Jónsdóttir

IGC Proceedings (1977-2023)

Managing ecological systems sustainably requires a deep understanding of ecosystem structure and the processes driving their dynamics. Conceptual models can lead to improved management, by providing a framework for organizing knowledge about a system and identifying the causal agents of change. We developed state-and-transition models (STMs) to describe landscape changes in Iceland over three historical periods with different human influence, from pre-settlement to present days. Our models identified the set of possible states, transitions and thresholds in these ecosystems and their changes over time. To illustrate the use of these models for predicting and improving management interventions, we applied our …

Soil Water Movement In A Watershed In The Chilean Patagonia, J. Ivelic-Sáez, P. Cisternas, J. Dörner, J. Arumí, J. Valenzuela, E. Muñoz, S. Valle, H. Alonso, R. López, H. Uribe

IGC Proceedings (1977-2023)

Magallanes region, located southern Chile, contains about 1.9 million sheep heads, in about 5 million hectares of rangelands. However, forage production is concentrated in small wetlands meadows called locally “Vegas” that only represent about 300.000 hectares. Those ecosystems that sustain patagonian ranches, produce 20 times more forage biomass than the surrounding natural rangelands. Patagonian vegas have concave topography with a hydrophyte (wet) center, and mesic slopes and xeric highlands of Festuca gracillima. Although the moisture content is controled by topography, there is scarce information about the movement of water through this concave topography. Also, the spatial variability of the …

Information For The Common Good In Mass Torts, Elizabeth Chamblee Burch, Alexandra D. Lahav

DePaul Law Review

No abstract provided.

Mdl Nationalism, Federalism, And The Opioid Epidemic, Abbe R. Gluck

DePaul Law Review

No abstract provided.

Effects Of Banana Peels On Chicken Weight Gain And Egg Production In The Urban And Peri-Urban Areas Of Aksum City, Ethiopia, H. G. Araya, S. G. Gebrekristos, W. V. Oliver

IGC Proceedings (1977-2023)

High feed cost of running urban-animal-agriculture and huge city wastes are challenges of the growing towns in modern Ethiopia. Egg production microenterprise is steadily growing due to its low initial investment and ready market in urban and peri-urban areas. However, cost of egg production is high due to the rising cost of corn, the main feed ingredient in poultry rations. Using banana peels, which forms a great proportion of city waste in Ethiopia, is seen as a way of not only reducing the waste, but also as an alternative low-cost feed supplement that could help enhance egg production by small-holder …

Sheep Grazing Patterns For Better Land Management: Adjusting Gps Tracking Protocol, J. Castro, L. M. Godoy, J. P. Castro, M. Castro

IGC Proceedings (1977-2023)

Small ruminant livestock systems in northeast Portugal are an extensive activity based on daily grazing paths across the landscape. The flocks use multiple patches of multiple land cover types in different ways throughout the year. Shepherd and flock interactions determine the resting and feeding spots utilized by sheep and goats according to the biotic and abiotic conditions. Information about the herding home range is central to managing the land use and vegetation cover and optimizing sheep and goats' productivity in traditional systems. This study's main objective is to contribute to calibrate a shepherding GPS protocol to monitor sheep flocks based …

Restoring Rangelands For Nutrition And Health For Humans And Livestock, I. Öborn, A. Bargués Tobella, G. Bostedt, A. Hörnell, P. Knutsson, K. Lindvall, D. Mpairwe, S. Mureithi, G. Nyberg, Y. Nyberg, B. Schumann, A. Turinawe, T. Vågen, D. Wakjira, L. Winowiecki, E. Wredle

IGC Proceedings (1977-2023)

Drylands cover 40% of the global land area and host 2 billion people, of which 90% live in low- or middleincome countries. Drylands often face severe land degradation, low agricultural productivity, rapid population growth, widespread poverty, and poor health. Governance structures and institutions are often eroded. Livestock-based livelihoods, largely depending on seasonal migration are common. Pastoralist communities and their land are highly vulnerable to climate shocks, while there are also changes in land tenure, insecurity/conflicts and rapid infrastructure development. Drylands Transform is an interdisciplinary research project revolving around the UN Sustainable Development Goals (SDGs). The project aim is to contribute …

Use Of Sperm In Vitro Capacitation And Flow Cytometry To Estimate Bull Fertility, Saulo Menegatti Zoca, Thomas W. Geary, Abigail L. Zezeski, Karl C. Kerns, Joseph C. Dalton, Bo R. Harstine, Matthew D. Utt, Robert A. Cushman, Julie Walker, George Perry

SDSU Beef Day 2022 Summary Publication

Study Description:

Frozen-thawed semen from five bulls previously identified as high (48.1% and 47.7%, bulls A and B, respectively), intermediary (45.5%, bull C) or low (43.1% and 40.7%, bulls D and E, respectively) fertility, based on pregnancy per AI, were evaluated with several laboratory measures. Measures included total motility, sperm plasma membrane integrity (viability), acrosome integrity, reactive oxygen species (ROS), mitochondrial membrane energy potential (mito-potential), zinc signatures (signatures 1 to 4), and CD9 protein populations at pre-wash, post-wash, h 0 (diluted with non-capacitation media), and at 0, 3, 6, and 24 h after dilution with capacitation media and incubation at …

Ventilation-Induced Lung Injury (Vili) In Neonates: Evidence-Based Concepts And Lung-Protective Strategies., Renjithkumar Kalikkot Thekkeveedu, Ahmed El-Saie, Varsha Prakash, Lakshmi Katakam, Binoy Shivanna

Manuscripts, Articles, Book Chapters and Other Papers

Supportive care with mechanical ventilation continues to be an essential strategy for managing severe neonatal respiratory failure; however, it is well known to cause and accentuate neonatal lung injury. The pathogenesis of ventilator-induced lung injury (VILI) is multifactorial and complex, resulting predominantly from interactions between ventilator-related factors and patient-related factors. Importantly, VILI is a significant risk factor for developing bronchopulmonary dysplasia (BPD), the most common chronic respiratory morbidity of preterm infants that lacks specific therapies, causes life-long morbidities, and imposes psychosocial and economic burdens. Studies of older children and adults suggest that understanding how and why VILI occurs is essential …