Digital Commons Network^™

Interactions Between Strains Govern The Eco-Evolutionary Dynamics Of Microbial Communities, Akshit Goyal, Leonora S. Bittleston, Gabriel E. Leventhal, Lu Lu, Otto X. Cordero

Biology Faculty Publications and Presentations

Genomic data has revealed that genotypic variants of the same species, that is, strains, coexist and are abundant in natural microbial communities. However, it is not clear if strains are ecologically equivalent, and at what characteristic genetic distance they might exhibit distinct interactions and dynamics. Here, we address this problem by tracking 10 taxonomically diverse microbial communities from the pitcher plant Sarracenia purpurea in the laboratory for more than 300 generations. Using metagenomic sequencing, we reconstruct their dynamics over time and across scales, from distant phyla to closely related genotypes. We find that most strains are not ecologically equivalent and …

Prkci Regulates Autophagy And Pancreatic Tumorigenesis In Mice, Kristin S. Inman, Yi Liu, Michele L. Scotti Buzhardt, Michael Leitges, Murli Krishna, Howard C. Crawford, Alan P. Fields, Nicole R. Murray

Research Administration Articles

Protein kinase C iota (PKCι) functions as a bonafide human oncogene in lung and ovarian cancer and is required for Kras(G12D)-mediated lung cancer initiation and progression. PKCι expression is required for pancreatic cancer cell growth and maintenance of the transformed phenotype; however, nothing is known about the role of PKCι in pancreas development or pancreatic tumorigenesis. In this study, we investigated the effect of pancreas-specific ablation of PKCι expression on pancreatic cellular homeostasis, susceptibility to pancreatitis, and Kras(G12D)-mediated pancreatic cancer development. Knockout of pancreatic Prkci significantly increased pancreatic immune cell infiltration, acinar cell DNA damage, and apoptosis, but reduced sensitivity …

Nest Records Of Nebraska Birds, Wayne J. Mollhoff

Zea E-Books Collection

Nebraska Ornithologists' Union Occasional Paper Number 9

This publication is an attempt to provide a synopsis of the breeding information accumulated in the past two centuries. As with any compilation like this, other workers would likely come to different conclusions in choosing which records to accept and which to reject. I have tried to state the reasons for my decisions as clearly as possible. Most difficult to categorize are species which are not well documented. Hopefully by laying out the evidence I could find, others will be prompted to do more research, uncover definitive proof, and put more of our …

Public Policy Should Foster Alzheimer’S Treatment Availability: Comment On The Draft Us Medicare Decision To Limit Payment For Aducanumab (Aduhelm™) To Patients Participating In Clinical Trials, Jeffrey L. Cummings

Brain Health Faculty Research

Aducanumab (AduhelmTM) was approved by the United States (US) Food and Drug Administration (FDA) for the treatment of Alzheimer’s disease on June 7, 2021. Soon after, the approved labeling was adjusted to direct treatment to mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and mild AD dementia reflecting the severity of cognitive impairment among participants in the clinical trials that led to the approval (1, 2).

Individuals over age 65 in the US are entitled to have the cost of prescription drugs partially paid by the Center for Medicare and Medicaid Services (CMS; “Medicare”) if they participate in an …

Design, Development, And Validation Of An Augmented Reality-Enabled Production Strategy Process, Hala Nassereddine, Dharmaraj Veeramani, Awad S. Hanna

Civil Engineering Faculty Publications

The Production Strategy Process (PSP) is an integral part of production planning and control as it defines how production processes are structured and designed and outlines how production will be executed. PSP involves massive information transfer and communication among project participants. While BIM can improve the flow of information, the paradox of designing 3D models in 2D space remains. This paradox indicates that new visualization technologies are needed to leverage the use of information in the PSP. As Industry 4.0, the fourth industrial revolution, continues to evolve, it is imperative that construction firms seek, find, and adopt new technologies. This …

Optimizing Management Of Invasions In An Uncertain World Using Dynamic Spatial Models, Kim M. Pepin, Amy J. Davis, Rebecca S. Epanchin-Niell, Andrew M. Gormley, Joslin L. Moore, Timothy J. Smyser, H. Bradley Shaffer, William L. Kendall, Katriona Shea, Michael C. Runge, Sophie Mckee

United States Department of Agriculture Wildlife Services: Staff Publications

Dispersal drives invasion dynamics of nonnative species and pathogens. Applying knowledge of dispersal to optimize the management of invasions can mean the difference between a failed and a successful control program and dramatically improve the return on investment of control efforts. A common approach to identifying optimal management solutions for invasions is to optimize dynamic spatial models that incorporate dispersal. Optimizing these spatial models can be very challenging because the interaction of time, space, and uncertainty rapidly amplifies the number of dimensions being considered. Addressing such problems requires advances in and the integration of techniques from multiple fields, including ecology, …

Interpreting The Interphase Gap Effect On The Electrically Evoked Compound Action Potential, Yi Yuan, Jeffrey Skidmore, Shuman He

Faculty Research, Scholarly, and Creative Activity

This study demonstrated the effects of using different quantification methods and parameter scales on the sensitivity of the electrically evoked compound action potential (eCAP) to changes in the interphase gap (IPG). The IPG effect measured in two groups of cochlear implant (CI) users with different cochlear nerve (CN) health on seven eCAP measures was quantified using an absolute and a proportional difference method. The IPG effect provides an indicator for the functional status of the CN in human CI users. Specifying how the IPG effect is quantified is critical for accurate result interpretation.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Regional Minimums In The U.S. Beef Complex, Elliott James Dennis, Bradley Lubben

Center for Agricultural Profitability

This report shows how the currently proposed policies differ; shows how these policies have aligned with historical market behavior; provides alternative specifications to regional minimums; and suggests policy alternatives to regional minimums.

The main purpose of this report is to show how current and potential alternative specifications of regional minimums would have historically aligned with observed market behavior. However, the fundamental question in the debate of the validity and effectiveness of regional minimums first rests on whether robust price discovery has historically occurred over time and within each USDA-AMS region. If there has been a lack of price discovery during …

Mir-196a Upregulation Contributes To Gefitinib Resistance Through Inhibiting Gltp Expression, Bing-Jie Liu, Fang-Fang Li, Yun-Xia Xie, Chong-Yuan Fan, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Tyrosine kinase inhibitor (TKI) therapy has greatly improved lung cancer survival in patients with epidermal growth factor receptor (EGFR) mutations. However, the development of TKI-acquired resistance is the major problem to be overcome. In this study, we found that miR-196a expression was greatly induced in gefitinib-resistant lung cancer cells. To understand the role and mechanism of miR-196a in TKI resistance, we found that miR-196a-forced expression alone increased cell resistance to gefitinib treatment in vitro and in vivo by inducing cell proliferation and inhibiting cell apoptosis. We identified the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) bound to the …

Volume Cxli, Number 4, February 4, 2022, Lawrence University

The Lawrentian

No abstract provided.

Highly Reliable Creation Of Floxed Alleles By Electroporating Single-Cell Embryos, Monica F Sentmanat, J Michael White, Evguenia Kouranova, Xiaoxia Cui

2020-Current year OA Pubs

BACKGROUND: Floxed (flanked by loxP) alleles are a crucial portion of conditional knockout mouse models. However, an efficient and reliable strategy to flox genomic regions of any desired size is still lacking.

RESULTS: Here, we demonstrate that the method combining electroporation of fertilized eggs with gRNA/Cas9 complexes and single-stranded oligodeoxynucleotides (ssODNs), assessing phasing of loxP insertions in founders using an in vitro Cre assay and an optional, highly specific and efficient second-round targeting ensures the generation of floxed F1 animals in roughly five months for a wide range of sequence lengths (448 bp to 160 kb reported here).

CONCLUSIONS: Floxed …

Evaluation Of Microbial Biomass In Agroforestry Systems Using Forage Cactus And Leucaena Leucocephala And Gliricidia Sepium, Dayanne Camelo, José C. B. Dubeux Jr., Mario De Andrade Lira Jr., Mércia V. F. Dos Santos, Diana Valadares Pessoa, Erick Santos

IGC Proceedings (1977-2023)

Vegetation type can affect soil microbiology in agroforestry systems. Plants release different organic exudates in the rhizosphere, affecting microbial growth. This study evaluated the effect of forage cactus intercropped with different tree legumes on soil microbial biomass. The research was performed in a tropical semiarid Regosol at Caruaru Experimental Station, Agronomic Institute of Pernambuco, Northeast Brazil. Treatments included: i) Gliricidia sepium (Jacq.) Steud and forage cactus IPA-Sertânia (Nopalea cochenillifera Salm Dyck); and ii) Leucaena leucocephala [Lam.] de Wit.) and forage cactus IPA-Sertânia. Treatments were allocated in a randomized complete block design in a split-split-plot scheme, with four replications. Main …

Elephants Mitigate The Effects Of Cattle On Wildlife And Other Ecosystem Traits: Experimental Evidence, Truman P. Young, Duncan N. Kimuyu, Kari E. Veblen, Corinna Riginos, Judith Sitters, Lauren Porensky, Wilfred O. Odadi

IGC Proceedings (1977-2023)

On rangelands worldwide, cattle interact with many ecosystem components, most obviously with soils, plants, and other large herbivores. Since 1995, we have been manipulating the presence of cattle, mesoherbivores, and megaherbivores (elephants and giraffes) in a series of eighteen 4-ha (10-acre) plots at the Kenya Long-term Exclosure Experiment. We have demonstrated a wide array of cattle effects on this savanna rangeland, including their reduction of grass cover, wildlife use, and soil nitrogen and phosphorus pools, but their increase of primary productivity and termite abundance. Strikingly, we demonstrate that the presence of mega-herbivores (elephants, mainly) reduces the sizes of these cattle. …

Ain't The 1950s Anymore, Ellen Stader

Exile

No abstract provided.

Summer Rules, Jim Cox

Exile

No abstract provided.

Fish Story, Jim Dixon

Exile

No abstract provided.

The Bison, February 3, 2022

The Bison Newspapers

No abstract provided.

Who's Publishing What: Storytellers' True Stories About Love, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

A story by Chicago writer and storyteller Julie Danis is featured in a new book, Storytellers' True Stories About Love.

New Opportunities And Untapped Scientific Potential In The Abyssal Ocean, Jeffrey J. Marlow, Rika E. Anderson, Anna Louise Reysenbach, Jeffrey S. Seewald, Timothy M. Shank, Andreas P. Teske, V. Dorsey Wanless, S. Adam Soule

Graduate School of Oceanography Faculty Publications

The abyssal ocean covers more than half of the Earth’s surface, yet remains understudied and underappreciated. In this Perspectives article, we mark the occasion of the Deep Submergence Vehicle Alvin’s increased depth range (from 4500 to 6500 m) to highlight the scientific potential of the abyssal seafloor. From a geologic perspective, ultra-slow spreading mid-ocean ridges, Petit Spot volcanism, transform faults, and subduction zones put the full life cycle of oceanic crust on display in the abyss, revealing constructive and destructive forces over wide ranges in time and space. Geochemically, the abyssal pressure regime influences the solubility of constituents such as …

An Appeal In Favor Of That Class Of Americans Called Africans, Lydia Maria Child, Paul Royster (Editor)

Zea E-Books in American Studies

The roots of white supremacy lie in the institution of negro slavery. From the 15th through the 19th century, white Europeans trafficked in abducted and enslaved Africans and justified the practice with excuses that seemed somehow to reconcile the injustice with their professed Christianity. The United States was neither the first nor the last nation to abolish slavery, but its proclaimed principles of freedom and equality were made ironic by the nation’s reluctance to extend recognition to all Americans.

“Americans” is what Mrs. Child calls those fellow countrymen of African ancestry in 1833; citizenship and equality were what she advocated …

Curriculum Subcommittee Minutes, February 3, 2022, Utah State University

Educational Policies Committee

Minutes

• Approval of 6 January 2022 Minutes
  
• Program Proposals
• Semester Course Approval Reviews https://usu.curriculog.com/
• College of Agriculture and Applied Sciences ADVS = 8 APEC = 3 ASTE = 11 AVTE = 49 (BCIS & BUSN hold all requests | including BCIS & BUSN all) LAEP = 30 NDFS = 21 OPDD = 1 PSC = 1
• Caine College of the Arts MUSC = 1 THEA = 9
• Jon M. Huntsman School of Business ACCT = 10 ECN = 9 DATA = 35 MSLE = 1
• Emma Eccles Jones College of Education and Human Services COMD = 10 HDFS = 1 …

Curriculum Subcommittee Agenda, February 3, 2022, Utah State University

Educational Policies Committee

• Approval of 6 January 2022 Minutes
• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn

Montana Kaimin, February 3, 2022, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Hypophosphatemia Causing St Elevation In A Critically Ill Noncardiac Surgery Postoperative Patient., Joey Junarta, Gregary D Marhefka

Division of Cardiology Faculty Papers

The patient is a 73-year-old female with peripheral vascular disease, coronary artery disease, and systemic lupus erythematosus, who underwent mesenteric artery bypass surgery. She suffered from a pneumonia after surgery, causing acute hypoxic respiratory failure and septic shock. Due to shock, she developed acute renal failure. She was intubated, ventilated, and received continuous veno-venous hemodialysis for renal failure. ST elevation was first observed on telemetry and subsequently confirmed on electrocardiogram. Marked ST elevation is present in the anterior leads with reciprocal ST depression in the inferior leads. A prolonged QT interval is also present. What is the most likely diagnosis?

Hawks' Herald -- Feb. 3, 2022, Roger Williams University

Hawk's Herald

No abstract provided.

Disentangling The Role Of Religiosity In Human Papillomavirus Vaccination Amidst Covid-19 Pandemic, Ayokunle Olagoke, Brenikki Floyd, Rachel Caskey, Jennifer Hebert-Beirne, Andrew D. Boyd, Yamilé Molina

Health and Kinesiology Faculty Publications

Religion is a complex and sociocultural driver of human papillomavirus (HPV) vaccination decisions, but its exact role has been mixed/unclear. We used a cross-sectional study of 342 Christian parents to examine the associations between the three domains of religiosity (organizational, non-organizational, and intrinsic) and the intention to (i) seek HPV information and (ii) receive the HPV vaccine. Organizational religiosity was the only domain that was positively associated with information-seeking intention regardless of the type of covariates included. Mixed findings in the association between religiosity and HPV vaccination decisions may depend on the religiosity domain being assessed.

Apoe Genetics Influence Murine Gut Microbiome, Diana J. Zajac, Stefan J. Green, Lance A. Johnson, Steven Estus

Physiology Faculty Publications

Apolipoprotein E (APOE) alleles impact pathogenesis and risk for multiple human diseases, making them primary targets for disease treatment and prevention. Previously, we and others reported an association between APOE alleles and the gut microbiome. Here, we evaluated effects of APOE heterozygosity and tested whether these overall results extended to mice maintained under ideal conditions for microbiome analyses. To model human APOE alleles, this study used APOE targeted replacement (TR) mice on a C57Bl/6 background. To minimize genetic drift, homozygous APOE3 mice were crossed to homozygous APOE2 or homozygous APOE4 mice prior to the study, and the resulting …

Drawing The Cyber Baseline: The Applicability Of Existing International Law To The Governance Of Information And Communication Technologies, Dapo Akande, Antonio Coco, Talita De Souza Dias

International Law Studies

"Cyberspace" is often treated as a new domain of State activity in international legal discourse. This has led to the assumption that for international law to apply to cyber operations carried out by States or non-State actors, "cyber-specific" State practice and opinio juris must be demonstrated. This article challenges that assumption on five different bases. First, it argues that rules of general international law are generally applicable to all domains, areas, or types of State activity. In their interpretation and application to purported new domains, limitations to their scope of application cannot be presumed. Second, this article demonstrates that the …

Retraction Note: Obesity-Induced Adipokine Imbalance Impairs Mouse Pulmonary Vascular Endothelial Function And Primes The Lung For Injury, Dilip Shah, Freddy Romero, Michelle Duong, Nadan Wang, Bishnuhari Paudyal, Benjamin T Suratt, Caleb B Kallen, Jianxin Sun, Ying Zhu, Kenneth Walsh, Ross Summer

Center for Translational Medicine Faculty Papers

The Authors have retracted this Article. Afer publication of this Article, concerns have been raised about irregularities in the western blot data. In particular, the following bands appear to be duplicated: – Fig. 1e HFD/p-Src lane 1 and 3; – Fig. 4c NCD/Ve-cadherin lane 1 and 3 – Fig. 5e HFD+APN/ICAM-1 lane 1 and 2 – Fig. 5f HFD/beta-catenin lane 2 and HFD+APN/beta-catenin lane 1 – Fig. S1d HFD/beta-catenin all lanes – Fig. S4c NCD/beta-catenin lane 1 and 3. Additionally, the beta-catenin subpanel in Fig. 5f was subsequently reused in another study [1] and described as showing GRP87. Te Authors …