Digital Commons Network^™

Antioxidant Content In Plant-Based Diets Versus Meat-Based Diets, Lia Meadows, Peeper Walker, Reveca Tomas

JSU Student Symposium 2022

The result of naturally occurring free radicals in the body are oxidative-stress-related damages to cells, tissues, and biomolecules. Oxidative stress occurs when the balance between reactive oxygen species (ROS) outnumbers antioxidants, producing negative effects. Antioxidants exist as a natural defense mechanism utilized by the body. This defense exists in two distinct forms: enzymatic and non-enzymatic antioxidants. Non-enzymatic antioxidants consist of vitamins and bioactive compounds, such as phenols. In previous studies, plant-based diets showed promising results in reducing damage caused by oxidative-stress. The purpose of this study was to determine the extent to which antioxidant concentration differs between meat-based diet and …

Bentham’S Public Utilitarianism And Its Jurisprudential Significance, Dan Priel

Articles & Book Chapters

One of the ways by which Gerald Postema’s Bentham and the Common Law Tradition revolutionized the study of Bentham’s jurisprudence was by challenging the idea, made popular by Hart (both in his jurisprudential work and his interpretation of Bentham), that the study of law in general is normatively neutral. Against this view, Postema argued that one must understand Bentham’s views on law and jurisprudence in relation to his utilitarianism. At the time of publishing the book, Bentham went very much against the grain, but this view has since gained considerable support. In my paper I seek to refine it. As …

Similarly Efficacious Anti-Malarial Drugs Sj733 And Pyronaridine Differ In Their Ability To Remove Circulating Parasites In Mice, Arya Sheelanair, Aleksandra S. Romanczuk, Rosemary A. Aogo, Rohit Nemai Haldar, Lianne I. M. Lansink, Deborah Cromer, Yandira G. Salinas, R. Kiplin Guy, James S. Mccarthy, Miles P. Davenport, Ashraful Haque, David S. Khoury

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Artemisinin-based combination therapy (ACT) has been a mainstay for malaria prevention and treatment. However, emergence of drug resistance has incentivised development of new drugs. Defining the kinetics with which circulating parasitized red blood cells (pRBC) are lost after drug treatment, referred to as the "parasite clearance curve", has been critical for assessing drug efficacy; yet underlying mechanisms remain partly unresolved. The clearance curve may be shaped both by the rate at which drugs kill parasites, and the rate at which drug-affected parasites are removed from circulation.

METHODS: In this context, two anti-malarials, SJ733, and an ACT partner drug, pyronaridine …

A Current Model Of Sex Including All Biological Components Of Sexual Reproduction, Joshua D. Safer

Law and Contemporary Problems

No abstract provided.

Unlawful Genders, Anthony Michael Kreis

Law and Contemporary Problems

No abstract provided.

Stall Wars: Sex And Civil Rights In The Public Bathroom, Wickliffe Shreve

Law and Contemporary Problems

No abstract provided.

Differences In Psychosocial Constructs Among Elementary School Staff That Implement Physical Activity Programs: A Step In Designing Implementation Strategies, Jacob Szeszulski, Timothy J Walker, Michael C Robertson, Maria E Fernandez

Faculty, Staff and Student Publications

Multiple types of school staff members (e.g., classroom teachers, principals) are involved in implementing physical activity programs (e.g., classroom-based, gym), but factors specific to their job responsibilities may inhibit their ability to implement programming effectively. Thus, implementation strategies tailored by job type may be needed. We compare perceptions of behavioral constructs related to implementation of school-based physical activity programs, by job type, among school staff. School staff (n = 139), including principals/assistant principals (n = 21), physical education teachers (n = 41), and classroom teachers (n = 77), from elementary schools (n = 25), completed a cross-sectional survey measuring perceptions …

Feasibility Of Administering Human Pancreatic Cancer Chemotherapy In A Spontaneous Pancreatic Cancer Mouse Model, Abagail M Delahoussaye, Joseph Abi Jaoude, Morgan Green, Tara N Fujimoto, Jessica Molkentine, Carolina J Garcia Garcia, Jason P Gay, Ningping Feng, Joseph Marszalek, Natalie Fowlkes, Cullen M Taniguchi

Faculty, Staff and Student Publications

Background: Both modified FOLFIRINOX (mFFX) and gemcitabine/nab-paclitaxel chemotherapy regimens have been shown to improve clinical outcomes in patients with pancreatic cancer, and are often used interchangeably as the standard of care. Preclinical studies often do not use these regimens, since administering these multiagent approaches can be difficult. In this study, we assessed the feasibility of administering these two chemotherapy regimens in spontaneous pancreatic tumors using KPC mice with the ultimate goal of advancing preclinical studies.

Methods: KPC mice were created by breeding KrasLSL-G12D/+ to Trp53fl/fl;Ptf1αCre/+, resulting in KrasLSL-G12D/+;p53fl/+;Ptf1αCre/+ mice. At 14 weeks of age, mice were palpated for spontaneous tumor …

Spatial Transcriptomics Of Dorsal Root Ganglia Identifies Molecular Signatures Of Human Nociceptors, Diana Tavares-Ferreira, Stephanie Shiers, Pradipta R Ray, Andi Wangzhou, Vivekanand Jeevakumar, Ishwarya Sankaranarayanan, Anna M Cervantes, Jeffrey C Reese, Alexander Chamessian, Bryan A Copits, Patrick M Dougherty, Robert W Gereau, Michael D Burton, Gregory Dussor, Theodore J Price

Faculty, Staff and Student Publications

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These neurons are critical for the generation of neuronal signals that ultimately create the perception of pain. Nociceptors are also primary targets for treating acute and chronic pain. Single-cell transcriptomics on mouse nociceptors has transformed our understanding of pain mechanisms. We sought to generate equivalent information for human nociceptors with the goal of identifying transcriptomic signatures of nociceptors, identifying species differences and potential drug targets. We used spatial transcriptomics to molecularly characterize transcriptomes of single DRG …

Pharmacological Modulation Of Kv13 Potassium Channel Selectively Triggers Pathological B Lymphocyte Apoptosis In Vivo In A Genetic Cll Model, Filippo Severin, Andrea Urbani, Tatiana Varanita, Magdalena Bachmann, Michele Azzolini, Veronica Martini, Marco Pizzi, Angelo Paolo Dei Tos, Federica Frezzato, Andrea Mattarei, Paolo Ghia, Maria Teresa Sabrina Bertilaccio, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Gianpietro Carlo Semenzato, Luigi Leanza, Livio Trentin, Ildiko Szabò

Faculty, Staff and Student Publications

Background: Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells, compared to healthy lymphocytes. In vitro, inhibition of mitoKv1.3 by PAPTP was shown to kill ex vivo primary human CLL cells, while targeting IKCa with TRAM-34 decreased CLL cell proliferation.

Methods: Here we evaluated the effect of the above drugs in CLL cells from ibrutinib-resistant patients and in combination with Venetoclax, two drugs used in the clinical practice. The effects of the drugs were tested also in the Eμ-TCL1 …

A Synergistic Combination Of Dha, Luteolin, And Urolithin A Against Alzheimer’S Disease, Dona P.W. Jayatunga, Eugene Hone, Binosha W.M.A. Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. The classical AD brain is characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates as senile plaques and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated forms of the microtubule-associated protein Tau. There has been limited success in clinical trials for some proposed therapies for AD, so attention has been drawn toward using alternative approaches, including prevention strategies. As a result, nutraceuticals have become attractive compounds for their potential neuroprotective capabilities. The objective of the present study was to derive a synergistic nutraceutical combination in …

Visualizing Connectivity For Wildlife In A World Without Roads, Catherine De Rivera, Leslie Bliss-Ketchum, Martin Lafrenz, A. V. Hanson, L. E. Mckinney-Wise, A. H. Rodriguez, J. Schultz, Alana Simmons, D. Taylor Rodriguez, Multiple Additional Authors

Environmental Science and Management Faculty Publications and Presentations

Roads are not the only determining factor for wildlife movement across the landscape, but due to the extensive distribution of the road network their impact can be dramatic. Although it has been well documented that roads decrease habitat connectivity for wildlife due to animal-vehicle collisions, habitat fragmentation, and avoidance behavior, approaches for identifying connectivity across the landscape often do not fully examine the barrier effect of roads. Here, we explored the extent of the impact of roadways on wildlife connectivity by using Omniscape to model connectivity including and without the barrier effect of roads, then evaluating the difference between these …

Evaluation Of Herbage Intake Estimation Methods For Dairy Cattle Grazing On Semi-Extensive Pastures, S. Perdana-Decker, E. Velasco, J. Werner, U. Dickhoefer

IGC Proceedings (1977-2023)

Available empirical and mechanistic models to estimate total dry matter intake (DMI) and pasture dry matter intake (PDMI) of grazing lactating dairy cows have mainly been developed under intensive grazing conditions. The objective was to evaluate the adequacy of such existent models for use under semi-extensive grazing conditions, characterised by semi-natural grassland and less intensive resource use. Feed intake of lactating cows was measured on three commercial organic dairy farms in South Germany during one or two 6-d-periods/farm in 2019. Each period, DMI was determined in 10 or 20 cows per farm from their daily faecal output measured using titanium …

Tracing The Path Of Technology Diffusion: The Case Of Nturumenti, Narok, Kenya, Paul N. Katiku, R. Kimitei, S. Amboga, G. A. Keya, B. Korir, J. Nginyi

IGC Proceedings (1977-2023)

An array of technologies; growing improved wheat varieties, bulking and collective marketing of wheat grains, sheep breed improvement, ram sharing, feedlot sheep fattening for market, strategic sheep deworming, pasture establishment and conservation practices; were introduced to members of a community based organization (CBO) in Nturumenti, anti-female genital mutilation and anti-poverty organization (AFAPO) in 2014. The CBO members, composed of youthful 19 men and 7 females, were intensively exposed and involved in the new skills both theoretically and practically in the farmers’ field school model. Even though the 8 farming technology options were suitable for the study environment, their adoption and …

The Use Of Sunn Hemp As Forage In Florida, João M. B. Vendramini, J. E. Garzon Alfonso, H. M. Da Silva, Maria L. Silveira, J. C. B. Dubeux Jr., M. Kaneko

IGC Proceedings (1977-2023)

Sunn hemp (Crotalaria juncea L.) is a warm-season annual legume that has been widely used as cover crop; however, there is potential to use sunn hemp as forage in subtropical regions. The objective of this study was to evaluate management practices to improve the efficiency of using sunn hemp as a forage crop. The study was conducted in Ona, Florida, USA from 2016 to 2018 and tested the factorial arrangement of five sunn hemp genotypes (Crescent Sunn, Ubon, Blue Leaf, and AU Golden) and two harvest times (60 d after seeding or flowering) with four replicates. There was a …

The Optimum Seeding And Harvesting Dates Of Sorghum-Sudangrass Hybrid (Sorghum Bicolor L.) Via Optimum Moving Response Surface Methodology, M. Kim, J. Y. Kim, M. H. Jo, C. H. Kim, K. Sung

IGC Proceedings (1977-2023)

This study aimed to detect the optimum seeding and harvesting dates, and to verify the variation of dry matter yield (DMY) for sorghum-sudangrass hybrid (SSH) via optimum moving RSM proposed to optimize the RSM in metadata. For detecting the optimum point, a response surface methodology (RSM) has been known well in agricultural science. The SSH metadata (n = 856) consists of individual experiments that could be performed to check the optimum seeding and harvesting dates by classic RSM. However, the SSH metadata failed to produce an effective single equation which can be detected the optimum seeding and harvesting dates due …

The Importance Of Soil Seed Bank Dynamics As Potential Indicators Of Desertification Tipping Point, N. Hamunyela, W. C. Nesongano, K. Tielbörger

IGC Proceedings (1977-2023)

Soil seed banks play a major role in the vegetation dynamics of drylands, where annual rainfall is unpredictable and plants depend on a persistent stage (seeds) to survive over the dry season. The purpose of the study is to understand the behaviour of the rangeland system in terms of soil seed bank dynamics before, during and after crossing the “so called” DTP and to determine whether different management systems plays a role in accelerating the desertification process. Through the use of the Space for Time Substitution Approach the study analysed spatial grazing gradients (gradients radiating from water points) to predict …

Abolish Copaganda!: An Acab Analysis Of Sisters And The Wicker Man And The Ramifications Of Abolitionist Spectatorship, Anjali Moore

Tapestries: Interwoven voices of local and global identities

After the 2020 Twin Cities Uprising, the term “ACAB” (All Cops Are Bastards) surged in popularity though it has been in circulation for nearly a century. Applying an ACAB lens to films suggests an intentional approach to spectatorship by integrating a critical consciousness about the systemic racism that the police embody. Portrayals of police are an omnipresent occurrence in media of all kinds and often function to cultivate trust in their authority. Brian DePalma’s 1973 slasher Sisters and Robin Hardy’s 1973 cult classic The Wicker Man exhibit notable anti-police sentiment that may feel unexpectedly radical for a pre-Uprising world. Using …

Tapestries 2022: Message From The Professor, Karin Aguilar-San Juan

Tapestries: Interwoven voices of local and global identities

Professor Karín Aguilar-San Juan introduces the 2022 issue of Tapestries with a short essay that addresses the politics of disappointment and draws from freewriting by members of the journal's collective as a way to process the positive and negative feelings of entering Senior Year in a time of continuing global pandemic.

Interview With William Brannen, Zach S. Henderson Library Special Collections

Zach S. Henderson Library Special Collections Oral History Collection

A part of the "Our Hometown Heroes" series. William Brannen interviewed by Linda Awe, November 13, 1999.

Interview With Judges Dorothy Beasley, Anthony Alaimo, Zach S. Henderson Library Special Collections

Zach S. Henderson Library Special Collections Oral History Collection

Judges Dorothy Beasley and Anthony Alaimo interviewed by an unknown interviewer, April 12, 1991. Find this collection in the University Libraries' catalog!

Interview With Carl Atwell, Zach S. Henderson Library Special Collections

Zach S. Henderson Library Special Collections Oral History Collection

A part of the "Our Home Town Heroes" series. Carl Atwell interviewed by Linda Awe, November 13, 1999. Find this collection in the University Libraries' catalog!

Lecture By Judges Dorothy Beasley And Anthony Alaimo, Zach S. Henderson Library Special Collections

Zach S. Henderson Library Special Collections Oral History Collection

Lecture given by Judges Dorothy Beasley and Anthony Alaimo, given April 12, 1991. Find this collection in the University Libraries' catalog

Promoting Rangeland Restoration And Climate Resilience Through Grazing Case Studies, T. D. Hudson, S. A. Hall, G. G. Yorgey, S. Neibergs, M. R. Reeves, S. Jensen

IGC Proceedings (1977-2023)

Cow-calf beef operations are the primary users of the 8.75 million hectares of rangelands in the U.S. Pacific Northwest and will have to adapt to ongoing and future climate change. Management directed toward current rangeland stressors which may be amplified under a changing climate—including fire risk, invasive plants, and droughts—is likely to improve future resilience. And although climate change discussions have become highly politicized, our experience suggests that Pacific Northwest ranchers support "no-regrets” strategies that provide ecological and economic benefits under a variety of future conditions. Our goal is to foster adoption of these strategies by sharing individual success stories. …

The Effects Of Microbial Inoculation On Short-To-Long Fermentation And Aerobic Stability Of Grass-Legume Silage Ensiled In Big Bales, J. Jatkauskas, V. Vrotniakiene, K. L. Witt, G. Copani, I. Eisner

IGC Proceedings (1977-2023)

Wilted (35.9 % DM and 2.6% WSC) moderately difficult to ensile grass-legume mixture (red clover, alfalfa and timothy 50:20:30) was ensiled in cylindrical big bales (1.2 m hight and 1.2 m diameter) with a weight about 700 kg. The crop was ensiled for 8, 32 and 120 days with or without a microbial inoculation (SiloSolve^® FC containing Lactococcus lactis DSM 11037/1k2081 and Lactobacillus buchneri DSM 22501/1k20738 applied at 1.5×10⁵ CFU g^-1 forage). Ten bales per treatment were prepared for each fermentation period. After each period of ensiling the big bales were opened, sampled, and tested for fermentation …

Spatial And Temporal Variation Of Stocking Rate In A Rotational Grazing System On A Namibian Cattle And Sheep Farm From 2006 To 2017, L. Ludwig, C. Huelsebusch

IGC Proceedings (1977-2023)

The debate on appropriate stocking rates (SR) increasingly recognizes the importance of variable, targeted and adaptive stocking in response to a temporally variable and spatially heterogeneous resource distribution, particularly in challenging environments such as the Namibian savannah. In common extensive ranching systems, a farmer’s scope of action is often limited to flexibly adjusting the number and concentration of livestock to the available forage in space and time. SRs are commonly set according to carrying capacity recommendations which usually have a low spatio-temporal resolution. This may lead to punctual under- and overutilization. The Namibian Rangeland Management Strategy advocates adjusting SR in …

Omar Truman Burleson Papers, 1947-1979, Omar Truman Burleson

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

Salmon Week Three Clean Transcript, Tally Eastman, Hannah Miller, Aiden Modrell, Aiyana Montez

Heritage Conversation Partners

No abstract provided.

Classifywiki: A Framework For Building Generic-Type Wikipedia Classifiers, Michel Naim Gerguis, M. Watheq El-Kharashi, Cherif Salama

Faculty Journal Articles

No abstract provided.

Reversible Lysine Fatty Acylation Of An Anchoring Protein Mediates Adipocyte Adrenergic Signaling., Rushita A Bagchi, Emma L Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A Tharp, Hanan Qasim, Kathleen M Gavin, Julie Pires Da Silva, Jennifer L Major, Bradley K Mcconnell, Edward Seto, Hening Lin, Timothy A Mckinsey

Biochemistry and Molecular Medicine Faculty Publications

No abstract provided.