Digital Commons Network^™

Slc7a8 Is Essential For Metabolic Fitness And Function Of Th2 Cells, Santosh K Panda, Do-Hyun Kim, Pritesh Desai, Shitong Wu, Patrick Fernandes Rodrigues, Raki Sudan, Yizhou Liu, Haerin Jung, Intelly Lee, Susan Gilfillan, Marina Cella, Steven J Van Dyken, Marco Colonna

2020-Current year OA Pubs

Amino acids are essential for the activation and function of CD4 T helper (Th) cells, which differentiate into Th1, Th2, Th17, and Treg subsets to coordinate immune responses. While specific amino acid transporters have been identified for Th1, Th17, and Tregs, a transporter regulating Th2 cells remains unknown. This study identifies SLC7A8 as a Th2-specific amino acid transporter in the Th compartment. We found that Slc7a8 expression is upregulated in Th2 cells compared with other T helper subsets, and Slc7a8 deficiency impairs Th2 cell proliferation and cytokine production. Furthermore, SLC7A8 was found to be crucial for an effective type 2 …

Amyloidosis Of Bridging Veins Is A Pathologic Feature Of Alzheimer's Disease, Leon C D Smyth, Daan Verhaege, Elio Standen-Bloom, Yue Wu, Steffen E Storck, Pavle Boskovic, Benjamin A Plog, Tornike Mamuladze, Jose A Mazzitelli, Zhuoying Wang, Daniel D Lee, Gwendalyn J Randolph, Katherine E Schwetye, Song Hu, Jonathan Kipnis, Et Al.

2020-Current year OA Pubs

Alzheimer's disease (AD) is characterized by the accumulation of extracellular aggregated amyloid beta, resulting from impaired waste clearance. We recently identified new cerebrospinal fluid (CSF) efflux structures termed arachnoid cuff exit (ACE) points and speculated that these may be impacted in AD, leading to impaired waste clearance function. Using 5XFAD mice, we found progressive amyloidosis of bridging veins at ACE points. Indeed, in 5XFAD mice, there is impaired CSF efflux to the dura mater, impaired CSF flow along bridging veins, and impaired blood flow through bridging veins. These observations suggest that ACE point amyloidosis plays a role in waste clearance …

A Fijian Barkcloth In The May Weber Ethnographic Study Collection, Delaney M. Bahns

Department of Anthropology

This report examines an object in the May Weber Ethnographic Study Collection, a barkcloth attributed to the Fiji Islands. The report discusses the attribution, as well as the distinction of the object as Fijian masi kesa. The report discusses the techniques used to make bark cloth, as well as past studies of bark cloth in the Pacific Islands. It also examines the gendered context of masi, as well as the issue of cultural intellectual property in recent uses of masi motifs for commercial purposes.

The Usability And Influence Of Comprehensive Sports Nutrition Handouts For Adolescent-Aged Female Athletes, Chloe Brassie

Theses

Objective: This study aimed to examine the usability and influence of comprehensive sports nutrition handouts for adolescent-aged female athletes. Design: Cross-sectional online survey incorporating post retrospective-pre self-assessment Participants: Adolescent female athletes between 13 and 17 years of age Methods: Participants received a series of digital nutrition handouts every day for seven days and completed an online survey. Variables: Age, sport, engagement, knowledge, behavior, features of interest, and experience with nutrition education. Analysis: Quantitative data were analyzed with descriptive statistics and qualitative data were examined using thematic analysis. A Wilcoxon signed-rank test assessed the change in responses for both knowledge and …

Osimertinib Activates A Tgf-Β2-Dependent Secretory Program That Drives Lung Adenocarcinoma Progression, Madhurima Ghosh, Chao Wu, Abhishek Kumar, Monique Nilsson, John V. Heymach, Weina Zhao, Jiang Yu, Xin Liu, Na Ding, Shike Wang, Guan Yu Xiao, Angelo Chen, Kate Grimley, William K. Russell, Chad J. Creighton, Xiaochao Tan, Jonathan M. Kurie

Markey Cancer Center Faculty Publications

EGFR-mutant lung adenocarcinomas (LUADs) that are vulnerable to the EGFR antagonist osimertinib (Osi) eventually relapse, owing in part to the emergence of drug-tolerant persister (DTP) cells that arise through epigenetic mechanisms. Intratumoral DTP cells can herald a worse clinical outcome, but the way in which DTP cells influence LUAD progression remains unclear. Osi-resistant (OR) cells exhibit typical DTP cell features, including a propensity to undergo senescence and epithelial-mesenchymal transition (EMT), which can activate heightened secretory states. Therefore, we postulated that OR cells influence LUAD progression through paracrine mechanisms. To test this hypothesis, we utilized congenic pairs of EGFR-mutant LUAD cell …

Green Rules, Fragmented Fields: Member-State Approaches To Sustainability In Eu Competition Law, Niccolò Galli, Armando Santoni

Yearbook of Antitrust and Regulatory Studies

This article provides a comparative, normative-evaluative examination of how sustainability is being incorporated into European competition law. Combining doctrinal legal analysis with economic reasoning, it clarifies competing definitions of sustainability, maps the contest between the consumer-welfare paradigm and sustainability proponents, and evaluates the legal and institutional implications of the Commission’s 2023 Horizontal Cooperation Guidelines. Drawing on national initiatives across Member States plus the UK, the study highlights contrasting instruments, from Austria’s statutory environmental exemption to the Dutch soft-law safe harbour and Greece’s experimental sustainability sandbox, and shows how these divergent approaches produce fragmentation and legal uncertainty for cross-border cooperative initiatives. …

Osimertinib Activates A Tgf-Β2-Dependent Secretory Program That Drives Lung Adenocarcinoma Progression, Madhurima Ghosh, Chao Wu, Abhishek Kumar, Monique Nilsson, John V Heymach, Weina Zhao, Jiang Yu, Xin Liu, Na Ding, Shike Wang, Guan-Yu Xiao, Angelo Chen, Kate Grimley, William K Russell, Chad J Creighton, Xiaochao Tan, Jonathan M Kurie

Faculty, Staff and Student Publications

EGFR-mutant lung adenocarcinomas (LUADs) that are vulnerable to the EGFR antagonist osimertinib (Osi) eventually relapse, owing in part to the emergence of drug-tolerant persister (DTP) cells that arise through epigenetic mechanisms. Intratumoral DTP cells can herald a worse clinical outcome, but the way in which DTP cells influence LUAD progression remains unclear. Osi-resistant (OR) cells exhibit typical DTP cell features, including a propensity to undergo senescence and epithelial-mesenchymal transition (EMT), which can activate heightened secretory states. Therefore, we postulated that OR cells influence LUAD progression through paracrine mechanisms. To test this hypothesis, we utilized congenic pairs of EGFR-mutant LUAD cell …

Chimes: February 2, 2026, Calvin University

Chimes

Provost Noah Toly to step down by Maya Oeverman

Michigan's Supreme Court to hear Joseph Kuilema v. Calvin University by Ashley Hamons

Student Senate welcomes new advisors, sets vision for Spring Semester by Ellery Johnson

Students face snowy start to spring semester by Ian Tjoelker

New year, new me: Accomplishing your goals and resolutions by McKenna Wilkinson

Men's volleyball starts strong under first-year head coach Aaron Sagraves by Zach Kern & Hendrik Beelen

Mapping The Causal Chain From Genetic Risk Variants To Lipid Dysmetabolism In Parkinson’S Disease, Ruth B De-Paula, Jonggeol Kim, Herve Rhinn, Hiba Saade, Fatima Chavez, Téah Segura, Maria Valeria Lozano, Michelle Etoundi, Karla Silos, Naomi Kass, Viktoriya Korchina, Harshavardhan Doddapaneni, Eric Venner, Joseph C Masdeu, Valory Pavlik, Melissa M Yu, Chi-Ying R Lin, Joseph Jankovic, Aron S Buchman, Donna Muzny, Richard A Gibbs, Sarah H Elsea, Asa Abeliovich, Peter Lansbury, Nora Vanegas-Arroyave, Chad A Shaw, Joshua M Shulman

Faculty, Staff and Students Publications

The molecular pathways linking genetic variants to Parkinson's disease (PD) onset and progression remain incompletely defined; however, risk alleles in multiple genes, including GBA1, strongly implicate lipid metabolism. To systematically identify causal biomarker signatures, we analyzed comprehensive metabolome profiles from blood plasma in 149 PD patients and 150 controls, along with complementary genetic, RNA-sequencing, and metabolic data from other available clinical and pathologic cohorts. Using colocalization and summary-data-based Mendelian randomization, we tested whether expression and metabolic quantitative trait loci mediate the association between implicated genetic variants and PD risk. We further integrated differential metabolomics and proteomics from blood and brain …

From Classroom To Field: Rural Teachers’ Integration Of Science And The Outdoors, Steph N. Dean, Julianne A. Wenner

The Rural Educator

This study explored how rural educators in the US use outdoor environments to enhance science instruction, addressing the educational marginalization of rural students. Using rural cultural wealth as a theoretical framework, we investigated how rural teachers integrate local nature-based resources and students’ out-of-school experiences into science learning. We conducted interviews and observations with rural teachers, using reflexive thematic analysis as our qualitative approach. Three key themes emerged that highlight the ways our participants use the outdoor environment to teach science: (a) harness rural community partnerships, (b) engage students through relational teaching, and (c) design learning opportunities that honor students as …

A Case Against Mass Deportation: The Japanese American Internment Camps And Recent Treatment Of Korematsu, Isaac Bloch

UC Law Journal

The large-scale deportation of non-citizens has become a preeminent policy issue. Unfortunately, executive curtailment of immigrant communities’ liberty is not without historical parallels. During World War II, federal officials sent individuals of Japanese descent to internment camps through a series of executive orders and military proclamations. Although attorneys in the Department of Justice believed aspects of these actions were unconstitutional at the time, the administration prevailed at the nation’s highest court. Can recognition of this past wrong aid challenges to contemporary immigration enforcement regimes? How do our courts formally account for the most egregious jurisprudential errors of the past, and …

Rick Marcus, Andrew Bradt

UC Law Journal

No abstract provided.

February 2026, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Nasx 105.Vh1: Introduction To Native American Studies / Hamilton, Erin D. Rosenkrance

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Psyx 100s.04: Introduction To Psychology, Patrick O. Hanni

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Ahrc 231.02: Respiratory Critical Care, Paul J. Crockford

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Ahrc 250.02: Respiratory Care Laboratory Ii, Paul J. Crockford

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Csci 150.50: Introduction To Computer Science, Jeffrey J. Arends

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Cstn 191.01: Introduction To Woodworking, Rio A. Sabella

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Cstn 206.01: Advanced Carpentry Lab, Buck Priest

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Cula 161.02: Meats And Vegetables, Wilbert P. Gahagan, Sebastian E. Robataille

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Biob 375.01: General Genetics, Sarah J. Certel

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Bioh 370.01: Human Anatomy And Physiology For Health Professions Ii, Bret W. Tobalske

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Biom 250n.01: Microbiology For Health Sciences, Amanda L. Andreas

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Biom 415.01: Microbial Diversity, Ecology, And Evolution, Matthew Church

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Cstn 205.01: Advanced Carpentry, Buck Priest

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Bard Observer Vol. 24 No.4 (February 2026), Bard College

Bard Observer, 2020 - 2029

No abstract provided.

Planting Forest Trees And Shrubs In Indiana, Ron Rathfon, Douglass Jacobs, Lenny Farlee

Purdue Extension Numbered Publications

Discover the essential guide for anyone looking to plant forest trees or shrubs in Indiana. Whether you're a first‑time landowner or an experienced conservationist, Planting Forest Trees and Shrubs in Indiana walks you through the 10 proven steps for establishing healthy, resilient plantings that thrive for generations. From choosing the right species to preparing your site, planting with confidence and ensuring long‑term success, this publication distills expert forestry knowledge into clear, practical advice.

Psyx 100s.52: Introduction To Psychology, Brittany King

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Biob 425.01: Advanced Cellular & Molecular Biology, Jesse C. Hay

University of Montana Course Syllabi, 2026-2030

No abstract provided.