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The Beacon, April 8, 2022, The Beacon Staff

The Beacon, 2021-2022

Unsung Heroes: Drew Schmidt; NW celebration of research display; Bublé steps out of his usual Christmas cave; Struggling plot meets simple hero action movie; The missing piece to the English department; Sharing their gifts and love of God through music; Welcher discusses purity culture; SOSs planned for this summer; Why we must stand firm with others; Political deception is not pro-life; Would you rather be a human or a zombie?; Softball splits against Concordia in home opener; NW men’s tennis fall to Concordia in windy match; Red Raider eSports back in action this semester; The Humans vs. Zombies tradition; Business …

Independent And Interactive Effects Of Genetic Background And Sex On Tissue Metabolomes Of Adipose, Skeletal Muscle, And Liver In Mice., Ann E Wells, William T Barrington, Stephen Dearth, Nikhil Milind, Gregory W. Carter, David W Threadgill, Shawn R Campagna, Brynn H Voy

Faculty Research 2022

Genetics play an important role in the development of metabolic diseases. However, the relative influence of genetic variation on metabolism is not well defined, particularly in tissues, where metabolic dysfunction that leads to disease occurs. We used inbred strains of laboratory mice to evaluate the impact of genetic variation on the metabolomes of tissues that play central roles in metabolic diseases. We chose a set of four common inbred strains that have different levels of susceptibility to obesity, insulin resistance, and other common metabolic disorders. At the ages used, and under standard husbandry conditions, these lines are not overtly diseased. …

Ucc Minutes Apr 8, 2022, Undergraduate Curriculum Committee

Undergraduate Currirculum Committee Minutes

No abstract provided.

A Content And Sentiment Analysis Of Facebook Posts Regarding Wild Horse Management, Libbie Anderson

Student Research Symposium

Controversy surrounding wild horse populations and public lands use has directly affected 177 herd management areas over 26.9 million acres across 10 western states, and grasped the attention of thousands across the nation. As a topic that impacts agriculture, public land use policy, and sparks public conversation, there is a need to understand how wild horse management is being communicated and perceived. The purpose of this study was to better understand public sentiment and current conversations on Facebook regarding wild horse management practices, including fertility control, roundups, and adoption. This was done by conducting a quantitative content analysis and social …

Id104 Oral History, Uniting Cultures

Uniting Cultures: Who We Are, How We Got Here: Collecting Stories Oral History Collection

A male born in the early 1990s in Mexico. He is the oldest of four children and has only been living in the U.S. for the last two years. He came to the United States with a TN visa. He lived with his cousin before coming to St. James and sends money to his family back in Mexico. Currently, he lives and works in St. James.

Always Running At Sunset, Amelia O'Neill

Theses and Dissertations

My thesis show includes paintings that depict scenes of the trails that my dog and I frequent in Utah. These paintings are a response to experiences I have in nature and explore my relationship with my dog and the surrounding flora and fauna along the local trails. The paintings include images of rocks, sticks, dirt, trails, dogs, clouds, and dried sunflowers in the wind. In addition to realistic depictions of nature, my paintings reflect on the psychological and emotional state of being in nature. The title of the show is Always Running at Sunset, which is meant to be taken …

A Choral Conductor's Study, Rehearsal, And Performance Guide To Selected Pieces By Brahms, Josquin, Källman, Mozart, Nystedt, And Purcell, Amanda Massengill

Research Papers

This document is an overview of the research and rehearsal considerations made in preparation for works programmed on a choral conducting recital. The pieces on the program are: Josquin’s El Grillo, Purcell’s “Man That Is Born of a Woman,” Mozart’s Te Deum Laudamus, Brahms’ “Sehnsucht,” Källman’s Peze Kafé, and Nystedt’s “Peace I Leave With You.” The program is ultimately a chronology spanning from the Baroque era into the Modern era. When selecting these pieces, it was of high importance to locate works that both showcased the nuances of each major musical time period and combined to form …

Investigating Student Learning About Disease Spread And Prevention In The Context Of Agent-Based Computational Modeling, Siyu Wu

Student Research Symposium

The COVID-19 pandemic has highlighted a need to help students learn about public health issues, including the transmission of disease and methods for the prevention of epidemics. This study presents data from a project aimed at developing a computational modeling microworld to help middle school students learn about the spread of disease. The microworld is meant to help students model and test their ideas about how a disease spreads through a population and how an epidemic can be prevented. I employed a lab-based case study approach to conduct one-on-one 1.5-hour interviews through Zoom with four middle school students (ages 12-14). …

Intact Mitochondrial Substrate Efflux Is Essential For Prevention Of Tubular Injury In A Sex-Dependent Manner, Allison Mccrimmon, Kerin M. Cahill, Claudia Kruger, Margaret E. Mangelli, Emily Bouffard, Timothy Dobroski, Kelly N. Michanczyk, Susan J. Burke, Robert C. Noland, Daria V. Ilatovskaya, Krisztian Stadler

Division of Basic Science Faculty Publications

The importance of healthy mitochondrial function is implicated in the prevention of chronic kidney disease (CKD) and diabetic kidney disease (DKD). Sex differences also play important roles in DKD. Our previous studies revealed that mitochondrial substrate overload (modeled by homozygous deletion of carnitine acetyl-transferase [CrAT]) in proximal tubules causes renal injury. Here, we demonstrate the importance of intact mitochondrial substrate efflux by titrating the amount of overload through the generation of a heterozygous CrAT-KO model (PT-CrATHET mouse). Intriguingly, these animals developed renal injury similarly to their homozygous counterparts. Mitochondria were structurally and functionally impaired in both sexes. Transcriptomic analyses, however, …

Auxora Vs. Placebo For The Treatment Of Patients With Severe Covid-19 Pneumonia: A Randomized-Controlled Clinical Trial, Charles Bruen, Mukhtar Al-Saadi, Edward A. Michelson, Maged Tanios, Raul Mendoza-Ayala, Joseph B. Miller, Jeffrey Zhang, Kenneth Stauderman, Sudarshan Hebbar, Peter C. Hou

Emergency Medicine Articles

BACKGROUND: Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia.

METHODS: CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in adults with severe COVID-19 pneumonia. Eligible patients were adults with ≥ 1 symptom consistent with COVID-19 infection, a diagnosis of COVID-19 confirmed by laboratory testing using polymerase chain reaction or other assay, and pneumonia documented by chest imaging. Patients were also required to be receiving oxygen therapy using either a high …

Id112 Oral History, Uniting Cultures

Uniting Cultures: Who We Are, How We Got Here: Collecting Stories Oral History Collection

Salvadoran man born in the early 60s and came to California in the 1990s. Got a college education and was a teacher and entrepreneur in El Salvador. Work in clothing design and printing in California and bought a house. Pushed by economic precarity around 2008 to move to St. James where he already had family members and a real estate investment. One of his children was in college in Mankato at the time of the interview.

Guide To Lionfish Management In The Mediterranean, P Kleitou, Jm Hall-Spencer, S Rees, D Kletou

School of Biological and Marine Sciences

No abstract provided.

Effects Of Optical Configuration And Sampling Efficiency On The Response Of Low-Cost Optical Particle Counters, Brady Scott Hales

Theses and Dissertations

Hazards associated with air pollution motivate the search for technologies capable of monitoring individual exposure to gaseous pollutants and particulate matter (PM). A Low-cost Optical Particle Counter (OPC), costing less than 50 USD, is an example of such technologies. Currently, OPCs are widely used to measure the concentration of particle matter in ambient air. While these low-cost air quality sensors are widely available, the accuracy and precision of these devices is highly uncertain. Consequently, the purpose of this thesis is to present an analytical model of two generic, low-cost OPCs based on the Laws of Conservation of Mass, Momentum, and …

Developing An Educational Foundation For Incorporating Animal Assisted Interventions Into Rehabilitation Settings, Chandni Vyas

OTD Capstone Projects

The purpose of this capstone experience was to identify and fill the need for standardized education in the field of occupational and physical therapy regarding the implementation of animal-assisted interventions (AAI) into treatment. Working with Belmont University Professor, Dr. Christi Williams, PTT, DPT, OCS, Cert MDT, a course describing the foundations of AAI in practice was created to provide occupational and physical therapy practitioners with a standardized educational course for incorporating therapy animal teams into client-centered interventions. The course was piloted on students in both fields, and a feedback survey was utilized to learn about the attitudes regarding the appropriateness …

Correction Of F508del And G542x Mutations In Sheep Fibroblasts Of Cystic Fibrosis Models Using Crispr/Cas9 And Piggybac, Kaden Bunch

Student Research Symposium

Cystic Fibrosis (CF) is a human genetic disease caused by mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. Among the ~2000 known CF mutations, F508del mutation is found in 84% and G542X in 4.6% of the CF patients in US, respectively. The F508del mutation occurs in the exon 11 and is characterized by the deletion of the ‘CTT’ nucleotides that ultimately deletes the Phenylalanine residue at the position 508 of CFTR. It causes the misfolding of the CFTR protein, which is further degraded by proteases. The G542X is a nonsense mutation found in the exon 12 and associated with …

Curricular Adaptations By Paraprofessionals During Their Computer Lab Instruction Using Block-Based Coding, Prasina Parameswaran

Student Research Symposium

Classroom adaptation is one of the key elements in filling the gap between understanding and application of knowledge in the real world. Our work emphasizes upon the classroom adaptations in the Math classroom. We are studying 5th grade students and computer science (CS) paraprofessionals in the Western United States. Paraprofessionals are provided professional development (PD) to familiarize them with CS and Scratch. Scratch is a block based coding program which uses visual interface and is used for making animations, games, digital stories etc. As paraprofessionals are not certified teachers, this PD works towards helping them understand the Math content and …

Creating Calming Healthcare Environments, Abbey Oborn

Student Research Symposium

Going to a healthcare facility can make anyone feel stressed and anxious, so what can these facilities do in order to improve their sense of calmness and reduce anxiety in patients? The overall brand of healthcare facilities improves the sense of calmness and reduces anxiety in patients and staff members when these facilities consider and implement specific elements in the following categories: Interior Design, Exterior Design, Wayfinding Experience Design, Gathering Areas for Patients, Staff, and Families, Efficient Spatial Design, Universally Understood Infographics, Noise Reduction, Visual Privacy, Positive Distractions, Biophilia, Reduce Medical Smells. When healthcare facilities consider and implement these elements, …

Impacts Of Cftr Mutations On Pulmonary Development In Sheep, Kaden Bunch

Student Research Symposium

Due to various mutations, the loss of cystic fibrosis transmembrane conductance regulator (CFTR) function causes cystic fibrosis (CF), predisposing the lungs to chronic infection and inflammation. In young infants with CF, structural airway defects are increasingly recognized before the onset of significant lung disease, which suggests a developmental origin and a possible role in lung disease pathogenesis. The function of CFTR in lung development is unclear and developmental studies in humans with CF are not feasible. Young CF sheep show similar lung development and spontaneous postnatal lung disease similar to humans impacted by CF. We studied lung development in the …

Then And Now: The Evolution Of The Psychology Undergraduate Program At Utah State University, Abigail Hamblin, Amy Mackliet, River Mckinlay

Student Research Symposium

The history of Utah State University’s Psychology Department has significantly influenced the current activities and goals of the department, and this presentation will exemplify how that is so. Throughout the Psychology Department’s history, a common theme was focusing on research, teacher education programs, and instructing the individual undergraduate student to be more prepared for their life after graduation (USU Mission Statement, n.d.). This theme has continued on today through the department’s mission. For instance, the program strives to inspire scientific inquiry and critical thinking, which is done through various courses, including both undergraduate and graduate courses that focus on research …

Effect Of Partner Loss On Oxytocin Measures In The Social Brain Of Monogamous Coyotes, Blake Nielson

Student Research Symposium

Oxytocin is a neuropeptide that is important in social behavior and in the formation of pair bonds between mates. One study found that oxytocin receptor levels in monogamous female prairie voles were lower in animals which had been separated from their mate for some time. In order to further study oxytocin's importance in social bond formation and to test for any possible effects partner loss could have on oxytocin in the brain, I conducted a study on monogamous female coyote brain tissue. Four brain specimens were examined from paired female coyotes, while three brain specimens were examined from widowed female …

Efficacy Of Excipients Against Cytomegalovirus, Alisa Dabb, Dallin Fairbourn

Student Research Symposium

Cytomegalovirus (CMV) is a herpesvirus that affects most of the world’s population. Although most people infected with CMV experience only mild symptoms, it can result in death for those who are immunocompromised. It is one of the leading causes of sensorineural hearing loss in infants. Currently, the most common treatment for CMV is ganciclovir (GCV), but GCV is highly cytotoxic. It has also been shown to cause birth defects in mice. Even though GCV is cytotoxic, GCV needs to be taken frequently for it to be effective. Recent studies in our lab have found using the excipients quercetin and poloxamer …

Effects Of Life-Extension Biotechnology On Global Society, David Suisse

Student Research Symposium

For much of human history, diseases and disorders ranging from tuberculosis and the flu to cancer and Alzheimer’s have appeared inevitable and unstoppable. Yet modern medicine offers remedies to many illnesses that used to be fatal and continues to make astounding steps against other disorders that experts now understand to be treatable. In the last 10 years, scientists have made remarkable progress regarding the causes of aging itself, and current trends in technological, medical, and genetic research indicate that groundbreaking lifespan-extending and vitality-extending biotechnologies will soon be developed and may be implemented within decades. Some experts suggest that “curing” aging …

Alpha-Fetoprotein (Afp) And Afp-L3 Is Most Useful In Detection Of Recurrence Of Hepatocellular Carcinoma In Patients After Tumor Ablation And With Low Afp Level, Madison Force, Grace Park, Divya Chalikonda, Christopher G. Roth, Micah Cohen, Dina Halegoua-De Marzio, Hie-Won Hann

Department of Medicine Faculty Papers

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and is a leading cause of mortality worldwide. While there are many risk factors for HCC including alcohol, obesity, and diabetes, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection still account for the majority of HCC worldwide. Globally, HBV is the leading risk factor for HCC. Patients with chronic hepatitis B (CHB) and advanced liver disease are at high risk for HCC. Screening for HCC is done routinely with ultrasound with or without alpha-fetoprotein (AFP) at six-month intervals. The combination of ultrasound and AFP has been …

Oregon State Rank Assessment For Owyhee Clover (Trifolium Owyheense), Lindsey K. Wise

Institute for Natural Resources Publications

Oregon state conservation status assessment for Owyhee clover (Trifoilum owyheense) using NatureServe methodology, 2022.

Targeting Fatty Acid Β-Oxidation Impairs Monocyte Differentiation And Prolongs Heart Allograft Survival, Yuehui Zhu, Hao Dun, Li Ye, Yuriko Terada, Leah P. Shriver, Gary J. Patti, Daniel Kreisel, Andrew E. Gelman, Brian W. Wong

Open Access Publications

Monocytes play an important role in the regulation of alloimmune responses after heart transplantation (HTx). Recent studies have highlighted the importance of immunometabolism in the differentiation and function of myeloid cells. While the importance of glucose metabolism in monocyte differentiation and function has been reported, a role for fatty acid β-oxidation (FAO) has not been explored. Heterotopic HTx was performed using hearts from BALB/c donor mice implanted into C57BL/6 recipient mice and treated with etomoxir (eto), an irreversible inhibitor of carnitine palmitoyltransferase 1 (Cpt1), a rate-limiting step of FAO, or vehicle control. FAO inhibition prolonged HTx survival, reduced early T …

Effects Of Per- And Polyfluorinated Alkyl Substances (Pfas) On Amphibian Body Condition: Is Altered Lipid Metabolism The Driver?, Anna Bushong, Tyler Hoskins, Maria Sepulveda

FNR Annual Poster Competition

Per- and polyfluoroalkyl substances (PFAS) are globally distributed contaminants with widespread use in commercial and consumer products. Due to their aquatic and terrestrial life cycle, amphibians are particularly susceptible to sublethal effects of PFAS exposure and are regularly exposed in the field. In amphibians experimentally-exposed to PFAS, body condition, measured using the scaled mass index (SMI), is often affected. In vitro and rodent studies have demonstrated that PFAS can alter lipid metabolism, but whether changes in fat stores can explain previously observed PFAS-mediated changes in amphibian SMI remains unexplored. Because lipids are a primary fuel for anuran metamorphosis and reproduction, …

Association Of Age-Related Macular Degeneration With Prior Hyperthyroidism And Hypothyroidism: A Case-Control Study, Shih-Han Hung, Sudha Xirasagar Mbbs., Ph.D., Tung-Mei Tammy Kuang, Wei-Wen Chang, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Publications

Prior studies suggest a possible association between thyroid disease and the subsequent development of age-related macular degeneration (AMD), although it remains inconclusive. This study aimed to evaluate the association of AMD with prior hyper-/hypothyroidism based on nationwide population-based data. We retrieved records of the study patients from the National Health Insurance Research Database, 7522 patients with a first-time diagnosis of AMD and 7522 propensity score-matched controls. Multiple logistic regression analyses were performed to explore the association of neovascular AMD with previously diagnosed hyperthyroidism or hypothyroidism. The Chi-square test shows that there was a statistically significant difference in the prevalence of …

Pre-Growth Environmental Stresses Affect Foodborne Pathogens Response To Subsequent Chemical Treatments, Amandeep Singh, Veerachandra K. Yemmireddy

School of Earth, Environmental, & Marine Sciences Faculty Publications

Foodborne pathogens such as Salmonella, E. coli O157:H7, and Listeria monocytogenes are known to survive under different environmental stresses with an effect on their physiological properties. The purpose of this study was to determine the effect of different environmental stresses on the foodborne pathogens response to subsequent chemical treatments. Three types of pathogens Salmonella, E. coli O157:H7, and Listeria monocytogenes were subjected to different environmental stresses: (i) Desiccation (ii) high salt (iii) low pH, and (iv) temperatures (14, 23, and 37 °C) during their growth. The cells harvested at their early stationary growth phase were subsequently subjected to chlorine (100 …

Association Of Age-Related Macular Degeneration With Prior Hyperthyroidism And Hypothyroidism: A Case-Control Study, Shih-Han Hung, Sudha Xirasagar, Tung-Mei Tammy Kuang, Wei-Wen Chang, Yen-Fu Cheng, Nai-Wen Kuo, Herng-Ching Lin

Faculty Publications

Prior studies suggest a possible association between thyroid disease and the subsequent development of age-related macular degeneration (AMD), although it remains inconclusive. This study aimed to evaluate the association of AMD with prior hyper-/hypothyroidism based on nationwide population-based data. We retrieved records of the study patients from the National Health Insurance Research Database, 7522 patients with a first-time diagnosis of AMD and 7522 propensity score-matched controls. Multiple logistic regression analyses were performed to explore the association of neovascular AMD with previously diagnosed hyperthyroidism or hypothyroidism. The Chi-square test shows that there was a statistically significant difference in the prevalence of …

Meta-Analysis Of Genome-Wide Association Studies Identifies Ancestry-Specific Associations Underlying Circulating Total Tau Levels, Chloé Sarnowski, Mohsen Ghanbari, Joshua C Bis, Mark Logue, Myriam Fornage, Aniket Mishra, Shahzad Ahmad, Alexa S Beiser, Eric Boerwinkle, Vincent Bouteloup, Vincent Chouraki, L Adrienne Cupples, Vincent Damotte, Charles S Decarli, Anita L Destefano, Luc Djoussé, Alison E Fohner, Carol E Franz, Tiffany F Kautz, Jean-Charles Lambert, Michael J Lyons, Thomas H Mosley, Kenneth J Mukamal, Matthew P Pase, Eliana C Portilla Fernandez, Robert A Rissman, Claudia L Satizabal, Ramachandran S Vasan, Amber Yaqub, Stephanie Debette, Carole Dufouil, Lenore J Launer, William S Kremen, William T Longstreth, M Arfan Ikram, Sudha Seshadri

Faculty, Staff and Student Publications

Circulating total-tau levels can be used as an endophenotype to identify genetic risk factors for tauopathies and related neurological disorders. Here, we confirmed and better characterized the association of the 17q21 MAPT locus with circulating total-tau in 14,721 European participants and identified three novel loci in 953 African American participants (4q31, 5p13, and 6q25) at P < 5 × 10-8. We additionally detected 14 novel loci at P < 5 × 10-7, specific to either Europeans or African Americans. Using whole-exome sequence data in 2,279 European participants, we identified ten genes associated with circulating total-tau when aggregating rare variants. Our genetic study sheds light on genes reported to be associated with neurological diseases including stroke, Alzheimer's, and Parkinson's (F5, MAP1B, and BCAS3), with Alzheimer's pathological hallmarks (ADAMTS12, IL15, and FHIT), or with an important function in the brain (PARD3, ELFN2, UBASH3B, SLIT3, and NSD3), and suggests that the genetic architecture of circulating total-tau may differ according to ancestry.