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Articles 109351 - 109380 of 735073
Full-Text Articles in Entire DC Network
Sr 21-22-23 Ucc, Marshall University Faculty Senate
Sr 21-22-23 Ucc, Marshall University Faculty Senate
Recommendations
No abstract provided.
Sr 21-22-24 Ucc, Marshall University Faculty Senate
Sr 21-22-24 Ucc, Marshall University Faculty Senate
Recommendations
No abstract provided.
Meet Our New Fellows! - February 2022, The Center For Peace And Conflict Studies
Meet Our New Fellows! - February 2022, The Center For Peace And Conflict Studies
Center for Peace and Conflict Studies Newsletter
No abstract provided.
Chromosome-Level Genome Of Schistosoma Haematobium Underpins Genome-Wide Explorations Of Molecular Variation., Andreas J Stroehlein, Pasi K Korhonen, V Vern Lee, Stuart A Ralph, Margaret Mentink-Kane, Hong You, Donald P Mcmanus, Louis-Albert Tchuem Tchuenté, J Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M Emery, Bonnie L Webster, Paul J. Brindley, David Rollinson, Bill C H Chang, Robin B Gasser, Neil D Young
Chromosome-Level Genome Of Schistosoma Haematobium Underpins Genome-Wide Explorations Of Molecular Variation., Andreas J Stroehlein, Pasi K Korhonen, V Vern Lee, Stuart A Ralph, Margaret Mentink-Kane, Hong You, Donald P Mcmanus, Louis-Albert Tchuem Tchuenté, J Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M Emery, Bonnie L Webster, Paul J. Brindley, David Rollinson, Bill C H Chang, Robin B Gasser, Neil D Young
Microbiology, Immunology, and Tropical Medicine Faculty Publications
Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenital tissues, and can lead to increased susceptibility to HIV/AIDS and squamous cell carcinoma of the bladder. To complement available treatment programs and break the transmission of disease, sound knowledge and understanding of the biology and ecology of S. haematobium is required. Hybridisation/introgression events and molecular variation among members of the S. haematobium-group might effect important biological and/or disease traits as well as the morbidity of disease …
Indigenous Science Network Resources
Indigenous Science Network Resources
Indigenous Science Network
A set of Australian and global resources to support the teaching of Indigenous perspectives in Science.
Indigenous Science Network Bulletin - February 2022
Indigenous Science Network Bulletin - February 2022
Indigenous Science Network
In this edition we present another collection of items related to First Nations peoples and their science knowledge for a global audience of teachers, scientists and interested community members. We are based in Australia and consequently have a focus on Australian items, but we also have many items from other parts of the world. In this edition, we continue to look at the various definitions and understandings of the relationship between Indigenous Science and Western Science.
Amjambo Africa! (February 2022), Kathreen Harrison
Amjambo Africa! (February 2022), Kathreen Harrison
Amjambo Africa!
In this Issue
Afghan Resettlement ............2/3
Lunar New Year ........................4
Maine Youth Network .............5
Afrofuturism with MHC......... 7
Editorial .....................................8
Translations French .........................9/13
Swahili .......................10/13
Somali .......................11/13
Kinyarwanda ............12/13
Portuguese ................28/30
Spanish ......................29/30
MCF grant opportunities ......14
Legislative update ...................15
Tips & Info ........................16/31
New Roots Farm .....................17
The Samosa Story .............18/19
Health&Wellness... ............20-27
Cardiac Health In English & translations
Columns ..................................32
Maine Equal Justice South Portland Sustainability MIRC
Tax Season...33
In English & translations
New Voices columns ..............34
Rupal Ramesh Shah Roseline Souebele
Hope in Augusta .................... 37
A Multitarget Approach To Evaluate The Efficacy Of Aquilaria Sinensis Flower Extract Against Metabolic Syndrome, Hee Sung Chae, Olivia Dale, Tahir Maqbool Mir, Bharathi Avula
A Multitarget Approach To Evaluate The Efficacy Of Aquilaria Sinensis Flower Extract Against Metabolic Syndrome, Hee Sung Chae, Olivia Dale, Tahir Maqbool Mir, Bharathi Avula
Faculty and Student Publications
Aquilaria sinensis (Lour.) Spreng is known for its resinous secretion (agarwood), often secreted in defense against injuries. We investigated the effects of A. sinensis flower extract (AF) on peroxisome proliferator-activated receptors alpha and gamma (PPARα and PPARγ), liver X receptor (LXR), glucose uptake, and lipid accumulation (adipogenesis). Activation of PPARα, PPARγ and LXR was determined in hepatic (HepG2) cells by reporter gene assays. Glucose uptake was determined in differentiated muscle (C2C12) cells using 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose). Adipogenesis was determined in adipocytes (3T3-L1 cells) by Oil red O staining. At a concentration of 50 µg/mL, AF caused 12.2-fold activation of PPARα and …
Playing With Math And Science In The Early Childhood Classroom, Cassandra Armstrong, Lindsey Herlehy
Playing With Math And Science In The Early Childhood Classroom, Cassandra Armstrong, Lindsey Herlehy
Publications & Research
Young students are equipped with the curiosity and creativity to be successful scientists and mathematicians. In today’s classrooms, strong foundational skills in STEM promote success for years to come. Through play, young students can subitize, sort, draw, recognize patterns, and explore loose parts. Participants will actively take part in several activities highlighting each of these skills.
Salmon Week One Clean Transcript, Tally Eastman, Hannah Miller, Aiden Modrell, Aiyana Montez, Kayla Watkins
Salmon Week One Clean Transcript, Tally Eastman, Hannah Miller, Aiden Modrell, Aiyana Montez, Kayla Watkins
Heritage Conversation Partners
No abstract provided.
The Effects Of Trauma On Identity Formation: Pursuing And Obtaining Individual Freedom In Emerson’S Nature And Creech’S Chasing Redbird, Mckenzie Hershberger
The Effects Of Trauma On Identity Formation: Pursuing And Obtaining Individual Freedom In Emerson’S Nature And Creech’S Chasing Redbird, Mckenzie Hershberger
English Senior Capstone
Nature and Chasing Redbird provide poignant examples of the restorative power found in the natural world, and a thorough analysis of the works and lives of the authors reveal past trauma created the need for this restoration. Traumatic experiences shape an individual’s thought processes, as each decision the individual makes is based upon fearing an uncertain outcome. Throughout Nature, Emerson references a child’s innocence, demonstrating that a child’s perspective has not yet been tainted by experience. Emerson idealizes his past childhood as he endured grievances that motivated him to confront his trauma while in nature himself. An example for Emerson’s …
The Inevitable Church, Min Choi
The Inevitable Church, Min Choi
Doctor of Ministry
The Inevitable Church is a YouTube channel about the semiotics of digital technological forces and how they are shaping the future of church and culture. Its aim is to be a repository of resources and videos that models and teaches the unique principles and strategies required to navigate our modern mediums of communication and connection.
The NPO statement for this project is: The modern network revolution is shifting our primary medium for social interdependence from print to digital, which is reforming our social and cultural structures and creating a critical need for innovation in ministry strategies, recontextualization of orthodox Biblical …
Convergence: Eos News And Updates, February 2022, Unh Institute For The Study Of Earth, Oceans And Space
Convergence: Eos News And Updates, February 2022, Unh Institute For The Study Of Earth, Oceans And Space
Convergence: EOS News and Updates
No abstract provided.
Nathan Richardson, Nathan Richardson
Nathan Richardson, Nathan Richardson
Black History Month 2022: Flash Interviews
No abstract provided.
Ranking The Biases: The Choice Of Otus Vs. Asvs In 16s Rrna Amplicon Data Analysis Has Stronger Effects On Diversity Measures Than Rarefaction And Otu Identity Threshold, Marlène Chiarello, Mark Mccauley, Sébastien Villéger, Colin R. Jackson
Ranking The Biases: The Choice Of Otus Vs. Asvs In 16s Rrna Amplicon Data Analysis Has Stronger Effects On Diversity Measures Than Rarefaction And Otu Identity Threshold, Marlène Chiarello, Mark Mccauley, Sébastien Villéger, Colin R. Jackson
Faculty and Student Publications
Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away from sequence identity-based clustering (producing Operational Taxonomic Units, OTUs) to denoising methods (producing amplicon sequence variants, ASVs). While denoising methods have several inherent properties that make them desirable compared to clustering-based methods, questions remain as to the influence that these pipelines have on the ecological patterns being assessed, especially when compared to other methodological choices made when processing data (e.g. rarefaction) and computing diversity indices. We compared the respective influences of two widely used methods, namely DADA2 (a denoising …
Note: Self-Regulation By The Private Industry And Its Effectiveness In Today's Online Environment, Stephanie Wong
Note: Self-Regulation By The Private Industry And Its Effectiveness In Today's Online Environment, Stephanie Wong
Notre Dame Journal on Emerging Technologies
Over 30 years ago, self-regulation served as a hopeful potential regulatory framework that would allow private companies to provide effective privacy protections for consumers. The aspiration for a data protection self-regulation regime arose due to the emergence and development of online commercial activity. E-commerce benefited companies that conducted business online but presented new challenges for the protection of consumer data. The Federal Trade Commission encouraged companies that collect consumer data to develop their own forms of self-regulation to protect the personal data of online consumers. If properly implemented, self-regulation promised efficient reorganization of privacy protections to meet the challenges of …
Covid’S Counterpunch: State Legislative Assaults On Publichealth Emergency Powers, James G. Hodge Jr., Jennifer L. Piatt
Covid’S Counterpunch: State Legislative Assaults On Publichealth Emergency Powers, James G. Hodge Jr., Jennifer L. Piatt
Brigham Young University Journal of Public Law
Amid the most impactful health crisis in over a century, COVID’s “counterpunch” entails aggressive efforts by numerous state legislatures to diminish state and local public health emergency powers. It is an incredulous movement facially supported by a need to appropriately balance economic interests and rights with communal health objectives. At its political core, however, is a “power grab” by legislatures to free their constituents from extensive emergency powers (e.g., social distancing, assembly limits, and business closures). Never mind the fact that these interventions, when used effectively and constitutionally, save lives and reduce morbidity. Public health agents and activists are understandably …
2022 Gray Wolf Questions And Answers, United States Fish And Wildlife Service
2022 Gray Wolf Questions And Answers, United States Fish And Wildlife Service
United States Fish and Wildlife Service: Publications
2022 Gray Wolf Questions and Answers
What does the February 10, 2022, ruling mean?
How does this ruling affect wolves in the Northern Rocky Mountains?
When does the court decision to vacate the delisting rule go into effect?
What is the legal status of gray wolves as of this ruling?
Is the Service continuing its status review of wolves in the western United States?
Is emergency listing an option for the Northern Rocky Mountain population?
Are wolf hunts going to stop as a result of the court decision?
How does this ruling affect wolves in Yellowstone National Park?
Where can …
Houtman Abrolhos Islands Fish Habitat Protection Area: A Summary Of Marine Resource Use And Ecological Attributes, Scott N. Evans, Nick Konzewitsch, Lynda M. Bellchambers
Houtman Abrolhos Islands Fish Habitat Protection Area: A Summary Of Marine Resource Use And Ecological Attributes, Scott N. Evans, Nick Konzewitsch, Lynda M. Bellchambers
Fisheries Research Reports
The Houtman Abrolhos Islands (Abrolhos) is an archipelago of up to 210 small islands and associated reefs located approximately 65-90 km offshore from Geraldton, Western Australia (WA). The islands and waters of the Abrolhos are of significance for both land-based and marine based values. The marine state territorial waters of the Abrolhos are managed by the Department of Primary Industries and Regional Development (DPIRD) as the Houtman Abrolhos Islands Fish Habitat Protection Area (Abrolhos FHPA). This report aims to provide a summary of the DPIRD data on aquatic resource use (e.g., aquaculture, commercial, recreational and charter fishing) and ecological attributes …
Premier: The Magazine Of The Unlv Harrah College Of Hospitality, Matt Jacob, Angela Ramsey, Caitlyn Lopez, Stowe Shoemaker, Maggie Hausbeck, Alexandra Liebman
Premier: The Magazine Of The Unlv Harrah College Of Hospitality, Matt Jacob, Angela Ramsey, Caitlyn Lopez, Stowe Shoemaker, Maggie Hausbeck, Alexandra Liebman
Premier: The Magazine of the UNLV Harrah Hotel College
Of the countless hospitality programs around the world, why does the Harrah College of Hospitality consistently rank at the top? I believe the college's excellence stems from our ability to leverage our strengths with those of our partners to do great things. It's that simple.
This approach has certainly been in play as we've navigated the difficulties of the past two years. We've worked with our friends in industry and academia to bolster our internship and mentorship programs, research, and interdisciplinary projects, all with the intent of expanding the knowledge base of the hospitality discipline and building a pipeline of …
Kentucky Warbler (Vol. 98, No. 1), Kentucky Library Research Collections
Kentucky Warbler (Vol. 98, No. 1), Kentucky Library Research Collections
The Kentucky Warbler
No abstract provided.
Discovering Life Through Loss And Grief, Darcy L. Hansen
Discovering Life Through Loss And Grief, Darcy L. Hansen
Doctor of Ministry
In times of loss, communities of faith come alongside bereaved individuals to offer support. That support is often short lived. When the casseroles stop, grieving people feel isolated and underserved in communities of faith when pastors and community members are ill-equipped and unprepared to care for them.(2)
The reason pastors and community members are ill-prepared to care for those grieving is historically, culturally, and theologically complex. Tackling such complexity is beyond the scope of this project. Implementing Occam’s Razor, where the simplest solution, with the least moving parts, suffices, enables me to address my NPO in a creative way.(3)
For …
Utilization Of The Calm Apparatus To Adult Men And Women With Atrial Fibrillation To Decrease Emergency Department Visits For Atrial Fibrillation, Ami Klein
Doctor of Nursing Practice Scholarly Projects
The purpose of this project is two-fold. The first is to determine if the CALM APP use by adult men and women with atrial fibrillation (AF) will decrease anxiety. The second is to determine if decreased anxiety utilizing the CALM APP will deter admissions to the emergency department (ED) for AF in the first month post-catheter ablation of AF. The Zung SAS was used to determine the pre- and post-anxiety scores. The Seven Days of Calm (free app) was used to teach deep breathing and meditation. This study showed a moderate decrease in ED visits with use of the Calm …
Use Of Magnetic Iron-Coated Halloysite Nanotubes In Cell Growth, Differentiation, And Combating Cancerous Growth, Christopher Daniel Candler
Use Of Magnetic Iron-Coated Halloysite Nanotubes In Cell Growth, Differentiation, And Combating Cancerous Growth, Christopher Daniel Candler
Master's Theses
Magnetic Halloysite Nanotubes can be used in multiple ways in combating growth of osteosarcoma. The adsorption ability of the inner and outer surfaces of halloysite nanotubes allows for attachment of different molecules, including anti-cancer drugs, polymer layering for controlled drug release, and magnetic coating. This magnetic coating would allow for cell membrane disruption, hyperthermia, and for targeting of specific tissue. In this project, the goal was to create these magnetic nanotubes and test their cytotoxicity against stem cells and osteosarcoma cells.
To create these magnetic nanotubes, we used electrodeposition to adsorb ferrous oxide nanoparticles (FeNPs) onto halloysite nanotubes (HNTs) to …
Transient Thermal Response Of Tissues Surrounding An Implanted Medical Device During Inductive Charging, Peter C. Leboeuf
Transient Thermal Response Of Tissues Surrounding An Implanted Medical Device During Inductive Charging, Peter C. Leboeuf
Master's Theses
Inductive charging as a means of power delivery to implanted device is becoming more commonplace as increasingly sophisticated implants with higher power requirements enter clinical use. When such devices undergo inductive charging, losses within the system result in dissipated heat that must be absorbed by the surrounding tissue. The skin-mounted primary antenna and components within the implanted device such as the metal casing, battery, and secondary antenna are all susceptible to temperature increase during a charging cycle. Heating of this kind must be considered when designing modern implants utilizing this mode of power transfer in order to safeguard surrounding tissues …
The Casnr L.I.N.K.S. Newsletter: Learning Innovation Network For K-12 Schools, Edition 2, February 2022, Bailey Feit, Tammy Mittelstet
The Casnr L.I.N.K.S. Newsletter: Learning Innovation Network For K-12 Schools, Edition 2, February 2022, Bailey Feit, Tammy Mittelstet
CASNR L.I.N.K.S. Newsletter
The purpose of this L.I.N.K.S. newsletter is to provide a monthly update of opportunities and resources for K-12 schools to connect with the University of Nebraska's CASNR Food, Energy, Water, and Societal Systems (FEWS²) programs and partners.
Included in this edition:
Classroom resources for all levels
Eye on new curriculum
Teacher opportunities
List of new partnerships
Ask an expert
Eye on CASR research: Travis Mulliniks
Student experiences
Send your students to campus
Success stories
A Virtual Reality Platform For The Measurement Of Drinking Topography, Victor Schneider, Nicholas Bush, Darya Vitus, Ryan Carpenter, Michael Robinson, Jeff Boissoneault
A Virtual Reality Platform For The Measurement Of Drinking Topography, Victor Schneider, Nicholas Bush, Darya Vitus, Ryan Carpenter, Michael Robinson, Jeff Boissoneault
Psychology Faculty Works
BackgroundThe assessment of alcohol consumption during a drinking bout, known as drinking topography, may help improve understanding of biopsychosocial mechanisms underlying alcohol consumption. However, past studies have been limited by effort-intensive, time-consuming, and error-prone processes involved in collecting, organizing, and standardizing drinking topography data. Recent technologies allowing integrated data collection and greater environmental control, such as virtual reality (VR), could resolve these problems.MethodsIn this pilot project, we assessed alcohol consumption topography of participants in a VR drinking environment with a programmable virtual confederate (i.e., bar goer) during two testing sessions. In one, the confederate drank quickly (30-60 s sip interval). …
Marooned, Richard R. Dipirro
Marooned, Richard R. Dipirro
The Lindenwood Review: a journal of literary prose
No abstract provided.
Consensus Recommendation For Mouse Models Of Ocular Hypertension To Study Aqueous Humor Outflow And Its Mechanisms., Colleen M Mcdowell, Krishnakumar Kizhatil, Michael H Elliott, Darryl R Overby, Joseph Van Batenburg-Sherwood, J Cameron Millar, Markus H Kuehn, Gulab Zode, Ted S Acott, Michael G Anderson, Sanjoy K Bhattacharya, Jacques A Bertrand, Terete Borras, Diane E Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A Faralli, Rudolf Fuchshofer, Preethi S Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W M John, Paul L Kaufman, Kate E Keller, Mary J Kelley, Ruth A Kelly, David Krizaj, Ajay Kumar, Brian C Leonard, Raquel L Lieberman, Paloma Liton, Yutao Liu, Katy C Liu, Navita N Lopez, Weiming Mao, Timur Mavlyutov, Fiona Mcdonnell, Gillian J Mclellan, Philip Mzyk, Andrews Nartey, Louis R Pasquale, Gaurang C Patel, Padmanabhan P Pattabiraman, Donna M Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R Samples, E Griffen Samples, Najam Sharif, Joel S Schuman, Val C Sheffield, Cooper H Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B Toris, Karen Y Torrejon, Amir Vahabikashi, Janice A Vranka, Ting Wang, Colin E Willoughby, Chen Xin, Hongmin Yun, Hao F Zhang, Michael P Fautsch, Ernst R Tamm, Abbot F Clark, C Ross Ethier, W Daniel Stamer
Consensus Recommendation For Mouse Models Of Ocular Hypertension To Study Aqueous Humor Outflow And Its Mechanisms., Colleen M Mcdowell, Krishnakumar Kizhatil, Michael H Elliott, Darryl R Overby, Joseph Van Batenburg-Sherwood, J Cameron Millar, Markus H Kuehn, Gulab Zode, Ted S Acott, Michael G Anderson, Sanjoy K Bhattacharya, Jacques A Bertrand, Terete Borras, Diane E Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A Faralli, Rudolf Fuchshofer, Preethi S Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W M John, Paul L Kaufman, Kate E Keller, Mary J Kelley, Ruth A Kelly, David Krizaj, Ajay Kumar, Brian C Leonard, Raquel L Lieberman, Paloma Liton, Yutao Liu, Katy C Liu, Navita N Lopez, Weiming Mao, Timur Mavlyutov, Fiona Mcdonnell, Gillian J Mclellan, Philip Mzyk, Andrews Nartey, Louis R Pasquale, Gaurang C Patel, Padmanabhan P Pattabiraman, Donna M Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R Samples, E Griffen Samples, Najam Sharif, Joel S Schuman, Val C Sheffield, Cooper H Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B Toris, Karen Y Torrejon, Amir Vahabikashi, Janice A Vranka, Ting Wang, Colin E Willoughby, Chen Xin, Hongmin Yun, Hao F Zhang, Michael P Fautsch, Ernst R Tamm, Abbot F Clark, C Ross Ethier, W Daniel Stamer
Faculty Research 2022
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build …
Extensive Identification Of Genes Involved In Congenital And Structural Heart Disorders And Cardiomyopathy., Nadine Spielmann, Gregor Miller, Tudor I Oprea, Chih-Wei Hsu, Gisela Fobo, Goar Frishman, Corinna Montrone, Hamed Haseli Mashhadi, Jeremy Mason, Violeta Munoz Fuentes, Stefanie Leuchtenberger, Andreas Ruepp, Matias Wagner, Dominik S Westphal, Cordula Wolf, Agnes Görlach, Adrián Sanz-Moreno, Yi-Li Cho, Raffaele Teperino, Stefan Brandmaier, Sapna Sharma, Isabella Rikarda Galter, Manuela A Östereicher, Lilly Zapf, Philipp Mayer-Kuckuk, Jan Rozman, Lydia Teboul, Rosie K A Bunton-Stasyshyn, Heather Cater, Michelle Stewart, Skevoulla Christou, Henrik Westerberg, Amelia M Willett, Janine M Wotton, Willson B Roper, Audrey E Christiansen, Christopher S Ward, Jason D Heaney, Corey L Reynolds, Jan Prochazka, Lynette Bower, David Clary, Mohammed Selloum, Ghina Bou About, Olivia Wendling, Hugues Jacobs, Sophie Leblanc, Hamid Meziane, Tania Sorg, Enrique Audain, Arthur Gilly, Nigel W Rayner, Impc Consortium, Genomics England Research Consortium, Marc-Phillip Hitz, Eleftheria Zeggini, Eckhard Wolf, Radislav Sedlacek, Stephen A Murray, Karen L. Svenson, Robert E Braun, Jacqueline K White, Lois Kelsey, Xiang Gao, Toshihiko Shiroishi, Ying Xu, Je Kyung Seong, Fabio Mammano, Glauco P Tocchini-Valentini, Arthur L Beaudet, Terrence F Meehan, Helen Parkinson, Damian Smedley, Ann-Marie Mallon, Sara E Wells, Harald Grallert, Wolfgang Wurst, Susan Marschall, Helmut Fuchs, Steve D M Brown, Ann M Flenniken, Lauryl M J Nutter, Colin Mckerlie, Yann Herault, K C Kent Lloyd, Mary E Dickinson, Valerie Gailus-Durner, Martin Hrabe De Angelis
Extensive Identification Of Genes Involved In Congenital And Structural Heart Disorders And Cardiomyopathy., Nadine Spielmann, Gregor Miller, Tudor I Oprea, Chih-Wei Hsu, Gisela Fobo, Goar Frishman, Corinna Montrone, Hamed Haseli Mashhadi, Jeremy Mason, Violeta Munoz Fuentes, Stefanie Leuchtenberger, Andreas Ruepp, Matias Wagner, Dominik S Westphal, Cordula Wolf, Agnes Görlach, Adrián Sanz-Moreno, Yi-Li Cho, Raffaele Teperino, Stefan Brandmaier, Sapna Sharma, Isabella Rikarda Galter, Manuela A Östereicher, Lilly Zapf, Philipp Mayer-Kuckuk, Jan Rozman, Lydia Teboul, Rosie K A Bunton-Stasyshyn, Heather Cater, Michelle Stewart, Skevoulla Christou, Henrik Westerberg, Amelia M Willett, Janine M Wotton, Willson B Roper, Audrey E Christiansen, Christopher S Ward, Jason D Heaney, Corey L Reynolds, Jan Prochazka, Lynette Bower, David Clary, Mohammed Selloum, Ghina Bou About, Olivia Wendling, Hugues Jacobs, Sophie Leblanc, Hamid Meziane, Tania Sorg, Enrique Audain, Arthur Gilly, Nigel W Rayner, Impc Consortium, Genomics England Research Consortium, Marc-Phillip Hitz, Eleftheria Zeggini, Eckhard Wolf, Radislav Sedlacek, Stephen A Murray, Karen L. Svenson, Robert E Braun, Jacqueline K White, Lois Kelsey, Xiang Gao, Toshihiko Shiroishi, Ying Xu, Je Kyung Seong, Fabio Mammano, Glauco P Tocchini-Valentini, Arthur L Beaudet, Terrence F Meehan, Helen Parkinson, Damian Smedley, Ann-Marie Mallon, Sara E Wells, Harald Grallert, Wolfgang Wurst, Susan Marschall, Helmut Fuchs, Steve D M Brown, Ann M Flenniken, Lauryl M J Nutter, Colin Mckerlie, Yann Herault, K C Kent Lloyd, Mary E Dickinson, Valerie Gailus-Durner, Martin Hrabe De Angelis
Faculty Research 2022
Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and mechanisms of action challenging. By using in vivo electrocardiography, transthoracic echocardiography and microcomputed tomography imaging to screen 3,894 single-gene-null mouse lines for structural and functional cardiac abnormalities, here we identify 705 lines with cardiac arrhythmia, myocardial hypertrophy and/or ventricular dilation. Among these 705 genes, 486 have not been previously associated with cardiac dysfunction in humans, and some of them represent variants of unknown relevance (VUR). Mice with mutations in Casz1, Dnajc18, Pde4dip, Rnf38 or Tmem161b genes show developmental cardiac structural abnormalities, …