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Activity Budgets Of Inland Versus Coastal Larus Argentatus Populations In Maine, Rebecca Cusick, Cassie Ferri Mar 2022

Activity Budgets Of Inland Versus Coastal Larus Argentatus Populations In Maine, Rebecca Cusick, Cassie Ferri

Undergraduate Research (Journal)

Comparing the behavior of wildlife populations residing in different habitats can give insight into external factors that influence behavior and explain why certain behaviors are exhibited by a species. In this study, we compared the average activity budgets of Herring Gulls (Larus argentatus) residing around inland and coastal habitats. We hypothesized that gulls in inland settings would be more likely to exhibit inactive behaviors such as loafing and sleeping, while gulls in coastal settings would exhibit more active behaviors such as foraging, walking, and squabbling. We observed a total of 100 individual gulls throughout the state of Maine, with 50 …


A Closer Look At Precision Hard Turning Of Aisi4340: Multi-Objective Optimization For Simultaneous Low Surface Roughness And High Productivity, Mohamed F. Aly, Islam H. Abdelgaliel, Adel T. Abbas, Abdulhamid A. Al-Abduljabbar Mar 2022

A Closer Look At Precision Hard Turning Of Aisi4340: Multi-Objective Optimization For Simultaneous Low Surface Roughness And High Productivity, Mohamed F. Aly, Islam H. Abdelgaliel, Adel T. Abbas, Abdulhamid A. Al-Abduljabbar

Faculty Journal Articles

This article reports an extended investigation into the precision hard turning of AISI 4340 alloy steel when machined by two different types of inserts: wiper nose and conventional round nose. It provides a closer look at previously published work and aims at determining the optimal process parameters for simultaneously minimizing surface roughness and maximizing productivity. In the mathematical models developed by the authors, surface roughness at different cutting speeds, depths of cut and feed rates is treated as the objective function. Three robust multi-objective techniques, (1) multi-objective genetic algorithm (MOGA), (2) multi-objective Pareto search algorithm (MOPSA) and (3) multi-objective emperor …


The Targeted Smac Mimetic Sw Iv-134 Augments Platinum-Based Chemotherapy In Pre-Clinical Models Of Ovarian Cancer, Pratibha S Binder, Yassar M Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Suwanna Vangveravong, David G Mutch, William G Hawkins, Matthew A Powell, Dirk Spitzer Mar 2022

The Targeted Smac Mimetic Sw Iv-134 Augments Platinum-Based Chemotherapy In Pre-Clinical Models Of Ovarian Cancer, Pratibha S Binder, Yassar M Hashim, James Cripe, Tommy Buchanan, Abigail Zamorano, Suwanna Vangveravong, David G Mutch, William G Hawkins, Matthew A Powell, Dirk Spitzer

2020-Current year OA Pubs

BACKGROUND: Ovarian cancer is initially responsive to frontline chemotherapy. Unfortunately, it often recurs and becomes resistant to available therapies and the survival rate for advanced and recurrent ovarian cancer is unacceptably low. We thus hypothesized that it would be possible to achieve more durable treatment responses by combining cisplatin chemotherapy with SW IV-134, a cancer-targeted peptide mimetic and inducer of cell death. SW IV-134 is a recently developed small molecule conjugate linking a sigma-2 ligand with a peptide analog (mimetic) of the intrinsic death pathway activator SMAC (second-mitochondria activator of caspases). The sigma-2 receptor is overexpressed in ovarian cancer and …


Ruminant Livestock Production Systems And Imperatives For Sustainable Development, J. W. Smith Mar 2022

Ruminant Livestock Production Systems And Imperatives For Sustainable Development, J. W. Smith

IGC Proceedings (1977-2023)

No abstract provided.


Biodiversity Conservation And Sustainable Livelihoods In Rangelands: Trends, Challenges And Opportunities, J. Waithaka Mar 2022

Biodiversity Conservation And Sustainable Livelihoods In Rangelands: Trends, Challenges And Opportunities, J. Waithaka

IGC Proceedings (1977-2023)

Rangelands cover about 54% of the earth’s surface and are essential for agricultural and livestock production, environmental protection and the in-situ conservation of genetic resources. Despite providing services that support life on earth, rangelands have been neglected to a large extent when compared to other types of ecosystems. This paper provides an overview of the importance of rangelands in conserving biodiversity and supporting the livelihoods of millions of people globally. Rangelands have lost ecological integrity due to unsustainable anthropogenic land-use changes and impacts. It is estimated that over 80% of Key Biodiversity Areas (KBAs) are either not adequately protected or …


Feasibility Of Organic Certification Of Sheep And Goats Produced In Pastoral Systems In Northern Kenya, F. Von Steimker, H. T. Wario, B. Kaufmann Mar 2022

Feasibility Of Organic Certification Of Sheep And Goats Produced In Pastoral Systems In Northern Kenya, F. Von Steimker, H. T. Wario, B. Kaufmann

IGC Proceedings (1977-2023)

In pastoral systems of Kenya, sale of small ruminants is the main regular income source for most households. Although the meat of small ruminants produced in Marsabit county is preferred in the domestic market, no mechanisms are in place that allow for a respective price differentiation. Establishing value chains for labelled sheep and goat meat would be an option to allow pastoralists to profit from their high process and product quality. The aim of the current study is to assess the requirements and feasibility to establish a value chain for labelled products (e.g. origin labelled, organic certified) together with the …


Uses Of Native Plant Species Of A Communal Rangeland Within ‘Sierra De Huautla’ Protected Area, México, E. Cortés-Díaz, T. González-Bonilla, L. López-Aguilar, Pedro A. Martínez-Hernández, A. Hernández-Tapia Mar 2022

Uses Of Native Plant Species Of A Communal Rangeland Within ‘Sierra De Huautla’ Protected Area, México, E. Cortés-Díaz, T. González-Bonilla, L. López-Aguilar, Pedro A. Martínez-Hernández, A. Hernández-Tapia

IGC Proceedings (1977-2023)

Sustainability of communal rangelands has become a major concern at national and international levels because land use conflicts and associated social conflicts allows for over-utilization of selected species making a high pressure on them and given away their places to species with no use at all becoming lands degraded and unproductive. The objective of the study was to determine floristic composition and native plant uses by local peasants. The range surface is of 4262 ha, belongs to the communal land ‘El Limon’, in Tepalcingo, Morelos, Mexico, and it is within the Natural Reserve Area “Sierra de Huautla”. Native vegetation is …


Sustainable Intensification In Crop-Livestock Systems, P. Rovira, Paulo C. De F. Carvalho, J. Terra, F. Lattanzi, R. Pizzio, W. Ayala Mar 2022

Sustainable Intensification In Crop-Livestock Systems, P. Rovira, Paulo C. De F. Carvalho, J. Terra, F. Lattanzi, R. Pizzio, W. Ayala

IGC Proceedings (1977-2023)

Extensive livestock production is the main animal source food system in the Pampas and Campos sub-regions in South America. Beef cattle and sheep convert forage biomass that humans cannot eat into nutrient-dense human-edible foods (meat and milk) and valuable co-products (wool). However, diverse global pressures are acting on Pampas systems including increasing demand for protein sources (food security), climate change, environmental footprint, and competition for land. The integration of small areas of pasture-crop rotations is an alternative for increasing efficiency and sustainable intensification of agroecosystems based on natural grasslands. Rotations led by improved pastures increase the carrying capacity and productivity …


The Comparative Effects Of Short Duration, High Density And Conventional, Rotational Grazing On Different Soil, Vegetation And Animal Parameters In Dry And Mesic Grasslands Of South Africa, Jamie Paulse, Paul Malan, Nico Smit Mar 2022

The Comparative Effects Of Short Duration, High Density And Conventional, Rotational Grazing On Different Soil, Vegetation And Animal Parameters In Dry And Mesic Grasslands Of South Africa, Jamie Paulse, Paul Malan, Nico Smit

IGC Proceedings (1977-2023)

Short duration, high density grazing is a grazing management strategy that incorporates the rotation of large livestock herds, often at double or triple the normal prescribed stocking densities of the specific area. It is claimed that this type of grazing management can improve rangeland health by improving soil and vegetation condition, and subsequently influencing animal performance. Regardless of the scarcity of scientific evidence validating these claims, the change from conventional rotational grazing systems to short duration, high density grazing systems is on the increase in South Africa. This study aims to assess these claims, through the quantification of various rangeland …


Enhancing Grassland Biodiversity And Its Consequences For Grassland Management And Utilisation, Johannes Isselstein Mar 2022

Enhancing Grassland Biodiversity And Its Consequences For Grassland Management And Utilisation, Johannes Isselstein

IGC Proceedings (1977-2023)

Key points

1. Grasslands make an important contribution to the biodiversity of rural landscapes.

2. Biodiversity has the potential to support the production function of grassland. The conditions for this are largely unexplored.

3. The enhancement of biodiversity on agriculturally improved, species-poor grasslands is difficult to achieve due to seed limitation and high residual soil fertility.

4. Measures to overcome constraints are addition of propagules, depletion of soil nutrients, and the use of specific sward treatments.

5. Agri-environmental schemes will play an increasing role in achieving the biodiversity targets in the future, however, the efficiency of such schemes needs improvement.


Factors Of Future Teachers’ Motivation Formation For The Physical Improvement, Anna Hakman, Olena Andrieieva, Vitalii Kashuba, Halyna Bezverkhnia, Viktoria Tsybulska, Mykola Maievskyi, Tetiana Osadchenko, Andrii Semenov, Olena Kljus, Oksana Tsiuniak, Nataliia Nikula, Oleksandr Tomenko Mar 2022

Factors Of Future Teachers’ Motivation Formation For The Physical Improvement, Anna Hakman, Olena Andrieieva, Vitalii Kashuba, Halyna Bezverkhnia, Viktoria Tsybulska, Mykola Maievskyi, Tetiana Osadchenko, Andrii Semenov, Olena Kljus, Oksana Tsiuniak, Nataliia Nikula, Oleksandr Tomenko

Baltic Journal of Health and Physical Activity

Background: The article uses factor analysis to obtain an insight into the peculiarities of the motivation for physical improvement of students from the Faculty of Primary Education with different modes of attendance. Material and methods: Analysis and synthesis of references, surveying, psychological testing, pedagogical experiment, and methods of mathematical statistics were applied. The study involved 173 female students (18–22 years of age) of pedagogical profile with full- and part-time attendance. Results: The survey highlighted the motivational factors that affect the involvement of female students of pedagogical profile in physical improvement. The motivational factors for second- and fourth-year female students with …


Searching For Mirror Books For Young Asian/Asian-American Children With Disabilities, Sohyun Meacham, Su-Jeong Wee, Wu-Ying Hsieh, Pei-Chun Chen, Bryce Davis Mar 2022

Searching For Mirror Books For Young Asian/Asian-American Children With Disabilities, Sohyun Meacham, Su-Jeong Wee, Wu-Ying Hsieh, Pei-Chun Chen, Bryce Davis

Asian American Literature: Discourses & Pedagogies

America’s changing demographics and the increasing number of children with disabilities call for appropriate representations of race/ethnicity and disabilities in materials (e.g., books) for inclusive classrooms. This study analyzed how Asian/Asian-American (A/AA) people with disabilities had been portrayed in picture books with the Asian/Pacific American Award for Literature (APAAL) or the Schneider Family Award (SFA). We addressed the intersectionality of Asian racial cultures and disabilities, focusing on the picture books with these awards, due to the potential impact of these portrayals on children. We used 35 picture books with the APAAL from 2001 to 2020 and 18 with the SFA …


Orientalism Restated In The Era Of Covid-19, Joey Kim Mar 2022

Orientalism Restated In The Era Of Covid-19, Joey Kim

Asian American Literature: Discourses & Pedagogies

This essay bridges a gap between an analysis of anti-Asian targeting and an analysis of Orientalism. Because histories of Orientalism and anti-Asian targeting pre-date the current moment, I demonstrate the centrality of Orientalism to the evolution of xenophobic language and sentiment in U.S.-foreign historical relations. I recount instances of anti-Asian, xenophobic, and “Yellow-Peril” rhetoric in the wake of the global COVID-19 pandemic. In doing so, I examine the racialization of COVID-19 as a trope of orientalism. This racialization, I argue, places the Asian-presenting body in a state of heightened visibility, precarity, and susceptibility to plunder. The newfound precarity of the …


Greater Numbers Of Antral Follicles In The Ovary Are Associated With Increased Concentrations Of Glucose In Uterine Luminal Fluid Of Beef Heifers, Alexandria P. Snider, Matthew S. Crouse, Shelby L. Rosasco, Kaitlin M. Epperson, Emmalee J. Northrop-Albrecht, Jerica J.J. Rich, Chadwick C. Chase Jr., Jeremy R. Miles, George A. Perry, Adam F. Summers, Robert A. Cushman Mar 2022

Greater Numbers Of Antral Follicles In The Ovary Are Associated With Increased Concentrations Of Glucose In Uterine Luminal Fluid Of Beef Heifers, Alexandria P. Snider, Matthew S. Crouse, Shelby L. Rosasco, Kaitlin M. Epperson, Emmalee J. Northrop-Albrecht, Jerica J.J. Rich, Chadwick C. Chase Jr., Jeremy R. Miles, George A. Perry, Adam F. Summers, Robert A. Cushman

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Increased antral follicles are associated with greater fertility and a uterine environment that is more supportive of early embryonic development in beef heifers. Glucose is a primary energy source for embryos, and glucose concentrations are elevated in uterine luminal fluid (ULF) of pregnant heifers. We hypothesized that ULF glucose concentrations and endometrial transcript abundance for glucose transporters on d16 after insemination would be greater in heifers with increased numbers of antral follicles. Heifers classified with either increased or diminished antral follicle counts were artificially inseminated following the CO-Synch protocol (d0). On d16 after insemination, reproductive tracts of heifers were collected …


The Fierce Green Fire: Vol. 12 Issue 13, Wofford College. Department Of Environmental Studies Mar 2022

The Fierce Green Fire: Vol. 12 Issue 13, Wofford College. Department Of Environmental Studies

The Fierce Green Fire

No abstract provided.


The Student Movement Volume 106 Issue 16: Making History, One Step At A Time: Au Celebrates Women's History Month, Grace No, Lauren Kim, Solana Campbell, Megan Napod, Kaela Mcfadden, Hannah Cruse, Abigail Lee, Chris Ngugi, Evin-Nazya Musgrove, Angelina Nesmith, Alexander Navarro, Isabella Koh, Alannah Tjhatra, Karenna Lee, Qualyn Robinson Mar 2022

The Student Movement Volume 106 Issue 16: Making History, One Step At A Time: Au Celebrates Women's History Month, Grace No, Lauren Kim, Solana Campbell, Megan Napod, Kaela Mcfadden, Hannah Cruse, Abigail Lee, Chris Ngugi, Evin-Nazya Musgrove, Angelina Nesmith, Alexander Navarro, Isabella Koh, Alannah Tjhatra, Karenna Lee, Qualyn Robinson

The Student Movement v. 106 (2021-2022)

HUMANS

A Life in Books, Interviewed by: Grace No

WEAAU President Interview: Caryn Cruz, Interviewed by: Lauren Kim

Women Who Inspire Us, Solana Campbell

ARTS & ENTERTAINMENT

AU Music Fest Vespers Concert, Solana Campbell

Creative Spotlight: Paige Swanson, Interviewed by: Megan Napod

Current Favorites: Women's History Month, Kaela McFadden

Where Have All the Good Women Gone?, Hannah Cruse

NEWS

March Events on Campus, Abigail Lee

Running Like a Girl, Alyssa Henriquez

"She Leads" Vespers Honors Women in Leadership, Abigail Lee

The Ukraine War: How It Began, Chris Ngugi

The Ukraine War: How It's Going, Chris Ngugi

The Ukraine War: Run, …


Fat As An Adjunct In Nerve Surgery, Allison Podsednik, Raysa Cabrejo, Joseph Rosen Mar 2022

Fat As An Adjunct In Nerve Surgery, Allison Podsednik, Raysa Cabrejo, Joseph Rosen

School of Medicine Publications

No abstract provided.


Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosis, Yukako Kayashima, Connor A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Ed Harris Mar 2022

Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosis, Yukako Kayashima, Connor A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Ed Harris

Department of Biochemistry: Faculty Publications

We have previously identified a novel atherosclerosis quantitative trait locus (QTL), Arch atherosclerosis 5 (Aath5), on mouse chromosome 10 by three-way QTL analyses between Apoe−/− mice on a DBA/2J, 129S6 and C57BL/6J background. The DBA/2J haplotype at the Aath5 locus was associated with smaller plaque size. One of the candidate genes underlying Aath5 was Stabilin-2 (Stab2), which encodes a clearance receptor for hyaluronan (HA) predominantly expressed in liver sinusoidal endothelial cells (LSECs). However, the role of Stab2 in atherosclerosis is unknown. A congenic line of Apoe−/− mice carrying Aath5 covering the Stab2 …


2022 Genz Story Expression Projects: Jack Pechter, Sindee Kerker Mar 2022

2022 Genz Story Expression Projects: Jack Pechter, Sindee Kerker

GenZ Story Expression Projects eBooks

On February 14, 2022, Lynn University hosted its 11th GenZ Story Expression Workshop, and features Holocaust survivor Jack Pechter.

There were approximately 135 students from eight different classes with 17 facilitators and two rabbis who participated in this event. The workshop was conducted on Zoom with the technical assistance of Dr. Sanne Unger. Dr. Unger moderated the Q&A after the Holocaust survivor, Mr. Pechter, shared his story.


Mmu: 04/11/22–04/17/22, Student Bar Association Mar 2022

Mmu: 04/11/22–04/17/22, Student Bar Association

Monday Morning Update

This Week @ NDLS

General Announcements

Stoic Start to the Week

Lilla in London

Sport Report by Davis Lovvorn

1L of the Week: Andrew Athenson

2Ls Taking Ls: Carol Graffeo

Ask a 3L: Henry Lay


Ucc Minutes Mar 11, 2022, Undergraduate Curriculum Committee Mar 2022

Ucc Minutes Mar 11, 2022, Undergraduate Curriculum Committee

Undergraduate Currirculum Committee Minutes

No abstract provided.


A Guide To Common Nutrition, Troy Scheer Mar 2022

A Guide To Common Nutrition, Troy Scheer

Honors Program: Senior Projects (Public)

The purpose of this project was to use the knowledge I have gained through my undergraduate courses and apply it in a format that would be beneficial for the average consumer. This project was researched, written, and designed to be accessible by someone without a background in science or nutrition with the goal of educating the reader of some basic nutrition principles. With this knowledge, it is my hope that the reader will be able to make better nutritional choices and liver a longer and healthier lifestyle by first learning how to choose the right foods. While putting this project …


Creation Of An Influenza A Virus Neuraminidase Consensus Vaccine In An Adenoviral Vector, Leigh Jahnke Mar 2022

Creation Of An Influenza A Virus Neuraminidase Consensus Vaccine In An Adenoviral Vector, Leigh Jahnke

Honors Program: Senior Projects (Public)

In the last decade, the estimated annual burden of the flu includes 12,000-52,000 deaths, 140,000-710,000 hospitalizations, and 9 million – 41 million illnesses (Centers for Disease Control and Prevention: Disease burden of the flu). Influenza A virus can mutate and infect a variety of different hosts, which results in frequent antigenic changes and even pandemics. This has led to increased attention on the creation of a universal Influenza A vaccine containing broader immunogenic coverage than current vaccines. Our research involved detailing the steps of the cloning process utilizing a consensus neuraminidase antigen. We utilized the pAdEasy Adenoviral Vector …


A Theory Of City Biogeography And The Origin Of Urban Species, Ryan A. Martin Mar 2022

A Theory Of City Biogeography And The Origin Of Urban Species, Ryan A. Martin

Faculty Scholarship

Many of the choices humans make with regard to infrastructure, urban planning and other phenomena have impacts that will last thousands of years. This can readily be seen in modern cities in which contemporary streets run along street grids that were laid out thousands of years prior or even in which ancient viaducts still play a role. However, rarely do evolutionary biologists explicitly consider the future of life likely to be associated with the decisions we are making today. Here, we consider the evolutionary future of species in cities with a focus on the origin of lineages and species. We …


A Conversation With Comics Not Otherwise Specified (Cnos) (Interview), Miranda J. Brady, Kennedy L. Ryan, Margaret Janse Van Rensburg, Kelly Fritsch, Comics Not Otherwise Specified Mar 2022

A Conversation With Comics Not Otherwise Specified (Cnos) (Interview), Miranda J. Brady, Kennedy L. Ryan, Margaret Janse Van Rensburg, Kelly Fritsch, Comics Not Otherwise Specified

Faculty and Staff Publications

No abstract provided.


Exploiting Radiation Induction Of Antigens In Cancer: Targeted Drug Delivery, Vaishali Kapoor, Abhay K Singh, Calvin D Lewis, Sapna Deore, Dennis E Hallahan Mar 2022

Exploiting Radiation Induction Of Antigens In Cancer: Targeted Drug Delivery, Vaishali Kapoor, Abhay K Singh, Calvin D Lewis, Sapna Deore, Dennis E Hallahan

Open Access Publications

Therapeutic antibodies used to treat cancer are effective in patients with advanced-stage disease. For example, antibodies that activate T-lymphocytes improve survival in many cancer subtypes. In addition, antibody-drug conjugates effectively target cytotoxic agents that are specific to cancer. This review discusses radiation-inducible antigens, which are stress-regulated proteins that are over-expressed in cancer. These inducible cell surface proteins become accessible to antibody binding during the cellular response to genotoxic stress. The lead antigens are induced in all histologic subtypes and nearly all advanced-stage cancers, but show little to no expression in normal tissues. Inducible antigens are exploited by using therapeutic antibodies …


Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosisstabilin, Yukako Kayashima1*,, Conner A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Edward N. Harris Mar 2022

Reduction Of Stabilin-2 Contributes To A Protection Against Atherosclerosisstabilin, Yukako Kayashima1*,, Conner A. Clanton, Amanda M. Lewis, Xinghui Sun, Sylvia Hiller, Phillip Huynh, Jennifer Wilder, John Hagaman, Feng Li, Nobuyo Maeda-Smithies, Edward N. Harris

Department of Biochemistry: Faculty Publications

We have previously identified a novel atherosclerosis quantitative trait locus (QTL), Arch atherosclerosis 5 (Aath5), on mouse chromosome 10 by three-way QTL analyses between Apoe−/− mice on a DBA/2J, 129S6 and C57BL/6J background. The DBA/2J haplotype at the Aath5 locus was associated with smaller plaque size. One of the candidate genes underlying Aath5 was Stabilin-2 (Stab2), which encodes a clearance receptor for hyaluronan (HA) predominantly expressed in liver sinusoidal endothelial cells (LSECs). However, the role of Stab2 in atherosclerosis is unknown. A congenic line of Apoe−/− mice carrying Aath5 covering the Stab2DBA allele …


The Last Conversation, Muhammad Ismail Khalid Yousaf Mar 2022

The Last Conversation, Muhammad Ismail Khalid Yousaf

Journal of Wellness

The brain-death exam is one of the most sensitive undertakings for a physician, especially a neurologist, because of its social and legal implications. It is the vital examination establishing a clear lack of meaningful vitals, allowing a family to mark the end of a journey and a life finally complete. Physicians who perform and establish this death-decision must ensure they are au courant with the family's sentiments and concerns. It would behoove this obligated physician to bear in mind that it is a human being who will go through this invasive and rough exam. This comatose person is a father …


Synergy Of Venetoclax And 8-Chloro-Adenosine In Aml: The Interplay Of Rrna Inhibition And Fatty Acid Metabolism, Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S Chen, Bin Zhang, Vinod Pullarkat, Steven T Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen Mar 2022

Synergy Of Venetoclax And 8-Chloro-Adenosine In Aml: The Interplay Of Rrna Inhibition And Fatty Acid Metabolism, Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S Chen, Bin Zhang, Vinod Pullarkat, Steven T Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen

Faculty, Staff and Student Publications

It is known that 8-chloro-adenosine (8-Cl-Ado) is a novel RNA-directed nucleoside analog that targets leukemic stem cells (LSCs). In a phase I clinical trial with 8-Cl-Ado in patients with refractory or relapsed (R/R) AML, we observed encouraging but short-lived clinical responses, likely due to intrinsic mechanisms of LSC resistance. LSC homeostasis depends on amino acid-driven and/or fatty acid oxidation (FAO)-driven oxidative phosphorylation (OXPHOS) for survival. We recently reported that 8-Cl-Ado and the BCL-2-selective inhibitor venetoclax (VEN) synergistically inhibit FAO and OXPHOS in LSCs, thereby suppressing acute myeloid leukemia (AML) growth in vitro and in vivo. Herein, we report that 8-Cl-Ado …


Assessment Of Diversity Of Antimicrobial Resistance Phenotypes And Genotypes Of Mannheimia Haemolytica Isolates From Bovine Nasopharyngeal Swabs, Hannah F. Carter, Robert W. Wills, Matthew A. Scott, Alexis C. Thompson, Randall S. Singer, John Dustin Loy, Brandi B. Karisch, William B. Epperson, Amelia R. Woolums Mar 2022

Assessment Of Diversity Of Antimicrobial Resistance Phenotypes And Genotypes Of Mannheimia Haemolytica Isolates From Bovine Nasopharyngeal Swabs, Hannah F. Carter, Robert W. Wills, Matthew A. Scott, Alexis C. Thompson, Randall S. Singer, John Dustin Loy, Brandi B. Karisch, William B. Epperson, Amelia R. Woolums

School of Veterinary and Biomedical Sciences: Faculty Publications

The threat of bovine respiratory disease (BRD) for cattle operations is exacerbated by increasing prevalence of antimicrobial resistance (AMR) in Mannheimia haemolytica, a leading cause of BRD. Characterization of AMR in M. haemolytica by culture and susceptibility testing is complicated by uncertainty regarding the number of colonies that must be selected to accurately characterize AMR phenotypes (antibiograms) and genotypes in a culture. The study objective was to assess phenotypic and genotypic diversity of M. haemolytica isolates on nasopharyngeal swabs (NPS) from 28 cattle at risk for BRD or with BRD. NPS were swabbed onto five consecutive blood agar plates; …