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Modeling The Impact Of Newcastle Disease Virus Vaccinations On Chicken Production Systems In Northeastern Madagascar, Akshaya Annapragada, Cortni Borgerson, Sarah Iams, M. Ando Ravelomanantsoa, Graham C. Crawford, Marika Helin, Evelin Jean Gasta Anjaranirina, Hervet J. Randriamady, Christopher D. Golden

Department of Anthropology Faculty Scholarship and Creative Works

Chickens are a key source of nutrition for rural Malagasy communities. Due to high endemic rates of Newcastle disease, it remains challenging to raise sustainable chicken flocks as a consistent food source. Here, we explore the impact of triannual Newcastle disease virus (NDV) vaccine interventions on the growth and herd immunity acquisition of Malagasy chicken flocks. Between 2011 and 2018 we collected longitudinal data to assess the population dynamics of chicken populations in remote Malagasy communities. In 2016, we launched a pilot campaign for vaccination in six rural communities to determine the impacts on chicken survivorship and productivity. We used …

Emergence Of Human Immunoprofiling In Health And Disease, Bhagirath Singh

Microbiology & Immunology Publications

The human immune system is critical for maintaining health and providing protection from infectious diseases and cancer. Major advances in our understanding of the immune system have largely emerged from studies using animal models such as mice. However, this mouse-centric research has also limited our ability to comprehend the human immune system and how it changes with age and disease state. The fact that we have yet to define what constitutes a normal human immune system has hampered our ability to diagnose, treat, and prevent many human diseases. Immunoprofiling that measures the frequency of human immune cells based upon their …

State Requirements For Mandatory Vaccine Education Prior To Exemption, Chelsea Lynn Schult

Theses and Dissertations

Background: To prevent the spread of Vaccine Preventable Diseases (VPD’s), school-aged children in the United States are required to receive vaccinations. In certain states, parents have the option to exempt their child from becoming vaccinated due to medical, religious, or personal reasons. The purpose of this research was to identify which states require mandatory vaccination education prior to granting vaccine exemptions and to identify the various types of required vaccination education.Methods: Immunization program managers from states requiring parents seeking exemptions to receive mandatory vaccination education were asked a series of open-ended questions. The interviews were conducted via telephone. The education-related …

Mathematical Modeling Of Vaccinations: Modified Sir Model, Vaccination Effects, And Herd Immunity, Tina Huyen Luong

University Honors Theses

Despite the clear effects and benefits of vaccinations on a population, there are many individuals that choose to not vaccinate for non-medical reasons, giving rise to anti-vaccination movements and vaccine hesitancy. This paper introduces the different types of vaccines and the effects of vaccines in the body and provides an examination of a case study of the 2019 Pacific Northwest measles outbreak. The outbreak is modeled using a proposed modified SIR model and solved using the Fourth-Order Runge-Kutta method. The results suggest that around day 20, almost the entire population becomes infected with the vaccine-resistant strain, which outcompetes the wild-type …

Aluminum Adjuvants In Vaccines: Movement Towards Understanding Their Role And Mechanism Of Action, Thad Rehmert

BIO 410 Spring 2019 Research Papers

Aluminum adjuvants have been used in vaccines for over 80 years in order to increase the immune response in vaccinated individuals. While the addition of aluminum adjuvants has been extremely successful, the success powered the adjuvants to be used in numerous vaccines without a proper understanding of their mechanisms of action. Advancements in medical understanding over the last 4-5 decades has resulted in researchers understanding the harsh reality of aluminum toxicity. Due to this, researchers have begun to delve into the actions and mechanisms of these adjuvants in an effort to enhance understanding of how they work. This review will …

Chronic Wasting Disease Management Through Culling, Baiting, And Vaccination Methods, Jake Brockman

BIO 410 Spring 2019 Research Papers

Chronic wasting disease (CWD) is a lethal, progressive, and highly infectious disease that targets cervid populations through transmission by prions. There are currently no treatment options that are highly effective at stopping CWD, but the scientific community has great knowledge on CWD’s transmission and effects. In this literature review: culling, baiting and vaccination techniques are analyzed and compared to view which method could potentially work the best to control CWD. Long term effects of CWD could result in cervid population extermination and enormous economic losses for areas that are inhabited by cervids.

Human Papillomavirus Vaccine Program, Magdalena Ruiz

Doctoral Projects

Pediatric primary care focuses on maintaining patients’ health, preventing diseases, and assessing children’s developmental milestones. Vaccine administration and disease prevention are key components of a well-child exam for pediatric patients; however, vaccine refusal is an important complication of pediatric patient care. Of particular interest to this researcher is the HPV vaccine which was approved by the Federal Drug Administration and is currently recommended by the Centers for Disease Control and Prevention (2016) for both males and females, beginning at 11 or 12 years of age through age 26 years. The HPV vaccine protects against diseases and cancers caused by the …

Evaluation Of A Community Health Worker Intervention On Rates Of Measles, Mumps And Rubella Immunization In A Somali Population In Lexington, Nebraska, Melanie Menning

Capstone Experience: Master of Public Health

Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine.

There have been increasing outbreaks of measles to waning immunization. This study sought to evaluate rates of Measles, Mumps and Rubella (MMR) immunization in a Somali population living in Lexington, Nebraska and to evaluate a community health worker intervention to improve immunization rates. NESIIS data for Lexington Regional Health Center (LRHC) was queried to assess MMR trends for all clinic patients between 15 and 72 months both before and after implementation of the …

Comparative Study On Knowledge, Attitude, And Vaccination Intent Between Standard Care And Educational Intervention Of Hpv And The Hpv Vaccine Among Somali Population In Columbus, Ladan Barnes

Undergraduate Distinction Papers

Somali mothers have a negative cultural association with Human Papillomavirus (HPV) vaccination and youth are failing to complete the HPV vaccination series. Somali immigrants and refugees are the fastest growing groups in the U.S. Somalia also has one of the highest cervical cancer mortality rates and U.S. Somali populations have lower screening completion rates. To prevent cross over disparities, efficient intervention strategies for the Somali population need to be explored. This research aims to identify strategies to combat HPV health disparities in the Somali community while promoting agency to make self-empowered health decisions. It is hypothesized that participants who undergo …

Vaccination Investigation, Lindsey Smith

Children's Book and Media Review

No abstract provided.

Beyond The Ethical Boundaries Of Solidarity: Increasing Vaccination Rates Through Mandatory Education To Solidarity, Nili Karako- Eyal Dr.

Texas A&M Law Review

Mandatory vaccination laws require children to be vaccinated against certain communicable diseases to attend school. These laws also provide exemptions to school vaccination requirements.1 All states exempt children from vaccination requirements for medical reasons, and most states also provide an exemption for religious and/or other personal reasons.2 Seven states include an educational component in their religious or philosophical exemption process, requiring that parents receive information regarding the benefits of vaccination and the risks of not being vaccinated.3 Of these seven states, five require that information regarding the social benefits of vaccination will be provided to parents.4

This type of legislation …

Knowledge And Awareness Of Human Papillomavirus Among College Students In South Carolina, Salima Kasymova, Sayward Harrison, Caroline Pascal

Faculty Publications

Despite the existence of a safe and effective vaccine, human papillomavirus (HPV) remains prevalent in the United States, with late adolescence and early adulthood being periods of increased risk. Thus, targeting college-aged individuals for HPV prevention and vaccination promotion is critical—particularly in regions such as the Deep South where vaccination rates remain low. This study sought to examine awareness and knowledge of HPV as well as experiences and attitudes regarding HPV vaccination among college students in the Deep South. Specifically, we completed a cross-sectional survey of 256 undergraduate students from a large public university in South Carolina. Although a majority …

Biotechnological Application In Aquaculture And Its Sustainability Constraints, Olaganathan Rajee, Tang Kar Mun Alicia

Publications

The valuable nutritional and biochemical properties have made fisheries products one of the most vital high-quality protein sources for human consumption. Aquaculture has become the great alternative to substitute wild catches when the yield from fishing are no longer sufficient to sustain the massive food demand of the human population which is constantly burgeoning. However, aquaculture requires multidisciplinary approaches with holistic and environmental-friendly management measures to ensure its long term success and sustainability. Biotechnological applications have enhanced the effectiveness and cost-efficiencies of aquaculture by augmenting the productivity of aquaculture to meet global needs. Despite the benefits, the biotechnological application in …

Analyzing Public View Towards Vaccination Using Twitter, Mahajan Rutuja

Browse all Theses and Dissertations

Educating people about vaccination tends to target vaccine acceptance and reduction of hesitancy. Social media provides a promising platform for studying public perception regarding vaccination. In this study, we harvested tweets over a year related to vaccines from February 2018 to January 2019. We present a two-stage classifier to: (1) classify the tweets as relevant or non-relevant and (2) categorize them in terms of pro-vaccination, anti-vaccination, or neutral outlook. We found that the classifier was able to distinguish clearly between anti-vaccination and pro-vaccination tweets, but also misclassified many of these as neutral. Using Latent Dirichlet Allocation, we found that two …

Interventions To Increase Completion Of Hepatitis B Vaccination In People Who Inject Drugs: A Systematic Review And Meta-Analysis, Stacy Tressler, Ruchi Bhandari

Faculty & Staff Scholarship

Abstract

Increases in opioid misuse and injection drug use have resulted in a rise in acute cases of hepatitis B. We conducted a systematic review and meta-analysis of randomized studies to determine the effect (pooled odds ratio) of interventions to increase hepatitis B vaccination completion in people who inject drugs (PWID). Odds ratios from the included studies were combined to create a pooled odds ratio (OR) using the Inverse Heterogeneity Model. Eleven studies met the eligibility criterion of having a randomized intervention to increase hepatitis B virus vaccination completion among PWID. The odds of vaccine completion in the intervention group …

Examining The Effect Of Socioeconomic Factors On Kindergarten Vaccination Rates In Kentucky Counties, Abigail Wiggins

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The purpose of this project is to examine the relationship between county-level socioeconomic factors and immunization compliance rates among kindergarten age children. All 120 counties in Kentucky were included in this evaluation.

County-level percent of uninsured children, number of children in poverty, children receiving free lunch (percentage), unemployment rate (percentage), and high school graduation rate were assessed. Socioeconomic data for each county were compared to county-level kindergarten vaccination rates. All vaccination data were obtained from the 2015-2016 Kentucky Annual School Immunization Survey Report. All socioeconomic county data were obtained from the 2016 County Health Rankings data, published by the Robert …

Benefits Of Hpv Vaccination In Adolescent Males, Budd Theriot

Physician Assistant Scholarly Project Posters

HPV is the most common sexually transmitted infection in the United States, affecting approximately 75-80% of young adults at some point in their lives, and it is also known to be directly related to several forms of cancer including cervical, vaginal, penile, anal, oral, and oropharyngeal cancer. Vaccination against several high-risk strains of HPV first became available in the U.S. in June of 2006 and has been proven to be effective in creating antibodies against several strains of high-risk HPV, potentially decreasing and preventing more than 30,000 new cases of HPV related cancers each year. Despite this fact, HPV vaccination …

Developing Product Label Information To Support Evidence-Informed Use Of Vaccines In Pregnancy, Terra A. Manca, Janice E. Graham, Ève Dubé, Melissa Kervin, Eliana Castillo, Natasha S. Crowcroft, Deshayne B. Fell, Michael Hadskis, Jaelene M. Mannerfeldt, Devon Greyson, Noni E. Macdonald, Karina A. Top, On Behalf Of The Canadian Vaccine Product Monograph Working Group

Articles, Book Chapters, & Popular Press

Background: Product labelling information describing the use of vaccines in pregnancy continues to contain cautionary language even after clinical and epidemiological evidence of safety becomes available. This language raises safety concerns among healthcare providers who may hesitate to recommend vaccines during pregnancy.

Purpose: To develop clear evidence-based language about vaccine safety and effectiveness in pregnancy for inclusion in vaccine product labels.

Methods: We conducted a three-stage consensus-methods project with stakeholders, including: healthcare providers, vaccine regulators, industry representatives, and experts in public health, communication, law, ethics, and social sciences. Using qualitative and quantitative methods, we held a nominal group technique (NGT) …

Barriers To Vaccination Service Delivery Within General Practice: Opportunity To Make A Sustainable Difference In Aboriginal Child Health?, Rebecca Carman, Lesley Andrew, Amanda Devine, Jacques Oosthuizen

Research outputs 2014 to 2021

Objective: To identify behavioural barriers of service provision within general practice that may be impacting the vaccination coverage rates of Aboriginal children in Perth, Western Australia (WA). Methods: A purposive developed survey was distributed to 316 general practices across Perth and three key informant interviews were conducted using a mixed-methods approach. Results: Of the surveyed participants (n=101), 67.4% were unaware of the low vaccination coverage in Aboriginal children; 64.8% had not received cultural sensitivity training in their workplace and 46.8% reported having inadequate time to follow up overdue child vaccinations. Opportunistic vaccination was not routinely performed by 30.8% of participants. …

'Links2healthierbubs' Cohort Study: Protocol For A Record Linkage Study On The Safety, Uptake And Effectiveness Of Influenza And Pertussis Vaccines Among Pregnant Australian Women, Mohinder Sarna, Ross M. Andrews, Hannah C. Moore, Michael J. Binks, Lisa Mchugh, Gavin F. Pereira, Christopher C. Blyth, Paul Van Buynder, Karin Lust, Paul Effler, Stephen B. Lambert, Saad B. Omer, Donna Mak, Thomas Snelling, Heather A. D'Antoine, Peter Mcintyre, Nicholas De Klerk, Damien Foo, Annette K. Regan

Medical Papers and Journal Articles

Introduction: Pregnant women and infants are at risk of severe influenza and pertussis infection. Inactivated influenza vaccine (IIV) and diphtheria-tetanus-acellular pertussis vaccine (dTpa) are recommended during pregnancy to protect both mothers and infants. In Australia, uptake is not routinely monitored but coverage appears sub-optimal. Evidence on the safety of combined antenatal IIV and dTpa is fragmented or deficient, and there remain knowledge gaps of population-level vaccine effectiveness. We aim to establish a large, population-based, multi-jurisdictional cohort of mother-infant pairs to measure the uptake, safety and effectiveness of antenatal IIV and dTpa vaccines in three Australian jurisdictions. This is a first …

A Modern Plague: U.S. Racial And Ethnic Vaccination Disparities During The 2009 H1n1 Influenza Pandemic, Andrew E. Burger

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

On June 11, 2009 the World Health Organization announced that a novel strain of H1N1 influenza was being classified a Phase 6 pandemic, the highest level of alarm indicating that the disease was present worldwide and its spread was inevitable. While seasonal influenza epidemics occur annually, the 2009 H1N1 strain was the first novel pandemic influenza since the 1968 Hong Kong flu. The 2009 H1N1 pandemic provides a case study of how the U.S. population responded to an emergent and potentially lethal infectious disease. The richness and variety of public health data presents an opportunity to examine predictors of vaccination …

Coverage And Determinants Of Second-Dose Measles Vaccination Among Under-Five Children In Aceh Jaya District, Aceh Province, Indonesia, Rizka Maulida, Lhuri Dwianti Rahmartani, Lila K. Hairani, Tri Yunis Miko Wahyono

Jurnal Epidemiologi Kesehatan Indonesia

Indonesia is aiming for measles elimination status by 2020. However, high number of measles cases are still prevalent and there are still coverage differences among provinces. Measles immunization coverage also varies among surveys and routine coverage report. With the addition of second dose measles vaccination (MCV2), measles infections in the country is expected to decrease. However, MCV2 coverage has been low after 2 years of implementation. Aceh Province was chosen for this study because its low coverage. This study aimed to measure the coverage and investigate the determinants of MCV2 in Aceh Jaya, Aceh Province. Dataset from “Assessment of the …

Human Papillomavirus: The Influence Of Prevention And Vaccination, Lacey N. Russell

Kentucky Journal of Undergraduate Scholarship

Human Papillomavirus infections (HPV) are the most common sexually transmitted diseases in the United States. Of cancers in parts of the body where HPV is often discovered about 80% originated from an HPV infection. Despite this knowledge and the effectiveness of the HPV vaccine, vaccination by both genders in Kentucky and on a national scale remains highly underutilized. As a result, preventable incidence and mortality rates from HPV-related illness are elevated. Health care delivery factors such as increased vaccination and preventative care, insurance coverage, and accessible rural health care are necessary for HPV prevention and promotion of holistic health. The …

Defending Wild Dogs: Population Dynamics And Disease In Endangered African Wild Dogs, Elizabeth Claire Arredondo

Graduate Theses and Dissertations

African wild dogs (Lycaon pictus) are endangered carnivores whose population is decreasing from habitat loss and fragmentation, interspecific competition, and disease. Survival rates are especially low in Kruger National Park (KNP), though it is unclear why. I estimated the abundance in KNP and survival rates over different time spans, six years and nine months, using public photographic survey data. In 2015, there were 298 (SE=12.1) individuals. Using a mark-recapture analysis in program R, I found that the survival rate between 2009-2015 was only 3.2%, and within the 9-month survey period (September 2014 – June 2015), monthly survival rates for the …

Cd8+ T-Cell Responses In Vaccination: Reconsidering Targets And Function In The Context Of Chronic Antigen Stimulation, Gabriela L. Cosma, Laurence Eisenlohr

Department of Microbiology and Immunology Faculty Papers

Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines. Thus far, CD8 T-cell vaccination strategies have had limited success therapeutically in contrast to those targeting antibody-based immunity. However, if the current challenges and gaps in the understanding of T-cell biology are overcome, the full potential of rational CD8 T-cell vaccine design might be realized. Here, we review recent progress in this direction, focusing on target selection and maintenance of function in the settings of chronic infections and cancers.

Influenza Vaccine Effectiveness In The Elderly, Sheryl Rudolf

Nursing Capstones

No abstract provided.

The Effect Of Race On Parents' Intent To Vaccinate Their Children Against Human Papillomavirus, Ariana L. Ruiz Aguilar

Honors Undergraduate Theses

Human papillomavirus (HPV) is a sexually transmitted disease that often presents as genital warts, but may also lead to cancers, including those of the vagina, penis, mouth and tonsils. Despite three vaccines being currently available to prevent HPV, the HPV vaccine retains a low national average vaccination rate when compared to the Tetanus-Diptheria- Pertussis (Tdap) vaccine. Considering the need for improvement it is important to identify factors that may be contributing to this low national immunization rate, one of them being parental race. The purpose of this literature review is to identify whether race affects parents' intent to vaccinate their …

Evaluating Parents' Decisions Regarding Recommended Childhood Vaccinations, Jennifer Kline

Walden Dissertations and Doctoral Studies

Vaccinations are among the greatest accomplishments of public health. However, many parents are choosing not to vaccinate. The purpose of this study was to explore the association between social media influence and parents' decisions to vaccinate their children. The health belief model indicates that individuals' likelihood of engaging in a health-related behavior is determined by their perceptions of susceptibility, severity, benefits, and barriers. The research questions addressed whether there is an association between parents' perception of their children's disease susceptibility and their decisions about vaccination, and whether there is an association between exposure to messaging from social media and parents' …

He Scenario Tree Epidemiological Model In Estimation Effects Of B. Melitensis Rev 1 Vaccination On Disease Prevalence, Sabina Seric Haracic, Nihad Fejzic, Ermin Saljic, Dzenita Hadzijunuzovic Alagic, Mo Salman

Turkish Journal of Veterinary & Animal Sciences

minant brucellosis. The stochastic scenario tree model was used to simulate vaccination and surveillance implementation during 8 years. Outputs were annual proportions of true positive, true negative, false positive, and false negative flocks. Vaccination coverage was described by the Pert distribution with average 70% and min and max 50% and 80%, respectively. Effects of risk factors (high prevalence-areas and transhumance) were considered. The model was separately simulated for three levels of initial average flock prevalence (2%, 5%, and 10%). In the following years, flock prevalence arising from the fitted distribution of the false negative flocks from the previous year increased …

Improving Hpv Vaccination Series Initiation Rates And Compliance Among Indigent Women In South Texas, Ages 19-26, Through Provider Recommendation And Additional Clinic Funding: A Quality Improvement Project, Lacey Cudd

Doctor of Nursing Practice

The purpose of this quality improvement project was to increase human papillomavirus vaccination series initiation rates among indigent women, ages 19-26, at a clinic in South Texas. The human papillomavirus is a sexually transmitted infection that has been associated with multiple types of cancers. Each year, approximately 6.2 million cases of the human papillomavirus infection are diagnosed; as many as 75% of all new infections occur among females 18-26 years of age. The human papillomavirus vaccination has a high efficacy in regards to cancer prevention, preventing as many as 76% of cancers with only one dose. The project included educating …