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Genetic Variation Of The Mitochondrial Dna Control Region Across Plains Bison Herds In Usa And Canada, Gaimi Davies, Blake Mccann, Lee Jones, Stefano Liccioli, Maria Cecilia Penedo, Igor V. Ovtchinnikov

Biology Faculty Publications

Once numbering in the tens of millions, bison (Bison bison) have faced a broad range of challenges over the past century, including genetic impacts from the population bottleneck in the 1800s, and significant loss and fragmentation of habitat resulting in little opportunity for population growth on remaining small, geographically isolated reserves. To identify best practices for bison stewardship against this backdrop, managers must understand the genetic composition of existing conservation herds. This study characterized 14 plains bison (Bison bison bison) herds managed by the U.S. Department of Interior and Parks Canada Agency based on complete mtDNA …

Atomic Structure Of The Predominant Gii4 Human Norovirus Capsid Reveals Novel Stability And Plasticity, Liya Hu, Wilhelm Salmen, Rong Chen, Yi Zhou, Frederick Neill, James E Crowe, Robert L Atmar, Mary K Estes, B V Venkataram Prasad

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) cause sporadic and epidemic viral gastroenteritis worldwide. The GII.4 variants are responsible for most HuNoV infections, and GII.4 virus-like particles (VLPs) are being used in vaccine development. The atomic structure of the GII.4 capsid in the native T = 3 state has not been determined. Here we present the GII.4 VLP structure with T = 3 symmetry determined using X-ray crystallography and cryo-EM at 3.0 Å and 3.8 Å resolution, respectively, which reveals unanticipated novel features. A novel aspect in the crystal structure determined without imposing icosahedral symmetry is the remarkable adaptability of the capsid protein VP1 …

Comparison Of Transcervical Insemination Versus Surgical Insemination Methods In Dogs At A Veterinary Clinic In Lincoln, Nebraska, Lauren Ahlers

Honors Program: Senior Projects (Public)

Artificial insemination paved the way for many advancements in reproductive technology. Two common artificial insemination methods recommended for use with frozen semen are transcervical insemination and surgical insemination. To better understand the conception rates of dogs for each method, data was collected from Hillcrest Animal Clinic. The data suggested that neither transcervical insemination nor surgical insemination was significantly better than the other. 50% of the dogs conceived when inseminated using the transcervical method, and 54.5% of the dogs conceived when inseminated using the surgical method. Based on the results, more data needs to be collected on both insemination procedures to …

Cytokines In The Pathogenesis Of Large Granular Lymphocytic Leukemia, Colleen Isabelle, Amy Boles, Nitin Chakravarti, Pierluigi Porcu, Jonathan Brammer, Anjali Mishra

Department of Medical Oncology Faculty Papers

Large granular lymphocytic leukemia (LGLL) is a lymphoproliferative disorder of older adults characterized by the clonal expansion of cytotoxic T/natural killer cells due to constitutive pro-survival signaling. In recent years, it has become clear that cytokines and their receptors are aberrantly expressed in LGLL cells. The exact initiation process of LGLL is unknown, although several cytokine-driven mechanisms have emerged. Elevated levels of several cytokines, including interleukin-15 (IL-15) and platelet-derived growth factor (PDGF), have been described in LGLL patients. Evidence from humans and animal models has shown that cytokines may also contribute to the co-occurrence of a wide range of autoimmune …

Withania Somnifera: Progress Towards A Pharmaceutical Agent For Immunomodulation And Cancer Therapeutics, Vivek K. Kashyap, Godwin Peasah Darkwah, Anupam Dhasmana, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Chemotherapy is one of the prime treatment options for cancer. However, the key issues with traditional chemotherapy are recurrence of cancer, development of resistance to chemotherapeutic agents, affordability, late-stage detection, serious health consequences, and inaccessibility. Hence, there is an urgent need to find innovative and cost-effective therapies that can target multiple gene products with minimal adverse reactions. Natural phytochemicals originating from plants constitute a significant proportion of the possible therapeutic agents. In this article, we reviewed the advances and the potential of Withania somnifera (WS) as an anticancer and immunomodulatory molecule. Several preclinical studies have shown the potential of WS …

Methane And Nitrous Oxide Emissions From Grazed Grasslands, Harry Clark, C. Pinares-Patiño, C. De Klein

IGC Proceedings (1977-2023)

Key points

1. Emissions of methane (CH₄) and nitrous oxide (N₂O) from grasslands make a substantial contribution to total agricultural emissions of these two gases.

2. At present practical mitigation options that relate to grazing ruminants and grazed pastures are limited.

3. Research into agricultural greenhouse gas emissions is of low priority in most developed countries.

4. Direct manipulation of the rumen ecosystem provides the best opportunity for large reductions in CH₄ in the long term.

5. Reducing the amount of nitrogen (N) excreted by grazing animals is a priority in N₂O research, …

Mesobuthus Zarudnyi Sp. N. From Azerbaijan (Scorpiones: Buthidae), Nizami E. Novruzov, František Kovařík, Victor Fet

Euscorpius

A new species Mesobuthus zarudnyi sp. n. is described from Azerbaijan, fully illustrated with color photos. We compare the new species with two other species, M. eupeus (C. L. Koch, 1839) and M. persicus (Pocock, 1899), both found also in Azerbaijan.

Phenotypic Evaluation Of Energycane Varieties For Bioenergy, Wyatt Eason, D. M. Hollowell, Anna Hale, Jesse Ira Morrison, Brian Baldwin

IGC Proceedings (1977-2023)

The need for renewable and carbon-neutral energy is growing as fossil fuel supplies decrease and concerns of climate change increase. C₄ grasses are among the most efficient carbon accumulators. Sugarcane (Saccharum officinarum) is a renewable bioenergy crop with low inputs and high yields, but it is limited to tropical and sub-tropical climates. A close relative, Saccharum spontaneum, readily hybridizes with S. officinarum. S. spontaneum lends cold tolerance and higher yields to the hybrid progeny, called energycane. The Sugarcane Breeding Unit (USDA, Houma, Louisiana, USA) selected twenty-six genotypes for testing at Mississippi State University to determine production …

Man And His World, Clark Baise

Exile

No abstract provided.

The Queen Is Dead, Long Live The Queen, James Funaro

Exile

No abstract provided.

The Gates Of Hell; What The Chorus Said, James Funaro

Exile

No abstract provided.

The Guest, Dennis Trudell

Exile

No abstract provided.

Evergreen Session Six Clean Transcript, Liner Solarte

Heritage Conversation Partners

No abstract provided.

Effect Of Winter Canola Cultivar On Seed Yield, Oil, And Protein Content, Kyle D. Mcgeary, Jason P. De Koff, Bharat Pokharel, Richard Link, Priya Saini, Taqdeer Gill

Agricultural and Environmental Sciences Faculty Research

Winter canola (Brassica napus L.) production has increased in the United States over the past several decades; however, there is little research in the southeastern United States on its agronomic production and growth characteristics under different nitrogen (N) fertilizer rates. The objectives of this study were to determine the effects of N rates on winter mortality, yield, oil and protein content, and seedpod shatter resistance across cultivars. Canola was grown in a randomized split complete block design with four replicates under five different N rates (0, 56, 112, 168, and 224 kg N ha−1) with four different cultivars (Hekip, Inspiration, …

After A Difficult Year For The Huntington’S Disease Cause, Chdi Chief Scientist Feels ‘Reinvigorated’ And ‘Optimistic’ About Quest For Therapies, Kenneth P. Serbin Phd

At Risk for Huntington's Disease

No abstract provided.

The Suicide Rule—Cotten V. Wilson: Tennessee’S Incremental Progress Away From A Stubborn Exculpatory Tradition, Paden Hemphill

University of Memphis Law Review

No abstract provided.

Considering Sustainability From The Perspective Of Accountability: Rethinking Consumerism And The Environment, Tabassum Fahim Ruby, Madeline Mulcahey, Christine Recchi

Sustainability Research & Practice Seminar Presentations

Professor Tabassum Ruby, Women’s and Gender Studies, with Madeline Mulcahey and Christine Recchi - Considering Sustainability from the Perspective of Accountability: Rethinking Consumerism and the Environment

Astrocyte-Secreted Chordin-Like 1 Regulates Spine Density After Ischemic Injury, Elena Blanco-Suarez, Nicola J Allen

Department of Neuroscience Faculty Papers

Ischemic injury occurs when the brain is deprived of blood flow, preventing cells from receiving essential nutrients. The injury core is the brain region directly deprived and is surrounded by the peri-infarct area, the region with recovery potential. In the peri-infarct area neurons undergo acute loss of dendritic spines, which modifies synaptic plasticity and determines neuronal survival. Astrocytes can be protective or detrimental to the ischemic injury response depending on the specific stage, yet we lack clear understanding of the underlying mechanisms. Chordin-like 1 (Chrdl1) is an astrocyte-secreted protein that promotes synaptic maturation and limits experience-dependent plasticity in the mouse …

Neave Trio, March 9, 2022 [Program], University Of Northern Iowa. School Of Music.

Music Recital Programs

Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.

The Lumberjack, March 09, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Nasty Woman: An Analysis Of Women's Rage In Popular Culture, Sarah Kee

Honors Program: Senior Projects (Public)

The goal of this senior project was to analyze the underlying cause for why certain female characters in popular culture were villainized for their behavior and generally deemed to be “nasty woman.” After reading numerous books and viewing films that contained “nasty woman”, there was a common denominator that linked their behavior and influenced their decision to enact their often-bloody retribution: the patriarchy. These women were a victim of some aspect of the patriarchy, commonly sexual assault, and could not receive the support they needed, so they decided to take matters into their own hands. The “nasty women” analyzed in …

Covid-19 Testing And Education At The Allen Family Center, Zoe Beck, Elijah Chong-Gum, Josselyn Gonzalez Perea, Sydnie Gould, Emily Planck, Kamila Tracey

Nursing Leadership in Community Engagement Projects

COVID-19 Testing and Education at the Allen Family Center

COVID-19 Testing and Education at the Allen Family Center The Mount Baker community is home to many families experiencing homelessness and housing instability. According to the Department of Community and Health Services, there is an estimate of 40,800 people in King County who experienced homelessness in 2020 (King County Department of Community, 2021). The Allen Family Center (AFC) is an inviting community resource, partnered with Mary’s Place and Mercy Housing Northwest, that serves families by providing assistance with housing, medical care, and childcare; recently, the AFC began providing COVID-19 testing available …

Key Factors For Improving Rigor And Reproducibility: Guidelines, Peer Reviews, And Journal Technical Reviews, Hong S. Lu, Alan Daugherty

Saha Cardiovascular Research Center Faculty Publications

To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing detailed prospective experimental designs and providing raw data are essential premises of rigor and reproducibility. Standard peer reviews and journal-specific technical and statistical reviews are critical factors for enhancing rigor and reproducibility. This brief review also shares some experience from Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal, that has implemented several mechanisms to enhance rigor and reproducibility for preclinical research.

An Observation Of Spring Mating In Silver-Haired Bats, Jeff Clerc, Elizabeth J. Rogers, Emma Kunkle, Nathan W. Fuller

Western North American Naturalist

The mating behavior of North American tree bats (Lasiurus spp. and Lasionycteris noctivagans) is not well understood. The majority of records suggest that this group of species mates during the autumn migratory period and that females store sperm throughout the winter before resuming the reproductive cycle in spring. On 16 May 2019, while mist-netting in Bernalillo County, New Mexico, USA, we observed a male and female silver-haired bat (Lasionycteris noctivagans) copulating on the ground. Both individuals were captured and processed to obtain further details on reproductive status. To our knowledge this is the first published record …

T-Cell Responses To Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses To The Colorectal Cancer Antigen, Guanylyl Cyclase C, John C. Flickinger, Jagmohan Singh, Yanki Yarman, Robert D Carlson, Joshua Barton, Scott A Waldman, Adam E. Snook

Department of Pharmacology and Experimental Therapeutics Faculty Papers

The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. To date, over 30 clinical trials have been initiated testing Lm cancer vaccines across a wide variety of cancers, including lung, cervical, colorectal, and pancreatic. Here, we assessed the immunogenicity of an Lm vaccine against the colorectal tumor antigen GUCY2C (Lm-GUCY2C). Surprisingly, Lm-GUCY2C vaccination did not prime naïve GUCY2C-specific CD8+ T-cell responses towards the dominant H-2Kd-restricted epitope, GUCY2C254-262. However, Lm-GUCY2C produced robust CD8+ T-cell responses towards Lm-derived peptides suggesting that GUCY2C254-262 peptide may be subdominant to Lm-derived peptides. Indeed, incorporating immunogenic Lm peptides into an adenovirus-based GUCY2C …

Economic Impact Of Western Michigan University Homer Stryker M.D. School Of Medicine, Jim Robey, Kathleen Bolter, W.E. Upjohn Institute For Employment Research

Reports

No abstract provided.

Quantitative Assessment Of The Trophic Ecology Of The Oceanic Ctenophore, Bolinopsis Infundibulum, In Monterey Bay, California, Victoria C. Scriven

USF Tampa Graduate Theses and Dissertations

Bolinopsis infundibulum is a wide-ranging, ubiquitous ctenophore whose fragile nature makes the collection of specimens and quantification of key predator-prey activities in controlled laboratory experiments, challenging. Thus, in situ methods often represent the best means for data collection. However, while present in surface waters, these animals can also be abundant at depths well beyond those attainable by divers. As a result, very little empirical data exist over the depth range of their natural habitats which limits our ability to assess key predator-prey interactions needed to assess their ecological role in midwater food webs. Working in Monterey Bay, California, remotely operated …

Impact Of New Technologies On Weed Control In Louisiana Rice Production, David C. Walker

LSU Doctoral Dissertations

Field studies were conducted in 2018-2021 at the LSU Agricultural Center’s H.R. Caffey Rice Research Station (RRS) near Crowley, LA, and the Dean Lee Research and Extension Center (DLREC) near Alexandria, LA to evaluate off-target florpyrauxifen movement on soybean. Soybean was treated with florpyrauxifen at the V4-V5 or R1-R2 growth stages. Soybean injury was evaluated at 1, 7, 14, and 28 days after treatment (DAT) and soybean plant height (cm) was recorded at 7, 14, and 28 DAT. At soybean maturity, yield and individual yield components were subjected to regression analysis to describe the relationship between florpyrauxifen rate and soybean …

Applications Of Simulation Analysis To Generate Reference Points And Evaluate Management Control Rules In Three Eastern Us Fisheries, Laura Solinger

Dissertations

Myriad sources of uncertainty are characteristic of or impact all commercial and recreational fisheries, contributing uncertainty to the determination of stock status. In the face of these uncertainties, fisheries managers tend to reserve fishery resources from the management targets to allow for variability. Simulation analysis is a useful tool to complement and extend formal stock assessment models to better inform managers of the risk that a management strategy results in an overfished stock or overfishing occurs over some period of time. Three examples of simulation analysis are presented to address risk-tolerance and development of management thresholds for three commercially important …

Oxygen Ion Escape At Venus Associated With Three-Dimensional Kelvin-Helmholtz Instability, Tong Dang, Xuanye Ma, Jiuhou Le, Binzheng Zhang, Tielong Zhang, Zhonghua Yao, John Lyon, Sudong Xiao, Maodong Yan, Oliver Brambles, Kareem Sorathia

Publications

How oxygens escape from Venus has long been a fundamental but controversial topic in the planetary research. Among various key mechanisms, the Kelvin-Helmholtz instability (KHI) has been suggested to play an important role in the oxygen ion escape from Venus. Limited by either scarce in-situ observations or simplified theoretical estimations, the mystery of oxygen ion escape process associated with KHI is still unsettled. Here we present the first three-dimensional configuration of KHI at Venus with a global multifluid magnetohydrodynamics model, showing a significantly fine structure and evolution of the KHI. KHI mainly occurred at the low latitude boundary layer if …